Stephen Strom

About me
Publications
Public outreach and news

About me

Professor of Cell Transplantation Research at the Department of Laboratory
Medicine.

Articles

Article: MOLECULAR THERAPY. 2021;29(5):1903-1917
Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes
Zabulica M; Srinivasan RC; Akcakaya P; Allegri G; Bestas B; Firth M; Hammarstedt C; Jakobsson T; Jakobsson T; Ellis E; Jorns C; Makris G; Scherer T; Rimann N; van Zuydam NR; Gramignoli R; Forslow A; Engberg S; Maresca M; Rooyackers O; Thony B; Haberle J; Rosen B; Strom SC
Article: MECHANISMS OF AGEING AND DEVELOPMENT. 2021;194:111426
A geroscience approach for Parkinson ' s disease: Conceptual framework and design of PROPAG-AGEING project
Pirazzini C; Azevedo T; Baldelli L; Bartoletti-Stella A; Calandra-Buonaura G; Dal Molin A; Dimitri GM; Doykov I; Gomez-Garre P; Hagg S; Hallqvist J; Halsband C; Heywood W; Jesus S; Jylhava J; Kwiatkowska KM; Labrador-Espinosa MA; Licari C; Maturo MG; Mengozzi G; Meoni G; Milazzo M; Perinan-Tocino MT; Ravaioli F; Sala C; Sambati L; Schade S; Schreglmann S; Spasov S; Tenori L; Williams D; Xumerle L; Zago E; Bhatia KP; Capellari S; Cortelli P; Garagnani P; Houlden H; Lio P; Luchinat C; Delledonne M; Mills K; Mir P; Mollenhauer B; Nardini C; Pedersen NL; Provini F; Strom S; Trenkwalder C; Turano P; Bacalini MG; Franceschi C
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1217
Gene Editing Correction of a Urea Cycle Defect in Organoid Stem Cell Derived Hepatocyte-like Cells
Zabulica M; Jakobsson T; Ravaioli F; Vosough M; Gramignoli R; Ellis E; Rooyackers O; Strom SC
Article: HEPATOLOGY. 2020;72(2):656-670
Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans
Minniti ME; Pedrelli M; Vedin L-L; Delbes A-S; Denis RGP; Oorni K; Sala C; Pirazzini C; Thiagarajan D; Nurmi HJ; Grompe M; Mills K; Garagnani P; Ellis ECS; Strom SC; Luquet SH; Wilson EM; Bial J; Steffensen KR; Parini P
Article: CELLS. 2020;9(7):E1696-1696
Effects of Cryogenic Storage on Human Amnion Epithelial Cells
Srinivasan RC; Strom SC; Gramignoli R
Article: SCIENTIFIC REPORTS. 2020;10(1):7052
Systemic modified messenger RNA for replacement therapy in alpha 1-antitrypsin deficiency
Karadagi A; Cavedon AG; Zemack H; Nowak G; Eybye ME; Zhu X; Guadagnin E; White RA; Rice LM; Frassetto AL; Strom S; Jorns C; Martini PGV; Ellis E
Article: NUTRIENTS. 2020;12(2):E277-277
Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver
Gensous N; Ravaioli F; Pirazzini C; Gramignoli R; Ellis E; Storci G; Capri M; Strom S; Laconi E; Franceschi C; Garagnani P; Marongiu F; Bacalini MG
Article: STEM CELLS AND DEVELOPMENT. 2019;28(14):907-919
Guide to the Assessment of Mature Liver Gene Expression in Stem Cell-Derived Hepatocytes
Zabulica M; Srinivasan RC; Vosough M; Hammarstedt C; Wu T; Gramignoli R; Ellis E; Kannisto K; de l'Hortet AC; Takeishi K; Soto-Gutierrez A; Strom SC
Article: INTERNATIONAL JOURNAL OF CANCER. 2019;144(10):2613-2624
Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma
Augello G; Emma MR; Cusimano A; Azzolina A; Mongiovi S; Puleio R; Cassata G; Gulino A; Belmonte B; Gramignoli R; Strom SC; McCubrey JA; Montalto G; Cervello M
Article: JOURNAL OF IMMUNOLOGY. 2019;202(3):724-735
Ectonucleotidase Expression on Human Amnion Epithelial Cells: Adenosinergic Pathways and Dichotomic Effects on Immune Effector Cell Populations
Morandi F; Horenstein AL; Quarona V; Faini AC; Castella B; Srinivasan RC; Strom SC; Malavasi F; Gramignoli R
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2019;74(1):1-8
Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature
Bacalini MG; Franceschi C; Gentilini D; Ravaioli F; Zhou X; Remondini D; Pirazzini C; Giuliani C; Marasco E; Gensous N; Di Blasio AM; Ellis E; Gramignoli R; Castellani G; Capri M; Strom S; Nardini C; Cescon M; Grazi GL; Garagnani P
Article: PLOS ONE. 2019;14(4):e0215490
Applying hydrodynamic pressure to efficiently generate induced pluripotent stem cells via reprogramming of centenarian skin fibroblasts
Vosough M; Ravaioli F; Zabulica M; Capri M; Garagnani P; Franceschi C; Piccand J; Kraus MR-C; Kannisto K; Gramignoli R; Strom SC
Article: CYTOTHERAPY. 2019;21(1):113-124
Evaluation of different routes of administration and biodistribution of human amnion epithelial cells in mice
Srinivasan RC; Kannisto K; Strom SC; Gramignoli R
Article: CURRENT TRANSPLANTATION REPORTS. 2017;4(4):280-289
Clinical Hepatocyte Transplantation: What Is Next?
