Theodoros Foukakis

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Articles

Article: INTERNATIONAL JOURNAL OF CANCER. 2025;156(8):1621-1633
Prognostic and predictive implications of sterile alpha motif and HD domain-containing protein 1 (SAMHD1) expression in breast cancer
Kouvaraki M; Zerdes I; Sifakis EG; Sarafidis M; Matikas A; Tzoras E; Kjallquist U; Stathopoulou K; Lovrot J; Alkodsi A; Hartman J; Sotiriou C; Richard F; Hatschek T; Herold N; Bergh J; Rassidakis GZ; Foukakis T
Article: EUROPEAN JOURNAL OF RADIOLOGY. 2025;183:111895
Effect of needle size on outcomes of vacuum-assisted excision of breast lesions. A randomized controlled trial
Zouzos A; Fredriksson I; Karakatsanis A; Aristokleous I; Foukakis T; Strand F
Article: LANCET REGIONAL HEALTH-EUROPE. 2025;49:101162
Benefit from dose-dense adjuvant chemotherapy for breast cancer: subgroup analyses from the randomised phase 3 PANTHER trial
Matikas A; Papakonstantinou A; Loibl S; Steger GG; Untch M; Johansson H; Tsiknakis N; Hellstrom M; Greil R; Moebus V; Gnant M; Bergh J; Foukakis T
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2025;:djaf015
Comprehensive genome profiling for treatment decisions in patients with metastatic tumors: real-world evidence meta-analysis and registry data implementation
Zerdes I; Filis P; Fountoukidis G; El-Naggar AI; Kalofonou F; D'Alessio A; Pouptsis A; Foukakis T; Pentheroudakis G; Ahlgren J; Smith D; Valachis A
Article: EJSO. 2025;51(3):109587
Long-term outcome for neoadjuvant versus adjuvant chemotherapy in early breast cancer and the prognostic impact of nodal therapy response: A population-based study
Liu X; Bergman LE; Boman C; Foukakis T; Matikas A
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2024;391(21):1981-1991
Overall Survival with Pembrolizumab in Early-Stage Triple-Negative Breast Cancer
Schmid P; Cortes J; Dent R; McArthur H; Pusztai L; Kuemmel S; Denkert C; Park YH; Hui R; Harbeck N; Takahashi M; Im S-A; Untch M; Fasching PA; Mouret-Reynier M-A; Foukakis T; Ferreira M; Cardoso F; Zhou X; Karantza V; Tryfonidis K; Aktan G; O'Shaughnessy J
Article: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(26):3077-3082
Tailored Dose-Dense Versus Standard Adjuvant Chemotherapy for High-Risk Early Breast Cancer: End-of-Study Results of the Randomized PANTHER Trial
Matikas A; Moebus V; Greil R; Andersson A; Steger GG; Untch M; Fornander T; Malmstroem P; Schmatloch S; Johansson H; Hellstroem M; Brandberg Y; Gnant M; Loibl S; Foukakis T; Bergh J
Article: BRITISH JOURNAL OF CANCER. 2024;131(4):718-728
A population-based study on trajectories of HER2 status during neoadjuvant chemotherapy for early breast cancer and metastatic progression
Boman C; Liu X; Eriksson Bergman L; Sun W; Tranchell C; Toli MA; Acs B; Bergh J; Foukakis T; Matikas A
Article: NATURE MEDICINE. 2024;30(9):2623-2630
AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial
Salim M; Liu Y; Sorkhei M; Ntoula D; Foukakis T; Fredriksson I; Wang Y; Eklund M; Azizpour H; Smith K; Strand F
Journal article: ANNALS OF ONCOLOGY. 2024;35:s355-s356
EORTC-2129-BCG: Elacestrant for treating ER+/HER2-breast cancer patients with ctDNA relapse (TREAT ctDNA)
Ignatiadis M; Saloustros E; Joaquim A; Casas JG; Kelly CM; Razis E; Lambertini M; Foukakis T; Fehr M; van Oordt CWM-VDH; Crestani TA; Simon SP; Bussels B; Hanssens M; Neven P; Xenophontos E; Meyskens T; Bidard FC; Poncet C; Janni W
Journal article: ANNALS OF ONCOLOGY. 2024;35:s262
Comprehensive cancer genome profiling as supportive tool for treatment decision-making in patients with metastatic solid tumors: Real-world evidence-based meta-analysis and nationwide cancer registry data implementation
Zerdes I; Filis P; Fountoukidis G; El-Naggar AI; Kalofonou F; D'Alessio A; Pouptsis A; Foukakis T; Pentheroudakis G; Ahlgren J; Smith D; Valachis A
Article: IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS. 2024;28(9):5312-5322
Unveiling the Power of Model-Agnostic Multiscale Analysis for Enhancing Artificial Intelligence Models in Breast Cancer Histopathology Images
Tsiknakis N; Manikis G; Tzoras E; Salgkamis D; Vidal JM; Wang K; Zaridis D; Sifakis E; Zerdes I; Bergh J; Hartman J; Acs B; Marias K; Foukakis T
Journal article: ANNALS OF ONCOLOGY. 2024;35:s356
A randomized trial of trastuzumab deruxtecan and biologydriven selection of neoadjuvant treatment for HER2-positive breast cancer (ARIADNE)
Foukakis T; Naume B; Karakatsanis A; Andersson A; Barnekow E; Kessler LE; Einbeigi Z; Engebraten O; Killander F; Linderholm BK; Schiza A; Valachis A; Bergh J; Villacampa G; Zouzos A; Hellstrom M; Hartman J; Matikas A
Journal article: ANNALS OF ONCOLOGY. 2024;35:s1112
Grading the evidence for physical activity and all outcomes in cancer survivors: An umbrella review of more than 700 meta-analytic associations
Filis P; Markozannes G; Chan D; Mauri D; Foukakis T; Matikas A; Droufakou S; Pentheroudakis G; Tsilidis K
Article: SCIENTIFIC REPORTS. 2024;14(1):18275
Systematic review and feasibility study on pre-analytical factors and genomic analyses on archival formalin-fixed paraffin-embedded breast cancer tissue
Salgkamis D; Sifakis EG; Agartz S; Wirta V; Hartman J; Bergh J; Foukakis T; Matikas A; Zerdes I
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(16_suppl):521
Estimating benefit from dose dense adjuvant chemotherapy for early breast cancer in the PANTHER randomized phase 3 trial.
Matikas A; Gnant M; Johansson H; Untch M; Tsiknakis N; Greil R; Loibl S; Foukakis T; Bergh JCS
Article: NATURE COMMUNICATIONS. 2024;15(1):3837
Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer
Wang K; Zerdes I; Johansson HJ; Sarhan D; Sun Y; Kanellis DC; Sifakis EG; Mezheyeuski A; Liu X; Loman N; Hedenfalk I; Bergh J; Bartek J; Hatschek T; Lehtio J; Matikas A; Foukakis T
Journal article: CANCER RESEARCH. 2024;84(9_Supplement):ps12-09-ps12-09
Abstract PS12-09: Capivasertib plus cyclin-dependent kinase 4/6 inhibitor and fulvestrant in hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: updated Phase 1b analysis from CAPItello-292
Hamilton E; Neven P; Pistilli B; Beeram M; Borges V; Campone M; Guimarães JLM; Foukakis T; Kodahl AR; Lau P; Lim E; Ługowska I; Rychlik G; Gresty C; Miller C; Sommavilla R; Sudhan D; Rugo H
Journal article: CANCER RESEARCH. 2024;84(9_Supplement):lbo1-01-lbo1-01
Abstract LBO1-01: Neoadjuvant pembrolizumab or placebo plus chemotherapy followed by adjuvant pembrolizumab or placebo for early-stage triple-negative breast cancer: Updated event-free survival results from the phase 3 KEYNOTE-522 study
Schmid P; Cortés J; Dent R; Pusztai L; McArthur H; Küemmel S; Denkert C; Park YH; Hui R; Harbeck N; Takahashi M; Foukakis T; Mouret-Reynier M-A; Ferreira M; Im S-A; Cardoso F; Ding Y; Pan W; Tryfonidis K; O'Shaughnessy J
Journal article: ESMO OPEN. 2024;9:103131
144P Factors affecting long term outcomes in patients with pathologic complete response after neoadjuvant chemotherapy for early breast cancer: A population-based study
Boman CE; Tranchell C; Liu X; Bergman LE; Toli MA; Bergh J; Foukakis T; Matikas A
Journal article: ESMO OPEN. 2024;9:103074
68P Application of a machine learning model for identifying an ultra-low risk group of early breast cancer patients
Sarafidis M; Sifakis EG; Bergh J; Foukakis T; Matikas A
Journal article: ESMO OPEN. 2024;9:103124
137P Adherence to and optimization of guidelines for risk of recurrence/Prosigna testing using a machine learning model: A Swedish multicenter study
Kjällquist U; Tsiknakis N; Acs B; Margolin S; Ekholm M; Kessler LE; Lundgren C; Garcia SG; Olsson EJ; Lindman H; Valachis A; Hartman J; Foukakis T; Matikas A
Journal article: ESMO OPEN. 2024;9:103099
111MO Tailored dose-dense versus standard adjuvant chemotherapy for high-risk early breast cancer: Efficacy outcomes and key subgroups after 10 years of follow-up in the randomized phase III PANTHER trial
Foukakis T; Matikas A; Möbus V; Greil R; Andersson A; Steger GG; Untch M; Fornander T; Malmstrom P; Johansson H; Hellström M; Brandberg Y; Gnant MI; Loibl S; Bergh J
Journal article: ESMO OPEN. 2024;9:103116
129P Adherence to adjuvant endocrine therapy in the era of combination treatments: A population-based study
Bergman LE; Matikas A; Liu X; Foukakis T
Article: BREAST CANCER RESEARCH AND TREATMENT. 2024;204(2):299-308
The role of serum thymidine kinase 1 activity in neoadjuvant-treated HER2-positive breast cancer: biomarker analysis from the Swedish phase II randomized PREDIX HER2 trial
Zhu Y; Zerdes I; Matikas A; Cruz IR; Bergqvist M; Elinder E; Bosch A; Lindman H; Einbeigi Z; Andersson A; Carlsson L; Dreifaldt AC; Isaksson-Friman E; Hellstrom M; Johansson H; Wang K; Bergh JCS; Hatschek T; Foukakis T
Article: BREAST CANCER RESEARCH. 2024;26(1):38
Clinically relevant gene signatures provide independent prognostic information in older breast cancer patients
Castresana-Aguirre M; Johansson A; Matikas A; Foukakis T; Lindstroem LS; Tobin NP
Article: BREAST CANCER RESEARCH. 2024;26(1):24
Prognostic impact of HER2 biomarker levels in trastuzumab-treated early HER2-positive breast cancer
Ronnlund C; Sifakis EG; Schagerholm C; Yang Q; Karlsson E; Chen X; Foukakis T; Weidler J; Bates M; Fredriksson I; Robertson S; Hartman J
Article: BREAST CANCER RESEARCH. 2024;26(1):4
Identification of a Notch transcriptomic signature for breast cancer
Braune E-B; Geist F; Tang X; Kalari K; Boughey J; Wang L; Leon-Ferre RA; D'Assoro AB; Ingle JN; Goetz MP; Kreis J; Wang K; Foukakis T; Seshire A; Wienke D; Lendahl U
Journal article: ECLINICALMEDICINE. 2024;67:102335
Gonadotropin Releasing Hormone agonist (GnRHa) during chemotherapy and post-cancer childbirths - a Nationwide population-based cohort study of 24,922 women diagnosed with cancer in Sweden.
