Timo Sorsa

Publications
Public outreach and news

Articles

Article: ACTA ODONTOLOGICA SCANDINAVICA. 2025;84:418-425
Oral rehabilitation with dental implants in patients with tooth agenesis: a retrospective study in Helsinki University Hospital, Helsinki, Finland
Mikkola M; Kiukkonen A; Avellan N-L; Stoor P; Mattila V; Furuholm JO; Sorsa T; Nylund K
Article: JOURNAL OF PERIODONTOLOGY. 2025;96(8):835-847
Salivary advanced glycated end products, their receptors, and aMMP-8 in periodontitis patients with varying glycemic levels: A cross-sectional study
Thomas JT; Joseph B; Varghese S; Vijayakumari BK; Sorsa T; Mauramo M; Anil S; Waltimo T
Article: EUROPEAN JOURNAL OF DENTISTRY. 2025
Diagnostic Potential of aMMP-8 PoCT in Oral Fluids: Insights from Periodontitis and Metabolic Syndrome Interplay
Thomas JT; Joseph B; Sorsa T; Anil S; Waltimo T
Article: SCIENTIFIC REPORTS. 2025;15(1):24719
The prognostic significance of MMP-8 tissue Immunoexpression in pancreatic ductal adenocarcinoma after neoadjuvant therapy
Kesti E; Eurola A; Kaasinen M; Mustonen H; Hagstroem J; Sorsa T; Ristimaeki A; Seppaenen H; Haglund C; Sund M
Article: ORAL DISEASES. 2025;31(7):2084-2090
Effect of Oral Inflammatory Burden on Size and Stage of Oral Tongue Cancer
Saraneva O; Furuholm J; Hagstrom J; Sorsa T; Rita V; Tervahartiala T; Valimaa H; Ruokonen H
Article: DIAGNOSTICS. 2025;15(11):1411
Determination of the Stage of Periodontitis with 20 ng/mL Cut-Off aMMP-8 Mouth Rinse Test and Polynomial Functions in a Mobile Application
Penttala M; Sorsa T; Thomas JT; Grigoriadis A; Sakellari D; Sahni V; Gupta S; Parnanen P; Patila T; Raisanen IT
Article: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH. 2025;11(3):e70146
Peri-Implant Diseases: Enhanced Antibacterial Photodynamic Therapy
Lahteenmaki H; Patila T; Raisanen IT; Kalliala R; Sorsa T
Article: EUROPEAN JOURNAL OF DENTISTRY. 2025;19(02):305-314
Prediabetes Associates with Matrix Metalloproteinase-8 Activation and Contributes to the Rapid Destruction of Periodontal Tissues
Umeizudike KA; Aji NRAS; Niskanen K; Rantala I; Sakellari D; Grigoriadis A; Patila T; Gupta S; Sorsa T; Raisanen IT
Article: BIOMEDICINES. 2025;13(4):969
Effects of Non-Surgical Periodontal Therapy on Glycemic Control in Prediabetes and Diabetes Patients with Stage II-IV Periodontitis as Monitored by Active-Matrix Metalloproteinase-8 Levels
Umeizudike KA; Nwhator SO; Olaoye OI; Ogundana AC; Raisanen IT; Fasanmade OA; Ogundana O; Ajie O; Sorsa T
Article: ORAL DISEASES. 2025;31(4):1333-1341
Active-Matrix Metalloproteinase-8, Myeloperoxidase in Relation With Periodontics, Preterm Birth
Alan M; Sorsa T; Kantar PM; Raisanen IT; Gurlek O; Kanmaz B; Buduneli N
Article: DENTISTRY JOURNAL. 2025;13(3):127
Oral Medicine and Oral Clinical Chemistry Game Changers for Future Plaque Control and Maintenance: PerioSafe® aMMP-8 POCT, Lumoral® 2x PDT- and Lingora® Fermented Lingonberry Oral Rinse-Treatments
Aji NRAS; Sahni V; Penttala MT; Sakellari D; Grigoriadis A; Patila T; Parnanen P; Neefs D; Pfutzner A; Gupta S; Sorsa T; Raisanen IT
Article: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH. 2025;11(1):e70098
Radicular Cysts and Periapical Granulomas: Data Documentation for 696 Cases and Findings on Fibrosis, and Porphyromonas gingivalis and Fusobacterium nucleatum in These Lesions
Virkkunen S; Kaarela T; Laine M; Suominen A; Hagstrom J; Sorsa T; Haglund C
Article: DIAGNOSTICS. 2025;15(3):296
Periodontitis Home Screening with Mouth Rinse Cut-Off 20 Ng/mL aMMP-8 Test and Mobile Application
Penttala M; Sorsa T; Thomas JT; Grigoriadis A; Sakellari D; Gupta S; Parnanen P; Patila T; Raisanen IT
Article: SCIENTIFIC REPORTS. 2025;15(1):1440
Associations of serum and tissue TIMP1 with host response and survival in colorectal cancer
Kehusmaa A; Tuomisto A; Sirnio P; Karjalainen H; Kastinen M; Tapiainen VV; Aijala VK; Tervahartiala T; Sorsa T; Rintala J; Merilainen S; Saarnio J; Rautio T; Makinen MJ; Vayrynen JP
Article: ORAL DISEASES. 2025;31(1):225-238
Association between metabolic syndrome and salivary MMP-8, myeloperoxidase in periodontitis
Thomas JT; Joseph B; Varghese S; Thomas NG; Vijayakumary BK; Sorsa T; Anil S; Waltimo T
Article: CANCER CONTROL. 2025;32:10732748251351419
aMMP-8 and MMP-9: Potential Biomarkers for periodontitis Progression in Patients Receiving Radiotherapy for Head and Neck Carcinoma
Brandt E; Kaman W; Bikker F; Raisanen IT; Makitie A; Keskin M; Karacetin D; Hagstrom J; Rautava J; Sorsa T
Article: MEDICAL HYPOTHESES. 2024;193:111508
Stress and periodontal disease: Is the relationship bidirectional? If yes, is MMP-8 one of the connecting links?
Gupta S; Sareen S; Raisanen IT; Sorsa T; Brar PK
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(17):9421
aMMP-8 POCT vs. Other Potential Biomarkers in Chair-Side Diagnostics and Treatment Monitoring of Severe Periodontitis
Aji NRAS; Raisanen IT; Rathnayake N; Lundy FT; Mc Crudden MTC; Goyal L; Sorsa T; Gupta S
Article: NUTRIENTS. 2024;16(17):2896
Oral Anti-Inflammatory and Symbiotic Effects of Fermented Lingonberry Juice-Potential Benefits in IBD
Parnanen P; Raisanen IT; Sorsa T
Article: DIAGNOSTICS. 2024;14(17):1850
Prevention of Initial Periodontitis Is an Investment in the Future
Heikkinen AM; Raivisto T; Raisanen IT; Sorsa T
Article: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2024;144:107066
Long-term remission of candidiasis with fermented lingonberry mouth rinse in an adult patient with APECED
Parnanen P; Suojanen J; Laine M; Sorsa T; Ranki A
Article: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH. 2024;10(3):e883
Diagnostic value of aMMP-8 and azurocidin in peri-implant sulcular fluid as biomarkers of peri-implant health or disease
Xanthopoulou V; Raisanen IT; Sorsa T; Tortopidis D; Sakellari D
Article: DIAGNOSTICS. 2024;14(10):1011
In Vivo Regulation of Active Matrix Metalloproteinase-8 (aMMP-8) in Periodontitis: From Transcriptomics to Real-Time Online Diagnostics and Treatment Monitoring
Aji NRAS; Yucel-Lindberg T; Raeisaenen IT; Kuula H; Nieminen MT; Mc Crudden MTC; Listyarifah D; Lundmark A; Lundy FT; Gupta S; Sorsa T
Article: ORAL DISEASES. 2024;30(3):1660-1668
Salivary and serum levels of neutrophil proteases in periodontitis and rheumatoid arthritis
Yilmaz D; Niskanen K; Gonullu E; Tervahartiala T; Gursoy UK; Sorsa T
Article: BIO-PROTOCOL. 2024;14(6):e4958
Preparation and Purification of β-1,3-glucan-Linked Candida glabrata Cell Wall Proteases by Ion-Exchange Chromatography, Gel Filtration, and MDPF-Gelatin-Zymography Assay
Parnanen P; Sorsa T; Tervahartiala T; Nikula-Ijas P
Article: CURRENT EYE RESEARCH. 2024;49(3):288-294
Association between Oral Active-Matrix Metalloproteinase-8 Levels and Subretinal Fibrosis among Wet Age-Related Macular Degeneration Patients
Karesvuo M; Sorsa T; Tuuminen R
Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2024;51(3):365
MMP-8 and active MMP-8 (aMMP-8) are not synonymous in periodontal disease diagnostics
Sahni V; Raisanen IT; Sorsa T
Article: ORAL DISEASES. 2024;30(2):624-630
Oral active matrix metalloproteinase-8 immunotest may be less accurate in haemato-oncologic patients
Mauramo M; Uutela P; Sorsa T; Tervahartiala T; Bornstein MM; Waltimo T
Article: ODONTOLOGY. 2024;112(1):250-255
Applicability of an active matrix metalloproteinase-8 point-of-care test in an oral and maxillofacial surgery clinic: a pilot study
Kallio E; Puolakkainen T; Tervahartiala T; Snaell J; Marttila E; Sorsa T; Uittamo J
Article: JOURNAL OF APPLIED ORAL SCIENCE. 2024;32:e20240122
The effect of calcium hydroxide and double antibiotic paste on radiographic outcomes and periapical MMP-8 levels in regenerative endodontic procedures: a randomized clinical trial
Pekpinarli B; Kaval ME; Cogulu D; Ilhan B; Sorsa T; Tervahartiala T; Oncag O
Article: BIOMEDICINES. 2023;12(1):27
Induction of Collagenolytic MMP-8 and -9 Tissue Destruction Cascade in Mouth by Head and Neck Cancer Radiotherapy: A Cohort Study
Brandt E; Keskin M; Raisanen IT; Tervahartiala T; Makitie A; Harmankaya I; Karacetin D; Hagstrom J; Rautava J; Sorsa T
Article: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH. 2023;9(6):1021-1033
Correlations between different protein species of oral rinse MMP-8 and patient-related factors
Leppilahti JM; Tervahartiala T; Kautiainen H; Raisanen I; Ahonen M-M; Uitto V-J; Sorsa T; Mantyla P
Article: BIOMEDICINES. 2023;11(11):2885
Active Matrix Metalloproteinase-8 (aMMP-8) Versus Total MMP-8 in Periodontal and Peri-Implant Disease Point-of-Care Diagnostics
Raisanen IT; Aji NRAS; Sakellari D; Grigoriadis A; Rantala I; Patila T; Heikkila P; Gupta S; Sorsa T