Squires JE; Soltys KA; McKiernan P; Squires RH; Strom SC; Fox IJ; Soto-Gutierrez A
Article: PLACENTA. 2017;59:139-145
Differentiation of amniotic epithelial cells into various liver cell types and potential therapeutic applications
Fanti M; Gramignoli R; Serra M; Cadoni E; Strom SC; Marongiu F
Article: JOURNAL OF HEPATOLOGY. 2017;66(5):987-1000
Host conditioning and rejection monitoring in hepatocyte transplantation in humans
Soltys KA; Setoyama K; Tafaleng EN; Gutierrez AS; Fong J; Fukumitsu K; Nishikawa T; Nagaya M; Sada R; Haberman K; Gramignoli R; Dorko K; Tahan V; Dreyzin A; Baskin K; Crowley JJ; Quader MA; Deutsch M; Ashokkumar C; Shneider BL; Squires RH; Ranganathan S; Reyes-Mugica M; Dobrowolski SF; Mazariegos G; Elango R; Stolz DB; Strom SC; Vockley G; Roy-Chowdhury J; Cascalho M; Guha C; Sindhi R; Platt JL; Fox IJ
Article: METHODS IN MOLECULAR BIOLOGY. 2017;1506:3-16
Hepatocyte Transplantation in Special Populations: Clinical Use in Children.
Khan Z; Strom SC
Article: PLOS ONE. 2017;12(5):e0177279
Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression
Karadagi A; Johansson H; Zemack H; Salipalli S; Mork L-M; Kannisto K; Jorns C; Gramignoli R; Strom S; Stokkeland K; Ericzon B-G; Jonigk D; Janciauskiene S; Nowak G; Ellis ECS
Article: HUMAN IMMUNOLOGY. 2016;77(9):734-739
Human amnion epithelial cells expressing HLA-G as novel cell-based treatment for liver disease
Strom SC; Gramignoli R
Article: DRUG METABOLISM AND DISPOSITION. 2016;44(7):1027-1037
Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny
Giebel NL; Shadley JD; McCarver DG; Dorko K; Gramignoli R; Strom SC; Yan K; Simpson PM; Hines RN
Article: JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY. 2016;6(2):87-93
Addition of Dexamethasone Alters the Bile Acid Composition by Inducing CYP8B1 in Primary Cultures of Human Hepatocytes.
Mörk L-M; Strom SC; Mode A; Ellis ECS
Article: CURRENT PROTOCOLS IN STEM CELL BIOLOGY. 2016;37:1E.10.1-1E.10.13
Isolation of Human Amnion Epithelial Cells According to Current Good Manufacturing Procedures.
Gramignoli R; Srinivasan RC; Kannisto K; Strom SC
Article: AMERICAN JOURNAL OF TRANSPLANTATION. 2016;16(3):1021-1030
De Novo Donor-Specific HLA Antibody Formation in Two Patients With Crigler-Najjar Syndrome Type I Following Human Hepatocyte Transplantation With Partial Hepatectomy Preconditioning
Jorns C; Nowak G; Nemeth A; Zemack H; Mork L-M; Johansson H; Gramignoli R; Watanabe M; Karadagi A; Alheim M; Hauzenberger D; van Dijk R; Bosma PJ; Ebbesen F; Szakos A; Fischler B; Strom S; Ellis E; Ericzon B-G
Article: MOLECULAR BIOSYSTEMS. 2016;12(2):566-574
The proteome of methylmalonic acidemia (MMA): the elucidation of altered pathways in patient livers
Caterino M; Chandler RJ; Sloan JL; Dorko K; Cusmano-Ozog K; Ingenito L; Strom SC; Imperlini E; Scolamiero E; Venditti CP; Ruoppolo M
Article: STEM CELL REPORTS. 2015;5(1):22-30
Amelioration of Hyperbilirubinemia in Gunn Rats after Transplantation of Human Induced Pluripotent Stem Cell-Derived Hepatocytes
Chen Y; Li Y; Wang X; Zhang W; Sauer V; Chang C-J; Han B; Tchaikovskaya T; Avsar Y; Tafaleng E; Girija SM; Tar K; Polgar Z; Strom S; Bouhassira EE; Guha C; Fox IJ; Roy-Chowdhury J; Roy-Chowdhury N
Article: HEPATOLOGY. 2015;62(1):147-157
Induced pluripotent stem cells model personalized variations in liver disease resulting from 1-antitrypsin deficiency
Tafaleng EN; Chakraborty S; Han B; Hale P; Wu W; Soto-Gutierrez A; Feghali-Bostwick CA; Wilson AA; Kotton DN; Nagaya M; Strom SC; Roy-Chowdhury J; Stolz DB; Perlmutter DH; Fox IJ
Article: STEM CELLS AND DEVELOPMENT. 2015;24(12):1429-1435
Rat-Derived Amniotic Epithelial Cells Differentiate into Mature Hepatocytes In Vivo with No Evidence of Cell Fusion
Marongiu M; Serra MP; Contini A; Sini M; Strom SC; Laconi E; Marongiu F
Article: CELL. 2015;160(1-2):299-312
Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
Huch M; Gehart H; van Boxtel R; Hamer K; Blokzijl F; Verstegen MMA; Ellis E; van Wenum M; Fuchs SA; de Ligt J; van de Wetering M; Sasaki N; Boers SJ; Kemperman H; de Jonge J; Ijzermans JNM; Nieuwenhuis EES; Hoekstra R; Strom S; Vries RRG; van der Laan LJW; Cuppen E; Clevers H
Article: CURRENT PROTOCOLS IN TOXICOLOGY / EDITORIAL BOARD, MAHIN D. MAINES (EDITOR-IN-CHIEF) ... [ET AL.]. 2014;62:14.12.1-14.1223
The history and use of human hepatocytes for the treatment of liver diseases: the first 100 patients.