Rodriguez-Wallberg KA; Kieler H; Foukakis T; Li J; Gissler M; Oberg AS; Bergh J; Lundberg FE
Article: ECLINICALMEDICINE. 2024;67:102335
Gonadotropin Releasing Hormone agonist (GnRHa) during chemotherapy and post-cancer childbirths - a Nationwide population-based cohort study of 24,922 women diagnosed with cancer in Sweden
Rodriguez-Wallberg KA; Kieler H; Foukakis T; Li J; Gissler M; Oberg AS; Bergh J; Lundberg FE
Article: BMJ OPEN. 2023;13(12):e078023
ProFertil study protocol for the investigation of gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy aiming at fertility protection of young women and teenagers with cancer in Sweden-a phase III randomised double-blinded placebo-controlled study
Rodriguez-Wallberg KA; Nilsson HP; Bergh J; Malmros J; Ljungman P; Foukakis T; Stragliotto CL; Friman EI; Linderholm B; Valachis A; Andersson A; Harrysson S; Vennstrom L; Frisk P; Moerse H; Eloranta S
Journal article: MOLECULAR CANCER THERAPEUTICS. 2023;22(12_Supplement):b013
Abstract B013: Identification of a Notch transcriptomic signature for breast cancer
Braune E-B; Geist F; Tang X; Kalari K; Boughey J; Wang L; Leon-Ferre RA; D’Assoro AB; Ingle JN; Goetz MP; Wang K; Foukakis T; Seshire A; Wienke D; Lendahl U
Article: JOURNAL OF CLINICAL ONCOLOGY. 2023;41(33):5118-5130
Impact of BMI in Patients With Early Hormone Receptor-Positive Breast Cancer Receiving Endocrine Therapy With or Without Palbociclib in the PALLAS Trial
Pfeiler G; Hlauschek D; Mayer EL; Deutschmann C; Kacerovsky-Strobl S; Martin M; Meisel JL; Zdenkowski N; Loibl S; Balic M; Park H; Prat A; Isaacs C; Bajetta E; Balko JM; Bellet-Ezquerra M; Bliss J; Burstein H; Cardoso F; Fohler H; Foukakis T; Gelmon KA; Goetz M; Haddad TC; Iwata H; Jassem J; Lee S-C; Linderholm B; Los M; Mamounas EP; Miller KD; Morris PG; Munzone E; Gal-Yam EN; Ring A; Shepherd L; Singer C; Thomssen C; Tseng L-M; Valagussa P; Winer EP; Wolff AC; Zoppoli G; Machacek-Link J; Schurmans C; Huang X; Gauthier E; Fesl C; Dueck AC; DeMichele A; Gnant M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(22):e166666
FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters
Li M; Nishimura T; Takeuchi Y; Hongu T; Wang Y; Shiokawa D; Wang K; Hirose H; Sasahara A; Yano M; Ishikawa S; Inokuchi M; Ota T; Tanabe M; Tada K-I; Akiyama T; Cheng X; Liu C-C; Yamashita T; Sugano S; Uchida Y; Chiba T; Asahara H; Nakagawa M; Sato S; Miyagi Y; Shimamura T; Nagai LAE; Kanai A; Katoh M; Nomura S; Nakato R; Suzuki Y; Tojo A; Voon DC; Ogawa S; Okamoto K; Foukakis T; Gotoh N
Journal article: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:108455
O-59 Preclinical evaluation of [89Zr]Zr-DFO*-sacituzumab, a PET tracer for imaging of whole body TROP-2 expression as a potential selection tool for treatment with TROP-2 antibody drug conjugates (ADC)
Bratteby K; Smertinaite L; Omer S; Lu L; Milton S; Jussing E; Siikanen J; Samen E; Axelsson R; Foukakis T; Altena R; Tran T
Journal article: ANNALS OF ONCOLOGY. 2023;34:s1257
Pembrolizumab or placebo plus chemotherapy followed by pembrolizumab or placebo for early-stage TNBC: Updated EFS results from the phase III KEYNOTE-522 study
Schmid P; Cortes J; Dent RA; Pusztai L; McArthur HL; Kummel S; Denkert C; Park YH; Hui R; Harbeck N; Takahashi M; Foukakis T; Reynier MAM; Ferreira MIR; Im SA; Cardoso F; Ding Y; Pan W; Tryfonidis KE; O'Shaughnessy J
Article: ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. ANNUAL INTERNATIONAL CONFERENCE. 2023;2023:1-4
Multiresolution Self-Supervised Feature Integration via Attention Multiple Instance Learning for Histopathology Analysis
Tsiknakis N; Tzoras E; Zerdes I; Manikis GC; Acs B; Hartman J; Hatschek T; Foukakis T; Marias K
Journal article: ESMO OPEN. 2023;8(1):101395
206P Capivasertib (C) + palbociclib (P) and fulvestrant (F) in patients (pts) with HR+/HER2- advanced breast cancer (ABC): Phase Ib data from CAPItello-292
Neven P; Hamilton E; Pistilli B; Borges V; Campone M; Foukakis T; Kodahl AR; Lau PKH; Lim E; Lugowska I; Collins J; Gresty C; Miller C; Sommavilla R; Sudhan D; Rugo HS
Journal article: ESMO OPEN. 2023;8(1):101447
259TiP Treatment of oligometastatic breast cancer (OMBC): A randomised phase III trial comparing stereotactic ablative radiotherapy (SABR) and systemic treatment with systemic treatment alone as first-line treatment - TAORMINA
Linderholm BK; Valachis A; Flote VG; Poortmans P; Person OK; Niligal-Yam E; O'Reilly S; Duane F; Marinko T; Ekholm M; Andersson A; Bergqvist J; Foukakis T; Kadum M; Kulbacka-Ortiz K; Nilsson-Ek A; Visani L; Lundstedt D; Meattini I
Journal article: BREAST. 2023;68:s63-s64
P125 Neoadjuvant pembrolizumab + chemotherapy vs placebo + chemotherapy followed by adjuvant pembrolizumab vs placebo for early TNBC: surgical outcomes from the phase 3 KEYNOTE-522 study
Kümmel S; Schmid P; Harbeck N; Takahashi M; Untch M; Boileau J-F; Cortes J; McArthur H; Dent R; O’Shaughnessy J; Pusztai L; Foukakis T; Park YH; Hui R; Cardoso F; Denkert C; Zhu Y; Pan W; Karantza V; Fasching P
Journal article: CANCER RESEARCH. 2023;83(5_Supplement):pd3-01-pd3-01
Abstract PD3-01: Neoadjuvant pembrolizumab + chemotherapy vs placebo + chemotherapy followed by adjuvant pembrolizumab vs placebo for early TNBC: Post hoc analysis of adjuvant radiation therapy in the phase 3 KEYNOTE-522 study
McArthur H; Cortés J; Dent R; O’Shaughnessy J; Pusztai L; Küemmel S; Foukakis T; Park YH; Hui R; Harbeck N; Takahashi M; Untch M; Fasching PA; Cardoso F; Denkert C; Zhu Y; Ding Y; Pan W; Schmid P
Article: CLINICAL CANCER RESEARCH. 2023;29(3):532-540
Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Gryback P; Bjohle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellstrom M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(1):e2209856120
Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction
Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Min ATH; Lovrot J; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
Journal article: EUROPEAN JOURNAL OF CANCER. 2022;175:s40
126 (PB-039) Poster A multimodal approach for the management of co-morbid cardiotoxicity in the elderly breast cancer patients
Karanasiou G; Grigoriadis G; Alexandraki A; Antoniades A; Brown C; Bucur A; Cipolla C; Economopoulou P; Foukakis T; Goossens J; Keramida K; Lakkas L; Marias K; Naka K; Papakonstantinou A; Pravettoni G; Ribnikar D; Šeruga B; Zacharia M; Tsiknakis M; Fotiadis DI
Article: BREAST CANCER RESEARCH AND TREATMENT. 2022;194(1):49-56
Women with short survival after diagnosis of metastatic breast cancer: a population-based registry study
Boman C; Kessler LE; Bergh J; Matikas A; Foukakis T
Article: MOLECULAR ONCOLOGY. 2022;16(12):2413-2431
Integrated multi-omics profiling of high-grade estrogen receptor-positive, HER2-negative breast cancer
Wang K; Li L; Franch-Exposito S; Le X; Tang J; Li Q; Wu Q; Bassaganyas L; Camps J; Zhang X; Li H; Foukakis T; Xiang T; Wu J; Ren G
Article: CANCERS. 2022;14(11):2615
Real World Evaluation of the Prosigna/PAM50 Test in a Node-Negative Postmenopausal Swedish Population: A Multicenter Study
Kjallquist U; Acs B; Margolin S; Karlsson E; Kessler LE; Hernandez SG; Ekholm M; Lundgren C; Olsson E; Lindman H; Foukakis T; Matikas A; Hartman J
Journal article: CANCER RESEARCH. 2022;82(4_Supplement):p4-12-01-p4-12-01
Abstract P4-12-01: Adherence with adjuvant endocrine therapy with or without Palbociclib in the PALLAS trial
Shinn E; Zahrieh D; DeMichele A; Zdenkowski N; Lemieux J; Mao J; Bjelic-Radisic V; Naughton M; Pfeiler G; Gelmon K; Mayer I; Egle D; Zoppoli G; Traina T; Jiménez MM; Novoa SA; Haddad T; Chan A; Ring AE; Wolff A; Lorenzo JJ; Sabanathan D; Burstein H; Nowecki ZI; Pristauz-Telsnigg G; Brufsky A; Bellet-Ezquerra M; Foukakis T; Novik Y; Rubovszky G; Muehlbacher K; Metzger O; Goulioti T; Law E; Partridge A; Carey L; Zoroufy A; Hlauschek D; Fesl C; Mayer E; Gnant M
Journal article: CANCER RESEARCH. 2022;82(4):p3-18-03-p3-18-03
Long-term outcomes for breast conservation plus radiotherapy versus mastectomy in early breast cancer after neoadjuvant systemic therapy: Results from the Swedish national breast cancer register (NKBC)
Wang K; Duinmeijer A; Matikas A; Altena R; Johansson H; Fredholm H; Foukakis T
Article: NPJ BREAST CANCER. 2021;7(1):144
Interplay between copy number alterations and immune profiles in the early breast cancer Scandinavian Breast Group 2004-1 randomized phase II trial: results from a feasibility study
Zerdes I; Simonetti M; Matikas A; Harbers L; Acs B; Boyaci C; Zhang N; Salgkamis D; Agartz S; Moreno-Ruiz P; Bai Y; Rimm DL; Hartman J; Mezheyeuski A; Bergh J; Crosetto N; Foukakis T
Journal article: BRITISH JOURNAL OF SURGERY. 2021;108(9):1120-1125
Axillary evaluation in ductal cancer in situ of the breast: challenging the diagnostic accuracy of clinical practice guidelines
Karakatsanis A; Charalampoudis P; Pistioli L; Di Micco R; Foukakis T; Valachis A
Article: CANCERS. 2021;13(18):4655
Discordance of PD-L1 Expression at the Protein and RNA Levels in Early Breast Cancer
Zerdes I; Karafousia V; Mezheyeuski A; Stogiannitsi M; Kuiper R; Ruiz PM; Rassidakis G; Bergh J; Hatschek T; Foukakis T; Matikas A
Article: JAMA ONCOLOGY. 2021;7(9):1360-1367
Neoadjuvant Trastuzumab, Pertuzumab, and Docetaxel vs Trastuzumab Emtansine in Patients With ERBB2-Positive Breast Cancer A Phase 2 Randomized Clinical Trial
Hatschek T; Foukakis T; Bjohle J; Lekberg T; Fredholm H; Elinder E; Bosch A; Pekar G; Lindman H; Schiza A; Einbeigi Z; Adra J; Andersson A; Carlsson L; Dreifaldt AC; Isaksson-Friman E; Agartz S; Azavedo E; Gryback P; Hellstrom M; Johansson H; Maes C; Zerdes I; Hartman J; Brandberg Y; Bergh J
Article: ESMO OPEN. 2021;6(4):100217
Benefit of pazopanib in advanced gastrointestinal stromal tumours: results from a phase II trial (SSG XXI, PAGIST)
Eriksson M; Reichardt P; Joensuu H; Krarup-Hansen A; Hagberg O; Hohenberger P; Hagberg H; Hansson L; Foukakis T; Pulkkanen K; Bauer S; Goplen D; Rossen PB; Hall KS
Article: CLINICAL NUTRITION. 2021;40(5):3370-3378
Vitamin K intake and breast cancer incidence and death: results from a prospective cohort study
Wang K; Wu Q; Li Z; Reger MK; Xiong Y; Zhong G; Li Q; Zhang X; Li H; Foukakis T; Xiang T; Zhang J; Ren G
Article: ESMO OPEN. 2021;6(2):100076
bPrognostic role of serum thymidine kinase 1 kinetics during neoadjuvant chemotherapy for early breast cancer
Matikas A; Wang K; Lagoudaki E; Acs B; Zerdes I; Hartman J; Azavedo E; Bjohle J; Carlsson L; Einbeigi Z; Hedenfalk I; Hellstrom M; Lekberg T; Loman N; Saracco A; von Wachenfeldt A; Rotstein S; Bergqvist M; Bergh J; Hatschek T; Foukakis T
Article: NPJ BREAST CANCER. 2021;7(1):21
Risk of hematologic malignancies after breast ductal carcinoma in situ treatment with ionizing radiation
Wang K; Li Z; Chen X; Zhang J; Xiong Y; Zhong G; Shi Y; Li Q; Zhang X; Li H; Xiang T; Foukakis T; Radivoyevitch T; Ren G
Article: ACTA ONCOLOGICA. 2020;59(11):1382-1387
Efficacy and safety of cyclin dependent kinases 4/6 inhibitors in the treatment of metastatic breast cancer: a real-world experience
Kessler LE; Wiklander O; Hamberg E; Bergh J; Foukakis T; Matikas A
Article: ESMO OPEN. 2020;5(6):e001032
PD-1 protein and gene expression as prognostic factors in early breast cancer
Matikas A; Zerdes I; Lovrot J; Sifakis E; Richard F; Sotiriou C; Rassidakis G; Bergh J; Valachis A; Foukakis T
Article: JAMA ONCOLOGY. 2020;6(10):1581-1588
External Evaluation of 3 Commercial Artificial Intelligence Algorithms for Independent Assessment of Screening Mammograms
Salim M; Wahlin E; Dembrower K; Azavedo E; Foukakis T; Liu Y; Smith K; Eklund M; Strand F
Article: BREAST CANCER RESEARCH AND TREATMENT. 2020;181(3):645-651
Chemotherapy use near the end-of-life in patients with metastatic breast cancer
Kessler LE; Sigfridsson J; Hatzidaki D; Bergh J; Foukakis T; Georgoulias V; Matikas A
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2020;38(15_suppl):590
One-year follow-up of health-related quality of life in the Swedish PREDIX HER 2 trial, evaluating docetaxel, trastuzumab sc, pertuzumab versus trastuzumab emtansine as neoadjuvant treatment of HER2 positive breast cancer.