Article: EUROPEAN JOURNAL OF DENTISTRY. 2023;17(04):1235-1240
Antimicrobial and Anti-Inflammatory Oral Effects of Fermented Lingonberry Juice-A One-Year Prospective Human Intervention Study
Parnanen P; Lomu S; Raisanen IT; Tervahartiala T; Sorsa T
Article: HISTOLOGY AND HISTOPATHOLOGY. 2023;38(8):889-892
Ex vivo detection of lipopolysaccharide immunopositivity in Rushton bodies
Virkkunen S; Willberg J; Haglund C; Sund M; Sorsa T; Hagstroem J
Article: DENTISTRY JOURNAL. 2023;11(7):170
Oral Potentially Malignant Disorders and Candida in Oral Tongue Squamous Cell Carcinoma Patients
Saraneva O; Furuholm J; Hagstrom J; Sorsa T; Rita V; Tervahartiala T; Valimaa H; Ruokonen H
Article: EUROPEAN JOURNAL OF DENTISTRY. 2023;17(03):924-928
Active MMP-8 as a Biomarker of Peri-implant Health or Disease
Xanthopoulou V; Raisanen I; Sorsa T; Sakellari D
Article: JOURNAL OF PERIODONTAL RESEARCH. 2023;58(2):325-335
Accuracy of aMMP-8 point-of-care test in indicating periodontal treatment outcomes in stage III/IV periodontitis: A 24-week follow-up study
Yilmaz M; Sorsa T; Demir E; Gursoy M; Suominen A; Tervahartiala T; Raisanen IT; Gursoy UK
Article: DIAGNOSTICS. 2023;13(5):903
A Comparative Analysis of Treatment-Related Changes in the Diagnostic Biomarker Active Metalloproteinase-8 Levels in Patients with Periodontitis
Keskin M; Rintamarttunen J; Gulcicek E; Raisanen IT; Gupta S; Tervahartiala T; Patila T; Sorsa T
Article: APPLIED SCIENCES-BASEL. 2023;13(4):2056
Oral Cavity Beta-Defensin Levels Are Regulated Differently during Radiotherapy in Head and Neck Cancer Patients
Keskin M; Suomi E; Harmankaya I; Karacetin D; Sorsa T; Gursoy UK
Article: ORAL DISEASES. 2023;29(1):285-289
Linking oral microbial proteolysis to aMMP-8 PoC diagnostics along with the stage and grade of periodontitis: A cross-sectional study
Gupta S; Sahni V; Raisanen IT; Grigoriadis A; Sakellari D; Gieselmann D-R; Sorsa T
Article: CANCER CONTROL. 2023;30:10732748231163653
Radiotherapy Increases aMMP-8-Levels and Neutrophil/Lymphocyte Ratio Rapidly in Head and Neck Cancer Patients: A Pilot Study
Brandt E; Keskin M; Tervahartiala T; Yilmaz M; Harmankaya I; Karacetin D; Ipek T; Gursoy UK; Rautava J; Gupta S; Hagstrom J; Raisanen IT; Sorsa T
Article: HORMONE RESEARCH IN PAEDIATRICS. 2022;96(4):385-394
Effects of a 2-year early childhood vitamin D3 intervention on tooth enamel and oral health at age 6-7 years
Arponen H; Waltimo-Siren J; Hauta-Alus HH; Tuhkiainen M; Sorsa T; Tervahartiala T; Andersson S; Makitie O; Holmlund-Suila E
Article: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH. 2022;8(6):1322-1330
Fermented lingonberry juice's effects on active MMP-8 (aMMP-8), bleeding on probing (BOP), and visible plaque index (VPI) in dental implants-A clinical pilot mouthwash study
Lahteenmaki H; Tervahartiala T; Raisanen IT; Parnanen P; Sorsa T
Article: NEOPLASMA. 2022;69(6):1418-1424
TLR2 and TLR4 in colorectal cancer: relationship to tumor necrosis and markers of systemic inflammation
Paarnio K; Vaeyrynen JP; Vaeyrynen SA; Kantola T; Karhu T; Tervahartiala T; Klintrup K; Sorsa T; Salo T; Maekelae J; Karttunen TJ
Article: DENTISTRY JOURNAL. 2022;10(11):206
Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP) Three-Month Interim Results
Pakarinen S; Saarela RKT; Valimaa H; Heikkinen AM; Kankuri E; Noponen M; Alapulli H; Tervahartiala T; Raisanen IT; Sorsa T; Patila T
Article: ANTICANCER RESEARCH. 2022;42(11):5415-5430
Prognostic Role of Porphyromonas gingivalis Gingipain Rgp and Matrix Metalloproteinase 9 in Oropharyngeal Squamous Cell Carcinoma
Kylmae AK; Sorsa T; Jouhi L; Mustonen HK; Mohamed H; Randen-brady R; Maekitie A; Atula T; Hagstrom J; Haglund C
Article: JOURNAL OF PERIODONTOLOGY. 2022;93(11):1626-1634
Common complement factor H polymorphisms are linked with periodontitis in elderly patients
Salminen A; Pietiainen M; Paju S; Sorsa T; Mantyla P; Buhlin K; Sinisalo J; Pussinen PJ
Article: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH. 2022;8(5):1142-1148
Implementing of aMMP-8 point-of-care test with a modified new disease classification in Finnish adolescent cohorts
Heikkinen AM; Raivisto T; Raisanen I; Tervahartiala T; Bostanci N; Sorsa T
Article: CURRENT ISSUES IN MOLECULAR BIOLOGY. 2022;44(10):4439-4446
Oral Cavity Calprotectin and Lactoferrin Levels in Relation to Radiotherapy
Keskin M; Kompuinen J; Harmankaya I; Karacetin D; Nissila V; Gursoy M; Sorsa T; Gursoy UK
Article: JOURNAL OF PERIODONTOLOGY. 2022;93(9):1325-1335
Association of peptidoglycan recognition protein 1 to post-myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study
Rathnayake N; Gustafsson A; Sorsa T; Norhammar A; Bostanci N
Article: FRONTIERS IN ORAL HEALTH. 2022;3:956072
Oral health associated with incident diabetes but not other chronic diseases: A register-based cohort study
Heikkila P; Niskanen L; But A; Sorsa T; Haukka J
Article: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH. 2022;8(4):988-1001
Validation of a noninvasive aMMP-8 point-of-care diagnostic methodology in COVID-19 patients with periodontal disease
Gupta S; Mohindra R; Singla M; Khera S; Kumar A; Rathnayake N; Sorsa T; Pfuetzner A; Raisanen IT; Soni RK; Kanta P; Jain A; Gauba K; Goyal K; Singh MP; Ghosh A; Kajal K; Mahajan V; Suri V; Bhalla A
Article: EUROPEAN JOURNAL OF DENTISTRY. 2022;16(03):514-520
Is There a Link between COVID-19 and Periodontal Disease? A Narrative Review
Grigoriadis A; Raisanen IT; Parnanen P; Tervahartiala T; Sorsa T; Sakellari D
Article: BIOPRESERVATION AND BIOBANKING. 2022;20(3):297-301
Insights into Preservation of Blood Biomarkers in Biobank Samples
Juurikka K; astroem P; Pekkala T; oehman H; Sorsa T; Tervahartiala T; Salo T; Lehenkari P; Nyberg P
Article: JOURNAL OF PERIODONTAL RESEARCH. 2022;57(3):558-567
Ability of matrix metalloproteinase-8 biosensor, IFMA, and ELISA immunoassays to differentiate between periodontal health, gingivitis, and periodontitis
Umeizudike KA; Lahteenmaki H; Raisanen IT; Taylor JJ; Preshaw PM; Bissett SM; Tervahartiala T; Nwhator S; Parnanen P; Sorsa T
Article: BIOMEDICINE & PHARMACOTHERAPY. 2022;149:112841
Potential pathobionts in vaginal microbiota are affected by fish oil and/or probiotics intervention in overweight and obese pregnant women
Houttu N; Mokkala K; Saleem WT; Virtanen S; Juhila J; Koivuniemi E; Pellonpera O; Tertti K; Luokola P; Sorsa T; Salonen A; Lahti L; Laitinen K
Article: DENTISTRY JOURNAL. 2022;10(4):69
Effects of Fermented Lingonberry Juice Mouthwash on Salivary Parameters-A One-Year Prospective Human Intervention Study
Parnanen P; Lomu S; Raisanen IT; Tervahartiala T; Sorsa T
Article: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH. 2022;8(2):485-496
Active MMP-8 point-of-care (PoC)/chairside enzyme-test as an adjunctive tool for early and real-time diagnosis of peri-implantitis
Lahteenmaki H; Tervahartiala T; Raisanen IT; Parnanen P; Mauramo M; Gupta S; Sampson V; Rathnayake N; Heikkinen A-M; Alassiri S; Gieselmann D-R; Frankenberger R; Sorsa T
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(6):3314
Matrix Metalloproteinase 8 Expression in a Tumour Predicts a Favourable Prognosis in Pancreatic Ductal Adenocarcinoma
Kaasinen M; Hagstrom J; Mustonen H; Sorsa T; Sund M; Haglund C; Seppanen H
Article: CURRENT ISSUES IN MOLECULAR BIOLOGY. 2022;44(3):1273-1283
Repeated Home-Applied Dual-Light Antibacterial Photodynamic Therapy Can Reduce Plaque Burden, Inflammation, and aMMP-8 in Peri-Implant Disease-A Pilot Study
Lahteenmaki H; Patila T; Raisanen IT; Kankuri E; Tervahartiala T; Sorsa T
Article: CLINICAL ORAL INVESTIGATIONS. 2022;26(2):1361-1374
The clinical association between Periodontitis and COVID-19
Gupta S; Mohindra R; Singla M; Khera S; Sahni V; Kanta P; Soni RK; Kumar A; Gauba K; Goyal K; Singh MP; Ghosh A; Kajal K; Mahajan V; Bhalla A; Sorsa T; Raeisaenen I
Article: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH. 2021;7(5):833-839
Human leukocyte antigens are associated with salivary level of active MMP-8
Mauramo M; Mauramo E; Sorsa T; Tervahartiala T; Raisanen IT; Waltimo T
Article: JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES. 2021;24:484-487
Dual-Light Photodynamic Therapy Effectively Eliminates Streptococcus Oralis Biofilms
Hentila J; Laakamaa N; Sorsa T; Meurman J; Valimaa H; Nikinmaa S; Kankuri E; Tauriainen T; Patila T
Article: ACTA HISTOCHEMICA. 2021;123(6):151767
Periodontitis and peri-implantitis tissue levels of Treponema denticola-CTLP and its MMP-8 activating ability
Petain S; Kasnak G; Firatli E; Tervahartiala T; Gursoy UK; Sorsa T