Hansel MC; Gramignoli R; Skvorak KJ; Dorko K; Marongiu F; Blake W; Davila J; Strom SC
Article: TOXICOLOGICAL SCIENCES. 2014;141(2):538-546
Potency of Individual Bile Acids to Regulate Bile Acid Synthesis and Transport Genes in Primary Human Hepatocyte Cultures
Liu J; Lu H; Lu Y-F; Lei X; Cui JY; Ellis E; Strom SC; Klaassen CD
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(30):20583-20593
Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase
Tso S-C; Gui W-J; Wu C-Y; Chuang JL; Qi X; Skvorak KJ; Dorko K; Wallace AL; Morlock LK; Lee BH; Hutson SM; Strom SC; Williams NS; Tambar UK; Wynn RM; Chuang DT
Article: DRUG METABOLISM AND DISPOSITION. 2014;42(4):695-699
Why Do Most Human Liver Cytosol Preparations Lack Xanthine Oxidase Activity?
Barr JT; Choughule KV; Nepal S; Wong T; Chaudhry AS; Joswig-Jones CA; Zientek M; Strom SC; Schuetz EG; Thummel KE; Jones JP
Article: CELL TRANSPLANTATION. 2014;23(8):1009-1018
Strategies for Short-Term Storage of Hepatocytes for Repeated Clinical Infusions
Jorns C; Gramignoli R; Saliem M; Zemack H; Mork L-M; Isaksson B; Nowak G; Ericzon B-G; Strom S; Ellis E
Article: CELL TRANSPLANTATION. 2014;23(12):1537-1544
Potential Barriers to Human Hepatocyte Transplantation in MUP-uPA^tg(+/+)Rag2^-/-γC^-/- Mice
Komori J; De Ward AD; Gramignoli R; Strom SC; Fontes P; Lagasse E
Article: CELL TRANSPLANTATION. 2014;23(12):1545-1556
Rapid and Sensitive Assessment of Human Hepatocyte Functions
Gramignoli R; Tahan V; Dorko K; Venkataramanan R; Fox IJ; Ellis ECS; Vosough M; Strom SC
Article: CELL TRANSPLANTATION. 2014;23(1):27-38
Increased Reprogramming of Human Fetal Hepatocytes Compared With Adult Hepatocytes in Feeder-Free Conditions
Hansel MC; Gramignoli R; Blake W; Davila J; Skvorak K; Dorko K; Tahan V; Lee BR; Tafaleng E; Guzman-Lepe J; Soto-Gutierrez A; Fox IJ; Strom SC
Article: CELL TRANSPLANTATION. 2014;23(9):1143-1151
Hypothermic Storage of Human Hepatocytes for Transplantation
Gramignoli R; Dorko K; Tahan V; Skvorak KJ; Ellis E; Jorns C; Ericzon B-G; Fox IJ; Strom SC
Article: STEM CELLS AND DEVELOPMENT. 2013;22:96-102
Translation of Amnion Stem Cells to the Clinic
Strom SC; Skvorak K; Gramignoli R; Marongiu F; Miki T
Article: DRUG METABOLISM AND DISPOSITION. 2013;41(10):1843-1851
Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib-an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer
Pillai VC; Venkataramanan R; Parise RA; Christner SM; Gramignoli R; Strom SC; Rudek MA; Beumer JH
Article: DEVELOPMENT. 2013;140(15):3285-3296
Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes
Ogawa S; Surapisitchat J; Virtanen C; Ogawa M; Niapour M; Sugamori KS; Wang S; Tamblyn L; Guillemette C; Hoffmann E; Zhao B; Strom S; Laposa RR; Tyndale RF; Grant DM; Keller G
Article: DRUG METABOLISM AND DISPOSITION. 2013;41(8):1538-1547
Genetic Variation in Aldo-Keto Reductase 1D1 (AKR1D1) Affects the Expression and Activity of Multiple Cytochrome P450s
Chaudhry AS; Thirumaran RK; Yasuda K; Yang X; Fan Y; Strom SC; Schuetz EG
Article: STEM CELL RESEARCH. 2013;11(1):563-573
New potential cell source for hepatocyte transplantation: Discarded livers from metabolic disease liver transplants
Gramignoli R; Tahan V; Dorko K; Skvorak KJ; Hansel MC; Zhao W; Venkataramanan R; Ellis ECS; Jorns C; Ericzon B-G; Rosenborg S; Kuiper R; Soltys KA; Mazariegos GV; Fox IJ; Wilson EM; Grompe M; Strom SC
Article: MOLECULAR GENETICS AND METABOLISM. 2013;109(2):132-138
Improved Amino Acid, Bioenergetic Metabolite and Neurotransmitter Profiles following Human Amnion Epithelial Cell Transplant in Intermediate Maple Syrup Urine Disease Mice
Skvorak KJ; Dorko K; Marongiu F; Tahan V; Hansel MC; Gramignoli R; Arning E; Bottiglieri T; Gibson KM; Strom SC
Article: HEPATOLOGY. 2013;57(3):1017-1023
Placental stem cell correction of murine intermediate maple syrup urine disease
Skvorak KJ; Dorko K; Marongiu F; Tahan V; Hansel MC; Gramignoli R; Gibson KM; Strom SC
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2013;74:126-132
A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC-MS/MS.
