Theodoros Foukakis

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CV
Public outreach and news

Articles

Article: NATURE COMMUNICATIONS. 2024;15(1):3837
Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer
Wang K; Zerdes I; Johansson HJ; Sarhan D; Sun Y; Kanellis DC; Sifakis EG; Mezheyeuski A; Liu X; Loman N; Hedenfalk I; Bergh J; Bartek J; Hatschek T; Lehtio J; Matikas A; Foukakis T
Article: BREAST CANCER RESEARCH AND TREATMENT. 2024;204(2):299-308
The role of serum thymidine kinase 1 activity in neoadjuvant-treated HER2-positive breast cancer: biomarker analysis from the Swedish phase II randomized PREDIX HER2 trial
Zhu Y; Zerdes I; Matikas A; Cruz IR; Bergqvist M; Elinder E; Bosch A; Lindman H; Einbeigi Z; Andersson A; Carlsson L; Dreifaldt AC; Isaksson-Friman E; Hellstrom M; Johansson H; Wang K; Bergh JCS; Hatschek T; Foukakis T
Article: BREAST CANCER RESEARCH. 2024;26(1):38
Clinically relevant gene signatures provide independent prognostic information in older breast cancer patients
Castresana-Aguirre M; Johansson A; Matikas A; Foukakis T; Lindstroem LS; Tobin NP
Article: BREAST CANCER RESEARCH. 2024;26(1):24
Prognostic impact of HER2 biomarker levels in trastuzumab-treated early HER2-positive breast cancer
Ronnlund C; Sifakis EG; Schagerholm C; Yang Q; Karlsson E; Chen X; Foukakis T; Weidler J; Bates M; Fredriksson I; Robertson S; Hartman J
Article: BREAST CANCER RESEARCH. 2024;26(1):4
Identification of a Notch transcriptomic signature for breast cancer
Braune E-B; Geist F; Tang X; Kalari K; Boughey J; Wang L; Leon-Ferre RA; D'Assoro AB; Ingle JN; Goetz MP; Kreis J; Wang K; Foukakis T; Seshire A; Wienke D; Lendahl U
Article: ECLINICALMEDICINE. 2024;67:102335
Gonadotropin Releasing Hormone agonist (GnRHa) during chemotherapy and post-cancer childbirths - a Nationwide population-based cohort study of 24,922 women diagnosed with cancer in Sweden
Rodriguez-Wallberg KA; Kieler H; Foukakis T; Li J; Gissler M; Oberg AS; Bergh J; Lundberg FE
Article: BMJ OPEN. 2023;13(12):e078023
ProFertil study protocol for the investigation of gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy aiming at fertility protection of young women and teenagers with cancer in Sweden-a phase III randomised double-blinded placebo-controlled study
Rodriguez-Wallberg KA; Nilsson HP; Bergh J; Malmros J; Ljungman P; Foukakis T; Stragliotto CL; Friman EI; Linderholm B; Valachis A; Andersson A; Harrysson S; Vennstrom L; Frisk P; Moerse H; Eloranta S
Article: JOURNAL OF CLINICAL ONCOLOGY. 2023;41(33):5118-5130
Impact of BMI in Patients With Early Hormone Receptor-Positive Breast Cancer Receiving Endocrine Therapy With or Without Palbociclib in the PALLAS Trial
Pfeiler G; Hlauschek D; Mayer EL; Deutschmann C; Kacerovsky-Strobl S; Martin M; Meisel JL; Zdenkowski N; Loibl S; Balic M; Park H; Prat A; Isaacs C; Bajetta E; Balko JM; Bellet-Ezquerra M; Bliss J; Burstein H; Cardoso F; Fohler H; Foukakis T; Gelmon KA; Goetz M; Haddad TC; Iwata H; Jassem J; Lee S-C; Linderholm B; Los M; Mamounas EP; Miller KD; Morris PG; Munzone E; Gal-Yam EN; Ring A; Shepherd L; Singer C; Thomssen C; Tseng L-M; Valagussa P; Winer EP; Wolff AC; Zoppoli G; Machacek-Link J; Schurmans C; Huang X; Gauthier E; Fesl C; Dueck AC; DeMichele A; Gnant M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(22):e166666
FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters
Li M; Nishimura T; Takeuchi Y; Hongu T; Wang Y; Shiokawa D; Wang K; Hirose H; Sasahara A; Yano M; Ishikawa S; Inokuchi M; Ota T; Tanabe M; Tada K-I; Akiyama T; Cheng X; Liu C-C; Yamashita T; Sugano S; Uchida Y; Chiba T; Asahara H; Nakagawa M; Sato S; Miyagi Y; Shimamura T; Nagai LAE; Kanai A; Katoh M; Nomura S; Nakato R; Suzuki Y; Tojo A; Voon DC; Ogawa S; Okamoto K; Foukakis T; Gotoh N
Article: ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. ANNUAL INTERNATIONAL CONFERENCE. 2023;2023:1-4
Multiresolution Self-Supervised Feature Integration via Attention Multiple Instance Learning for Histopathology Analysis.