Article: DIAGNOSTICS. 2021;11(8):1503
Active MMP-8 Quantitative Test as an Adjunctive Tool for Early Diagnosis of Periodontitis
Hernandez M; Baeza M; Raisanen IT; Contreras J; Tervahartiala T; Chaparro A; Sorsa T; Hernandez-Rios P
Article: PANCREATOLOGY. 2021;21(5):862-869
Activated matrix metalloproteinase 8 in serum predicts severity of acute pancreatitis
Turunen A; Kuuliala K; Kuuliala A; Tervahartiala T; Mustonen H; Puolakkainen P; Kylanpaa AL; Sorsa T
Article: PLOS ONE. 2021;16(5):e0252046
Matrix metalloproteinase MMP-8, TIMP-1 and MMP-8/TIMP-1 ratio in plasma in methicillin-sensitive Staphylococcus aureus bacteremia
Forsblom E; Tervahartiala T; Ruotsalainen E; Jarvinen A; Sorsa T
Article: DENTISTRY JOURNAL. 2021;9(5):52
Indocyanine Green-Assisted and LED-Light-Activated Antibacterial Photodynamic Therapy Reduces Dental Plaque
Nikinmaa S; Moilanen N; Sorsa T; Rantala J; Alapulli H; Kotiranta A; Auvinen P; Kankuri E; Meurman JH; Patila T
Article: DIAGNOSTICS. 2021;11(4):711
An aMMP-8 Point-of-Care and Questionnaire Based Real-Time Diagnostic Toolkit for Medical Practitioners
Raisanen IT; Lahteenmaki H; Gupta S; Grigoriadis A; Sahni V; Suojanen J; Seppanen H; Tervahartiala T; Sakellari D; Sorsa T
Article: DIAGNOSTICS. 2021;11(4):662
Salivary Biomarkers and Oral Health in Liver Transplant Recipients, with an Emphasis on Diabetes
Norrman AE; Tervahartiala T; Sahlberg E; Sorsa T; Ruokonen H; Gronroos L; Meurman JH; Isoniemi H; Nordin A; Aberg F; Helenius-Hietala J
Article: JOURNAL OF PERIODONTAL RESEARCH. 2021;56(2):289-297
Low association between bleeding on probing propensity and the salivary aMMP-8 levels in adolescents with gingivitis and stage I periodontitis
Raisanen IT; Sorsa T; Tervahartiala T; Raivisto T; Heikkinen AM
Article: ARCHIVES OF ORAL BIOLOGY. 2021;124:104955
Evaluation of active matrix metalloproteinase-8 (aMMP-8) chair-side test as a diagnostic biomarker in the staging of periodontal diseases
Ozturk VO; Emingil G; Umeizudike K; Tervahartiala T; Gieselmann D-R; Maier K; Kose T; Sorsa T; Alassiri S
Article: ARCHIVES OF ORAL BIOLOGY. 2021;124:105065
Regulation of matrix metalloproteinases-8,-9 and endogenous tissue inhibitor-1 in oral biofluids during pregnancy and postpartum
Ozturk VO; Meric P; Sorsa T; Tervahartiala T; Bostanci N; Nwhator SO; Emingil G
Article: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH. 2021;7(1):63-69
MMP-7, -8, -9, E-cadherin, and beta-catenin expression in 34 ameloblastoma cases
Kelppe J; Thoren H; Haglund C; Sorsa T; Hagstrom J
Article: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH. 2021;7(1):85-92
Prediabetes/diabetes screening strategy at the periodontal clinic
Grigoriadis A; Raisanen IT; Parnanen P; Tervahartiala T; Sorsa T; Sakellari D
Article: JOURNAL OF PERIODONTOLOGY. 2021;92(2):205-215
Early pregnancy levels of gingival crevicular fluid matrix metalloproteinases-8 and-9 are associated with the severity of periodontitis and the development of gestational diabetes mellitus
Chaparro A; Realini O; Hernandez M; Albers D; Weber L; Ramirez V; Param F; Kusanovic JP; Sorsa T; Rice GE; Illanes SE
Article: MICROBIOLOGY INSIGHTS. 2021;14:11786361211050086
Antibacterial Activity of 2-Hydroxyisocaproic Acid (HICA) Against Obligate Anaerobic Bacterial Species Associated With Periodontal Disease.
Sakko M; Rautemaa-Richardson R; Sakko S; Richardson M; Sorsa T
Article: ONCOLOGY. 2021;99(12):766-779
Serum Matrix Metalloproteinase-8 and Myeloperoxidase Predict Survival after Resection of Colorectal Liver Metastases
Reijonen P; Peltonen R; Tervahartiala T; Sorsa T; Isoniemi H
Article: PATHOLOGY RESEARCH AND PRACTICE. 2021;217:153293
Matrix metalloproteinase-7,-8,-9,-15, and-25 in minor salivary gland adenoid cystic carcinoma
Hametoja H; Makitie A; Back L; Leivo I; Haglund C; Sorsa T; Hagstrom J
Article: ONCOLOGY. 2021;99(3):144-160
High Expression of MMP-9 in Primary Tumors and High Preoperative MPO in Serum Predict Improved Prognosis in Colorectal Cancer with Operable Liver Metastases
Peltonen R; Hagstrom J; Tervahartiala T; Sorsa T; Haglund C; Isoniemi H
Article: BIOMOLECULES. 2020;11(1):E5-5
The Impacts of Fish Oil and/or Probiotic Intervention on Low-Grade Inflammation, IGFBP-1 and MMP-8 in Pregnancy: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial
Houttu N; Mokkala K; Koivuniemi E; Pellonpera O; Juhila J; Sorsa T; Laitinen K
Article: MICROBIAL PATHOGENESIS. 2020;149:104547
Isolation, characterization and regulation of moonlighting proteases from Candida glabrata cell wall
Parnanen P; Sorsa T; Tervahartiala T; Nikula-Ijas P
Article: JOURNAL OF PERIODONTAL RESEARCH. 2020;55(6):887-894
Local and systemic levels of aMMP-8 in gingivitis and stage 3 grade C periodontitis
Yucel ZPK; Afacan B; Emingil G; Tervahartiala T; Kose T; Sorsa T
Article: TRANSPLANTATION PROCEEDINGS. 2020;52(10):3231-3235
Salivary Biomarkers of Oral In fl ammation Are Associated With Cardiovascular Events and Death Among Kidney Transplant Patients
Ortiz F; Nylund KM; Ruokonen H; Meurman JH; Furuholm J; Bostanci N; Sorsa T
Article: DENTISTRY JOURNAL. 2020;8(4):E124-124
Adjunctive Antiseptic Irrigation of Periodontal Pockets: Effects on Microbial and Cytokine Profiles
Vitt A; Babenka A; Bostrom EA; Gustafsson A; Lira RJ; Slizen V; Sorsa T; Tervahartiala T; Buhlin K
Article: MEDICAL HYPOTHESES. 2020;144:110276
Periodontal disease and targeted prevention using aMMP-8 point-of-care oral fluid analytics in the COVID-19 era
Raeisaenen IT; Umeizudike KA; Parnanen P; Heikkila P; Tervahartiala T; Nwhator SO; Grigoriadis A; Sakellari D; Sorsa T
Article: BIOMOLECULES. 2020;10(11):E1500-1500
MMP-8, TRAP-5, and OPG Levels in GCF Diagnostic Potential to Discriminate between Healthy Patients', Mild and Severe Periodontitis Sites
Hernandez M; Baeza M; Contreras J; Sorsa T; Tervahartiala T; Valdes M; Chaparro A; Hernandez-Rios P
Article: JOURNAL OF PERIODONTOLOGY. 2020;91(10):1339-1347
Salivary biomarkers in the context of gingival inflammation in children with cystic fibrosis
Yucel ZPK; Silbereisen A; Emingil G; Tokgoz Y; Kose T; Sorsa T; Tsilingaridis G; Bostanci N
Article: JDR CLINICAL AND TRANSLATIONAL RESEARCH. 2020;5(4):332-341
Regulation of Salivary Peptidoglycan Recognition Protein1in Adolescents
Raivisto T; Heikkinen AM; Silbereisen A; Kovanen L; Ruokonen H; Tervahartiala T; Haukka J; Sorsa T; Bostanci N
Article: DIAGNOSTICS. 2020;10(8):E562-562
aMMP-8 Point-of-Care/Chairside Oral Fluid Technology as a Rapid, Non-Invasive Tool for Periodontitis and Peri-Implantitis Screening in a Medical Care Setting
Lahteenmaki H; Umeizudike KA; Heikkinen AM; Raisanen IT; Rathnayake N; Johannsen G; Tervahartiala T; Nwhator SO; Sorsa T
Article: DIAGNOSTICS. 2020;10(8):E560-560
Immunological and Microbiological Profiling of Cumulative Risk Score for Periodontitis
Liukkonen J; Gursoy UK; Kononen E; Akhi R; Salminen A; Liljestrand JM; Pradhan-Palikhe P; Pietiainen M; Sorsa T; Persson GR; Mantyla P; Buhlin K; Paju S; Sinisalo J; Horkko S; Pussinen PJ
Article: HELIYON. 2020;6(8):e04788
Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women
Mokkala K; Juhila J; Houttu N; Sorsa T; Laitinen K
Article: ORAL ONCOLOGY. 2020;107:104778
In HPV-negative oropharyngeal squamous cell carcinoma, elevated toll-like receptor 2 immunoexpression may increase the risk of disease-specific mortality
Kylma AK; Jouhi L; Mohamed H; Randen-Brady R; Makitie A; Atula T; Haglund C; Sorsa T; Hagstrom J
Article: BMC PREGNANCY AND CHILDBIRTH. 2020;20(1):401
Metformin and insulin treatment of gestational diabetes: effects on inflammatory markers and IGF-binding protein-1-secondary analysis of a randomized controlled trial
Huhtala MS; Tertti K; Juhila J; Sorsa T; Ronnemaa T
Article: ORAL DISEASES. 2020;26(5):1045-1052
The relationship between oral diseases and infectious complications in patients under dialysis
Arenius I; Ruokonen H; Ortiz F; Furuholm J; Valimaa H; Bostanci N; Eskola M; Heikkinen AM; Meurman JH; Sorsa T; Nylund K
Article: EXPERIMENTAL AND MOLECULAR PATHOLOGY. 2020;114:104435
Elevated TLR5 expression in vivo and loss of NF-κB activation via TLR5 in vitro detected in HPV-negative oropharyngeal squamous cell carcinoma
Kylma AK; Tolvanen TA; Carpen T; Haglund C; Makitie A; Mattila PS; Grenman R; Jouhi L; Sorsa T; Lehtonen S; Hagstrom J
Article: PLOS ONE. 2020;15(5):e0232775
Dual-light photodynamic therapy administered daily provides a sustained antibacterial effect on biofilm and prevents Streptococcus mutans adaptation
Nikinmaa S; Alapulli H; Auvinen P; Vaara M; Rantala J; Kankuri E; Sorsa T; Meurman J; Patila T