Pillai VC; Strom SC; Caritis SN; Venkataramanan R
Article: DRUG METABOLISM AND DISPOSITION. 2013;41(2):296-304
Hepatobiliary Disposition of 17-OHPC and Taurocholate in Fetal Human Hepatocytes: A Comparison with Adult Human Hepatocytes
Sharma S; Ellis ECS; Gramignoli R; Dorko K; Tahan V; Hansel M; Mattison DR; Caritis SN; Hines RN; Venkataramanan R; Strom SC
Article: MOLECULAR ENDOCRINOLOGY. 2013;27(1):106-115
Regulation of the Human Hydroxysteroid Sulfotransferase (SULT2A1) by RORα and RORγ and Its Potential Relevance to Human Liver Diseases
Ou Z; Shi X; Gilroy RK; Kirisci L; Romkes M; Lynch C; Wang H; Xu M; Jiang M; Ren S; Gramignoli R; Strom SC; Huang M; Xie W
Article: PLOS ONE. 2013;8(11):e78550
Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism
Ellis ECS; Nauglers S; Parini P; Mork L-M; Jorns C; Zemack H; Sandblom AL; Bjorkhem I; Ericzon B-G; Wilson EM; Strom SC; Grompe M
Article: JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY. 2012;2(4):323-332
Treprostinil Improves Hepatic Cytochrome P450 Activity during Rat Liver Transplantation.
Ghonem N; Yoshida J; Murase N; Strom SC; Venkataramanan R
Article: JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY. 2012;2(4):315-322
Comparison of culture media for bile Acid transport studies in primary human hepatocytes.
Mörk L-M; Isaksson B; Boran N; Ericzon B-G; Strom S; Fischler B; Ellis E
Article: MOLECULAR PHARMACOLOGY. 2012;82(5):918-928
The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).
Laurenzana EM; Chen T; Kannuswamy M; Sell BE; Strom SC; Li Y; Omiecinski CJ
Article: DIABETES. 2012;61(8):2004-2015
ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation
Metukuri MR; Zhang P; Basantani MK; Chin C; Stamateris RE; Alonso LC; Takane KK; Gramignoli R; Strom SC; O'Doherty RM; Stewart AF; Vasavada RC; Garcia-Ocana A; Scott DK
Article: XENOBIOTICA. 2012;42(5):409-416
Effect of voriconazole and other azole antifungal agents on CYP3A activity and metabolism of tacrolimus in human liver microsomes.
Zhang S; Pillai VC; Mada SR; Strom S; Venkataramanan R
Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2012;12(4):651-656
Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes.
Noreault-Conti TL; Fellows A; Jacobs JM; Trask HW; Strom SC; Evans RM; Wrighton SA; Sinclair PR; Sinclair JF; Nichols RC
Article: GASTROENTEROLOGY. 2012;142(1):25-28
Frequent aneuploidy among normal human hepatocytes.
Duncan AW; Hanlon Newell AE; Smith L; Wilson EM; Olson SB; Thayer MJ; Strom SC; Grompe M
Article: CELL TRANSPLANTATION. 2012;21(6):1245-1260
Development and Application of Purified Tissue Dissociation Enzyme Mixtures for Human Hepatocyte Isolation
Gramignoli R; Green ML; Tahan V; Dorko K; Skvorak KJ; Marongiu F; Zao W; Venkataramanan R; Ellis ECS; Geller D; Breite AG; Dwulet FE; McCarthy RC; Strom SC
Article: DIABETES. 2011;60(11):2763-2774
FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver
Kim DH; Perdomo G; Zhang T; Slusher S; Lee S; Phillips BE; Fan Y; Giannoukakis N; Gramignoli R; Strom S; Ringquist S; Dong HH
Article: HEPATOLOGY. 2011;54(2):644-654
Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis.
Meyer zu Schwabedissen HE; Ware JA; Finkelstein D; Chaudhry AS; Mansell S; Leon-Ponte M; Strom SC; Zaher H; Schwarz UI; Freeman DJ; Schuetz EG; Tirona RG; Kim RB
Article: TISSUE ENGINEERING PART C-METHODS. 2011;17(6):677-686
A Whole-Organ Regenerative Medicine Approach for Liver Replacement
Soto-Gutierrez A; Zhang L; Medberry C; Fukumitsu K; Faulk D; Jiang H; Reing J; Gramignoli R; Komori J; Ross M; Nagaya M; Lagasse E; Stolz D; Strom SC; Fox IJ; Badylak SF
Article: HEPATOLOGY. 2011;53(5):1719-1729
Hepatic Differentiation of Amniotic Epithelial Cells
Marongiu F; Gramignoli R; Dorko K; Miki T; Ranade AR; Serra MP; Doratiotto S; Sini M; Sharma S; Mitamura K; Sellaro TL; Tahan V; Skvorak KJ; Ellis ECS; Badylak SF; Davila JC; Hines R; Laconi E; Strom SC
Article: MOLECULAR ENDOCRINOLOGY. 2011;25(4):584-596
MicroRNA hsa-miR-613 Targets the Human LXRα Gene and Mediates a Feedback Loop of LXRα Autoregulation
Ou Z; Wada T; Gramignoli R; Li S; Strom SC; Huang M; Xie W
Article: CLINICAL IMMUNOLOGY. 2011;138(1):41-49
Status of bacterial colonization, Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers.