Tsiknakis N; Tzoras E; Zerdes I; Manikis GC; Acs B; Hartman J; Hatschek T; Foukakis T; Marias K
Article: CLINICAL CANCER RESEARCH. 2023;29(3):532-540
Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Gryback P; Bjohle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellstrom M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(1):e2209856120
Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction
Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Min ATH; Lovrot J; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
Article: BREAST CANCER RESEARCH AND TREATMENT. 2022;194(1):49-56
Women with short survival after diagnosis of metastatic breast cancer: a population-based registry study
Boman C; Kessler LE; Bergh J; Matikas A; Foukakis T
Article: MOLECULAR ONCOLOGY. 2022;16(12):2413-2431
Integrated multi-omics profiling of high-grade estrogen receptor-positive, HER2-negative breast cancer
Wang K; Li L; Franch-Exposito S; Le X; Tang J; Li Q; Wu Q; Bassaganyas L; Camps J; Zhang X; Li H; Foukakis T; Xiang T; Wu J; Ren G
Article: CANCERS. 2022;14(11):2615
Real World Evaluation of the Prosigna/PAM50 Test in a Node-Negative Postmenopausal Swedish Population: A Multicenter Study
Kjallquist U; Acs B; Margolin S; Karlsson E; Kessler LE; Hernandez SG; Ekholm M; Lundgren C; Olsson E; Lindman H; Foukakis T; Matikas A; Hartman J
Article: NPJ BREAST CANCER. 2021;7(1):144
Interplay between copy number alterations and immune profiles in the early breast cancer Scandinavian Breast Group 2004-1 randomized phase II trial: results from a feasibility study
Zerdes I; Simonetti M; Matikas A; Harbers L; Acs B; Boyaci C; Zhang N; Salgkamis D; Agartz S; Moreno-Ruiz P; Bai Y; Rimm DL; Hartman J; Mezheyeuski A; Bergh J; Crosetto N; Foukakis T
Article: CANCERS. 2021;13(18):4655
Discordance of PD-L1 Expression at the Protein and RNA Levels in Early Breast Cancer
Zerdes I; Karafousia V; Mezheyeuski A; Stogiannitsi M; Kuiper R; Ruiz PM; Rassidakis G; Bergh J; Hatschek T; Foukakis T; Matikas A
Article: JAMA ONCOLOGY. 2021;7(9):1360-1367
Neoadjuvant Trastuzumab, Pertuzumab, and Docetaxel vs Trastuzumab Emtansine in Patients With ERBB2-Positive Breast Cancer A Phase 2 Randomized Clinical Trial
Hatschek T; Foukakis T; Bjohle J; Lekberg T; Fredholm H; Elinder E; Bosch A; Pekar G; Lindman H; Schiza A; Einbeigi Z; Adra J; Andersson A; Carlsson L; Dreifaldt AC; Isaksson-Friman E; Agartz S; Azavedo E; Gryback P; Hellstrom M; Johansson H; Maes C; Zerdes I; Hartman J; Brandberg Y; Bergh J
Article: ESMO OPEN. 2021;6(4):100217
Benefit of pazopanib in advanced gastrointestinal stromal tumours: results from a phase II trial (SSG XXI, PAGIST)
Eriksson M; Reichardt P; Joensuu H; Krarup-Hansen A; Hagberg O; Hohenberger P; Hagberg H; Hansson L; Foukakis T; Pulkkanen K; Bauer S; Goplen D; Rossen PB; Hall KS
Article: CLINICAL NUTRITION. 2021;40(5):3370-3378
Vitamin K intake and breast cancer incidence and death: results from a prospective cohort study
Wang K; Wu Q; Li Z; Reger MK; Xiong Y; Zhong G; Li Q; Zhang X; Li H; Foukakis T; Xiang T; Zhang J; Ren G
Article: ESMO OPEN. 2021;6(2):100076
bPrognostic role of serum thymidine kinase 1 kinetics during neoadjuvant chemotherapy for early breast cancer
Matikas A; Wang K; Lagoudaki E; Acs B; Zerdes I; Hartman J; Azavedo E; Bjohle J; Carlsson L; Einbeigi Z; Hedenfalk I; Hellstrom M; Lekberg T; Loman N; Saracco A; von Wachenfeldt A; Rotstein S; Bergqvist M; Bergh J; Hatschek T; Foukakis T
Article: NPJ BREAST CANCER. 2021;7(1):21
Risk of hematologic malignancies after breast ductal carcinoma in situ treatment with ionizing radiation
Wang K; Li Z; Chen X; Zhang J; Xiong Y; Zhong G; Shi Y; Li Q; Zhang X; Li H; Xiang T; Foukakis T; Radivoyevitch T; Ren G