Article: PROTEOMICS CLINICAL APPLICATIONS. 2020;14(3):e1900050
Label-Free Quantitative Proteomics versus Antibody-Based Assays to Measure Neutrophil-Derived Enzymes in Saliva
Silbereisen A; Alassiri S; Bao K; Grossmann J; Nanni P; Fernandez C; Tervahartiala T; Nascimento GG; Belibasakis GN; Heikkinen A-M; Lopez R; Sorsa T; Bostanci N
Article: BIOSENSORS-BASEL. 2020;10(5):E44-44
Host-Modulation Therapy and Chair-Side Diagnostics in the Treatment of Peri-Implantitis
Sorsa T; Bacigalupo J; Kononen M; Parnanen P; Raisanen IT
Article: BIOMOLECULES. 2020;10(3):E395-395
An Oral Rinse Active Matrix Metalloproteinase-8 Point-of-Care Immunotest May Be Less Accurate in Patients with Crohn's Disease
Rautava J; Gursoy UK; Kullstrom A; Kononen E; Sorsa T; Tervahartiala T; Gursoy M
Article: DIAGNOSTICS. 2020;10(2):E61-61
Active MMP-8 (aMMP-8) as a Grading and Staging Biomarker in the Periodontitis Classification
Sorsa T; Alassiri S; Grigoriadis A; Raisanen IT; Parnanen P; Nwhator SO; Gieselmann D-R; Sakellari D
Article: JOURNAL OF PERIODONTOLOGY. 2020;91(1):102-109
A point-of-care test of active matrix metalloproteinase-8 predicts triggering receptor expressed on myeloid cells-1 levels in saliva
Raisanen IT; Heikkinen AM; Pakbaznejad Esmaeili E; Tervahartiala T; Pajukanta R; Silbereisen A; Bostanci N; Sorsa T
Article: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. 2019;95(4):114871
On the diagnostic discrimination ability of mouthrinse and salivary aMMP-8 point-of-care testing regarding periodontal health and disease
Raisanen IT; Heikkinen AM; Nwhator SO; Umeizudike KA; Tervahartiala T; Sorsa T
Article: MEDIATORS OF INFLAMMATION. 2019;2019:7436932-8
The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood
Savonius O; Roine I; Alassiri S; Tervahartiala T; Helve O; Fernandez J; Peltola H; Sorsa T; Pelkonen T
Article: DIAGNOSTICS. 2019;9(4):E151-151
Prediabetes/Diabetes Can Be Screened at the Dental Office by a Low-Cost and Fast Chair-Side/Point-of-Care aMMP-8 Immunotest
Grigoriadis A; Sorsa T; Raisanen I; Parnanen P; Tervahartiala T; Sakellari D
Article: FRONTIERS IN MEDICINE. 2019;6:220
Associations Between Glutathione-S-Transferase Genotypes and Bronchial Hyperreactivity Patients With Di-isocyanate Induced Asthma. A Follow-Up Study
Leppilahti J; Majuri M-L; Sorsa T; Hirvonen A; Piirila P
Article: JDR CLINICAL AND TRANSLATIONAL RESEARCH. 2019;4(4):352-359
Regulation of PGLYRP1 and TREM-1 during Progression and Resolution of Gingival Inflammation
Silbereisen A; Hallak AK; Nascimento GG; Sorsa T; Belibasakis GN; Lopez R; Bostanci N
Article: MICROORGANISMS. 2019;7(9):E331-331
Antimicrobial and Anti-Inflammatory Lingonberry Mouthwash-A Clinical Pilot Study in the Oral Cavity
Parnanen P; Nikula-Ijas P; Sorsa T
Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2019;68(8):1263-1272
High levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) in the serum are associated with poor prognosis in HPV-negative squamous cell oropharyngeal cancer
Carpen T; Sorsa T; Jouhi L; Tervahartiala T; Haglund C; Syrjanen S; Tarkkanen J; Mohamed H; Makitie A; Hagstrom J; Mattila PS
Article: BMC MICROBIOLOGY. 2019;19(1):167
Universal membrane-labeling combined with expression of Katushka far-red fluorescent protein enables non-invasive dynamic and longitudinal quantitative 3D dual-color fluorescent imaging of multiple bacterial strains in mouse intestine
Penate-Medina O; Tower RJ; Penate-Medina T; Will O; Saris PEJ; Suojanen J; Sorsa T; Huuskonen L; Hiippala K; Satokari R; Gluer CC; de Vos WM; Reunanen J
Article: CLINICAL ORAL INVESTIGATIONS. 2019;23(5):2207-2213
Oral symptoms and oral health-related quality of life in patients with chronic kidney disease from predialysis to posttransplantation
Ruokonen H; Nylund K; Meurman JH; Heikkinen AM; Furuholm J; Sorsa T; Roine R; Ortiz F
Article: ORAL DISEASES. 2019;25(4):1169-1174
BRAF V600E expression in ameloblastomas-A 36-patient cohort from Helsinki University Hospital
Kelppe J; Thoren H; Ristimaki A; Haglund C; Sorsa T; Hagstrom J
Article: JOURNAL OF PERIODONTOLOGY. 2019;90(5):475-483
Smoking confounds the periodontal diagnostics using saliva biomarkers
Landentausta L; Paju S; Mantyla P; Buhlin K; Pietiainen M; Tervahartiala T; Nieminen MS; Sinisalo J; Sorsa T; Pussinen PJ
Article: JOURNAL OF PERIODONTOLOGY. 2019;90(5):484-492
Cross-sectional analysis of risk factors for subclinical periodontitis; active matrix metalloproteinase-8 as a potential indicator in initial periodontitis in adolescents
Heikkinen AM; Raisanen IT; Tervahartiala T; Sorsa T
Article: DIAGNOSTICS. 2019;9(1):E34-34
Active Matrix Metalloproteinase-8 Point-of-Care (PoC)/Chairside Mouthrinse Test vs. Bleeding on Probing in Diagnosing Subclinical Periodontitis in Adolescents
Raisanen IT; Sorsa T; van der Schoor G-J; Tervahartiala T; van der Schoor P; Gieselmann D-R; Heikkinen AM
Article: CYTOKINE. 2019;115:135-141
Salivary levels of MPO, MMP-8 and TIMP-1 are associated with gingival inflammation response patterns during experimental gingivitis
Nascimento GG; Baelum V; Sorsa T; Tervahartiala T; Skottrup PD; Lopez R
Article: DENTISTRY JOURNAL. 2019;7(1):E9-9
Adjunctive Effects of a Sub-Antimicrobial Dose of Doxycycline on Clinical Parameters and Potential Biomarkers of Periodontal Tissue Catabolism
Emingil G; Gurkan A; Tervahartiala T; Hernandez M; Ozgul S; Sorsa T; Alassiri S
Article: ACTA ODONTOLOGICA SCANDINAVICA. 2019;77(1):82-87
Ameloblastoma: a retrospective single institute study of 34 subjects
Kelppe J; Hagstrom J; Sorsa T; Suominen AL; Apajalahti S; Haglundg C; Thoren H
Article: FETAL DIAGNOSIS AND THERAPY. 2019;46(2):103-110
Cervical and Amniotic Fluid Matrix Metalloproteinase-8 and Interleukin-6 Concentrations in Preterm Pregnancies with or without Preterm Premature Rupture of Membranes
Holmstrom E; Myntti T; Sorsa T; Kruit H; Juhila J; Paavonen J; Rahkonen L; Stefanovic V
Article: DIAGNOSTICS. 2018;8(4):E82-82
Enhanced Systemic Response of Matrix Metalloproteinases and Their Regulators in Campylobacter and Salmonella Patients
Nilsson A; Tervahartiala T; Lennebratt D; Lannergard A; Sorsa T; Rautelin H
Article: PLOS ONE. 2018;13(12):e0208800
High serum MMP-14 predicts worse survival in gastric cancer
Kasurinen A; Tervahartiala T; Laitinen A; Kokkola A; Sorsa T; Bockelman C; Haglund C
Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2018;45(12):1421-1428
Molecular forms and fragments of salivary MMP-8 in relation to periodontitis
Gursoy UK; Kononen E; Tervahartiala T; Gursoy M; Pitkanen J; Torvi P; Suominen AL; Pussinen P; Sorsa T
Article: ORAL DISEASES. 2018;24(8):1562-1571
Anti-rheumatic medication and salivary MMP-8, a biomarker for periodontal disease
Ayravainen L; Heikkinen AM; Kuuliala A; Ahola K; Koivuniemi R; Moilanen E; Hamalainen M; Tervahartiala T; Meurman JH; Leirisalo-Repo M; Sorsa T
Article: DIAGNOSTICS. 2018;8(4):E74-74
Point-of-Care/Chairside aMMP-8 Analytics of Periodontal Diseases' Activity and Episodic Progression
Raisanen IT; Heikkinen AM; Siren E; Tervahartiala T; Gieselmann D-R; van der Schoor G-J; van der Schoor P; Sorsa T
Article: JOURNAL OF OBSTETRICS AND GYNAECOLOGY. 2018;38(7):927-932
Cervical biomarkers as predictors of successful induction of labour by Foley catheter
Kruit H; Heikinheimo O; Sorsa T; Juhila J; Paavonen J; Rahkonen L
Article: INNATE IMMUNITY. 2018;24(7):439-447
Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype
Liukkonen J; Gursoy UK; Kononen E; Gursoy M; Metso J; Salminen A; Kopra E; Jauhiainen M; Mantyla P; Buhlin K; Paju S; Sorsa T; Nieminen MS; Lokki M-L; Sinisalo J; Pussinen PJ
Article: DIAGNOSTICS. 2018;8(3):E67-67
Diagnosis of Newly Delivered Mothers for Periodontitis with a Novel Oral-Rinse aMMP-8 Point-of-Care Test in a Rural Malawian Population
Leppilahti JM; Harjunmaa U; Jarnstedt J; Mangani C; Hernandez M; Tervahartiala T; Lopez R; Ashorn U; Ashorn P; Gieselmann D-R; Sorsa T
Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2018;45(9):1045-1055
Saliva and serum biomarkers in periodontitis and coronary artery disease
Lahdentausta LSJ; Paju S; Mantyla P; Buhlin K; Tervahartiala T; Pietiainen M; Alfthan H; Nieminen MS; Sinisalo J; Sorsa T; Pussinen PJ
Article: JOURNAL OF ORAL PATHOLOGY & MEDICINE. 2018;47(8):764-772
Treponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features
Listyarifah D; Nieminen MT; Makinen LK; Haglund C; Grenier D; Hayry V; Nordstrom D; Hernandez M; Yucel-Lindberg T; Tervahartiala T; Ainola M; Sorsa T; Hagstrom J
Article: TUMOR BIOLOGY. 2018;40(9):1010428318799266-101042831879926
Serum MMP-8 and TIMP-1 as prognostic biomarkers in gastric cancer.