Singh R; Bullard J; Kalra M; Assefa S; Kaul AK; Vonfeldt K; Strom SC; Conrad RS; Sharp HL; Kaul R
Article: VIROLOGY. 2010;407(1):160-170
The second extracellular loop dictates Occludin-mediated HCV entry.
Liu S; Kuo W; Yang W; Liu W; Gibson GA; Dorko K; Watkins SC; Strom SC; Wang T
Article: JOURNAL OF HEPATOLOGY. 2010;53(4):769-774
Barriers to the successful treatment of liver disease by hepatocyte transplantation.
Soltys KA; Soto-Gutiérrez A; Nagaya M; Baskin KM; Deutsch M; Ito R; Shneider BL; Squires R; Vockley J; Guha C; Roy-Chowdhury J; Strom SC; Platt JL; Fox IJ
Article: GENOME RESEARCH. 2010;20(8):1020-1036
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
Yang X; Zhang B; Molony C; Chudin E; Hao K; Zhu J; Gaedigk A; Suver C; Zhong H; Leeder JS; Guengerich FP; Strom SC; Schuetz E; Rushmore TH; Ulrich RG; Slatter JG; Schadt EE; Kasarskis A; Lum PY
Article: TOXICOLOGICAL SCIENCES. 2010;116(2):422-432
Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression.
Gross-Steinmeyer K; Stapleton PL; Tracy JH; Bammler TK; Strom SC; Eaton DL
Article: ENDOCRINOLOGY. 2010;151(8):3521-3535
FoxO1 Links Hepatic Insulin Action to Endoplasmic Reticulum Stress
Kamagate A; Kim DH; Zhang T; Slusher S; Gramignoli R; Strom SC; Bertera S; Ringquist S; Dong HH
Article: MOLECULAR ENDOCRINOLOGY. 2010;24(6):1151-1164
A Novel Bile Acid-Activated Vitamin D Receptor Signaling in Human Hepatocytes
Han S; Li T; Ellis E; Strom S; Chiang JYL
Article: DRUG METABOLISM AND DISPOSITION. 2010;38(5):723-727
Metabolism of 17α-Hydroxyprogesterone Caproate, an Agent for Preventing Preterm Birth, by Fetal Hepatocytes
Sharma S; Ellis ECS; Dorko K; Zhang S; Mattison DR; Caritis SN; Venkataramanan R; Strom SC
Article: CURRENT PROTOCOLS IN STEM CELL BIOLOGY. 2010;Chapter 1:Unit-1E.5
Isolation of amniotic mesenchymal stem cells.
Marongiu F; Gramignoli R; Sun Q; Tahan V; Miki T; Dorko K; Ellis E; Strom SC
Article: TISSUE ENGINEERING PART A. 2010;16(3):1075-1082
Maintenance of human hepatocyte function in vitro by liver-derived extracellular matrix gels.
Sellaro TL; Ranade A; Faulk DM; McCabe GP; Dorko K; Badylak SF; Strom SC
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2010;332(3):1088-1099
Genetic predictors of interindividual variability in hepatic CYP3A4 expression.
Lamba V; Panetta JC; Strom S; Schuetz EG
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2010;332(2):599-611
CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose.
Chaudhry AS; Urban TJ; Lamba JK; Birnbaum AK; Remmel RP; Subramanian M; Strom S; You JH; Kasperaviciute D; Catarino CB; Radtke RA; Sisodiya SM; Goldstein DB; Schuetz EG
Article: PEDIATRIC RESEARCH. 2010;67(2):183-187
ATPase Class I Type 8B Member 1 and Protein Kinase C ζ Induce the Expression of the Canalicular Bile Salt Export Pump in Human Hepatocytes
Chen F; Ellis E; Strom SC; Shneider BL
Article: BIOCHEMISTRY. 2010;49(2):393-400
The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor.
Schroeder JC; Dinatale BC; Murray IA; Flaveny CA; Liu Q; Laurenzana EM; Lin JM; Strom SC; Omiecinski CJ; Amin S; Perdew GH
Article: CELL MEDICINE. 2010;1(3):113-114
Tracking Cells Without Leaving a Trace.
Strom S
Article: CURRENT PROTOCOLS IN STEM CELL BIOLOGY. 2010;Chapter 1:Unit-1E.3
Isolation of amniotic epithelial stem cells.
Miki T; Marongiu F; Dorko K; Ellis ECS; Strom SC
Article: DRUG METABOLISM AND DISPOSITION. 2009;37(12):2323-2329
Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes.
Moody DE; Fang WB; Lin S-N; Weyant DM; Strom SC; Omiecinski CJ
Article: TOXICOLOGICAL SCIENCES. 2009;112(2):303-310
Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumols.
Gross-Steinmeyer K; Stapleton PL; Tracy JH; Bammler TK; Strom SC; Buhler DR; Eaton DL
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1791(10):991-996
Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice.
Li T; Ma H; Park YJ; Lee Y-K; Strom S; Moore DD; Chiang JYL
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1792(10):1004-1010
Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD).