Article: ESMO OPEN. 2020;5(6):e001032
PD-1 protein and gene expression as prognostic factors in early breast cancer
Matikas A; Zerdes I; Lovrot J; Sifakis E; Richard F; Sotiriou C; Rassidakis G; Bergh J; Valachis A; Foukakis T
Article: ACTA ONCOLOGICA. 2020;59(11):1382-1387
Efficacy and safety of cyclin dependent kinases 4/6 inhibitors in the treatment of metastatic breast cancer: a real-world experience
Kessler LE; Wiklander O; Hamberg E; Bergh J; Foukakis T; Matikas A
Article: JAMA ONCOLOGY. 2020;6(10):1581-1588
External Evaluation of 3 Commercial Artificial Intelligence Algorithms for Independent Assessment of Screening Mammograms
Salim M; Wahlin E; Dembrower K; Azavedo E; Foukakis T; Liu Y; Smith K; Eklund M; Strand F
Article: BREAST CANCER RESEARCH AND TREATMENT. 2020;181(3):645-651
Chemotherapy use near the end-of-life in patients with metastatic breast cancer
Kessler LE; Sigfridsson J; Hatzidaki D; Bergh J; Foukakis T; Georgoulias V; Matikas A
Article: ANNALS OF ONCOLOGY. 2020;31(5):569-581
Pembrolizumab plus chemotherapy as neoadjuvant treatment of high-risk, early-stage triple-negative breast cancer: results from the phase 1b open-label, multicohort KEYNOTE-173 study
Schmid P; Salgado R; Park YH; Munoz-Couselo E; Kim SB; Sohn J; Im S-A; Foukakis T; Kuemmel S; Dent R; Yin L; Wang A; Tryfonidis K; Karantza V; Cortes J; Loi S
Article: BREAST CANCER RESEARCH AND TREATMENT. 2020;181(1):87-96
Long-term (up to 16 months) health-related quality of life after adjuvant tailored dose-dense chemotherapy vs. standard three-weekly chemotherapy in women with high-risk early breast cancer
Brandberg Y; Johansson H; Hellstrom M; Gnant M; Mobus V; Greil R; Foukakis T; Bergh J
Article: MOLECULAR ONCOLOGY. 2020;14(5):951-963
Programmed death-ligand 1 gene expression is a prognostic marker in early breast cancer and provides additional prognostic value to 21-gene and 70-gene signatures in estrogen receptor-positive disease
Zerdes I; Sifakis EG; Matikas A; Chretien S; Tobin NP; Hartman J; Rassidakis GZ; Bergh J; Foukakis T
Article: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2020;106(5):958-967
Five-Year Results of the Preoperative Accelerated Partial Breast Irradiation (PAPBI) Trial
Bosma SCJ; Leij F; Vreeswijk S; de Maaker M; Wesseling J; van de Vijver M; Scholten A; Rivera S; Bourgier C; Auzac G; Foukakis T; Lekberg T; Bongard D; Loo C; Rutgers E; Bartelink H; Elkhuizen PHM
Article: CANCER. 2020;126(6):1175-1182
Efficacy and Safety of Tailored and Dose-Dense Adjuvant Chemotherapy and Trastuzumab for Resected HER2-Positive Breast Cancer: Results From the Phase 3 PANTHER Trial
Papakonstantinou A; Matikas A; Bengtsson NO; Malmstrom P; Hedayati E; Steger G; Untch M; Hubbert L; Johansson H; Hellstrom M; Gnant M; Loibl S; Greil R; Moebus V; Foukakis T; Bergh J
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2020;382(9):810-821
Pembrolizumab for Early Triple-Negative Breast Cancer
Schmid P; Cortes J; Pusztai L; McArthur H; Kuemmel S; Bergh J; Denkert C; Park YH; Hui R; Harbeck N; Takahashi M; Foukakis T; Fasching PA; Cardoso F; Untch M; Jia L; Karantza V; Zhao J; Aktan G; Dent R; O'Shaughnessy J
Article: ACTA ONCOLOGICA. 2020;59(1):75-81
Neutropenic complications in the PANTHER phase III study of adjuvant tailored dose-dense chemotherapy in early breast cancer
Papakonstantinou A; Hedayati E; Hellstrom M; Johansson H; Gnant M; Steger G; Greil R; Untch M; Moebus V; Loibl S; Foukakis T; Bergh J; Matikas A
Article: NPJ BREAST CANCER. 2020;6:36
Long-term anti-inflammatory diet in relation to improved breast cancer prognosis: a prospective cohort study.