Laitinen A; Hagström J; Mustonen H; Kokkola A; Tervahartiala T; Sorsa T; Böckelman C; Haglund C
Article: BRITISH JOURNAL OF CANCER. 2018;119(1):89-95
Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma
Kylma AK; Jouhi L; Listyarifah D; Mohamed H; Makitie A; Remes SM; Haglund C; Atula T; Nieminen MT; Sorsa T; Hagstrom J
Article: BMC CANCER. 2018;18(1):679
Serum MMP-8 and TIMP-1 predict prognosis in colorectal cancer
Bockelman C; Beilmann-Lehtonen I; Kaprio T; Koskensalo S; Tervahartiala T; Mustonen H; Stenman U-H; Sorsa T; Haglund C
Article: JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH. 2018;11(3):210-220
Serum MMP-9 Diagnostics, Prognostics, and Activation in Acute Coronary Syndrome and Its Recurrence
Lahdentausta L; Leskela J; Winkelmann A; Tervahartiala T; Sorsa T; Pesonen E; Pussinen PJ
Article: INTERNATIONAL JOURNAL OF CANCER. 2018;142(11):2244-2253
Periodontitis and cancer mortality: Register-based cohort study of 68,273 adults in 10-year follow-up
Heikkila P; But A; Sorsa T; Haukka J
Article: ANNALS OF MEDICINE. 2018;50(4):333-344
Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status
Ayravainen L; Heikkinen AM; Kuuliala A; Ahola K; Koivuniemi R; Laasonen L; Moilanen E; Hamalainen M; Tervahartiala T; Meurman JH; Leirisalo-Repo M; Sorsa T
Article: ORAL DISEASES. 2018;24(3):449-455
Associations of oral fluid MMP-8 with periodontitis in Swiss adult subjects
Mauramo M; Ramseier AM; Mauramo E; Buser A; Tervahartiala T; Sorsa T; Waltimo T
Article: ATHEROSCLEROSIS. 2018;271:9-14
Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke
Palm F; Pussinen PJ; Safer A; Tervahartiala T; Sorsa T; Urbanek C; Becher H; Grau AJ
Article: BRITISH JOURNAL OF CANCER. 2018;118(3):428-434
Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation
Nieminen MT; Listyarifah D; Hagstrom J; Haglund C; Grenier D; Nordstrom D; Uitto V-J; Hernandez M; Yucel-Lindberg T; Tervahartiala T; Ainola M; Sorsa T
Article: INTERNATIONAL JOURNAL OF DENTISTRY. 2018;2018:1586762-5
SNP Analysis of Caries and Initial Caries in Finnish Adolescents
Raivisto T; Heikkinen A; Kovanen L; Ruokonen H; Kettunen K; Tervahartiala T; Haukka J; Sorsa T
Article: JOURNAL OF PERIODONTOLOGY. 2018;89(1):117-129
Association of the salivary triggering receptor expressed on myeloid cells/its ligand peptidoglycan recognition protein 1 axis with oral inflammation in kidney disease
Nylund KM; Ruokonen H; Sorsa T; Heikkinen AM; Meurman JH; Ortiz F; Tervahartiala T; Furuholm J; Bostanci N
Article: ACTA DIABETOLOGICA. 2018;55(1):41-47
HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes
Odermarsky M; Pesonen E; Sorsa T; Lernmark A; Pussinen PJ; Liuba P
Article: ARCHIVES OF ORAL BIOLOGY. 2018;85:58-63
Probiotic intervention influences the salivary levels of Matrix Metalloproteinase (MMP)-9 and Tissue Inhibitor of metalloproteinases (TIMP)-1 in healthy adults
Jasberg H; Tervahartiala T; Sorsa T; Soderling E; Haukioja A
Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2017;10(6):e001731
Genetic Variants Contributing to Circulating Matrix Metalloproteinase 8 Levels and Their Association With Cardiovascular Diseases: A Genome-Wide Analysis
Salminen A; Vlachopoulou E; Havulinna AS; Tervahartiala T; Sattler W; Lokki M-L; Nieminen MS; Perola M; Salomaa V; Sinisalo J; Meri S; Sorsa T; Pussinen PJ
Article: JOURNAL OF CLINICAL VIROLOGY. 2017;97:4-9
Persistent Oral Human Papillomavirus (HPV) Infection is Associated with Low Salivary Levels of Matrix Metalloproteinase 8 (MMP-8)
Haukioja A; Tervahartiala T; Sorsa T; Syrjanen S
Article: ORAL DISEASES. 2017;23(8):1144-1154
Infection and apoptosis associated with inflammation in periodontitis: An immunohistologic study
Listyarifah D; Al-Samadi A; Salem A; Syaify A; Salo T; Tervahartiala T; Grenier D; Nordstrom DC; Sorsa T; Ainola M
Article: JOURNAL OF PERIODONTOLOGY. 2017;88(11):1145-1152
Gingival Inflammation and Salivary or Serum Granulocyte-Secreted Enzymes in Patients With Polycystic Ovary Syndrome
Akcali A; Bostanci N; Ozcaka O; Gumus P; Ozturk-Ceyhan B; Tervahartiala T; Husu H; Buduneli N; Sorsa T; Belibasakis GN
Article: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH. 2017;3(5):165-170
Salivary MMP-13 gender differences in periodontitis: A cross-sectional study from Sweden
Virtanen E; Yakob M; Tervahartiala T; Soder P-O; Andersson LC; Sorsa T; Meurman JH; Soder B
Article: JOURNAL OF PERIODONTAL RESEARCH. 2017;52(5):824-831
Association between serum and oral matrix metalloproteinase-8 levels and periodontal health status
Noack B; Kipping T; Tervahartiala T; Sorsa T; Hoffmann T; Lorenz K
Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2017;44(7):692-699
Saliva and plasma levels of cardiac-related biomarkers in post-myocardial infarction patients
Rathnayake N; Buhlin K; Kjellstrom B; Klinge B; Lowbeer C; Norhammar A; Ryden L; Sorsa T; Tervahartiala T; Gustafsson A
Article: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY. 2017;24(11):1136-1144
Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort
Kormi I; Nieminen MT; Havulinna AS; Zeller T; Blankenberg S; Tervahartiala T; Sorsa T; Salomaa V; Pussinen PJ
Article: PLOS ONE. 2017;12(6):e0179660
Metabolic milieu associates with impaired skeletal characteristics in obesity
Viljakainen HT; Koistinen HA; Tervahartiala T; Sorsa T; Andersson S; Makitie O
Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(6):586-600
Intestinal alkaline phosphatase at the crossroad of intestinal health and disease - a putative role in type 1 diabetes
Lassenius MI; Fogarty CL; Blaut M; Haimila K; Riittinen L; Paju A; Kirveskari J; Jaervelae J; Ahola AJ; Gordin D; Haerma M-A; Kumar A; Hamarneh SR; Hodin RA; Sorsa T; Tervahartiala T; Hoerkkoe S; Pussinen PJ; Forsblom C; Jauhiainen M; Taskinen M-R; Groop P-H; Lehto M
Article: JOURNAL OF PERIODONTAL RESEARCH. 2017;52(3):540-545
Mannose-binding lectin gene polymorphism in relation to periodontal infection
Liukkonen A; He Q; Gursoy UK; Pussinen PJ; Grondahl-Yli-Hannuksela K; Liukkonen J; Sorsa T; Suominen AL; Huumonen S; Kononen E
Article: PEDIATRIC RESEARCH. 2017;81(5):731-735
25-hydroxyvitamin D correlates with inflammatory markers in cord blood of healthy newborns
Rosendahl J; Holmlund-Suila E; Helve O; Viljakainen H; Hauta-alus H; Valkama S; Enlund-Cerullo M; Hytinantti T; Tervahartiala T; Sorsa T; Makitie O; Andersson S
Article: JOURNAL OF PERIODONTOLOGY. 2017;88(5):464-472
Pilot Study on the Genetic Background of an Active Matrix Metalloproteinase-8 Test in Finnish Adolescents
Heikkinen AM; Raivisto T; Kettunen K; Kovanen L; Haukka J; Pakbaznejad Esmaeili E; Elg J; Gieselmann D-R; Rathnayake N; Ruokonen H; Tervahartiala T; Sorsa T
Article: INTERNATIONAL ENDODONTIC JOURNAL. 2017;50(5):455-463
2-Hydroxyisocaproic acid is bactericidal in human dental root canals ex vivo
Sakko M; Tjaderhane L; Sorsa T; Hietala P; Rautemaa R
Article: CARDIOVASCULAR DIABETOLOGY. 2017;16(1):49
Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study
Vilmi-Kerala T; Lauhio A; Tervahartiala T; Palomaki O; Uotila J; Sorsa T; Palomaki A
Article: INFECTIOUS DISEASES. 2017;49(4):302-307
Systemic matrix metalloproteinase-8 response in chronic tonsillitis
Ilmarinen T; Lont T; Hagstrom J; Tervahartiala T; Sorsa T; Haglund C; Munck-Wickland E; Ramqvist T; Dalianis T; Aaltonen L-M
Article: PLOS ONE. 2017;12(3):e0173371
Low MMP-8/TIMP-1 reflects left ventricle impairment in takotsubo cardiomyopathy and high TIM P-1 may help to differentiate it from acute coronary syndrome
Parkkonen O; Nieminen MT; Vesterinen P; Tervahartiala T; Perola M; Salomaa V; Jousilahti P; Sorsa T; Pussinen PJ; Sinisalo J
Article: JOURNAL OF PERIODONTOLOGY. 2017;88(3):289-297
Proteolytic Mediators in Gestational Diabetes Mellitus and Gingivitis
