Susanne Löffler

Susanne Löffler

Affiliated to Research
Visiting address: Biomedicum, Solnavägen 9, 17165 Solna
Postal address: C4 Neurovetenskap, C4 AIMES, 171 77 Stockholm
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About me

  • I joined Agneta Richter-Dahlfors' group with the Swedish Medical Nanoscience
    center as a postdoctoral fellow in 2012. Here, I'm working to find solutions
    for problems in today's healthcare and medical sector. Working here gives me
    the chance to apply my interdisciplinary background from Life Sciences,
    Neuroscience, and Biomedical Engineering. I like learning new things everyday
    and seeing ideas progress from a thought to a sketch on a paper towel towards
    a scientific proof-of concept study to a device, that is actually helping
    people in real-life.
    PhD: ”Towards closed-loop Deep Brain Stimulation – An integratedApproach
    for Neural Recording and Microstimulation” [1]
    Department for Signal Processing, Faculty of Computer Science and
    Engineering, University of Lübeck, Germany
    BSc: Molecular Biotechnology, University of Lübeck, Germany (Thesis:
    ”High frequency electrical stimulation in the caudate nucleus in vivo:
    Quantification of the neurotransmitters GABA and glutamate”
    MSc: Molecular Life Sciences, University of Lübeck, Germany (Thesis:
    ”Characterization of the HFS induced GABA release in the corpus
    striatum of the rat in vivo”
    [1] http://www.students.informatik.uni-luebeck.de/zhb/ediss1108.pdf

Research

  • Organic electronics are a group of materials that combine the versability and
    flexibility of polymers with electronic conductivity. With the help of these
    conducting polymers, it becomes possible to built electronic devices from
    materials that have the same look and feel as the plastics, which we are
    using in our everyday life.
    Really interesting is the fact that these materials can change their physical
    properties depending on how we adres them electronically. That means, we can
    actively transform one material into another by applying an electrical
    potential.
    I'm investigating the use of these materials in Life Science and Medical
    applications as active surfaces for cell attachment, as delivery devices for
    neuroactive substances or as sensors for bacterial infection.
    * Active Surfaces for cell Attachment/Release: We're using different redox
    states of the polymers to prevent attachment or release cells
    * Artificial Synapse: We're using an organic electronic ion pump, which
    releases neurotransmitters with high spatiotemporal control and pair it
    with an entity for real-time neurotransmitter detection
    * Epithelial Integrity Sensing: We're using an organic electronic sensor,
    which has a large active surface area due to the porosity of the polymer
    to detect the paracellular diffusion at an epithelial cell layer.

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