Wang K; Sun J-Z; Wu Q-X; Li Z-Y; Li D-X; Xiong Y-F; Zhong G-C; Shi Y; Li Q; Zheng J; Shivappa N; Hébert JR; Foukakis T; Zhang X; Li H-Y; Xiang T-X; Ren G-S
Article: ONCOLOGIST. 2020;25(1):23-32
Effects of Exercise on Chemotherapy Completion and Hospitalization Rates: The OptiTrain Breast Cancer Trial
Mijwel S; Bolam KA; Gerrevall J; Foukakis T; Wengstrom Y; Rundqvist H
Article: CANCERS. 2019;11(10):E1479-1479
STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer
Zerdes I; Wallerius M; Sifakis EG; Wallmann T; Betts S; Bartish M; Tsesmetzis N; Tobin NP; Coucoravas C; Bergh J; Rassidakis GZ; Rolny C; Foukakis T
Article: BRITISH JOURNAL OF CANCER. 2019;120(10):959-967
Quality of life under extended continuous versus intermittent adjuvant letrozole in lymph node-positive, early breast cancer patients: the SOLE randomised phase 3 trial
Ribi K; Luo W; Colleoni M; Karlsson P; Chirgwin J; Aebi S; Jerusalem G; Neven P; Di Lauro V; Gomez HL; Ruhstaller T; Abdi E; Biganzoli L; Mueller B; Barbeaux A; Graas M-P; Rabaglio M; Francis PA; Foukakis T; Pagani O; Graff C; Vorobiof D; Maibach R; Di Leo A; Gelber RD; Goldhirsch A; Coates AS; Regan MM; Bernhard J
Article: LANCET. 2019;393(10179):1440-1452
Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37298 women with early breast cancer in 26 randomised trials
Boddington C; Bradley R; Braybrooke J; Burrett J; Clarke M; Davies C; Davies L; Dodwell D; Duane F; Evans V; Gettins L; Godwin J; Gray R; Hills R; James S; Liu H; Liu Z; MacKinnon E; Mannu G; McGale P; McHugh T; Morris P; Pan H; Peto R; Read S; Taylor C; Wang Y; Wang Z; Bradley R; Braybrooke J; Gray R; Bergh J; Peto R; Gray R; Bradley R; Braybrooke J; Liu Z; Peto R; Davies L; Dodwell D; McGale P; Pan H; Taylor C; Barlow W; Bliss J; Bruzzi P; Cameron D; Fountzilas G; Loibl S; Mackey J; Martin M; Del Mastro L; Moebus V; Nekljudova V; De Placido S; Swain S; Untch M; Pritchard KI; Bergh J; Norton L; Fasching P; Harbeck N; Untch M; Piedbois P; Gnant M; Steger G; Di Leo A; Dolci S; Francis P; Larsimont D; Nogaret JM; Philippson C; Piccart-Gebhart MJ; Linn S; Peer P; Tjan-Heijnen V; Vliek S; Mackey J; Martin M; Slamon D; Bartlett JMS; Bramwell VH; Chen BE; Chia SKL; Gelmon K; Goss PE; Levine MN; Parulekar W; Pater JL; Pritchard KI; Rakovitch E; Shepherd LE; Tu D; Whelan T; Berry D; Broadwater G; Cirrincione C; Muss H; Norton L; Weiss RB; Shan Y; Shao YF; Wang X; Xu B; Zhao DB; Bartelink H; Bijker N; Bogaerts J; Cardoso F; Cufer T; Julien JP; Poortmans PM; Rutgers E; van de Velde CJH; Carrasco E; Martin M; Segui MA; Blohmer JU; Costa SD; Gerber B; Jackisch C; Loibl S; Nekljudova V; von Minckwitz G; Bruzzi P; Giuliano M; De laurentiis M; De Placido S; Del Mastro L; Bamia C; Fountzilas G; Koliou G-A; Mavroudis D; A'Hern R; Bliss J; Cameron D; Ellis P; Kilburn L; Morden J; Yarnold JR; Sadoon M; Tulusan AH; Anderson S; Bass G; Costantino J; Dignam J; Fisher B; Geyer C; Mamounas EP; Paik S; Redmond C; Swain S; Wickerham L; Wolmark N; Del Mastro L; Venturini M; Bighin C; Bruzzi P; Del Mastro L; Pastorino S; Pronzato P; Sertoli MR; Barlow W; Bergh J; Foukakis T; Pritchard KI; Swain S; Cameron D; Albain K; Anderson S; Arriagada R; Barlow W; Bartlett J; Bergsten-Nordstrom E; Bliss J; Boccardo F; Bradley R; Brain E; Braybrooke J; Carey L; Clarke M; Coates A; Coleman R; Correa C; Costantino J; Cuzick J; Davidson N; Davies C; Davies L; Di Leo A; Dodwell D; Dowsett M; Duane F; Ewertz M; Forbes J; Francis P; Gelber R; Gnant M; Goldhirsch A; Goodwin P; Gray R; Hayes D; Hill C; Ingle J; Jagsi R; Janni W; Liu Z; Loibl S; MacKinnon E; Mannu G; Martin M; McGale P; Mukai H; Nekljudova V; Norton L; Ohashi Y; Paik S; Pan H; Peto R; Piccart M; Pierce L; Poortmans P; Raina V; Ravdin P; Rea D; Regan M; Robertson J; Rutgers E; Slamon D; Sparano J; Steger G; Taylor C; Tutt A; Viale G; Wang X; Whelan T; Wilcken N; Wolmark N; Wood W; Zambetti M
Article: BREAST CANCER RESEARCH. 2019;21(1):34
The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours
Lundberg A; Lindstroem LS; Li J; Harrell JC; Darai-Ramqvist E; Sifakis EG; Foukakis T; Perou CM; Czene K; Bergh J; Tobin NP
Article: ANNALS OF ONCOLOGY. 2019;30(1):109-114
Dose tailoring of adjuvant chemotherapy for breast cancer based on hematologic toxicities: further results from the prospective PANTHER study with focus on obese patients