Brandberg Y; Foukakis T; Andersson A; Bjohle J; Bosch A; Carlsson L; Einbeigi Z; Fredholm H; Isaksson-Friman E; Hellstrom M; Johansson H; Lekberg T; Lindman H; Bergh JCS; Hatschek T
Article: ANNALS OF ONCOLOGY. 2020;31(5):569-581
Pembrolizumab plus chemotherapy as neoadjuvant treatment of high-risk, early-stage triple-negative breast cancer: results from the phase 1b open-label, multicohort KEYNOTE-173 study
Schmid P; Salgado R; Park YH; Munoz-Couselo E; Kim SB; Sohn J; Im S-A; Foukakis T; Kuemmel S; Dent R; Yin L; Wang A; Tryfonidis K; Karantza V; Cortes J; Loi S
Article: MOLECULAR ONCOLOGY. 2020;14(5):951-963
Programmed death-ligand 1 gene expression is a prognostic marker in early breast cancer and provides additional prognostic value to 21-gene and 70-gene signatures in estrogen receptor-positive disease
Zerdes I; Sifakis EG; Matikas A; Chretien S; Tobin NP; Hartman J; Rassidakis GZ; Bergh J; Foukakis T
Article: BREAST CANCER RESEARCH AND TREATMENT. 2020;181(1):87-96
Long-term (up to 16 months) health-related quality of life after adjuvant tailored dose-dense chemotherapy vs. standard three-weekly chemotherapy in women with high-risk early breast cancer
Brandberg Y; Johansson H; Hellstrom M; Gnant M; Mobus V; Greil R; Foukakis T; Bergh J
Article: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2020;106(5):958-967
Five-Year Results of the Preoperative Accelerated Partial Breast Irradiation (PAPBI) Trial
Bosma SCJ; Leij F; Vreeswijk S; de Maaker M; Wesseling J; van de Vijver M; Scholten A; Rivera S; Bourgier C; Auzac G; Foukakis T; Lekberg T; Bongard D; Loo C; Rutgers E; Bartelink H; Elkhuizen PHM
Article: CANCER. 2020;126(6):1175-1182
Efficacy and Safety of Tailored and Dose-Dense Adjuvant Chemotherapy and Trastuzumab for Resected HER2-Positive Breast Cancer: Results From the Phase 3 PANTHER Trial
Papakonstantinou A; Matikas A; Bengtsson NO; Malmstrom P; Hedayati E; Steger G; Untch M; Hubbert L; Johansson H; Hellstrom M; Gnant M; Loibl S; Greil R; Moebus V; Foukakis T; Bergh J
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2020;382(9):810-821
Pembrolizumab for Early Triple-Negative Breast Cancer
Schmid P; Cortes J; Pusztai L; McArthur H; Kuemmel S; Bergh J; Denkert C; Park YH; Hui R; Harbeck N; Takahashi M; Foukakis T; Fasching PA; Cardoso F; Untch M; Jia L; Karantza V; Zhao J; Aktan G; Dent R; O'Shaughnessy J
Journal article: EJSO. 2020;46(2):e63
Axillary Evaluation in the Setting of a Preoperative Ductal Cancer in Situ (DCIS) Diagnosis. Do Guidelines (Mis)Guide?
Karakatsanis A; Valachis A; Pistioli L; Charalampoudis P; DiMicco R; Foukakis T; Wärnberg F
Article: ACTA ONCOLOGICA. 2020;59(1):75-81
Neutropenic complications in the PANTHER phase III study of adjuvant tailored dose-dense chemotherapy in early breast cancer
Papakonstantinou A; Hedayati E; Hellstrom M; Johansson H; Gnant M; Steger G; Greil R; Untch M; Moebus V; Loibl S; Foukakis T; Bergh J; Matikas A
Article: NPJ BREAST CANCER. 2020;6:36
Long-term anti-inflammatory diet in relation to improved breast cancer prognosis: a prospective cohort study.
Wang K; Sun J-Z; Wu Q-X; Li Z-Y; Li D-X; Xiong Y-F; Zhong G-C; Shi Y; Li Q; Zheng J; Shivappa N; Hébert JR; Foukakis T; Zhang X; Li H-Y; Xiang T-X; Ren G-S
Journal article: NPJ BREAST CANCER. 2020;6(1)
Long-term anti-inflammatory diet in relation to improved breast cancer prognosis: a prospective cohort study
Wang K; Sun J-Z; Wu Q-X; Li Z-Y; Li D-X; Xiong Y-F; Zhong G-C; Shi Y; Li Q; Zheng J; Shivappa N; Hebert JR; Foukakis T; Zhang X; Li H-Y; Xiang T-X; Ren G-S
Article: ONCOLOGIST. 2020;25(1):23-32
Effects of Exercise on Chemotherapy Completion and Hospitalization Rates: The OptiTrain Breast Cancer Trial
Mijwel S; Bolam KA; Gerrevall J; Foukakis T; Wengstrom Y; Rundqvist H
Journal article: ANNALS OF ONCOLOGY. 2019;30:v86-v87
258P Impact of menopause status on breast cancer outcomes and amenorrhea incidence during adjuvant tailored dose dense chemotherapy
Papakonstantinou A; Matikas A; Hellström M; Johansson H; Steger G; Greil R; Loibl S; Gnant M; Moebus V; Untch M; Foukakis T; Bergh J
Journal article: ANNALS OF ONCOLOGY. 2019;30:v853-v854
LBA8_PR KEYNOTE-522: Phase III study of pembrolizumab (pembro) + chemotherapy (chemo) vs placebo (pbo) + chemo as neoadjuvant treatment, followed by pembro vs pbo as adjuvant treatment for early triple-negative breast cancer (TNBC)
Schmid P; Cortés J; Dent R; Pusztai L; McArthur HL; Kuemmel S; Bergh J; Denkert C; Park YH; Hui R; Harbeck N; Takahashi M; Foukakis T; Fasching PA; Cardoso F; Jia L; Karantza V; Zhao J; Aktan G; O’Shaughnessy J
Journal article: ANNALS OF ONCOLOGY. 2019;30:v136
373P Administration of chemotherapy for metastatic breast cancer near the end of life: A population registry study
Kessler LE; Sigfridsson J; Bergh J; Foukakis T; Matikas A
Article: CANCERS. 2019;11(10):E1479-1479
STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer
Zerdes I; Wallerius M; Sifakis EG; Wallmann T; Betts S; Bartish M; Tsesmetzis N; Tobin NP; Coucoravas C; Bergh J; Rassidakis GZ; Rolny C; Foukakis T
Journal article: 2019
Pembrolizumab Plus Chemotherapy as Neoadjuvant Treatment for Locally Advanced Triple-Negative Breast Cancer: Results from the Phase 1b Open-Label, Multicohort KEYNOTE-173 Study
Schmid P; Salgado R; Park YH; Muñoz-Couselo E; Kim S-B; Sohn J; Foukakis T; Kuemmel S; Dent R; Yin L; Wang A; Tryfonidis K; Karantza V; Cortés J; Loi S
Article: BRITISH JOURNAL OF CANCER. 2019;120(10):959-967
Quality of life under extended continuous versus intermittent adjuvant letrozole in lymph node-positive, early breast cancer patients: the SOLE randomised phase 3 trial
Ribi K; Luo W; Colleoni M; Karlsson P; Chirgwin J; Aebi S; Jerusalem G; Neven P; Di Lauro V; Gomez HL; Ruhstaller T; Abdi E; Biganzoli L; Mueller B; Barbeaux A; Graas M-P; Rabaglio M; Francis PA; Foukakis T; Pagani O; Graff C; Vorobiof D; Maibach R; Di Leo A; Gelber RD; Goldhirsch A; Coates AS; Regan MM; Bernhard J
Article: LANCET. 2019;393(10179):1440-1452
Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37298 women with early breast cancer in 26 randomised trials
Boddington C; Bradley R; Braybrooke J; Burrett J; Clarke M; Davies C; Davies L; Dodwell D; Duane F; Evans V; Gettins L; Godwin J; Gray R; Hills R; James S; Liu H; Liu Z; MacKinnon E; Mannu G; McGale P; McHugh T; Morris P; Pan H; Peto R; Read S; Taylor C; Wang Y; Wang Z; Bradley R; Braybrooke J; Gray R; Bergh J; Peto R; Gray R; Bradley R; Braybrooke J; Liu Z; Peto R; Davies L; Dodwell D; McGale P; Pan H; Taylor C; Barlow W; Bliss J; Bruzzi P; Cameron D; Fountzilas G; Loibl S; Mackey J; Martin M; Del Mastro L; Moebus V; Nekljudova V; De Placido S; Swain S; Untch M; Pritchard KI; Bergh J; Norton L; Fasching P; Harbeck N; Untch M; Piedbois P; Gnant M; Steger G; Di Leo A; Dolci S; Francis P; Larsimont D; Nogaret JM; Philippson C; Piccart-Gebhart MJ; Linn S; Peer P; Tjan-Heijnen V; Vliek S; Mackey J; Martin M; Slamon D; Bartlett JMS; Bramwell VH; Chen BE; Chia SKL; Gelmon K; Goss PE; Levine MN; Parulekar W; Pater JL; Pritchard KI; Rakovitch E; Shepherd LE; Tu D; Whelan T; Berry D; Broadwater G; Cirrincione C; Muss H; Norton L; Weiss RB; Shan Y; Shao YF; Wang X; Xu B; Zhao DB; Bartelink H; Bijker N; Bogaerts J; Cardoso F; Cufer T; Julien JP; Poortmans PM; Rutgers E; van de Velde CJH; Carrasco E; Martin M; Segui MA; Blohmer JU; Costa SD; Gerber B; Jackisch C; Loibl S; Nekljudova V; von Minckwitz G; Bruzzi P; Giuliano M; De laurentiis M; De Placido S; Del Mastro L; Bamia C; Fountzilas G; Koliou G-A; Mavroudis D; A'Hern R; Bliss J; Cameron D; Ellis P; Kilburn L; Morden J; Yarnold JR; Sadoon M; Tulusan AH; Anderson S; Bass G; Costantino J; Dignam J; Fisher B; Geyer C; Mamounas EP; Paik S; Redmond C; Swain S; Wickerham L; Wolmark N; Del Mastro L; Venturini M; Bighin C; Bruzzi P; Del Mastro L; Pastorino S; Pronzato P; Sertoli MR; Barlow W; Bergh J; Foukakis T; Pritchard KI; Swain S; Cameron D; Albain K; Anderson S; Arriagada R; Barlow W; Bartlett J; Bergsten-Nordstrom E; Bliss J; Boccardo F; Bradley R; Brain E; Braybrooke J; Carey L; Clarke M; Coates A; Coleman R; Correa C; Costantino J; Cuzick J; Davidson N; Davies C; Davies L; Di Leo A; Dodwell D; Dowsett M; Duane F; Ewertz M; Forbes J; Francis P; Gelber R; Gnant M; Goldhirsch A; Goodwin P; Gray R; Hayes D; Hill C; Ingle J; Jagsi R; Janni W; Liu Z; Loibl S; MacKinnon E; Mannu G; Martin M; McGale P; Mukai H; Nekljudova V; Norton L; Ohashi Y; Paik S; Pan H; Peto R; Piccart M; Pierce L; Poortmans P; Raina V; Ravdin P; Rea D; Regan M; Robertson J; Rutgers E; Slamon D; Sparano J; Steger G; Taylor C; Tutt A; Viale G; Wang X; Whelan T; Wilcken N; Wolmark N; Wood W; Zambetti M
Article: BREAST CANCER RESEARCH. 2019;21(1):34
The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours
Lundberg A; Lindstroem LS; Li J; Harrell JC; Darai-Ramqvist E; Sifakis EG; Foukakis T; Perou CM; Czene K; Bergh J; Tobin NP
Article: ANNALS OF ONCOLOGY. 2019;30(1):109-114
Dose tailoring of adjuvant chemotherapy for breast cancer based on hematologic toxicities: further results from the prospective PANTHER study with focus on obese patients
Matikas A; Foukakis T; Moebus V; Greil R; Bengtsson N-O; Steger GG; Untch M; Johansson H; Hellstrom M; Malmstrom P; Gnant M; Loibl S; Bergh J
Article: BREAST CANCER RESEARCH AND TREATMENT. 2018;172(3):703-712
Prognosis in patients diagnosed with loco-regional failure of breast cancer: 34years longitudinal data from the Stockholm-Gotland cancer registry
Falato C; Taylor SK; Szulkin R; Nordblom A; Eriksson L; Sofiadis A; Fredriksson I; Hartman J; Bergh J; Foukakis T
Article: ONCOIMMUNOLOGY. 2018;7(9):e1466017
Dynamic evaluation of the immune infiltrate and immune function genes as predictive markers for neoadjuvant chemotherapy in hormone receptor positive, HER2 negative breast cancer
Matikas A; Lovrot J; Ramberg A; Eriksson M; Lindsten T; Lekberg T; Hedenfalk I; Loman N; Bergh J; Hatschek T; Erlandsson A; Foukakis T
