2017-present: Associate Professor at Karolinska Institutet, MTC
2008-2017: Group Leader at Ludwig Institute for Cancer Research
2006-2008: Instructor of Medicine, Dana-Farber Cancer Institute/Harvard Medical School, Boston, USA
2003-2006: Postdoctoral Fellow, Dana-Farber Cancer Institute/Harvard Medical School, Boston, USA
2002: PhD, Duke University Medical School, Durham, N.C., USA, 2002
1999: MSc, Humboldt University, Berlin, Germany
Our research concerns the mechanisms of how disruption of oxygen-sensing pathways can lead to cancer. Oxygen sensors enable the cell to adapt to low-oxygen environments and are critical for normal development and apoptosis. These events are often disrupted in the development of tumors. Oxygen sensing is mediated partly via prolyl hydroxylases that require molecular oxygen for enzymatic activity. Our work focuses on how prolyl hydroxylases execute apoptosis in neural precursors during development and how disruption of this process can lead to certain forms of nervous-system tumors.