Matikas A; Foukakis T; Moebus V; Greil R; Bengtsson N-O; Steger GG; Untch M; Johansson H; Hellstrom M; Malmstrom P; Gnant M; Loibl S; Bergh J
Article: BREAST CANCER RESEARCH AND TREATMENT. 2018;172(3):703-712
Prognosis in patients diagnosed with loco-regional failure of breast cancer: 34years longitudinal data from the Stockholm-Gotland cancer registry
Falato C; Taylor SK; Szulkin R; Nordblom A; Eriksson L; Sofiadis A; Fredriksson I; Hartman J; Bergh J; Foukakis T
Article: ONCOIMMUNOLOGY. 2018;7(9):e1466017
Dynamic evaluation of the immune infiltrate and immune function genes as predictive markers for neoadjuvant chemotherapy in hormone receptor positive, HER2 negative breast cancer
Matikas A; Lovrot J; Ramberg A; Eriksson M; Lindsten T; Lekberg T; Hedenfalk I; Loman N; Bergh J; Hatschek T; Erlandsson A; Foukakis T
Article: CELL. 2018;173(4):879-893.e13
Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing
Kim C; Gao R; Sei E; Brandt R; Hartman J; Hatschek T; Crosetto N; Foukakis T; Navin NE
Article: EJNMMI RESEARCH. 2018;8(1):25
Treatment response assessment with (R)-[¹¹CPAQ PET in the MMTV-PyMT mouse model of breast cancer
Tegnebratt T; Lu L; Eksborg S; Chireh A; Damberg P; Nikkhou-Aski S; Foukakis T; Rundqvist H; Holmin S; Kuiper RV; Samen E
Article: BRITISH JOURNAL OF CANCER. 2018;118(4):480-488
Immune gene expression and response to chemotherapy in advanced breast cancer
Foukakis T; Lovrot J; Matikas A; Zerdes I; Lorent J; Tobin N; Suzuki C; Brage SE; Carlsson L; Einbeigi Z; Linderholm B; Loman N; Malmberg M; Ferno M; Skoog L; Bergh J; Hatschek T
Article: CLINICAL CANCER RESEARCH. 2017;23(24):7512-7520
Gene Expression Signatures and Immunohistochemical Subtypes Add Prognostic Value to Each Other in Breast Cancer Cohorts
Lundberg A; Lindstrom LS; Harrell JC; Falato C; Carlson JW; Wright PK; Foukakis T; Perou CM; Czene K; Bergh J; Tobin NP
Article: CLINICAL CANCER RESEARCH. 2017;23(23):7225-7231
PAM50 Provides Prognostic Information When Applied to the Lymph Node Metastases of Advanced Breast Cancer Patients
Tobin NP; Lundberg A; Lindstrom LS; Harrell JC; Foukakis T; Carlsson L; Einbeigi Z; Linderholm BK; Loman N; Malmberg M; Ferno M; Czene K; Perou CM; Bergh J; Hatschek T
Article: CANCER CELL. 2017;32(5):669-683.e5
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression
Palazon A; Tyrakis PA; Macias D; Velica P; Rundqvist H; Fitzpatrick S; Vojnovic N; Phan AT; Loman N; Hedenfalk I; Hatschek T; Lovrot J; Foukakis T; Goldrath AW; Bergh J; Johnson RS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(45):E9635-E9644
Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production
Nakamura M; Zhang Y; Yang Y; Sonmez C; Zheng W; Huang G; Seki T; Iwamoto H; Ding B; Yin L; Foukakis T; Hatschek T; Li X; Hosaka K; Li J; Yu G; Wang X; Liu Y; Cao Y
Article: NATURE COMMUNICATIONS. 2017;8(1):228
Nanogrid single-nucleus RNA sequencing reveals phenotypic diversity in breast cancer
Gao R; Kim C; Sei E; Foukakis T; Crosetto N; Chan L-K; Srinivasan M; Zhang H; Meric-Bernstam F; Navin N
Article: LAKARTIDNINGEN. 2017;114:EEIS
[Chemotherapy and targeted drugs to reinforce each other].
Foukakis T; Bergh J
Article: ONCOTARGET. 2016;7(46):74966-74978
Periostin is identified as a putative metastatic marker in breast cancer-derived exosomes
Vardaki I; Ceder S; Rutishauser D; Baltatzis G; Foukakis T; Panaretakis T
Article: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2016;316(18):1888-1896
Effect of Tailored Dose-Dense Chemotherapy vs Standard 3-Weekly Adjuvant Chemotherapy on Recurrence-Free Survival Among Women With High-Risk Early Breast Cancer A Randomized Clinical Trial
Foukakis T; von Minckwitz G; Bengtsson N-O; Brandberg Y; Wallberg B; Fornander T; Mlineritsch B; Schmatloch S; Singer CF; Steger G; Egle D; Karlsson E; Carlsson L; Loibl S; Untch M; Hellstrom M; Johansson H; Anderson H; Malmstrom P; Gnant M; Greil R; Mobus V; Bergh J
Article: CLINICAL CANCER RESEARCH. 2016;22(10):2417-2426
An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors
Tobin NP; Wennmalm K; Lindstrom LS; Foukakis T; He L; Genove G; Ostman A; Landberg G; Betsholtz C; Bergh J
Article: JOURNAL OF CLINICAL ONCOLOGY. 2016;34(14):1573-1U58
Is Estradiol Monitoring Necessary in Women Receiving Ovarian Suppression for Breast Cancer?