Skvorak KJ; Hager EJ; Arning E; Bottiglieri T; Paul HS; Strom SC; Homanics GE; Sun Q; Jansen EEW; Jakobs C; Zinnanti WJ; Gibson KM
Article: MOLECULAR THERAPY. 2009;17(7):1266-1273
Hepatocyte Transplantation Improves Phenotype and Extends Survival in a Murine Model of Intermediate Maple Syrup Urine Disease
Skvorak KJ; Paul HS; Dorko K; Marongiu F; Ellis E; Chace D; Ferguson C; Gibson KM; Homanics GE; Strom SC
Article: GENES & DEVELOPMENT. 2009;23(8):986-996
Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation
Miao J; Xiao Z; Kanamaluru D; Min G; Yau PM; Veenstra TD; Ellis E; Strom S; Suino-Powell K; Xu HE; Kemper JK
Article: DRUG METABOLISM AND DISPOSITION. 2009;37(4):900-908
Human Pregnane X Receptor Activation and CYP3A4/CYP2B6 Induction by 2,3-Oxidosqualene: Lanosterol Cyclase Inhibition
Duniec-Dmuchowski Z; Fang H-L; Strom SC; Ellis E; Runge-Morris M; Kocarek TA
Article: GASTROENTEROLOGY. 2009;136(3):990-999
Differentiation and Transplantation of Human Embryonic Stem Cell-Derived Hepatocytes
Basma H; Soto-Gutierrez A; Yannam GR; Liu L; Ito R; Yamamoto T; Ellis E; Carson SD; Sato S; Chen Y; Muirhead D; Navarro-Alvarez N; Wong RJ; Roy-Chowdhury J; Platt JL; Mercer DF; Miller JD; Strom SC; Kobayashi N; Fox IJ
Article: CELL TRANSPLANTATION. 2009;18(4):477-486
Naive rat amnion-derived cell transplantation improved left ventricular function and reduced myocardial scar of postinfarcted heart.
Fujimoto KL; Miki T; Liu LJ; Hashizume R; Strom SC; Wagner WR; Keller BB; Tobita K
Article: HEPATOLOGY. 2009;49(1):297-305
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.
Song K-H; Li T; Owsley E; Strom S; Chiang JYL
Article: ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION. 2009;26(4):295-302
Long Term Cultures of Primary Human Hepatocytes as an Alternative to Drug Testing in Animals
Ullrich A; Soltz DB; Ellis EC; Strom SC; Michalopoulos GK; Hengstler JG; Runge D
Article: DRUG METABOLISM AND DISPOSITION. 2008;36(9):1896-1902
Identification of enzymes involved in the metabolism of 17alpha-hydroxyprogesterone caproate: an effective agent for prevention of preterm birth.
Sharma S; Ou J; Strom S; Mattison D; Caritis S; Venkataramanan R
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2008;231(2):216-224
Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures.
Goyak KMO; Johnson MC; Strom SC; Omiecinski CJ
Article: DRUG METABOLISM AND DISPOSITION. 2008;36(8):1689-1697
A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine.
Yasuda K; Ranade A; Venkataramanan R; Strom S; Chupka J; Ekins S; Schuetz E; Bachmann K
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2008;173(3):179-186
Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes.
Zamule SM; Strom SC; Omiecinski CJ
Article: PLOS BIOLOGY. 2008;6(5):e107
Mapping the genetic architecture of gene expression in human liver.
Schadt EE; Molony C; Chudin E; Hao K; Yang X; Lum PY; Kasarskis A; Zhang B; Wang S; Suver C; Zhu J; Millstein J; Sieberts S; Lamb J; GuhaThakurta D; Derry J; Storey JD; Avila-Campillo I; Kruger MJ; Johnson JM; Rohl CA; van Nas A; Mehrabian M; Drake TA; Lusis AJ; Smith RC; Guengerich FP; Strom SC; Schuetz E; Rushmore TH; Ulrich R
Article: DRUG METABOLISM AND DISPOSITION. 2008;36(4):780-795
Association of breast cancer resistance protein/ABCG2 phenotypes and novel promoter and intron 1 single nucleotide polymorphisms.
Poonkuzhali B; Lamba J; Strom S; Sparreboom A; Thummel K; Watkins P; Schuetz E
Article: MOLECULAR PHARMACOLOGY. 2008;73(3):891-899
Identification of oxysterol 7α-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor α ( RORα) (NR1F1) target gene and a functional cross-talk between RORα and liver X receptor (NR1H3)
Wada T; Kang HS; Angers M; Gong H; Bhatia S; Khadem S; Ren S; Ellis E; Strom SC; Jetten AM; Xie W
Article: DRUG METABOLISM AND DISPOSITION. 2008;36(1):169-181
Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression.
Lamba J; Lamba V; Strom S; Venkataramanan R; Schuetz E
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;364(4):743-747
Ethanol stimulates bile acid formation in primary human hepatocytes
Nilsson L-M; Sjoevall J; Strom S; Bodin K; Nowak G; Einarsson C; Ellis E
Article: HEPATOLOGY. 2007;46(6):1993-2002
Hepatocyte growth factor signaling pathway inhibits cholesterol 7α-hydroxylase and bile acid synthesis in human hepatocytes
Song K-H; Ellis E; Strom S; Chiang JYL
Article: BIOCHEMICAL PHARMACOLOGY. 2007;74(10):1535-1540
Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists
Duniec-Dmuchowski Z; Ellis E; Strom SC; Kocarek TA
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2007;467(1):132-138
Regulation of the human cathepsin E gene by the constitutive androstane receptor.
Page JL; Strom SC; Omiecinski CJ
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2007;323(2):586-598
Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin:: Roles of hepatocyte nuclear factor 4α and pregnane X receptor
Fang H-L; Strom SC; Ellis E; Duanmu Z; Fu J; Duniec-Dmuchowski Z; Falany CN; Falany JL; Kocarek TA; Runge-Morris M
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2007;20(10):1503-1512
Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites
Kostrubsky SE; Strom SC; Ellis E; Nelson SD; Mutlib AE
Article: JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2007;75(2):91-96
Identification of stem cell marker-positive cells by immunofluorescence in term human amnion.