Article: CELL. 2018;173(4):879-893.e13
Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing
Kim C; Gao R; Sei E; Brandt R; Hartman J; Hatschek T; Crosetto N; Foukakis T; Navin NE
Article: EJNMMI RESEARCH. 2018;8(1):25
Treatment response assessment with (R)-[¹¹CPAQ PET in the MMTV-PyMT mouse model of breast cancer
Tegnebratt T; Lu L; Eksborg S; Chireh A; Damberg P; Nikkhou-Aski S; Foukakis T; Rundqvist H; Holmin S; Kuiper RV; Samen E
Article: BRITISH JOURNAL OF CANCER. 2018;118(4):480-488
Immune gene expression and response to chemotherapy in advanced breast cancer
Foukakis T; Lovrot J; Matikas A; Zerdes I; Lorent J; Tobin N; Suzuki C; Brage SE; Carlsson L; Einbeigi Z; Linderholm B; Loman N; Malmberg M; Ferno M; Skoog L; Bergh J; Hatschek T
Journal article: LANCET ONCOLOGY. 2018;19(1):127-138
Extended adjuvant intermittent letrozole versus continuous letrozole in postmenopausal women with breast cancer (SOLE): a multicentre, open-label, randomised, phase 3 trial
Colleoni M; Luo W; Karlsson P; Chirgwin J; Aebi S; Jerusalem G; Neven P; Hitre E; Graas M-P; Simoncini E; Kamby C; Thompson A; Loibl S; Gavila J; Kuroi K; Marth C; Mueller B; O'Reilly S; Di Lauro V; Gombos A; Ruhstaller T; Burstein H; Ribi K; Bernhard J; Viale G; Maibach R; Rabaglio-Poretti M; Gelber RD; Coates AS; Di Leo A; Regan MM; Goldhirsch A
Article: CLINICAL CANCER RESEARCH. 2017;23(24):7512-7520
Gene Expression Signatures and Immunohistochemical Subtypes Add Prognostic Value to Each Other in Breast Cancer Cohorts
Lundberg A; Lindstrom LS; Harrell JC; Falato C; Carlson JW; Wright PK; Foukakis T; Perou CM; Czene K; Bergh J; Tobin NP
Article: CLINICAL CANCER RESEARCH. 2017;23(23):7225-7231
PAM50 Provides Prognostic Information When Applied to the Lymph Node Metastases of Advanced Breast Cancer Patients
Tobin NP; Lundberg A; Lindstrom LS; Harrell JC; Foukakis T; Carlsson L; Einbeigi Z; Linderholm BK; Loman N; Malmberg M; Ferno M; Czene K; Perou CM; Bergh J; Hatschek T
Article: CANCER CELL. 2017;32(5):669-683.e5
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression
Palazon A; Tyrakis PA; Macias D; Velica P; Rundqvist H; Fitzpatrick S; Vojnovic N; Phan AT; Loman N; Hedenfalk I; Hatschek T; Lovrot J; Foukakis T; Goldrath AW; Bergh J; Johnson RS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(45):E9635-E9644
Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production
Nakamura M; Zhang Y; Yang Y; Sonmez C; Zheng W; Huang G; Seki T; Iwamoto H; Ding B; Yin L; Foukakis T; Hatschek T; Li X; Hosaka K; Li J; Yu G; Wang X; Liu Y; Cao Y
Journal article: ANNALS OF ONCOLOGY. 2017;28:v68
219P Immune function and response to neoadjuvant chemotherapy in hormone receptor positive, HER2-negative breast cancer
Matikas A; Lövrot J; Ramberg A; Eriksson M; Lindsten T; Lekberg T; Hedenfalk I; Loman N; Bergh J; Erlandsson A; Hatschek T; Foukakis T
Journal article: ANNALS OF ONCOLOGY. 2017;28:v507
1422O CTCA toxicity scoring and EORTC quality of life questionnaire: A comparison of physicians’ and patients’ scoring of toxicity in the “Panther trial”
Brandberg Y; Loibl S; Foukakis T; Johansson H; Gnant M; Singer CF; von Minckwitz G; Bengtsson N-O; Karlsson E; Mlineritsch B; Hellström M; Steger G; Carlsson L; Egle D; Greil R; Bergh J
Journal article: ANNALS OF ONCOLOGY. 2017;28:v95
288P Prognosis after loco-regional recurrence of breast cancer: 35 years longitudinal data from the Stockholm cancer register
Falato C; Eriksson L; Sofiadis A; Taylor SK; Nordblom A; Fredriksson I; Hartman J; Bergh J; Foukakis T
Article: NATURE COMMUNICATIONS. 2017;8(1):228
Nanogrid single-nucleus RNA sequencing reveals phenotypic diversity in breast cancer
Gao R; Kim C; Sei E; Foukakis T; Crosetto N; Chan L-K; Srinivasan M; Zhang H; Meric-Bernstam F; Navin N
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2017;35:e12036
Long-term safety and survival outcomes from the Scandinavian Breast Group 2004-1 (SBG 2004-1) randomized trial of tailored dose adjuvant chemotherapy for early breast cancer.
Matikas A; Margolin S; Hellstrom M; Johansson H; Bengtsson N-O; Carlsson L; Edlund P; Karlsson P; Lidbrink E; Linderholm BK; Lindman H; Malmstrom P; Villman KK; Foukakis T; Bergh JCS
Article: LAKARTIDNINGEN. 2017;114:EEIS
[Chemotherapy and targeted drugs to reinforce each other].
Foukakis T; Bergh J
Article: ONCOTARGET. 2016;7(46):74966-74978
Periostin is identified as a putative metastatic marker in breast cancer-derived exosomes
Vardaki I; Ceder S; Rutishauser D; Baltatzis G; Foukakis T; Panaretakis T
Article: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2016;316(18):1888-1896
Effect of Tailored Dose-Dense Chemotherapy vs Standard 3-Weekly Adjuvant Chemotherapy on Recurrence-Free Survival Among Women With High-Risk Early Breast Cancer A Randomized Clinical Trial
Foukakis T; von Minckwitz G; Bengtsson N-O; Brandberg Y; Wallberg B; Fornander T; Mlineritsch B; Schmatloch S; Singer CF; Steger G; Egle D; Karlsson E; Carlsson L; Loibl S; Untch M; Hellstrom M; Johansson H; Anderson H; Malmstrom P; Gnant M; Greil R; Mobus V; Bergh J
Article: CLINICAL CANCER RESEARCH. 2016;22(10):2417-2426
An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors
Tobin NP; Wennmalm K; Lindstrom LS; Foukakis T; He L; Genove G; Ostman A; Landberg G; Betsholtz C; Bergh J
Article: JOURNAL OF CLINICAL ONCOLOGY. 2016;34(14):1573-1579
Is Estradiol Monitoring Necessary in Women Receiving Ovarian Suppression for Breast Cancer?
Papakonstantinou A; Foukakis T; Rodriguez-Wallberg KA; Bergh J
Journal article: NEW ENGLAND JOURNAL OF MEDICINE. 2016;374(14):1387
A 21-Gene Expression Assay in Breast Cancer.
Sparano JA
Article: MOLECULAR ONCOLOGY. 2016;10(4):517-525
Intrinsic subtypes and genomic signatures of primary breast cancer and prognosis after systemic relapse
Falato C; Tobin NP; Lorent J; Lindstrom LS; Bergh J; Foukakis T
Article: LANCET. 2015;386(9992):433-443
Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial
Gnant M; Pfeiler G; Dubsky PC; Hubalek M; Greil R; Jakesz R; Wette V; Balic M; Haslbauer F; Melbinger E; Bjelic-Radisic V; Artner-Matuschek S; Fitzal F; Marth C; Sevelda P; Mlineritsch B; Steger GG; Manfreda D; Exner R; Egle D; Bergh J; Kainberger F; Talbot S; Warner D; Fesl C; Singer CF
Article: MOLECULAR ONCOLOGY. 2015;9(7):1384-1391
Gene expression profiling of sequential metastatic biopsies for biomarker discovery in breast cancer
Foukakis T; Lovrot J; Sandqvist P; Xie H; Lindstrom LS; Giorgetti C; Jacobsson H; Hedayati E; Bergh J
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2015;33(15_suppl):e22090
Immunohistochemistry-based subtypes and gene expression signatures as predictors of prognosis in metastatic breast cancer.
Falato C; Tobin N; Lorent J; Lindström LS; Bergh JCS; Foukakis T
Article: ACTA ONCOLOGICA. 2015;54(4):522-529
A retrospective safety and efficacy analysis of the first patients treated with eribulin for metastatic breast cancer in Stockholm, Sweden
Kessler L; Falato C; Margolin S; Bergh J; Foukakis T
Journal article: RADIOTHERAPY AND ONCOLOGY. 2015;115:s188-s189
OC-0391: First results of the Preoperative Accelerated Partial Breast Irradiation (PAPBI) trial
Bosma SCJ; Van der Leij F; Van de Vijver MJ; Rivera S; Foukakis T; Van den Bongard HJGD; Vreeswijk SAOJ; Bartelink H; Rutgers EJ; Elkhuizen PHM
Article: RADIOTHERAPY AND ONCOLOGY. 2015;114(3):322-327
First results of the preoperative accelerated partial breast irradiation (PAPBI) trial
van der Leij F; Bosma SCJ; van de Vijver MJ; Wesseling J; Vreeswijk S; Rivera S; Bourgier C; Garbay J-R; Foukakis T; Lekberg T; van den Bongard DHJGD; van Vliet-Vroegindeweij C; Bartelink H; Rutgers EJ; Elkhuizen PHM
Article: CANCER CHEMOTHERAPY AND PHARMACOLOGY. 2014;74(3):549-558
Validation of a novel procedure for quantification of the formation of phosphoramide mustard by individuals treated with cyclophosphamide
von Stedingk H; Xie H; Hatschek T; Foukakis T; Ryden A; Bergh J; Rydberg P
Article: BREAST CANCER RESEARCH AND TREATMENT. 2014;147(2):407-414
Ki67 measured in metastatic tissue and prognosis in patients with advanced breast cancer
Falato C; Lorent J; Tani E; Karlsson E; Wright PK; Bergh J; Foukakis T
Journal article: NEW ENGLAND JOURNAL OF MEDICINE. 2014;371(1):86-87
Thyroid hormone inactivation in gastrointestinal stromal tumors.
Maynard MA; Huang SA
Article: BRITISH JOURNAL OF CANCER. 2014;110(5):1378-1384
Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics
Colzani E; Johansson ALV; Liljegren A; Foukakis T; Clements M; Adolfsson J; Hall P; Czene K
Article: BMC CANCER. 2013;13:473
Clinical instability of breast cancer markers is reflected in long-term in vitro estrogen deprivation studies
Milosevic J; Klinge J; Borg A-L; Foukakis T; Bergh J; Tobin NP
Article: JOURNAL OF SURGICAL ONCOLOGY. 2012;106(8):981-986
Anaplastic carcinoma of the thyroid gland: Treatment and outcome over 13 years at one institution
Segerhammar I; Larsson C; Nilsson I-L; Backdahl M; Hoog A; Wallin G; Foukakis T; Zedenius J
Article: ANNALS OF ONCOLOGY. 2012;23:x349-x353
When to order a biopsy to characterise a metastatic relapse in breast cancer
Foukakis T; Astrom G; Lindstrom L; Hatschek T; Bergh J
Article: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2012;308(2):147-156
Effect of Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid or Gemcitabine vs Observation on Survival in Patients With Resected Periampullary Adenocarcinoma The ESPAC-3 Periampullary Cancer Randomized Trial
Neoptolemos JP; Moore MJ; Cox TF; Valle JW; Palmer DH; McDonald AC; Carter R; Tebbutt NC; Dervenis C; Smith D; Glimelius B; Charnley RM; Lacaine F; Scarfe AG; Middleton MR; Anthoney A; Ghaneh P; Halloran CM; Lerch MM; Olah A; Rawcliffe CL; Verbeke CS; Campbell F; Buechler MW
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(15_suppl):e11510
Safety and efficacy of eribulin in patients with advanced breast cancer treated outside of a clinical trial: A single institution experience.