Papakonstantinou A; Foukakis T; Rodriguez-Wallberg KA; Bergh J
Article: MOLECULAR ONCOLOGY. 2016;10(4):517-525
Intrinsic subtypes and genomic signatures of primary breast cancer and prognosis after systemic relapse
Falato C; Tobin NP; Lorent J; Lindstrom LS; Bergh J; Foukakis T
Article: MOLECULAR ONCOLOGY. 2015;9(7):1384-1391
Gene expression profiling of sequential metastatic biopsies for biomarker discovery in breast cancer
Foukakis T; Lovrot J; Sandqvist P; Xie H; Lindstrom LS; Giorgetti C; Jacobsson H; Hedayati E; Bergh J
Article: ACTA ONCOLOGICA. 2015;54(4):522-529
A retrospective safety and efficacy analysis of the first patients treated with eribulin for metastatic breast cancer in Stockholm, Sweden
Kessler L; Falato C; Margolin S; Bergh J; Foukakis T
Article: RADIOTHERAPY AND ONCOLOGY. 2015;114(3):322-327
First results of the preoperative accelerated partial breast irradiation (PAPBI) trial
van der Leij F; Bosma SCJ; van de Vijver MJ; Wesseling J; Vreeswijk S; Rivera S; Bourgier C; Garbay J-R; Foukakis T; Lekberg T; van den Bongard DHJGD; van Vliet-Vroegindeweij C; Bartelink H; Rutgers EJ; Elkhuizen PHM
Article: BREAST CANCER RESEARCH AND TREATMENT. 2014;147(2):407-414
Ki67 measured in metastatic tissue and prognosis in patients with advanced breast cancer
Falato C; Lorent J; Tani E; Karlsson E; Wright PK; Bergh J; Foukakis T
Article: CANCER CHEMOTHERAPY AND PHARMACOLOGY. 2014;74(3):549-558
Validation of a novel procedure for quantification of the formation of phosphoramide mustard by individuals treated with cyclophosphamide
von Stedingk H; Xie H; Hatschek T; Foukakis T; Ryden A; Bergh J; Rydberg P
Article: BRITISH JOURNAL OF CANCER. 2014;110(5):1378-1384
Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics
Colzani E; Johansson ALV; Liljegren A; Foukakis T; Clements M; Adolfsson J; Hall P; Czene K
Article: BMC CANCER. 2013;13:473
Clinical instability of breast cancer markers is reflected in long-term in vitro estrogen deprivation studies
Milosevic J; Klinge J; Borg A-L; Foukakis T; Bergh J; Tobin NP
Article: JOURNAL OF SURGICAL ONCOLOGY. 2012;106(8):981-986
Anaplastic carcinoma of the thyroid gland: Treatment and outcome over 13 years at one institution
Segerhammar I; Larsson C; Nilsson I-L; Backdahl M; Hoog A; Wallin G; Foukakis T; Zedenius J
Article: ANNALS OF ONCOLOGY. 2012;23:349-353
When to order a biopsy to characterise a metastatic relapse in breast cancer
Foukakis T; Astrom G; Lindstrom L; Hatschek T; Bergh J
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2012;166(4):657-667
Proteomic profiling of follicular and papillary thyroid tumors
Sofiadis A; Becker S; Hellman U; Hultin-Rosenberg L; Dinets A; Hulchiy M; Zedenius J; Wallin G; Foukakis T; Hoog A; Auer G; Lehtio J; Larsson C
Article: BREAST CANCER RESEARCH AND TREATMENT. 2011;130(2):553-560
Age-specific trends of survival in metastatic breast cancer: 26 years longitudinal data from a population-based cancer registry in Stockholm, Sweden
Foukakis T; Fornander T; Lekberg T; Hellborg H; Adolfsson J; Bergh J
Article: THYROID. 2010;20(10):1067-1076
Proteomic Study of Thyroid Tumors Reveals Frequent Up-Regulation of the Ca²⁺-Binding Protein S100A6 in Papillary Thyroid Carcinoma
Sofiadis A; Dinets A; Orre LM; Branca RM; Juhlin CC; Foukakis T; Wallin G; Hoog A; Hulchiy M; Zedenius J; Larsson C; Lehtio J
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2009;35(2):369-374
Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy
Sofiadis A; Tani E; Foukakis T; Kjellman P; Skoog L; Hoog A; Wallin G; Zedenius J; Larsson C
Article: ENDOCRINE-RELATED CANCER. 2008;15(3):801-815
Array-CGH identifies cyclin D1 and UBCH10 amplicons in anaplastic thyroid carcinoma
Lee J-J; Au AYM; Foukakis T; Barbaro M; Kiss N; Clifton-Bligh R; Staaf J; Borg A; Delbridge L; Robinson BG; Wallin G; Hoog A; Larsson C
Article: JOURNAL OF PATHOLOGY. 2008;215(1):87-96
Frizzled-1 is down-regulated in follicular thyroid tumours and modulates growth and invasiveness
Ulivieri A; Lavra L; Dominici R; Giacomelli L; Brunetti E; Sciacca L; Trovato M; Barresi G; Foukakis T; Jia-Jing L; Larsson C; Bartolazzi A; Sciacchitano S
Article: ENDOCRINE-RELATED CANCER. 2007;14(2):381-391
A PCR-based expression signature of malignancy in follicular thyroid tumors
Foukakis T; Gusnanto A; Au AYM; Hoog A; Lui W-O; Larsson C; Wallin G; Zedenius J
Article: THYROID. 2007;17(4):289-301
Molecular cytogenetic profiles of novel and established human anaplastic thyroid carcinoma models