Miki T; Mitamura K; Ross MA; Stolz DB; Strom SC
Article: MOLECULAR PHARMACOLOGY. 2007;72(4):947-955
Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2diphenylethyl)amino]propyloxy] phenylacetic acid hydrochloride (GW3965)
Kotokorpi P; Ellis E; Parini P; Nilsson L-M; Strom S; Steffensen KR; Gustafsson J-A; Mode A
Article: NATURE MEDICINE. 2007;13(9):1078-1085
Lack of Fas antagonism by Met in human fatty liver disease.
Zou C; Ma J; Wang X; Guo L; Zhu Z; Stoops J; Eaker AE; Johnson CJ; Strom S; Michalopoulos GK; DeFrances MC; Zarnegar R
Article: NATURE BIOTECHNOLOGY. 2007;25(8):903-910
Robust expansion of human hepatocytes in Fah^-/-/Rag2^-/-/Il2rg^-/- mice
Azuma H; Paulk N; Ranade A; Dorrell C; Al-Dhalimy M; Ellis E; Strom S; Kay MA; Finegold M; Grompe M
Article: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. 2007;34(7):632-635
Induction of cyp3a in primary cultures of human hepatocytes by ginkgolides a and B.
He N; Cai H-B; Xie H-G; Collins X; Edeki TI; Strom SC
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2007;222(1):42-56
Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues.
Olsavsky KM; Page JL; Johnson MC; Zarbl H; Strom SC; Omiecinski CJ
Article: TOXICOLOGICAL SCIENCES. 2007;97(2):384-397
Gene expression profiling of extracellular matrix as an effector of human hepatocyte phenotype in primary cell culture.
Page JL; Johnson MC; Olsavsky KM; Strom SC; Zarbl H; Omiecinski CJ
Article: BMC MEDICAL GENETICS. 2007;8:24
Adenoviral-mediated correction of methylmalonyl-CoA mutase deficiency in murine fibroblasts and human hepatocytes.
Chandler RJ; Tsai MS; Dorko K; Sloan J; Korson M; Freeman R; Strom S; Venditti CP
Article: NUCLEIC ACIDS RESEARCH. 2007;35(7):2177-2190
Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites.
Stoner MA; Auerbach SS; Zamule SM; Strom SC; Omiecinski CJ
Article: XENOBIOTICA. 2006;36(10-11):989-1012
ADME transcriptome in Hispanic versus White donor livers: evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics.
Finkelstein D; Lamba V; Assem M; Rengelshausen J; Yasuda K; Strom S; Schuetz E
Article: HEPATOLOGY. 2006;44(4):1012-1024
Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas.
Luo J-H; Ren B; Keryanov S; Tseng GC; Rao UNM; Monga SP; Strom S; Demetris AJ; Nalesnik M; Yu YP; Ranganathan S; Michalopoulos GK
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(39):28745-28754
Insulin regulation of cholesterol 7 α-hydroxylase expression in human hepatocytes -: Roles of forkhead box O1 and sterol regulatory element-binding protein 1c
Li T; Kong X; Owsley E; Ellis E; Strom S; Chiang JYL
Article: HEPATOLOGY RESEARCH. 2006;35(3):169-177
An optimal culture condition maintains human hepatocyte phenotype after long-term culture.
Yamamoto N; Wu J; Zhang Y; Catana AM; Cai H; Strom S; Novikoff PM; Zern MA
Article: PHARMACOGENETICS AND GENOMICS. 2006;16(6):415-427
Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans.
Lamba JK; Chen X; Lan L-B; Kim JW; Wei Wang X; Relling MV; Kazuto Y; Watkins PB; Strom S; Sun D; Schuetz JD; Schuetz EG
Article: TOXICOLOGICAL SCIENCES. 2006;90(2):451-459
Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone.
Kostrubsky SE; Strom SC; Kalgutkar AS; Kulkarni S; Atherton J; Mireles R; Feng B; Kubik R; Hanson J; Urda E; Mutlib AE
Article: NATURE MEDICINE. 2006;12(4):425-432
Induction of leptin resistance through direct interaction of C-reactive protein with leptin.
Chen K; Li F; Li J; Cai H; Strom S; Bisello A; Kelley DE; Friedman-Einat M; Skibinski GA; McCrory MA; Szalai AJ; Zhao AZ
Article: CLINICAL PHARMACOLOGY & THERAPEUTICS. 2006;79(4):325-338
MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype.
Lamba J; Strom S; Venkataramanan R; Thummel KE; Lin YS; Liu W; Cheng C; Lamba V; Watkins PB; Schuetz E
Article: PHARMACOGENETICS AND GENOMICS. 2006;16(2):79-86
Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes.
Ramírez J; Komoroski BJ; Mirkov S; Graber AY; Fackenthal DL; Schuetz EG; Das S; Ratain MJ; Innocenti F; Strom SC
Article: STEM CELL REVIEWS AND REPORTS. 2006;2(2):133-142
Amnion-derived pluripotent/multipotent stem cells.
Miki T; Strom SC
Article: AMERICAN JOURNAL OF PATHOLOGY. 2005;167(5):1279-1292
Mouse fetal liver cells in artificial capillary beds in three-dimensional four-compartment bioreactors.
Monga SPS; Hout MS; Baun MJ; Micsenyi A; Muller P; Tummalapalli L; Ranade AR; Luo J-H; Strom SC; Gerlach JC
Article: STEM CELLS. 2005;23(10):1549-1559
Stem cell characteristics of amniotic epithelial cells.