Kessler L; Bergh J; Foukakis T
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(15_suppl):10083
A retrospective safety analysis of adult patients treated with high-dose methotrexate for osteosarcoma in Stockholm, Sweden.
Alm D; Linder Stragliotto C; Folin A; Bergh J; Foukakis T
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2012;166(4):657-667
Proteomic profiling of follicular and papillary thyroid tumors
Sofiadis A; Becker S; Hellman U; Hultin-Rosenberg L; Dinets A; Hulchiy M; Zedenius J; Wallin G; Foukakis T; Hoog A; Auer G; Lehtio J; Larsson C
Article: BREAST CANCER RESEARCH AND TREATMENT. 2011;130(2):553-560
Age-specific trends of survival in metastatic breast cancer: 26 years longitudinal data from a population-based cancer registry in Stockholm, Sweden
Foukakis T; Fornander T; Lekberg T; Hellborg H; Adolfsson J; Bergh J
Article: THYROID. 2010;20(10):1067-1076
Proteomic Study of Thyroid Tumors Reveals Frequent Up-Regulation of the Ca²⁺-Binding Protein S100A6 in Papillary Thyroid Carcinoma
Sofiadis A; Dinets A; Orre LM; Branca RM; Juhlin CC; Foukakis T; Wallin G; Hoog A; Hulchiy M; Zedenius J; Larsson C; Lehtio J
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2009;35(2):369-374
Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy
Sofiadis A; Tani E; Foukakis T; Kjellman P; Skoog L; Hoog A; Wallin G; Zedenius J; Larsson C
Article: ENDOCRINE-RELATED CANCER. 2008;15(3):801-815
Array-CGH identifies cyclin D1 and UBCH10 amplicons in anaplastic thyroid carcinoma
Lee J-J; Au AYM; Foukakis T; Barbaro M; Kiss N; Clifton-Bligh R; Staaf J; Borg A; Delbridge L; Robinson BG; Wallin G; Hoog A; Larsson C
Article: JOURNAL OF PATHOLOGY. 2008;215(1):87-96
Frizzled-1 is down-regulated in follicular thyroid tumours and modulates growth and invasiveness
Ulivieri A; Lavra L; Dominici R; Giacomelli L; Brunetti E; Sciacca L; Trovato M; Barresi G; Foukakis T; Jia-Jing L; Larsson C; Bartolazzi A; Sciacchitano S
Article: ENDOCRINE-RELATED CANCER. 2007;14(2):381-391
A PCR-based expression signature of malignancy in follicular thyroid tumors
Foukakis T; Gusnanto A; Au AYM; Hoog A; Lui W-O; Larsson C; Wallin G; Zedenius J
Article: THYROID. 2007;17(4):289-301
Molecular cytogenetic profiles of novel and established human anaplastic thyroid carcinoma models
Lee J-J; Foukakis T; Hashemi J; Grimelius L; Heldin N-E; Wallin G; Rudduck C; Lui W-O; Hoog A; Larsson C
Article: ENDOCRINE-RELATED CANCER. 2007;14(1):125-134
The Ras effectors NORE1A and RASSF1A are frequently inactivated in pheochromocytoma and abdominal paraganglioma
Geli J; Kiss N; Lanner F; Foukakis T; Natalishvili N; Larsson O; Kogner P; Hoog A; Clark GJ; Ekstrom TJ; Backdahl M; Farnebo F; Larsson C
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2006;91(3):1143-1149
The Ras effector NORE1A is suppressed in follicular thyroid carcinomas with a PAX8-PPARγ fusion
Foukakis T; Au AYM; Wallin G; Geli J; Forsberg L; Clifton-Bligh R; Robinson BG; Lui WO; Zedenius J; Larsson C
Article: TUMOR BIOLOGY. 2006;27(4):211-220
Molecular markers for discrimination of benign and malignant follicular thyroid tumors
Fryknas M; Wickenberg-Bolin U; Goransson H; Gustafsson MG; Foukakis T; Lee J-J; Landegren U; Hoog A; Larsson C; Grimelius L; Wallin G; Pettersson U; Isaksson A
Article: ONCOGENE. 2005;24(8):1467-1476
Expression profiling reveals a distinct transcription signature in follicular thyroid carcinomas with a PAX8-PPARγ fusion oncogene
Lui WO; Foukakis T; Lidén J; Thoppe SR; Dwight T; Höög A; Zedenius J; Wallin G; Reimers M; Larsson C
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2005;26(1):141-149
Molecular cytogenetic characterization of primary cultures and established cell lines from non-medullary thyroid tumors
Foukakis T; Thoppe SR; Lagercrantz S; Dwight T; Weng WH; Svensson A; Höög A; Zedenius J; Wallin G; Lui WO; Larsson C
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2003;88(9):4440-4445
Involvement of the PAX8/peroxisome proliferator-activated receptor γ rearrangement in follicular thyroid tumors
Dwight T; Thoppe SR; Foukakis T; Lui WO; Wallin G; Höög A; Frisk T; Larsson C; Zedenius J
Article: GENES CHROMOSOMES & CANCER. 2002;35(1):74-80
Silencing of the PTEN tumor-suppressor gene in anaplastic thyroid cancer
Frisk T; Foukakis T; Dwight T; Lundberg J; Höög A; Wallin G; Eng C; Zedenius J; Larsson C
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1992;33(4):861-869
Gene-specific promoter hypermethylation without global hypomethylation in follicular thyroid cancer
Lee J-J; Geli J; Larsson C; Wallin G; Karimi M; Zedenius J; Hoog A; Foukakis T
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All other publications

Review: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. 2025;207:104602
Grading the evidence for physical activity and any outcome in cancer survivors: An Umbrella review of 740 meta-analytic associations
Filis P; Markozannes G; Chan DSM; Mauri D; Foukakis T; Matikas A; Droufakou S; Pentheroudakis G; Tsilidis K
Review: CANCER TREATMENT REVIEWS. 2025;132:102853
Expert recommendations on treatment sequencing and challenging clinical scenarios in human epidermal growth factor receptor 2-positive (HER2-positive) metastatic breast cancer
Bartsch R; Cameron D; Ciruelos E; Criscitiello C; Curigliano G; Duhoux FP; Foukakis T; Gligorov J; Harbeck N; Levasseur N; Okines A; Penault-Llorca F; Mueller V
Conference publication: ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. ANNUAL INTERNATIONAL CONFERENCE. 2024;2024:1-5
Ensuring Model Fairness via Stratified Training: TP53 Mutation Prediction with Estrogen Receptor Stratification in Breast Histopathology.
Tsiknakis N; Wang K; Salgkamis D; Tzoras E; Manikis GC; Sifakis E; Bergh J; Zerdes I; Marias K; Matikas A; Foukakis T
Conference publication: CANCER RESEARCH. 2024;84(9):po4-01-05-po4-01-05
The prognostic importance of biological pathway enrichment patterns in trastuzumab-treated early HER2-positive breast cancer
Ronnlund C; Yang Q; Schagerholm C; Foukakis T; Fredriksson I; Chen X; Robertson S; Sifakis E; Hartman J
Conference publication: CANCER RESEARCH. 2024;84(9):po2-07-06-po2-07-06
Multimodal learning predictor of HER2-positive breast cancer therapy response in the randomized PREDIX HER2 trial
Wang K; Zhu Y; Zerdes I; Sifakis E; Manikis G; Salgkamis D; Tsiknakis N; Harbers L; Crosetto N; Bergh J; Matikas A; Hatschek T; Foukakis T
Conference publication: ESMO OPEN. 2024;9:103031
23P Longitudinal evaluation of PAM50 molecular subtypes in patients receiving neoadjuvant HER2-targeted therapy in the PREDIX HER2 trial
Zhu Y; Sifakis EG; Wang K; Zerdes I; Bergh J; Hatschek T; Matikas A; Foukakis T
Conference publication: ESMO OPEN. 2024;9:103075
69P Deep learning prognostication through prediction of TP53 gene mutation status on breast cancer hematoxylin and eosin slides
Tsiknakis N; Salgkamis D; Tzoras E; Wang K; Liu X; Manikis G; Sifakis EG; Bergh J; Marias K; Zerdes I; Matikas A; Foukakis T
Conference publication: ESMO OPEN. 2024;9:103110
122P Primary results and biomarker analysis from PREDIX LumB: A prospective randomized phase II trial investigating sequence of neoadjuvant chemotherapy and palbociclib/endocrine therapy for luminal breast cancer
Matikas A; Bjöhle J; Barnekow E; Isakssonfriman E; Zouzos A; Tzoras E; Johansson H; Margolin S; Acs B; Boyaci C; Sun W; Zerdes I; Kessler LE; Grybäck P; Hellström M; Hartman J; Brandberg Y; Bergh J; Hatschek T; Foukakis T
Conference publication: ESMO OPEN. 2024;9:103063
56P Longitudinal circulating plasma protein immune profiling reveals biomarkers of treatment response to neoadjuvant trastuzumab-emtansine (T-DM1) in early HER2-positive breast cancer: A secondary analysis of the phase II PREDIX HER2 trial
Zerdes I; Wang K; Salgkamis D; Zhu Y; Sifakis EG; Acs B; Hartman J; Hatschek T; Bergh J; Matikas A; Foukakis T
Preprint: RESEARCH SQUARE. 2024
Adherence to and optimization of guidelines for Risk of Recurrence/Prosigna testing using a machine learning model: a Swedish multicenter study
Kjällquist U; Tsiknakis N; Acs B; Margolin S; Kessler LE; Levy S; Ekholm M; Lundgren C; Olsson E; Lindman H; Valachis A; Hartman J; Foukakis T; Matikas A
Conference publication: EUROPEAN JOURNAL OF CANCER. 2024;200:113830
Multiomic profiling reveals predictive molecular characteristics of response to neoadjuvant antibody-drug conjugate versus chemotherapy and dual HER2 blockade in HER2 positive breast cancer
Foukakis T; Wang K; Zerdes I; Zhu Y; Sifakis E; Tsiknakis N; Manikis G; Salgkamis D; Harbers L; Bergh J; Johansson H; Crosetto N; Lehtio J; Matikas A; Hatschek T
Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2024;47:36
RESCUER - Data harmonization of multiple clinical trials - challenges and chances
Lehle S; Ernst M; Braso-Maristany F; Prat A; Engebraten O; Hatschek T; Foukakis T; Kyte JA; Rubner M; Uhrig S; Beckmann M; Fasching PA; Kristensen VN; Huebner H
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(16)
Estimating benefit from dose dense adjuvant chemotherapy for early breast cancer in the PANTHER randomized phase 3 trial
Matikas A; Gnant M; Johansson H; Untch M; Tsiknakis N; Greil R; Loibl S; Foukakis T; Bergh JCS
Review: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. 2023;192:104189
The ever-expanding landscape of antibody-drug conjugates (ADCs) in solid tumors: A systematic review
Filis P; Zerdes I; Soumala T; Matikas A; Foukakis T
Meeting abstract: ANNALS OF ONCOLOGY. 2023;34:s307-s308
Machine learning-based characterization of tumor-immune microenvironment at a spatial and multiplexed resolution in early breast cancer: A sub-study of the EORTC 10994/BIG 1-00 randomized phase III trial with long-term follow-up
Zerdes I; Matikas A; Mezheyeuski A; Acs B; Johansson H; Manikis G; Boyaci C; Boman CE; Poncet C; Ignatiadis M; Bai Y; Rimm D; MacGrogan G; Cameron DA; Bergh J; Bonnefoi H; Foukakis T
Editorial comment: MOLECULAR ONCOLOGY. 2023;17(4):545-547
The interplay between eosinophils and T cells in breast cancer immunotherapy
Zerdes I; Matikas A; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Figure S2 from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Figure S1 from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary File S1 from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Table S3 from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Figure S1 from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Table S1 from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Figure S3 from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary File S1 from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Data from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Figure S3 from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Figure S2 from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Table S1 from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Table S2 from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Data from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Table S2 from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Table S3 from Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Meeting abstract: CANCER RESEARCH. 2023;83(5):p2-21-02-p2-21-02