Lee J-J; Foukakis T; Hashemi J; Grimelius L; Heldin N-E; Wallin G; Rudduck C; Lui W-O; Hoog A; Larsson C
Article: ENDOCRINE-RELATED CANCER. 2007;14(1):125-134
The Ras effectors NORE1A and RASSF1A are frequently inactivated in pheochromocytoma and abdominal paraganglioma
Geli J; Kiss N; Lanner F; Foukakis T; Natalishvili N; Larsson O; Kogner P; Hoog A; Clark GJ; Ekstrom TJ; Backdahl M; Farnebo F; Larsson C
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2006;91(3):1143-1149
The Ras effector NORE1A is suppressed in follicular thyroid carcinomas with a PAX8-PPARγ fusion
Foukakis T; Au AYM; Wallin G; Geli J; Forsberg L; Clifton-Bligh R; Robinson BG; Lui WO; Zedenius J; Larsson C
Article: TUMOR BIOLOGY. 2006;27(4):211-220
Molecular markers for discrimination of benign and malignant follicular thyroid tumors
Fryknas M; Wickenberg-Bolin U; Goransson H; Gustafsson MG; Foukakis T; Lee J-J; Landegren U; Hoog A; Larsson C; Grimelius L; Wallin G; Pettersson U; Isaksson A
Article: ONCOGENE. 2005;24(8):1467-1476
Expression profiling reveals a distinct transcription signature in follicular thyroid carcinomas with a PAX8-PPARγ fusion oncogene
Lui WO; Foukakis T; Lidén J; Thoppe SR; Dwight T; Höög A; Zedenius J; Wallin G; Reimers M; Larsson C
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2005;26(1):141-149
Molecular cytogenetic characterization of primary cultures and established cell lines from non-medullary thyroid tumors
Foukakis T; Thoppe SR; Lagercrantz S; Dwight T; Weng WH; Svensson A; Höög A; Zedenius J; Wallin G; Lui WO; Larsson C
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2003;88(9):4440-4445
Involvement of the PAX8/peroxisome proliferator-activated receptor γ rearrangement in follicular thyroid tumors
Dwight T; Thoppe SR; Foukakis T; Lui WO; Wallin G; Höög A; Frisk T; Larsson C; Zedenius J
Article: GENES CHROMOSOMES & CANCER. 2002;35(1):74-80
Silencing of the PTEN tumor-suppressor gene in anaplastic thyroid cancer
Frisk T; Foukakis T; Dwight T; Lundberg J; Höög A; Wallin G; Eng C; Zedenius J; Larsson C
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1992;33(4):861-869
Gene-specific promoter hypermethylation without global hypomethylation in follicular thyroid cancer
Lee J-J; Geli J; Larsson C; Wallin G; Karimi M; Zedenius J; Hoog A; Foukakis T
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All other publications

Review: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. 2023;192:104189
The ever-expanding landscape of antibody-drug conjugates (ADCs) in solid tumors: A systematic review
Filis P; Zerdes I; Soumala T; Matikas A; Foukakis T
Editorial comment: MOLECULAR ONCOLOGY. 2023;17(4):545-547
The interplay between eosinophils and T cells in breast cancer immunotherapy
Zerdes I; Matikas A; Foukakis T
Review: JOURNAL OF IMAGING. 2022;8(11):303
Harmonization Strategies in Multicenter MRI-Based Radiomics
Stamoulou E; Spanakis C; Manikis GC; Karanasiou G; Grigoriadis G; Foukakis T; Tsiknakis M; Fotiadis DI; Marias K
Review: CANCERS. 2022;14(8):1999
Dissecting Tumor-Immune Microenvironment in Breast Cancer at a Spatial and Multiplex Resolution
Tzoras E; Zerdes I; Tsiknakis N; Manikis GC; Mezheyeuski A; Bergh J; Matikas A; Foukakis T
Review: FRONTIERS IN ONCOLOGY. 2022;12:999843
Expression patterns and prognostic implications of tumor-infiltrating lymphocytes dynamics in early breast cancer patients receiving neoadjuvant therapy: A systematic review and meta-analysis
Zhu Y; Tzoras E; Matikas A; Bergh J; Valachis A; Zerdes I; Foukakis T
Editorial comment: ANNALS OF ONCOLOGY. 2021;32(12):1457-1459
Adjuvant abemaciclib for high-risk breast cancer: the story continues
Spring L; Matikas A; Bardia A; Foukakis T
Review: ESMO OPEN. 2021;6(6):100289
The prognostic and predictive impact of low estrogen receptor expression in early breast cancer: a systematic review and meta-analysis
Paakkola N-M; Karakatsanis A; Mauri D; Foukakis T; Valachis A
Corrigendum: JAMA ONCOLOGY. 2021;7(9):1405-1406
Errors in Abstract and Results.
Review: CANCER TREATMENT REVIEWS. 2021;99:102257
Discordance of PD-L1 status between primary and metastatic breast cancer: A systematic review and meta-analysis
Boman C; Zerdes I; Martensson K; Bergh J; Foukakis T; Valachis A; Matikas A
Editorial comment: BREAST CARE. 2021;16(4):422-428
Expert Discussion: HER2-Positive Breast Cancer
Foukakis T; Matikas A; Oikonomidou O; Andreopoulou E; Mavroudis D
Editorial comment: ANNALS OF ONCOLOGY. 2021;32(2):129-132
SOLAR1s: alpelisib returns to earth?