Akcali A; Gumus P; Ozcaka O; Ozturk-Ceyhan B; Tervahartiala T; Husu H; Heikkinen AM; Sorsa T; Buduneli N
Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2017;44(3):247-254
Mucin 4 and matrix metalloproteinase 7 as novel salivary biomarkers for periodontitis
Lundmark A; Johannsen G; Eriksson K; Kats A; Jansson L; Tervahartiala T; Rathnayake N; Akerman S; Klinge B; Sorsa T; Yucel-Lindberg T
Article: INTERNATIONAL JOURNAL OF DENTISTRY. 2017;2017:6185395-6
The Effect of Fermented Lingonberry Juice on Candida glabrata Intracellular Protein Expression
Parnanen P; Nawaz A; Sorsa T; Meurman J; Nikula-Ijas P
Article: JOURNAL OF PERIODONTOLOGY. 2017;88(1):122-129
Systemic Aggregatibacter actinomycetemcomitans Leukotoxin-Neutralizing Antibodies in Periodontitis
Johansson A; Buhlin K; Sorsa T; Pussinen PJ
Article: JOURNAL OF PERIODONTOLOGY. 2017;88(1):26-33
Oral Health and Mortality in Patients With Chronic Kidney Disease
Ruokonen H; Nylund K; Furuholm J; Meurman JH; Sorsa T; Kotaniemi K; Ortiz F; Heikkinen AM
Article: DISEASE MARKERS. 2017;2017:8167276-9
Amniotic Fluid Infection in Preterm Pregnancies with Intact Membranes
Myntti T; Rahkonen L; Nupponen I; Patari-Sampo A; Tikkanen M; Sorsa T; Juhila J; Andersson S; Paavonen J; Stefanovic V
Article: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH. 2016;2(3):208-215
Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents
Heikkinen AM; Kettunen K; Kovanen L; Haukka J; Elg J; Husu H; Tervahartiala T; Pussinen P; Meurman J; Sorsa T
Article: JOURNAL OF PERINATOLOGY. 2016;36(12):1049-1054
Comparison of amniotic fluid matrix metalloproteinase-8 and cathelicidin in the diagnosis of intra-amniotic infection
Myntti T; Rahkonen L; Patari-Sampo A; Tikkanen M; Sorsa T; Juhila J; Helve O; Andersson S; Paavonen J; Stefanovic V
Article: JOURNAL OF PERIODONTAL RESEARCH. 2016;51(4):481-488
Cytokine (interleukin-1beta) and MMP levels in gingival crevicular fluid after use of platelet-rich fibrin or connective tissue graft in the treatment of localized gingival recessions
Eren G; Tervahartiala T; Sorsa T; Atilla G
Article: JOURNAL OF PATHOLOGY CLINICAL RESEARCH. 2016;2(3):187-198
Increased MMP-7 expression in biliary epithelium and serum underpins native liver fibrosis after successful portoenterostomy in biliary atresia
Kerola A; Lampela H; Lohi J; Heikkia P; Mutanen A; Hagstrom J; Tervahartiala T; Sorsa T; Haglund C; Jalanko H; Pakarinen MP
Article: ARCHIVES OF ORAL BIOLOGY. 2016;66:1-7
Human neutrophil peptide-1 affects matrix metalloproteinase-2,-8 and-9 secretions of oral squamous cell carcinoma cell lines in vitro
Musrati AA; Tervahartiala T; Gursoy M; Kononen E; Fteita D; Sorsa T; Uitto V-J; Gursoy UK
Article: JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH. 2016;10(5):ZC34-ZC38
Peri-Implant Sulcus Fluid (PISF) Matrix Metalloproteinase (MMP) - 8 Levels in Peri-Implantitis
Thierbach R; Maier K; Sorsa T; Mantyla P
Article: ARCHIVES OF ORAL BIOLOGY. 2016;64:80-84
Association of thalassemia major and gingival inflammation: A pilot study
Gumus P; Kahraman-Ceneli S; Akcali A; Sorsa T; Tervahartiala T; Buduneli N; Ozcaka O
Article: INTERNATIONAL ENDODONTIC JOURNAL. 2016;49(4):352-360
Antimicrobial 2-hydroxyisocaproic acid and chlorhexidine resist inactivation by dentine
Sakko M; Tjaderhane L; Sorsa T; Hietala P; Rautemaa R
Article: JOURNAL OF PERIODONTOLOGY. 2016;87(1):36-40
Pilot Study on Oral Health Status as Assessed by an Active Matrix Metalloproteinase-8 Chairside Mouthrinse Test in Adolescents
Heikkinen AM; Nwhator SO; Rathnayake N; Mantyla P; Vatanen P; Sorsa T
Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2016;43(1):34-45
Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: an exploratory study
Baeza M; Garrido M; Hernandez-Rios P; Dezerega A; Garcia-Sesnich J; Strauss F; Aitken JP; Lesaffre E; Vanbelle S; Gamonal J; Brignardello-Petersen R; Tervahartiala T; Sorsa T; Hernandez M
Article: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY. 2016;80(1):74-77
Decreased salivary matrix metalloproteinase-8 reflecting a defensive potential in juvenile parotitis
Saarinen R; Pitkaranta A; Kolho K-L; Tervahartiala T; Sorsa T; Lauhio A
Article: JOURNAL OF PERIODONTOLOGY. 2015;86(11):1212-1220
Periodontal Inflammatory Burden and Salivary Matrix Metalloproteinase-8 Concentration Among Patients With Chronic Kidney Disease at the Predialysis Stage
Nylund KM; Meurman JH; Heikkinen AM; Honkanen E; Vesterinen M; Furuholm JO; Tervahartiala T; Sorsa T; Ruokonen HM
Article: PHARMACOLOGICAL RESEARCH. 2015;99:44-51
Targeting matrix metalloproteinases with intravenous doxycycline in severe sepsis - A randomised placebo-controlled pilot trial
Nukarinen E; Tervahartiala T; Valkonen M; Hynninen M; Kolho E; Pettila V; Sorsa T; Backman J; Hastbacka J
Article: INNATE IMMUNITY. 2015;21(6):619-625
Elevated matrix metalloproteinase-8 in saliva and serum in polycystic ovary syndrome and association with gingival inflammation
Akcali A; Bostanci N; Ozcaka O; Ozturk-Ceyhan B; Gumus P; Tervahartiala T; Husu H; Buduneli N; Sorsa T; Belibasakis GN
Article: JOURNAL OF CLINICAL MICROBIOLOGY. 2015;53(7):2340-2342
Changes in MMP-9 and TIMP-1 Concentrations in Cerebrospinal Fluid after 1 Week of Treatment of Childhood Bacterial Meningitis
Roine I; Pelkonen T; Lauhio A; Lappalainen M; Cruzeiro ML; Bernardino L; Tervahartiala T; Sorsa T; Peltola H
Article: PLOS ONE. 2015;10(7):e0126370
Salivary Matrix Metalloproteinase-8 and-9 and Myeloperoxidase in Relation to Coronary Heart and Periodontal Diseases: A Subgroup Report from the PAROKRANK Study (Periodontitis and Its Relation to Coronary Artery Disease)
Rathnayake N; Gustafsson A; Norhammar A; Kjellstrom B; Klinge B; Ryden L; Tervahartiala T; Sorsa T
Article: JOURNAL OF PERIODONTOLOGY. 2015;86(6):777-787
The Utility of Gingival Crevicular Fluid Matrix Metalloproteinase-8 Response Patterns in Prediction of Site-Level Clinical Treatment Outcome
Leppilahti JM; Sorsa T; Kallio MA; Tervahartiala T; Emingil G; Han B; Mantyla P
Article: PLOS ONE. 2015;10(5):e0125918
Matrix Metalloproteinases-8 and-9 and Tissue Inhibitor of Metalloproteinase-1 in Burn Patients. A Prospective Observational Study
Hastbacka J; Freden F; Hult M; Bergquist M; Wilkman E; Vuola J; Sorsa T; Tervahartiala T; Huss F
Article: CYTOKINE. 2015;73(1):114-121
Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen peroxide-stimulated human periodontal ligament fibroblasts
Cavalla F; Osorio C; Paredes R; Antonieta Valenzuela M; Garcia-Sesnich J; Sorsa T; Tervahartiala T; Hernandez M
Article: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY. 2015;119(4):459-467
MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas
Omar AAH; Haglund C; Virolainen S; Hayry V; Atula T; Kontio R; Salo T; Sorsa T; Hagstrom J
Article: INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY. 2015;5(4):294-302
Local and systemic proteolytic responses in chronic rhinosinusitis with nasal polyposis and asthma
Katainen E; Kostamo K; Virkkula P; Sorsa T; Tervahartiala T; Haapaniemi A; Toskala E
Article: FASEB JOURNAL. 2015;29(4):1435-1445
Matrix metalloproteinase 8 degrades apolipoprotein A-I and reduces its cholesterol efflux capacity
Salminen A; Astrom P; Metso J; Soliymani R; Salo T; Jauhiainen M; Pussinen PJ; Sorsa T
Article: JOURNAL OF ORAL PATHOLOGY & MEDICINE. 2015;44(4):258-265
Toll-like receptors-4 and-5 in oral and cutaneous squamous cell carcinomas
Omar AAH; Korvala J; Haglund C; Virolainen S; Hayry V; Atula T; Kontio R; Rihtniemi J; Pihakari A; Sorsa T; Hagstrom J; Salo T
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2015;59(2):176-184
Systemic matrix metalloproteinase-8 and tissue inhibitor of metalloproteinases-1 levels in severe sepsis-associated coagulopathy