Longitudinal tumor-immune microenvironment changes in patients with clinical luminal A early breast cancer treated with neoadjuvant palbociclib and endocrine therapy: results from the Swedish randomized PREDIX Luminal A trial
Zerdes I; Salgkamis D; Matikas A; Selander L; Wang K; Tzoras E; Sifakis E; Agartz S; Chen X; Hellstrom M; Hartman J; Bergh J; Foukakis T; Hatschek T
Meeting abstract: CANCER RESEARCH. 2023;83(5):p5-02-20-p5-02-20
Correlative and longitudinal transcriptomic profiling predicts patient outcomes and the efficacy of neoadjuvant HER2-targeted treatments in the randomized PREDIX HER2 trial
Wang K; Zhu Y; Zerdes I; Matikas A; Sifakis E; Salgkamis D; Bjohle J; Elinder E; Margolin S; Campos AB; Pekar G; Lindman H; Schiza A; Einbeigi Z; Adra J; Andersson A; Carlsson L; Dreifaldt AC; Isaksson-Friman E; Agartz S; Johansson H; Hellstrom M; Azavedo E; Hartman J; Bergh J; Hatschek T; Foukakis T
Preprint: MEDRXIV. 2023
Clinically relevant gene signatures provide independent prognostic information in older breast cancer patients
Castresana-Aguirre M; Johansson A; Matikas A; Foukakis T; Lindström L; Tobin N
Conference publication: BREAST. 2023;68:S63-S64
Neoadjuvant pembrolizumab plus chemotherapy vs placebo plus chemotherapy followed by adjuvant pembrolizumab vs placebo for early TNBC: surgical outcomes from the phase 3 KEYNOTE-522 study
Kuemmel S; Schmid P; Harbeck N; Takahashi M; Untch M; Boileau J-F; Cortes J; McArthur H; Dent R; O'Shaughnessy J; Pusztai L; Foukakis T; Park YH; Hui R; Cardoso F; Denkert C; Zhu Y; Pan W; Karantza V; Fasching P
Conference publication: ANNALS OF SURGICAL ONCOLOGY. 2023;30(SUPPL 2):S295-S296
Neoadjuvant Pembrolizumab plus Chemotherapy vs Placebo plus Chemotherapy Followed by Adjuvant Pembrolizumab vs Placebo for Early TNBC: Surgical Outcomes from the Phase 3 KEYNOTE-522 Study
Kuemmel S; Schmid P; Harbeck N; Takahashi M; Untch M; Boileau J-F; Cortes J; McArthur H; Dent R; O'Shaughnessy J; Pusztai L; Foukakis T; Park YH; Hui R; Cardoso F; Denkert C; Zhu Y; Pan W; Karantza V; Fasching PA
Book chapter: INTRODUCTION TO ARTIFICIAL INTELLIGENCE: IMAGING INFORMATICS FOR HEALTHCARE PROFESSIONALS. 2023;p. 13-37
Using Commercial and Open-Source Tools for Artificial Intelligence: A Case Demonstration on a Complete Radiomics Pipeline
Stamoulou E; Spanakis C; Nikiforaki K; Karantanas AH; Tsiknakis N; Matikas A; Foukakis T; Manikis GC
Book chapter: BREAST CANCER MANAGEMENT FOR SURGEONS. 2023;p. 203-218
Principles of Primary Systemic Therapy
Foukakis T; Matikas A; Valachis A
Conference publication: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:S46
Preclinical evaluation of [⁸⁹Zr]Zr-DFO*-sacituzumab, a PET tracer for imaging of whole body TROP-2 expression as a potential selection tool for treatment with TROP-2 antibody drug conjugates (ADC)
Bratteby K; Smertinaite L; Omer S; Lu L; Milton S; Jussing E; Siikanen J; Samen E; Axelsson R; Foukakis T; Altena R; Tran T
Review: JOURNAL OF IMAGING. 2022;8(11):303
Harmonization Strategies in Multicenter MRI-Based Radiomics
Stamoulou E; Spanakis C; Manikis GC; Karanasiou G; Grigoriadis G; Foukakis T; Tsiknakis M; Fotiadis DI; Marias K
Meeting abstract: ANNALS OF ONCOLOGY. 2022;33(7):S1306
Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction
Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Lovrot J; Tay A; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
Meeting abstract: ANNALS OF ONCOLOGY. 2022;33(7):S614
The prognostic importance of high HER2 copy numbers and high HER2/CEP17 ratio in trastuzumab-treated early breast cancer
Ronnlund C; Robertson S; Sifakis EG; Fredriksson I; Foukakis T; Hartman J
Conference publication: CANCER RESEARCH. 2022;82(12_Supplement):2045
Abstract 2045: Spatial organization of the immune microenvironment after neoadjuvant treatment of breast cancer
Thomas N; Garaud S; Langouo M; Zerdes I; Sofronii D; Boisson A; Foukakis T; De Wind A; Salgado R; Awada A; Willard-Gallo K
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(16_suppl):e12598
Serum thymidine kinase 1 and its kinetics in HER2-positive breast cancer: Results from the Swedish phase II PREDIX HER2 trial.
Zhu Y; Wang K; Zerdes I; Matikas A; Bergqvist M; Elinder E; Bosch A; Lindman H; Einbeigi Z; Andersson A; Carlsson L; Dreifaldt AC; Isaksson-Friman E; Hellstrom M; Johansson H; Bergh JCS; Hatschek T; Foukakis T
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(16_suppl):e12620
Tumor-infiltrating lymphocytes (TILs) dynamics in breast cancer patients receiving neoadjuvant therapy: A systematic review and meta-analysis.
Zerdes I; Zhu Y; Tzoras E; Matikas A; Bergh JCS; Valachis A; Foukakis T
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(16_suppl):593
Combined assessment of metabolic response and tumor infiltrating lymphocytes as a predictor of outcomes following neoadjuvant therapy for HER2-positive breast cancer: Results from the randomized PREDIX HER2 trial.
Matikas A; Johansson H; Grybäck P; Bjöhle J; Lekberg T; Fredholm H; Acs B; Elinder E; Isaksson-Friman E; Agartz S; Hellstrom M; Zerdes I; Hartman J; Bergh JCS; Hatschek T; Foukakis T
Meeting abstract: ANNALS OF ONCOLOGY. 2022;33:S125
Longitudinal proteogenomic profiling reveals therapeutic vulnerabilities of immunometabolism in breast cancer
Wang K; Zerdes I; Sifakis EG; Johansson HJ; Mezheyeuski A; Lehtio J; Bergh J; Hatschek T; Matikas A; Foukakis T
Review: CANCERS. 2022;14(8):1999
Dissecting Tumor-Immune Microenvironment in Breast Cancer at a Spatial and Multiplex Resolution
Tzoras E; Zerdes I; Tsiknakis N; Manikis GC; Mezheyeuski A; Bergh J; Matikas A; Foukakis T
Meeting abstract: CANCER RESEARCH. 2022;82(4):p1-02-03-p1-02-03
Tumor-infiltrating lymphocytes but not HER2 copy number or ratio show prognostic value in trastuzumab-treated HER2-positive breast cancer
Robertson S; Ronnlund C; Fredriksson I; Foukakis T; Hartman J
Review: FRONTIERS IN ONCOLOGY. 2022;12:999843
Expression patterns and prognostic implications of tumor-infiltrating lymphocytes dynamics in early breast cancer patients receiving neoadjuvant therapy: A systematic review and meta-analysis
Zhu Y; Tzoras E; Matikas A; Bergh J; Valachis A; Zerdes I; Foukakis T
Conference publication: CANCER RESEARCH. 2022;82(12)
Spatial organization of the immune microenvironment after neoadjuvant treatment of breast cancer
Thomas N; Garaud S; Langouo M; Zerdes I; Sofronii D; Boisson A; Foukakis T; De Wind A; Salgado R; Awada A; Willard-Gallo K
Conference publication: EUROPEAN JOURNAL OF CANCER. 2022;175:S40
A multimodal approach for the management of co-morbid cardiotoxicity in the elderly breast cancer patients
Karanasiou G; Grigoriadis G; Alexandraki A; Antoniades A; Brown C; Bucur A; Cipolla C; Economopoulou P; Foukakis T; Goossens J; Keramida K; Lakkas L; Marias K; Naka K; Papakonstantinou A; Pravettoni G; Ribnikar D; Seruga B; Zacharia M; Tsiknakis M; Fotiadis DI
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(16)
Serum thymidine kinase 1 and its kinetics in HER2-positive breast cancer: Results from the Swedish phase II PREDIX HER2 trial.
Zhu Y; Wang K; Zerdes I; Matikas A; Bergqvist M; Elinder E; Bosch A; Lindman H; Einbeigi Z; Andersson A; Carlsson L; Dreifaldt AC; Isaksson-Friman E; Hellstrom M; Johansson H; Bergh JCS; Hatschek T; Foukakis T
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(16)
Tumor-infiltrating lymphocytes (TILs) dynamics in breast cancer patients receiving neoadjuvant therapy: A systematic review and meta-analysis.
Zerdes I; Zhu Y; Tzoras E; Matikas A; Bergh JCS; Valachis A; Foukakis T
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(16)
Combined assessment of metabolic response and tumor infiltrating lymphocytes as a predictor of outcomes following neoadjuvant therapy for HER2-positive breast cancer: Results from the randomized PREDIX HER2 trial.
Matikas A; Johansson H; Gryback P; Bjohle J; Lekberg T; Fredholm H; Acs B; Elinder E; Isaksson-Friman E; Agartz S; Hellstrom M; Zerdes I; Hartman J; Bergh JCS; Hatschek T; Foukakis T
Editorial comment: ANNALS OF ONCOLOGY. 2021;32(12):1457-1459
Adjuvant abemaciclib for high-risk breast cancer: the story continues
Spring L; Matikas A; Bardia A; Foukakis T
Review: ESMO OPEN. 2021;6(6):100289
The prognostic and predictive impact of low estrogen receptor expression in early breast cancer: a systematic review and meta-analysis
Paakkola N-M; Karakatsanis A; Mauri D; Foukakis T; Valachis A
Conference publication: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2021;9:A364
EFFECTS OF PEMBROLIZUMAB ON THE TUMOR MICROENVIRONMENT (TME) AFTER ONE PRESURGERY TREATMENT CYCLE IN PATIENTS WITH TRIPLE-NEGATIVE BREAST CANCER (TNBC): PHASE 1B KEYNOTE-173 STUDY
Schmid P; Park YH; Munoz-Couselo E; Kim S-B; Sohn J; Im S-A; Holgado E; Foukakis T; Kuemmel S; Dent R; Sun Y; Huang L; Yearley J; Jelinic P; Karantza V; Cortes J
Corrigendum: JAMA ONCOLOGY. 2021;7(9):1405-1406
Errors in Abstract and Results.
Review: CANCER TREATMENT REVIEWS. 2021;99:102257
Discordance of PD-L1 status between primary and metastatic breast cancer: A systematic review and meta-analysis
Boman C; Zerdes I; Martensson K; Bergh J; Foukakis T; Valachis A; Matikas A
Editorial comment: BREAST CARE. 2021;16(4):422-428
Expert Discussion: HER2-Positive Breast Cancer
Foukakis T; Matikas A; Oikonomidou O; Andreopoulou E; Mavroudis D
Conference publication: ANNALS OF ONCOLOGY. 2021;32:S70-S71
Women with short survival after diagnosis of metastatic breast cancer: A population-based registry study
Boman CE; Kessler LE; Bergh J; Matikas A; Foukakis T
Conference publication: CANCER RESEARCH. 2021;81(4_Supplement):ps18-27-ps18-27
Abstract PS18-27: Integrated immuno-genomic analyses in early breast cancer: Results from the Scandinavian breast group 2004-1 (SBG-2004-1) randomized phase II trial
Zerdes I; Simonetti M; Matikas A; Harbers L; Zhang N; Salgkamis D; Agartz S; Zacharouli M; Moreno-Ruiz P; Hartman J; Mezheyeuski A; Bergh J; Crosetto N; Foukakis T
Editorial comment: ANNALS OF ONCOLOGY. 2021;32(2):129-132
SOLAR1s: alpelisib returns to earth?
