Tianyi Li

Postdoctoral Researcher
Telephone: +46852482881
Visiting address: CCK R8:04, 17176 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Hartman, 171 77 Stockholm

Research

  • Nowadays, approximately 150, 000 different chemicals are in the market in USA,
    EU, Japan and China. We are exposed to many chemicals including those that
    are known to disrupt our endocrine system (i.e. endocrine disrupting
    chemicals, EDCs). Many EDCs are shown to disrupt reproductive performance,
    leading to adverse outcomes such as ovarian dysgenesis, early depletion of
    ovarian reserve and infertility. FREIA project aims to develop a screening
    and identification approach for endocrine disrupting chemicals targeting
    ovary. The novel endpoints and mechanisms of ovarian disruption are
    investigated using in-vitro ovarian tissue culture and primary cell culture.
    Tissues and primary ovarian cells are exposed to diethylstilbestrol and
    ketoconazole and effects on steroidogenesis and follicle features are
    studied. We aim to develop a human-relevant screening and identification
    approach for EDCs and implement the findings to regulatory guideline assays
    for reproductive toxicity in rats.

Articles

Employments

  • Postdoctoral Researcher, Department of Oncology-Pathology, Karolinska Institutet, 2024-2026
  • Phd Student, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2019-2024

Degrees and Education

  • Degree Of Master Of Medical Science 120 Credits, Karolinska Institutet, 2019

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