Sivula M; Hastbacka J; Kuitunen A; Lassila R; Tervahartiala T; Sorsa T; Pettila V
Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2015;64(2):173-180
Benefit of adjuvant interferon alfa-2b (IFN-α) therapy in melanoma patients with high serum MMP-8 levels
Vihinen P; Tervahartiala T; Sorsa T; Hansson J; Bastholt L; Aamdal S; Stierner U; Pyrhonen S; Syrjanen K; Lundin J; Hernberg M
Article: ARCHIVES OF ORAL BIOLOGY. 2015;60(1):134-143
Do salivary and serum collagenases have a role in an association between obstructive sleep apnea syndrome and periodontal disease? A preliminary case-control study
Nizam N; Basoglu OK; Tasbakan MS; Holthofer A; Teruahartiala T; Sorsa T; Buduneli N
Article: CARIES RESEARCH. 2015;49(1):1-8
Caries Correlates Strongly with Salivary Levels of Matrix Metalloproteinase-8
Hedenbjork-Lager A; Bjorndal L; Gustafsson A; Sorsa T; Tjaderhane L; Akerman S; Ericson D
Article: EXPERIMENTAL CELL RESEARCH. 2014;328(1):217-227
Matrix metalloproteinase-8 regulates transforming growth factor-β1 levels in mouse tongue wounds and fibroblasts in vitro
Astrom P; Piriltia E; Lithovius R; Heikkola H; Korpi JT; Hernandez M; Sorsa T; Salo T
Article: INFLAMMATION. 2014;37(5):1771-1778
Serum and Salivary Matrix Metalloproteinases, Neutrophil Elastase, Myeloperoxidase in Patients with Chronic or Aggressive Periodontitis
Nizam N; Gumus P; Pitkanen J; Tervahartiala T; Sorsa T; Buduneli N
Article: JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH. 2014;8(9):ZC82-ZC85
Common Matrix Metalloproteinases (Mmp-8, -9, -25, and -26) Cannot Explain Dentigerous Cyst Expansion
Suojanen J; Lehtonen N; Faerkkila E; Hietanen J; Teronen O; Sorsa T; Hagstroem J
Article: CLINICAL AND VACCINE IMMUNOLOGY. 2014;21(9):1240-1245
DL-2-Hydroxyisocaproic Acid Attenuates Inflammatory Responses in a Murine Candida albicans Biofilm Model
Nieminen MT; Hernandez M; Novak-Frazer L; Kuula H; Ramage G; Bowyer P; Warn P; Sorsa T; Rautemaa R
Article: JOURNAL OF PERIODONTOLOGY. 2014;85(8):1070-1080
Matrix Metalloproteinase (MMP)-8 and Tissue Inhibitor of MMP-1 (TIMP-1) Gene Polymorphisms in Generalized Aggressive Periodontitis: Gingival Crevicular Fluid MMP-8 and TIMP-1 Levels and Outcome of Periodontal Therapy
Emingil G; Han B; Gurkan A; Berdeli A; Tervahartiala T; Salo T; Pussinen PJ; Kose T; Atilla G; Sorsa T
Article: JOURNAL OF PERIODONTOLOGY. 2014;85(7):908-916
Evaluation of Systemic Levels of Neutrophilic Enzymes in Patients With Hypertension and Chronic Periodontitis
Turkoglu O; Baris N; Tervahartiala T; Senarslan O; Sorsa T; Atilla G
Article: BMC ORAL HEALTH. 2014;14:55
The effect of adjunctive chlorhexidine mouthrinse on GCF MMP-8 and TIMP-1 levels in gingivitis: a randomized placebo-controlled study
Turkoglu O; Becerik S; Tervahartiala T; Sorsa T; Atilla G; Emingil G
Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2014;41(5):442-450
Salivary biomarkers of bacterial burden, inflammatory response, and tissue destruction in periodontitis
Salminen A; Gursoy UK; Paju S; Hyvarinen K; Mantyla P; Buhlin K; Kononen E; Nieminen MS; Sorsa T; Sinisalo J; Pussinen PJ
Article: JOURNAL OF ORAL MICROBIOLOGY. 2014;6:24349
Intracellular localization of Treponema denticola chymotrypsin-like proteinase in chronic periodontitis
Marttila E; Jarvensivu A; Sorsa T; Grenier D; Richardson M; Kari K; Tervahartiala T; Rautemaa R
Article: ORAL DISEASES. 2013;19(7):694-701
Treponema denticola associates with increased levels of MMP-8 and MMP-9 in gingival crevicular fluid
Yakob M; Meurman JH; Sorsa T; Soder B
Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2013;167(2):362-368
The balance of serum matrix metalloproteinase-8 and its tissue inhibitor in acute coronary syndrome and its recurrence.
Pussinen PJ; Sarna S; Puolakkainen M; Öhlin H; Sorsa T; Pesonen E
Article: PLOS ONE. 2013;8(4):e61356
Salivary Biomarkers for Detection of Systemic Diseases
Rathnayake N; Akerman S; Klinge B; Lundegren N; Jansson H; Tryselius Y; Sorsa T; Gustafsson A
Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2013;40(2):140-147
Salivary biomarkers of oral health - a cross-sectional study
Rathnayake N; Akerman S; Klinge B; Lundegren N; Jansson H; Tryselius Y; Sorsa T; Gustafsson A
Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2012;39(3):256-263
Associations of periodontal microorganisms with salivary proteins and MMP-8 in gingival crevicular fluid
Yakob M; Kari K; Tervahartiala T; Sorsa T; Soder P-O; Meurman JH; Soder B
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2010;151(3):247-254
Effects of inhaled corticosteroids on metalloproteinase-8 and tissue inhibitor of metalloproteinase-1 in the airways of asthmatic children.
Obase Y; Rytilä P; Metso T; Pelkonen AS; Tervahartiala T; Turpeinen M; Mäkelä M; Saarialho-Kere U; Selroos O; Sorsa T; Haahtela T
Article: EXPERIMENTAL CELL RESEARCH. 2008;314(4):914-926
Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma.
Vilen S-T; Nyberg P; Hukkanen M; Sutinen M; Ylipalosaari M; Bjartell A; Paju A; Haaparanta V; Stenman U-H; Sorsa T; Salo T
Article: WOUND REPAIR AND REGENERATION. 2007;15(1):47-57
Collagenase-2 (MMP-8) and matrilysin-2 (MMP-26) expression in human wounds of different etiologies
Pirila E; Korpi JT; Korkiamaki T; Jahkola T; Gutierrez-Fernandez A; Lopez-Otin C; Saarialho-Kere U; Salo T; Sorsa T
Article: AMERICAN JOURNAL OF PATHOLOGY. 2005;167(4):1119-1124
Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue.
Stenman M; Ainola M; Valmu L; Bjartell A; Ma G; Stenman U-H; Sorsa T; Luukkainen R; Konttinen YT
Article: INTERNATIONAL ENDODONTIC JOURNAL. 2005;38(9):667-677
Effect of E. faecalis on the release of serine proteases elastase and cathepsin G, and collagenase-2 (MMP-8) by human polymorphonuclear leukocytes (PMNs).
Reynaud af Geijersstam A; Sorsa T; Stackelberg S; Tervahartiala T; Haapasalo M
Article: RHEUMATOLOGY INTERNATIONAL. 2000;19(4):141-147
Mast cell derangement in salivary glands in patients with Sjögren's syndrome.
Konttinen YT; Hietanen J; Virtanen I; Ma J; Sorsa T; Xu JW; Williams NP; Manthorpe R; Janin A
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 1999;28(2):106-112
T(H)1 cytokines are produced in labial salivary glands in Sjögren's syndrome, but also in healthy individuals.
Konttinen YT; Kemppinen P; Koski H; Li TF; Jumppanen M; Hietanen J; Santavirta S; Salo T; Larsson A; Hakala M; Sorsa T
Article: MATRIX BIOLOGY. 1998;17(5):335-347
Matrix metalloproteinase (MMP)-9 type IV collagenase/gelatinase implicated in the pathogenesis of Sjögren's syndrome.
Konttinen YT; Halinen S; Hanemaaijer R; Sorsa T; Hietanen J; Ceponis A; Xu JW; Manthorpe R; Whittington J; Larsson A; Salo T; Kjeldsen L; Stenman UH; Eisen AZ
Article: EMBO JOURNAL. 1997;16(13):3898-3911
Proteolytic processing regulates receptor specificity and activity of VEGF-C
Joukov V; Sorsa T; Kumar V; Jeltsch M; ClaessonWelsh L; Cao YH; Saksela O; Kalkkinen N; Alitalo K
Article: CLINICA CHIMICA ACTA. 1997;259(1-2):83-96
Salivary mucous glycoprotein MG1 in Sjögren's syndrome.
Saari H; Halinen S; Ganlöv K; Sorsa T; Konttinen YT
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Authors' Reply: "Association Between Metabolic Syndrome and Salivary MMP-8, MPO in Periodontitis"
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Phytonanoparticles as novel drug carriers for enhanced osteogenesis and osseointegration
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Periodontitis, Metabolic Syndrome and Diabetes: Identifying Patients at Risk for Three Common Diseases Using the aMMP-8 Rapid Test at the Dentist's Office
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Photodynamic therapy for oral mucositis in cancer patients- a systematic review and meta-analysis.