Matikas A; Foukakis T
Conference publication: CANCER RESEARCH. 2021;81(4)
Integrated immuno-genomic analyses in early breast cancer: Results from the Scandinavian breast group 2004-1 (SBG-2004-1) randomized phase II trial
Zerdes I; Simonetti M; Matikas A; Harbers L; Zhang N; Salgkamis D; Agartz S; Zacharouli M; Moreno-Ruiz P; Hartman J; Mezheyeuski A; Bergh J; Crosetto N; Foukakis T
Conference publication: ANNALS OF ONCOLOGY. 2020;31:S1241-S1242
KEYNOTE-522 Asian subgroup: Phase III study of neoadjuvant pembrolizumab (pembro) vs placebo (pbo) plus chemotherapy (chemo) followed by adjuvant pembro vs pbo for early triple-negative breast cancer (TNBC)
Dent R; Cortes J; Pusztai L; McArthur HL; Kuemmel S; Bergh J; Denkert C; Park YH; Hui R; Harbeck N; Takahashi M; Foukakis T; Fasching PA; Cardoso F; Jia L; Jensen E; Karantza V; Aktan G; O'Shaughnessy J; Schmid P
Meeting abstract: ANNALS OF ONCOLOGY. 2020;31:S328
Heterogeneity of PD-L1 expression at the protein and mRNA levels in early breast cancer
Zerdes I; Stogiannitsi M; Bergh J; Hatschek T; Foukakis T; Matikas A
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2020;38(15_suppl):545
PD-1 protein and gene expression in early breast cancer: Prognostic implications.
Zerdes I; Matikas A; Lövrot J; Sifakis EG; Richard F; Sotiriou C; Rassidakis GZ; Bergh JCS; Valachis A; Foukakis T
Meeting abstract: ANNALS OF ONCOLOGY. 2020;31:S49
PREDIX HER2 trial: Event-free survival and pathologic complete response in clinical subgroups and stromal TILs levels
Hatschek T; Andersson A; Bjohle J; Bosch A; Carlsson L; Dreifaldt AC; Einbeigi Z; Elinder E; Fredholm H; Isaksson-Friman E; Hellstrom M; Johansson H; Lekberg T; Lindman H; Zerdes I; Foukakis T; Hartman J; Brandberg Y; Bergh J
Conference publication: ANNALS OF ONCOLOGY. 2020;31:S54
Factors associated with mastectomy in women with small residual tumour after neoadjuvant chemotherapy for breast cancer
Bernell E; Duinmeijer A; Altena R; Foukakis T; Fredholm H
Corrigendum: BRITISH JOURNAL OF CANCER. 2020;122(7):1119
Correction: Quality of life under extended continuous versus intermittent adjuvant letrozole in lymph node-positive, early breast cancer patients: the SOLE randomised phase 3 trial.
Ribi K; Luo W; Colleoni M; Karlsson P; Chirgwin J; Aebi S; Jerusalem G; Neven P; Di Lauro V; Gomez HL; Ruhstaller T; Abdi E; Biganzoli L; Müller B; Barbeaux A; Graas M-P; Rabaglio M; Francis PA; Foukakis T; Pagani O; Graiff C; Vorobiof D; Maibach R; Di Leo A; Gelber RD; Goldhirsch A; Coates AS; Regan MM; Bernhard J; SOLE Investigators
Meeting abstract: CANCER RESEARCH. 2020;80(4):p3-08-07-p3-08-07
Expression of the novel tumor suppressor gene SAMHD1 correlates with favourable clinical outcome in basal-like (BL) early breast cancer
Kouvaraki M; Sifakis EG; Zerdes I; Herold N; Bergh J; Rassidakis GZ; Foukakis T
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2020;38(15)
PD-1 protein and gene expression in early breast cancer: Prognostic implications.
Zerdes I; Matikas A; Lovrot J; Sifakis EG; Richard F; Sotiriou C; Rassidakis GZ; Bergh JCS; Valachis A; Foukakis T
Conference publication: ANNALS OF SURGICAL ONCOLOGY. 2020;27(SUPPL 2):S337-S338
Axillary Staging in the Setting of a Preoperative Diagnosis of Ductal Cancer In Situ (DCIS): Results of an International Expert Panel and a Critical Guideline Performance Using Frequentist and Bayesian Analysis
Karakatsanis A; Foukakis T; Karlsson P; Mamounas E; Chagpar A; Boyages J; Rubio I; Naume B; Mauri D; van der Wall E; Shah C; Kwong A; McAuliffe P; Gentilini O; Ignatiadis M; Schlichting E; Zgajnar J; Meani F; Tasoulis MK; Whitworth P; Weber W; Charalampoudis P; Gulluoglu B; Pistioli L; Tvedskov TF; Leidenius M; Mann B; Witkamp A; Wyld L; di Micco R; Markopoulos C; Valachis A; Warnberg F
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2020;38(15)
One-year follow-up of health-related quality of life in the Swedish PREDIX HER 2 trial, evaluating docetaxel, trastuzumab sc, pertuzumab versus trastuzumab emtansine as neoadjuvant treatment of HER2 positive breast cancer.
Brandberg Y; Foukakis T; Andersson A; Bjohle J; Bosch A; Carlsson L; Einbeigi Z; Fredholm H; Isaksson-Friman E; Hellstrom M; Johansson H; Lekberg T; Lindman H; Bergh JCS; Hatschek T
Review: CLINICAL CANCER RESEARCH. 2019;25(18):5717-5726
Prognostic Implications of PD-L1 Expression in Breast Cancer: Systematic Review and Meta-analysis of Immunohistochemistry and Pooled Analysis of Transcriptomic Data
Matikas A; Zerdes I; Lovrot J; Richard F; Sotiriou C; Bergh J; Valachis A; Foukakis T
Review: ANNALS OF ONCOLOGY. 2019;30(7):1044-1050
Avoiding over- and undertreatment in patients with resected node-positive breast cancer with the use of gene expression signatures: are we there yet?
Matikas A; Foukakis T; Swain S; Bergh J
Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2019;37(15):550
Prognostic value of PD-L1 gene expression with Recurrence Score and 70-gene signature in patients with ER+/HER2-early breast cancer.
Zerdes I; Sifakis EG; Tobin N; Bergh JCS; Matikas A; Foukakis T
Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2019;37(15):e14284
Prognostic implications of PD-L1 expression in breast cancer at the protein and mRNA levels.
Matikas A; Zerdes I; Lovrot J; Richard F; Sotiriou C; Bergh JCS; Valachis A; Foukakis T
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2019;37(15):553
Tailored dose-dense chemotherapy in combination with trastuzumab as adjuvant therapy for HER2-positive breast cancer: A secondary analysis of the phase III PANTHER trial.
Foukakis T; Papakonstantinou A; Matikas A; Bengtsson N-O; Malmstrom P; Hedayati E; Steger GG; Untch M; Hubbert L; Johansson H; Hellstrom M; Gnant M; Loibl S; Greil R; Moebus V; Bergh JCS
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2019;37(15):583
Health-related quality of life in the Swedish PREDIX HER2 trial, evaluating docetaxel, trastuzumab, pertuzumab versus trastuzumab emtansine as neoadjuvant treatment of HER2-positive breast cancer.
Brandberg Y; Andersson A; Bjohle J; Bosch A; Carlsson L; Dreifaldt AC; Einbeigi Z; Fredholm H; Isaksson-Friman E; Foukakis T; Elinder E; Hellstrom M; Johansson H; Lekberg T; Lindman H; Bergh JCS; Hatschek T
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2019;37(15):501
Docetaxel, trastuzumab, pertuzumab versus trastuzumab emtansine as neoadjuvant treatment of HER2-positive breast cancer: Results from the Swedish PREDIX HER2 trial identifying a new potential de-escalation standard?
Bergh JCS; Andersson A; Bjohle J; Bosch A; Carlsson L; Dreifaldt AC; Einbeigi Z; Fredholm H; Isaksson-Friman E; Foukakis T; Elinder E; Hellstrom M; Johansson H; Lekberg T; Lindman H; Maes C; Brandberg Y; Hatschek T
Review: CANCERS. 2019;11(5):E628-628
Beyond PD-1/PD-L1 Inhibition: What the Future Holds for Breast Cancer Immunotherapy
Chretien S; Zerdes I; Bergh J; Matikas A; Foukakis T
Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2019;285(4):395-397
Minimally invasive tissue access as a tool for delivering personalized medicine - with focus on oncology
Matikas A; Foukakis T; Bergh J
Conference publication: RADIOTHERAPY AND ONCOLOGY. 2019;133:S310-S311
5 year results of the Preoperative Accelerated Partial Breast Irradiation (PAPBI) trial
Bosma S; van der Leij F; Vreeswijk S; van der Vijver M; Rivera S; Foukakis T; van den Bongard D; Rutgers E; Scholten A; Bartelink H; Elkhuizen P
Conference publication: CANCER RESEARCH. 2019;79(4):p3-10-09-p3-10-09
Relationship between tumor infiltrating lymphocytes (TILs) and response to pembrolizumab (Pembro) plus chemotherapy (Chemo) as neoadjuvant treatment (NAT) for triple-negative breast cancer (TNBC): phase Ib KEYNOTE-173 trial
Loi S; Schmid P; Cortes J; ark YH; Munoz-Couselo E; Kim S-B; Sohn J; Im S-A; Holgado E; Foukakis T; Kuemmel S; Dent R; Wang A; Aktan G; Karantza V; Salgado R
Conference publication: CANCER RESEARCH. 2019;79(4):pd5-01-pd5-01
KEYNOTE-173: Phase 1b multicohort study of pembrolizumab (Pembro) in combination with chemotherapy as neoadjuvant treatment for triple-negative breast cancer (TNBC)
Schmid P; Park YH; Munoz-Couselo E; Kim S-B; Sohn J; Im S-A; Holgado E; Foukakis T; Kuemmel S; Dent R; Yin L; Ding Y; Tryfonidis K; Cortes J
Meeting abstract: CANCER RESEARCH. 2019;79(4):p2-08-25-p2-08-25
PD-L1 expression at the protein and RNA levels as prognostic factor in early breast cancer
Zerdes I; Sifakis E; Matikas A; Tobin NP; Charlotte R; Rassidakis GZ; Bergh J; Foukakis T
Preprint: SSRN ELECTRONIC JOURNAL. 2019
Pembrolizumab Plus Chemotherapy as Neoadjuvant Treatment for Locally Advanced Triple-Negative Breast Cancer: Results from the Phase 1b Open-Label, Multicohort KEYNOTE-173 Study
Schmid P; Salgado R; Park YH; Muñoz-Couselo E; Kim S-B; Sohn J; Foukakis T; Kuemmel S; Dent R; Yin L; Wang A; Tryfonidis K; Karantza V; Cortés J; Loi S
Conference publication: ANNALS OF ONCOLOGY. 2019;30:86
Impact of menopause status on breast cancer outcomes and amenorrhea incidence during adjuvant tailored dose dense chemotherapy
Papakonstantinou A; Matikas A; Hellstrom M; Johansson H; Steger G; Greil R; Loibl S; Gnant M; Moebus V; Untch M; Foukakis T; Bergh J
Conference publication: ANNALS OF ONCOLOGY. 2019;30
Administration of chemotherapy for metastatic breast cancer near the end of life: A population registry study
Kessler LE; Sigfridsson J; Bergh J; Foukakis T; Matikas A
Conference publication: ANNALS OF ONCOLOGY. 2019;30:853-854
KEYNOTE-522: Phase III study of pembrolizumab (pembro) plus chemotherapy (chemo) vs placebo (pbo) plus chemo as neoadjuvant treatment, followed by pembro vs pbo as adjuvant treatment for early triple-negative breast cancer (TNBC)
Schmid P; Cortes J; Dent R; Pusztai L; McArthur HL; Kuemmel S; Bergh J; Denkert C; Park YH; Hui R; Harbeck N; Takahashi M; Foukakis T; Fasching PA; Cardoso F; Jia L; Karantza V; Zhao J; Aktan G; O'Shaughnessy J
Editorial comment: ANNALS OF ONCOLOGY. 2018;29(12):2278-2280
Carboplatin in the neoadjuvant treatment of triple-negative breast cancer-ready for prime time?
Foukakis T
Letter: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2018;110(11):1280-1281
RE: Receptor Conversion in Distant Breast Cancer Metastases: A Systematic Review and Meta-analysis
Matikas A; Foukakis T; Bergh J
Review: ONCOGENE. 2018;37(34):4639-4661
Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations
Zerdes I; Matikas A; Bergh J; Rassidakis GZ; Foukakis T
Editorial comment: LANCET ONCOLOGY. 2018;19(7):850-852
Ribociclib in premenopausal women with advanced breast cancer
Foukakis T
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2018;36(15):538
Dose tailoring of breast cancer adjuvant chemotherapy aiming at avoiding both over and undertreatment: Results from the prospective PANTHER study.
