Tian-Jie Lyu

I am a dedicated researcher specializing in the clinical and basic research of cerebrovascular diseases, with a particular focus on translational medicine. My research integrates clinical cohort data, genetic background, and multi-omics approaches to identify potential therapeutic targets for cerebrovascular diseases. I leverage molecular biology, immunohistochemistry, morphology, and animal behavior studies to validate clinical findings and elucidate underlying pathological mechanisms.

1. Cerebrovascular Disease Research: I investigate potential intervention targets that influence clinical outcomes in cerebrovascular disease patients by combining clinical cohort data, population genetics, and multi-omics analyses. To validate these clinical discoveries, I conduct basic experiments utilizing advanced techniques such as molecular biology, immunohistochemistry, and animal behavior studies.

2. Development of Translational Tools for Stroke Research: I am involved in the development of novel tools to advance stroke research, including ultrasound-guided, targeted embolization models and artificial intelligence-based automated systems for animal behavior evaluation. I also explore the design and application of physiological monitoring and neural modulation devices.

3. ASD Mouse Model Research: Previously, I developed a global knockout mouse model for Frmd5, a gene implicated in Autism Spectrum Disorder (ASD). Using a combination of biochemical, molecular, behavioral, electrophysiological, morphological, and proteomics techniques, I provided a comprehensive analysis of the FRMD5 protein's expression patterns across various developmental stages and biological systems. My work was the first to demonstrate how Frmd5 deletion leads to ASD-like neuronal morphology, synaptic dysfunction, and behavioral changes, potentially by disrupting the precise distribution of synapse-related proteins.