Joseph B; Mauramo M; Vijayakumary BK; Waltimo T; Anil S; Sorsa T
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Lingonberry (Vaccinium vitis-idaea L.) Fruit Phenolic Bioactivities-A Review of In Vitro and In Vivo Human Studies
Paernaenen P; Niikko S; Laehteenmaeki H; Raisaenen IT; Tervahartiala T; Sorsa T; Ranki A
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The Effectiveness of Curcumin Nanoparticle-Coated Titanium Surfaces in Osteogenesis: A Systematic Review
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Review: ORAL DISEASES. 2024;30(5):2784-2796
Expression of advanced glycation end products and their receptors in diabetic periodontitis patients
Thomas JT; Joseph B; Sorsa T; Mauramo M; Anil S; Waltimo T
Letter: CANCER CONTROL. 2024;31:10732748241255845
Periodontal Disease - A Late Complication of Head and Neck Cancer Radiotherapy
Brandt E; Keskin M; Raisanen IT; Makitie A; Patila T; Sorsa T; Gupta S
Editorial comment: BJS OPEN. 2023;7(5):zrad050
Association of periodontitis and complications after pancreatic surgery
Hermunen KM; Vuorela T; Louhimo JM; Lehto I; Hagstrom J; Haglund CH; Sorsa T; Seppanen HE
Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2023;27(7):627-637
aMMP-8 point-of-care-diagnostic methods and treatment modalities in periodontitis and peri-implantitis
Lahteenmaki H; Patila T; Parnanen CP; Raisanen I; Tervahartiala T; Gupta S; Sorsa T
Letter: CANCER CONTROL. 2023;30:10732748231187282
Author Response: Radiotherapy Increases aMMP-8-Levels and Neutrophil/Lymphocyte Ratio Rapidly in Head and Neck Cancer Patients: A Pilot Study
Brandt E; Keskin M; Tervahartiala T; Yilmaz M; Harmankaya I; Karacetin D; Ipek T; Gursoy UK; Gupta S; Raisanen IT; Hagstrom J; Rautava J; Sorsa T
Letter: CANCER CONTROL. 2023;30:10732748231214874
aMMP-8 POCT for Periodontal Disease: An Indicator of Poor Oral Health
Gupta S; Raisanen IT; Seppanen H; Hagstrom J; Grigoriadis A; Hermunen K; Sakellari D; Haglund C; Sorsa T
Letter: ORAL DISEASES. 2022;28:2616-2617
Toothbrush as a sampling methodology for detection of SARS-CoV-2
Gupta S; Mohindra R; Jain A; Singla M; Sorsa T; Raisanen I; Malhotra M; Soni RK; Kumar A; Kanta P; Gauba K; Singh MP; Ghosh A; Suri V
Other: DENTISTRY JOURNAL. 2022;10(9):163
Repeated Daily Use of Dual-Light Antibacterial Photodynamic Therapy in Periodontal Disease-A Case Report
Trujiilo K; Raisanen IT; Sorsa T; Patila T
Review: FRONTIERS IN ORAL HEALTH. 2022;3:897115
aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases
Sorsa T; Nwhator SO; Sakellari D; Grigoriadis A; Umeizudike KA; Brandt E; Keskin M; Tervahartiala T; Parnanen P; Gupta S; Mohindra R; Bostanci N; Buduneli N; Raisanen IT
Letter: LANCET INFECTIOUS DISEASES. 2022;22(3):314
Compromised periodontal status could increase mortality for patients with COVID-19
Gupta S; Saarikko M; Pfuetzner A; Raisanen I; Sorsa T
Review: CLINICAL AND EXPERIMENTAL DENTAL RESEARCH. 2022;8(1):359-365
Active matrix metalloproteinase-8: A potential biomarker of oral systemic link
Umeizudike K; Raisanen I; Gupta S; Nwhator S; Grigoriadis A; Sakellari D; Sorsa T
Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2022;26(2):93-105
The collagenases: are they tractable targets for preventing cartilage destruction in osteoarthritis?
Karila T; Tervahartiala T; Cohen B; Sorsa T
Letter: JOURNAL OF CLINICAL PERIODONTOLOGY. 2021;48(11):1495-1498
On the accuracy, sensitivity, and grading of mouthrinse active matrix metalloproteinase-8 (aMMP-8) point-of-care testing (POCT)
Sorsa T; Grigoriadis A; Sakellari D; Gupta S; Sahni V; Tervahartiala T; Raisanen IT
Review: NUTRIENTS. 2021;13(11):3738
Lingonberries-General and Oral Effects on the Microbiome and Inflammation
Parnaen P; Lahteenmaki H; Tervahartiala T; Raeisanen IT; Sorsa T
Review: EXPERT REVIEW OF PROTEOMICS. 2021;18(8):707-717
Active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) in the COVID-19 pandemic
Sorsa T; Sahni V; Buduneli N; Gupta S; Raisanen IT; Golub LM; Lee H-M; Patila T; Bostanci N; Meurman J; Parnanen P; Nwhator SO; Singla M; Gauba K
Letter: PHYSIOLOGICAL REPORTS. 2021;9(3):e14741
Lingonberry polyphenols: Potential SARS-CoV-2 inhibitors as nutraceutical tools?
Parnanen P; Lahteenmaki H; Raisanen I; Tervahartiala T; Sorsa T
Editorial comment: DIAGNOSTICS. 2020;10(12):E1050-1050
An Unexplored Pharmacologic/Diagnostic Strategy for Peri-Implantitis: A Protocol Proposal
Golub LM; Raisanen IT; Sorsa T; Preshaw PM
Review: EXPERT REVIEW OF PROTEOMICS. 2020;17(10):777-784
Active matrix metalloproteinase-8 and interleukin-6 detect periodontal degeneration caused by radiotherapy of head and neck cancer: a pilot study
Keskin M; Lahteenmaki H; Rathnayake N; Raisanen IT; Tervahartiala T; Parnanen P; Senisik AM; Karacetin D; Balkanay AY; Heikkila P; Hagstrom J; Rautava J; Haglund C; Gursoy UK; Silbereisen A; Bostanci N; Sorsa T
Corrigendum: HELIYON. 2020;6(10):e05248
Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women (vol 6, e04788, 2020)
Mokkala K; Juhila J; Houttu N; Sorsa T; Laitinen K
Editorial comment: DIABETES STOFFWECHSEL UND HERZ. 2020;29(4):234-238
Why do People with Diabetes have a higher Risk of severe SARS-CoV-2 Infection - and what could this have to do with oral Hygiene?
Pfuetzner A; Sorsa T; Nwhator SO; Raisanen IT; Sakellari D; Kunde J; Kleine-Gunk B; Frankenberger R
Letter: JOURNAL OF DENTAL RESEARCH. 2019;98(9):1045
Letter to the Editor: "MMP-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery"
Nwhator SO; Umeizudike KA; Sorsa T
Review: FRONTIERS IN IMMUNOLOGY. 2019;10:1664
Osteoimmunology of Oral and Maxillofacial Diseases: Translational Applications Based on Biological Mechanisms
Alvarez C; Monasterio G; Cavalla F; Cordova LA; Hernandez M; Heymann D; Garlet GP; Sorsa T; Parnanen P; Lee H-M; Golub LM; Vernal R; Kantarci A
Letter: JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH. 2018;11(6):526-527
The Use of Serum MMP-9 and TIMP-1 in Acute Coronary Syndrome
Lahdentausta L; Sorsa T; Pesonen E; Pussinen P
Review: INTERNATIONAL JOURNAL OF DENTISTRY. 2018;2018:7891323-27
Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases
Al-Majid A; Alassiri S; Rathnayake N; Tervahartiala T; Gieselmann D-R; Sorsa T
Review: DISEASE MARKERS. 2018;2018:1306396-5
The Ability of Quantitative, Specific, and Sensitive Point-of-Care/Chair-Side Oral Fluid Immunotests for aMMP-8 to Detect Periodontal and Peri-Implant Diseases
Alassiri S; Parnanen P; Rathnayake N; Johannsen G; Heikkinen A-M; Lazzara R; van der Schoor P; van der Schoor JG; Tervahartiala T; Gieselmann D; Sorsa T
Letter: NATURE REVIEWS DISEASE PRIMERS. 2017;3:17069
A quantitative point-of-care test for periodontal and dental peri-implant diseases
Sorsa T; Gieselmann D; Arweiler NB; Hernandez M
Review: DIAGNOSTICS. 2017;7(1):E7-7
Salivary Diagnostics: Point-of-Care diagnostics of MMP-8 in dentistry and medicine
Rathnayake N; Gieselmann D-R; Heikkinen AM; Tervahartiala T; Sorsa T
Review: INTERNATIONAL DENTAL JOURNAL. 2016;66(3):127-135
Non-antibacterial tetracycline formulations: host-modulators in the treatment of periodontitis and relevant systemic diseases
Golub LM; Elburki MS; Walker C; Ryan M; Sorsa T; Tenenbaum H; Goldberg M; Wolff M; Gu Y
Review: INNATE IMMUNITY. 2016;22(1):85-99
Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease
Alfakry H; Malle E; Koyani CN; Pussinen PJ; Sorsa T
Letter: CLINICAL INFECTIOUS DISEASES. 2015;61(6):1031-1032
The Use of Doxycycline and Tetracycline in Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae Colonization
Lauhio A; Tervahartiala T; Leppilahti J; Golub LM; Ryan ME; Sorsa T
Letter: CLINICAL INFECTIOUS DISEASES. 2015;61(6):1031
The Use of Doxycycline and Tetracycline in Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae Colonization.
Lauhio A; Tervahartiala T; Leppilahti J; Golub LM; Ryan ME; Sorsa T
Letter: ACUTE CARDIAC CARE. 2015;17(3):46-47
Practical implications of novel serum ELISA-assay for matrix metalloproteinase-8 in acute cardiac diagnostics.
Nieminen MT; Vesterinen P; Tervahartiala T; Kormi I; Sinisalo J; Pussinen PJ; Sorsa T
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