Matikas A; Foukakis T
Corrigendum: BRITISH JOURNAL OF CANCER. 2020;122(7):1119
Correction: Quality of life under extended continuous versus intermittent adjuvant letrozole in lymph node-positive, early breast cancer patients: the SOLE randomised phase 3 trial.
Ribi K; Luo W; Colleoni M; Karlsson P; Chirgwin J; Aebi S; Jerusalem G; Neven P; Di Lauro V; Gomez HL; Ruhstaller T; Abdi E; Biganzoli L; Müller B; Barbeaux A; Graas M-P; Rabaglio M; Francis PA; Foukakis T; Pagani O; Graiff C; Vorobiof D; Maibach R; Di Leo A; Gelber RD; Goldhirsch A; Coates AS; Regan MM; Bernhard J; SOLE Investigators
Review: CLINICAL CANCER RESEARCH. 2019;25(18):5717-5726
Prognostic Implications of PD-L1 Expression in Breast Cancer: Systematic Review and Meta-analysis of Immunohistochemistry and Pooled Analysis of Transcriptomic Data
Matikas A; Zerdes I; Lovrot J; Richard F; Sotiriou C; Bergh J; Valachis A; Foukakis T
Review: ANNALS OF ONCOLOGY. 2019;30(7):1044-1050
Avoiding over- and undertreatment in patients with resected node-positive breast cancer with the use of gene expression signatures: are we there yet?
Matikas A; Foukakis T; Swain S; Bergh J
Review: CANCERS. 2019;11(5):E628-628
Beyond PD-1/PD-L1 Inhibition: What the Future Holds for Breast Cancer Immunotherapy
Chretien S; Zerdes I; Bergh J; Matikas A; Foukakis T
Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2019;285(4):395-397
Minimally invasive tissue access as a tool for delivering personalized medicine - with focus on oncology
Matikas A; Foukakis T; Bergh J
Editorial comment: ANNALS OF ONCOLOGY. 2018;29(12):2278-2280
Carboplatin in the neoadjuvant treatment of triple-negative breast cancer-ready for prime time?
Foukakis T
Letter: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2018;110(11):1280-1281
RE: Receptor Conversion in Distant Breast Cancer Metastases: A Systematic Review and Meta-analysis
Matikas A; Foukakis T; Bergh J
Review: ONCOGENE. 2018;37(34):4639-4661
Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations
Zerdes I; Matikas A; Bergh J; Rassidakis GZ; Foukakis T
Editorial comment: LANCET ONCOLOGY. 2018;19(7):850-852
Ribociclib in premenopausal women with advanced breast cancer
Foukakis T
Published conference paper: BREAST CANCER RESEARCH AND TREATMENT. 2018;168(2):349-355
Long-term safety and survival outcomes from the Scandinavian Breast Group 2004-1 randomized phase II trial of tailored dose-dense adjuvant chemotherapy for early breast cancer
Matikas A; Margolin S; Hellstrom M; Johansson H; Bengtsson N-O; Karlsson L; Edlund P; Karlsson P; Lidbrink E; Linderholm B; Lindman H; Malmstrom P; Villman K; Foukakis T; Bergh J
Review: ACTA ONCOLOGICA. 2017;56(9):1143-1151
Dose intense, dose dense and tailored dose adjuvant chemotherapy for early breast cancer: an evolution of concepts
Matikas A; Foukakis T; Bergh J
Review: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. 2017;114:91-101
Tackling endocrine resistance in ER-positive HER2-negative advanced breast cancer: A tale of imprecision medicine
Matikas A; Foukakis T; Bergh J
Review: EXPERT REVIEW OF ANTICANCER THERAPY. 2017;17(4):319-326
Implementing neoadjuvant endocrine strategies in ER-positive, HER2-negative breast cancer
Matikas A; Foukakis T; Michalakis I; Georgoulias V
Letter: JOURNAL OF CLINICAL ONCOLOGY. 2017;35(1):121-122
Estradiol Level and Menopause Reply
Papakonstantinou A; Foukakis T; Rodriguez-Wallberg KA; Bergh J
Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2016;374(14):1386-1387
A 21-Gene Expression Assay in Breast Cancer
Foukakis T; Falato C; Bergh J
Review: JOURNAL OF INTERNAL MEDICINE. 2015;278(6):545-570
The importance of molecular markers for diagnosis and selection of targeted treatments in patients with cancer
Tobin NP; Foukakis T; De Petris L; Bergh J
Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2014;371(1):84-85
Thyroid Hormone Inactivation in Gastrointestinal Stromal Tumors
Foukakis T; Lovrot J; Bergh J
Review: ACTA ONCOLOGICA. 2007;46(3):277-285
Advances in the treatment of patients with gastric adenocarcinoma
Foukakis T; Lundell L; Gubanski M; Lind PA
Thesis / dissertation: 2005
Basic and translational studies of follicular thyroid neoplasia
Foukakis, Theodoros
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Employments

Senior Lecturer/Senior Physician, Department of Oncology-Pathology, Karolinska Institutet, 2020-

Degrees and Education

Docent, Karolinska Institutet, 2014
Doctor Of Philosophy, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2005

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