Matikas A; Foukakis T; Moebus V; Greil R; Bengtsson N-O; Steger GG; Untch M; Johansson H; Hellstrom M; Malmstrom P; Gnant M; Loibl S; Bergh JCS
Published conference paper: BREAST CANCER RESEARCH AND TREATMENT. 2018;168(2):349-355
Long-term safety and survival outcomes from the Scandinavian Breast Group 2004-1 randomized phase II trial of tailored dose-dense adjuvant chemotherapy for early breast cancer
Matikas A; Margolin S; Hellstrom M; Johansson H; Bengtsson N-O; Karlsson L; Edlund P; Karlsson P; Lidbrink E; Linderholm B; Lindman H; Malmstrom P; Villman K; Foukakis T; Bergh J
Review: ACTA ONCOLOGICA. 2017;56(9):1143-1151
Dose intense, dose dense and tailored dose adjuvant chemotherapy for early breast cancer: an evolution of concepts
Matikas A; Foukakis T; Bergh J
Conference publication: CANCER RESEARCH. 2017;77:418
Adaptive resistance to chemotherapy in triple-negative breast cancer revealed by single cell DNA and RNA sequencing
Kim C; Gao R; Sei E; Brandt R; Crosetto N; Foukakis T; Navin N
Review: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. 2017;114:91-101
Tackling endocrine resistance in ER-positive HER2-negative advanced breast cancer: A tale of imprecision medicine
Matikas A; Foukakis T; Bergh J
Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2017;35:e23088
Regulation of PD-L1 in breast cancer
Zerdes I; Tsesmetzis N; Lovrot J; Rolny C; Bergh JCS; Rassidakis G; Foukakis T
Review: EXPERT REVIEW OF ANTICANCER THERAPY. 2017;17(4):319-326
Implementing neoadjuvant endocrine strategies in ER-positive, HER2-negative breast cancer
Matikas A; Foukakis T; Michalakis I; Georgoulias V
Conference publication: CANCER RESEARCH. 2017;77:p1-07-07-p1-07-07
Gene expression signatures and immunohistochemical subtypes add prognostic value to each other
Lundberg A; Lindstrom LS; Falato C; Carlson JW; Foukakis T; Czene K; Bergh J; Tobin NP
Conference publication: EUROPEAN JOURNAL OF CANCER. 2017;72:S3
Sixteen months follow-up of health related quality of life in women with high-risk breast cancer after random assignment to adjuvant treatment with tailored dose-dense chemotherapy vs standard three-weekly adjuvant chemotherapy (PANTHER study)
Brandberg Y; Foukakis T; Johansson H; Hellstrom M; Gnant M; Loibl S; Bergh J
Letter: JOURNAL OF CLINICAL ONCOLOGY. 2017;35(1):121-122
Estradiol Level and Menopause Reply
Papakonstantinou A; Foukakis T; Rodriguez-Wallberg KA; Bergh J
Conference publication: ANNALS OF ONCOLOGY. 2017;28
CTCA toxicity scoring and EORTC quality of life questionnaire: A comparison of physicians' and patients' scoring of toxicity in the "Panther trial"
Brandberg Y; Loibl S; Foukakis T; Johansson H; Gnant M; Singer CF; von Minckwitz G; Bengtsson N-O; Karlsson E; Mlineritsch B; Hellstrom M; Steger G; Carlsson L; Egle D; Greil R; Bergh J
Conference publication: ANNALS OF ONCOLOGY. 2017;28
Prognosis after loco-regional recurrence of breast cancer: 35 years longitudinal data from the Stockholm cancer register
Falato C; Eriksson L; Sofiadis A; Taylor SK; Nordblom A; Fredriksson I; Hartman J; Bergh J; Foukakis T
Conference publication: ANNALS OF ONCOLOGY. 2017;28
Immune function and response to neoadjuvant chemotherapy in hormone receptor positive, HER2-negative breast cancer
Matikas A; Lovrot J; Ramberg A; Eriksson M; Lindsten T; Lekberg T; Hedenfalk I; Loman N; Bergh J; Erlandsson A; Hatschek T; Foukakis T
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2016;34(15):1035
The adjuvant PANTHER study: A randomized comparison between dose-dense and tailored epirubicin (E), cyclophosphamide (C) and docetaxel (D) vs. standard dose 5-fluorouracil (F), epirubicin (E), cyclophosphamide (C) and docetaxel-Health-related quality of life during ongoing therapy.
Brandberg Y; Johansson H; Hellstrom M; Foukakis T; Gnant M; von Minckwitz G; Bergh JCS
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2016;34(15):1002
PANTHER: Prospective randomized phase III trial of tailored and dose-dense versus standard tri-weekly adjuvant chemotherapy for high-risk breast cancer in the modern era of endocrine and anti-HER2 therapy.
Bergh JCS; Foukakis T; von Minckwitz G; Bengtsson N-O; Wallberg B; Fornander T; Mlineritsch B; Schmatloch S; Singer CF; Steger GG; Karlsson E; Carlsson L; Loibl S; Untch M; Hellstrom M; Johansson H; Malmstrom P; Gnant M; Greil R; Moebus V
Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2016;374(14):1386-1387
A 21-Gene Expression Assay in Breast Cancer
Foukakis T; Falato C; Bergh J
Conference publication: CANCER RESEARCH. 2016;76:ot2-04-03-ot2-04-03
An intrinsic subtype-based platform of translational randomized phase II trials of response-guided neoadjuvant therapy in breast cancer (PREDIX)
Foukakis T; Hellstrom M; Johansson H; Bergh J; Hatschek T
Review: JOURNAL OF INTERNAL MEDICINE. 2015;278(6):545-570
The importance of molecular markers for diagnosis and selection of targeted treatments in patients with cancer
Tobin NP; Foukakis T; De Petris L; Bergh J
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2015;33(15):1044
Gene expression of metastatic biopsies for prediction of response to palliative chemotherapy in breast cancer
Foukakis T; Lorent J; Tobin N; Lindstrom LS; Bergh JCS; Hatschek T
Conference publication: RADIOTHERAPY AND ONCOLOGY. 2015;115:S188-S189
First results of the Preoperative Accelerated Partial Breast Irradiation (PAPBI) trial
Bosma SCJ; Van der Leij F; Van de Vijver MJ; Rivera S; Foukakis T; Van den Bongard HJGD; Vreeswijk SAOJ; Bartelink H; Rutgers EJ; Elkhuizen PHM
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2015;33(15)
Immunohistochemistry-based subtypes and gene expression signatures as predictors of prognosis in metastatic breast cancer
Falato C; Tobin N; Lorent J; Lindstrom LS; Bergh JCS; Foukakis T
Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2014;371(1):84-85
Thyroid Hormone Inactivation in Gastrointestinal Stromal Tumors
Foukakis T; Lovrot J; Bergh J
Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2014;32(15):e22120
Sequential metastatic biopsies and functional imaging in breast cancer
Foukakis T; Lovrot J; Sandqvist P; Xie H; Lindstroem LS; Giorgetti C; Jacobsson H; Hedayati E; Bergh JCS
Conference publication: CANCER RESEARCH. 2013;73:p6-06-10-p6-06-10
Prognostic role of Ki67 determined on metastatic biopsies in patients with advanced breast cancer
Falato C; Lorent J; Kessler L; Karlsson E; Wilking U; Wright P; Skoog L; Bergh J; Foukakis T
Conference publication: CANCER RESEARCH. 2013;73:ot1-2-03-ot1-2-03
A prospective randomized phase II study to identify predictive biomarkers and mechanisms of resistance in patients with HER2-negative metastatic breast cancer treated with the combination of bevacizumab and paclitaxel
Foukakis T; Hartman J; Stone-Elander S; Jacobsson H; Bergh J
Meeting abstract: CANCER RESEARCH. 2013;73:p6-06-17-p6-06-17
Gene signature model predicts metastatic onset better than standard clinical markers - Nested case-control design uniquely enables enrichment for biologically relevant features
Lindstrom LS; Jauhiainen A; Wilking U; Foukakis T; Astrom G; Czene K; Bergh J
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(15)
Safety and efficacy of eribulin in patients with advanced breast cancer treated outside of a clinical trial: A single institution experience
Kessler L; Bergh J; Foukakis T
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(15)
A retrospective safety analysis of adult patients treated with high-dose methotrexate for osteosarcoma in Stockholm, Sweden.
Alm D; Stragliotto CL; Folin A; Bergh J; Foukakis T
Conference publication: BREAST. 2011;20:S28-S29
PROGNOSTIC ROLE OF KI67 DETERMINED ON METASTATIC TISSUE OF PATIENTS WITH ADVANCED BREAST CANCER
Falato C; Lindstrom L; Hosseini S; Czene K; Hall P; Sylwan M; Skoog L; Bergh J; Foukakis T
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2010;28(15):1058
Age-specific trends of survival in metastatic breast cancer: Data from a population-based cancer registry in Stockholm, Sweden.
Foukakis T; Fornander T; Lekberg T; Hellborg H; Adolfsson J; Bergh J
Conference publication: CANCER RESEARCH. 2009;69
Proteomic studies in well differentiated thyroid tumors
Sofiadis A; Zedenius J; Wallin G; Foukakis T; Hoog A; Orre L; Lehtio J; Larsson C
Book chapter: CLINICAL ENDOCRINE ONCOLOGY. 2008;p. 124-129
Pathogenesis of Thyroid Cancer
Zedenius J; Foukakis T
Review: ACTA ONCOLOGICA. 2007;46(3):277-285
Advances in the treatment of patients with gastric adenocarcinoma
Foukakis T; Lundell L; Gubanski M; Lind PA
Conference publication: HORMONE RESEARCH IN PAEDIATRICS. 2007;68:41
MIB-1 proliferation index in thyroid tumors' fine needle aspiration cytology (FNAC):: A prognostic tool?
Sofiadis A; Larsson C; Wallin G; Zedenius J; Foukakis T; Hoog A; Tani E; Kjellman P
Conference publication: CANCER RESEARCH. 2006;66(8)
Anti-tumorigenic effects of RASSF5 (NORE1) in human pheochromocytomas
Geli J; Kiss N; Natalishvili N; Foukakis T; Lanner F; Bertil H; Backdahl M; Farnebo F; Larsson C
Conference publication: CANCER RESEARCH. 2006;66(8)
Molecular cytogenetic characterization of anaplastic thyroid carcinoma
Lee J-J; Foukakis T; Lui W-O; Hashemi J; Heldin N-E; Grimelius L; Wallin G; Hoog A; Larsson C
Doctoral thesis: 2005
Basic and translational studies of follicular thyroid neoplasia
Foukakis T
Conference publication: AMERICAN JOURNAL OF HUMAN GENETICS. 2003;73(5):219
Cytogenetic characterization of thyroid tumors and cell lines using comparative genomic hybridization, spectral karyoyping and G-banding
Foukakis T; Thoppe SR; Lagercrantz S; Dwight T; Svensson A; Liu WO; Wallin G; Zedenius J; Larsson C
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Grants

Antibody-based TROP-2 targeted radiopharmaceuticals for improved theranostics of metastatic solid cancers
Swedish Research Council
1 January 2024 - 31 December 2027
Illuminating the origin and consequences of genomic structural variation in cancer
Swedish Research Council
1 January 2023 - 31 December 2026
Integrative digital diagnostics for therapy optimization in early breast cancer
Swedish Research Council
1 January 2022 - 31 December 2025
Foukakis, Theodoros – Integrative machine learning predictive models for neoadjuvant therapy optimization in breast cancer
Swedish Cancer Society
1 January 2022
Randomized Trials on Biology-Driven De-escalation of Neoadjuvant Treatment for HER2-positive Breast Cancer: ARIADNE master protocol
Swedish Research Council
1 December 2020 - 31 December 2024
Treatment of oligometastatic breast cancer – a randomised translational phase 3 trial comparing stereotactic ablative radiotherapy and systemic treatment with systemic treatment alone "TAORMINA"
Swedish Research Council
1 December 2020 - 4 March 2024
Refining pre-operative systemic therapy through repeated therapy evaluation and a cross-over design in a prospective randomized phase II study for primary HER2-amplified breast cancer.
Swedish Research Council
1 January 2019 - 31 March 2021
Optimizing treatment in HER2 positive breast cancer through insights in tumor biology
Swedish Research Council
1 January 2019 - 31 December 2021
Optimization of breast cancer treatment through better understanding of tumor biology
Swedish Cancer Society
1 January 2018
Translational studies for the development of predictive biomarkers in breast cancer
Swedish Cancer Society
1 January 2017
Translational studies for the development of predictive biomarkers in breast cancer
Swedish Cancer Society
1 January 2016
Translational studies for the development of predictive biomarkers in breast cancer
Swedish Cancer Society
1 January 2015

Employments

Professor/Senior Physician, Department of Oncology-Pathology, Karolinska Institutet, 2025-
Senior Lecturer/Senior Physician, Department of Oncology-Pathology, Karolinska Institutet, 2020-2025

Degrees and Education

Docent, Karolinska Institutet, 2014
Doctor Of Philosophy, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2005

Articles

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Grants

Employments

Degrees and Education

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