Miki T; Lehmann T; Cai H; Stolz DB; Strom SC
Article: CLINICAL CANCER RESEARCH. 2005;11(19 Pt 1):6972-6979
Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures.
Komoroski BJ; Parise RA; Egorin MJ; Strom SC; Venkataramanan R
Article: DIGESTIVE DISEASES AND SCIENCES. 2005;50(10):1755-1763
Side population cells derived from adult human liver generate hepatocyte-like cells in vitro.
Hussain SZ; Strom SC; Kirby MR; Burns S; Langemeijer S; Ueda T; Hsieh M; Tisdale JF
Article: TOXICOLOGICAL SCIENCES. 2005;87(1):146-155
Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes.
Kostrubsky SE; Sinclair JF; Strom SC; Wood S; Urda E; Stolz DB; Wen YH; Kulkarni S; Mutlib A
Article: MOLECULAR PHARMACOLOGY. 2005;68(2):403-413
A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development.
Mu Y; Stephenson CRJ; Kendall C; Saini SPS; Toma D; Ren S; Cai H; Strom SC; Day BW; Wipf P; Xie W
Article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2005;821(1):31-37
Determination of 13-O-demethyl tacrolimus in human liver microsomal incubates using liquid chromatography-mass spectrometric assay (LC-MS).
Feng Y; Zhang S; Poloyac S; Strom S; Venkataramanan R
Article: DRUG METABOLISM AND DISPOSITION. 2005;33(7):993-1003
Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes.
Noreault TL; Kostrubsky VE; Wood SG; Nichols RC; Strom SC; Trask HW; Wrighton SA; Evans RM; Jacobs JM; Sinclair PR; Sinclair JF
Article: XENOBIOTICA. 2005;35(5):419-438
Influence of Matrigel-overlay on constitutive and inducible expression of nine genes encoding drug-metabolizing enzymes in primary human hepatocytes.
Gross-Steinmeyer K; Stapleton PL; Tracy JH; Bammler TK; Lehman T; Strom SC; Eaton DL
Article: MOLECULAR PHARMACOLOGY. 2005;67(4):1257-1267
Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor.
Fang H-L; Strom SC; Cai H; Falany CN; Kocarek TA; Runge-Morris M
Article: CELL TRANSPLANTATION. 2005;14(2-3):151-157
Isolated hepatocyte transplantation for Crigler-Najjar syndrome type 1.
Ambrosino G; Varotto S; Strom SC; Guariso G; Franchin E; Miotto D; Caenazzo L; Basso S; Carraro P; Valente ML; D'Amico D; Zancan L; D'Antiga L
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2004;311(2):811-821
Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences.
Lamba JK; Lamba V; Yasuda K; Lin YS; Assem M; Thompson E; Strom S; Schuetz E
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2004;199(3):251-265
PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators.
Lamba V; Yasuda K; Lamba JK; Assem M; Davila J; Strom S; Schuetz EG
Article: PHARMACOGENETICS AND GENOMICS. 2004;14(9):595-605
Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene.
Wu MH; Chen P; Wu X; Liu W; Strom S; Das S; Cook EH; Rosner GL; Dolan ME
Article: XENOBIOTICA. 2004;34(7):619-632
Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes.
Gross-Steinmeyer K; Stapleton PL; Liu F; Tracy JH; Bammler TK; Quigley SD; Farin FM; Buhler DR; Safe SH; Strom SC; Eaton DL
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2004;39(6):584-593
Expanding hepatocytes in vitro before cell transplantation: donor age-dependent proliferative capacity of cultured human hepatocytes.
Walldorf J; Aurich H; Cai H; Runge D; Christ B; Strom SC; Fleig WE
Article: PHARMACOLOGICAL REVIEWS. 2004;56(2):159
PharmGKB update: II. CYP3A5, cytochrome P450, family 3, subfamily A, polypeptide 5.
Schuetz EG; Relling MV; Kishi S; Yang W; Das S; Chen P; Cook EH; Rosner GL; Pui CH; Blanco JG; Edick MJ; Hancock ML; Winick NJ; Dervieux T; Amylon MD; Bash RO; Behm FG; Camitta BM; Raimondi SC; Goh BC; Lee SC; Wang LZ; Fan L; Guo JY; Lamba J; Lim R; Lim HL; Ong AB; Lee HS; Kuehl P; Zhang J; Lin Y; Assem M; Schuetz J; Watkins PB; Daly A; Wrighton SA; Hall SD; Maurel P; Brimer C; Yasuda K; Venkataramanan R; Strom S; Thummel K; Boguski MS
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(21):22250-22257
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice.
Assem M; Schuetz EG; Leggas M; Sun D; Yasuda K; Reid G; Zelcer N; Adachi M; Strom S; Evans RM; Moore DD; Borst P; Schuetz JD
Article: DRUG METABOLISM AND DISPOSITION. 2004;32(5):512-518
Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures.
Komoroski BJ; Zhang S; Cai H; Hutzler JM; Frye R; Tracy TS; Strom SC; Lehmann T; Ang CYW; Cui YY; Venkataramanan R
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2003;307(3):906-922
Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression.
Lamba V; Lamba J; Yasuda K; Strom S; Davila J; Hancock ML; Fackenthal JD; Rogan PK; Ring B; Wrighton SA; Schuetz EG
Article: TOXICOLOGICAL SCIENCES. 2003;76(1):220-228
Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats.
Kostrubsky VE; Strom SC; Hanson J; Urda E; Rose K; Burliegh J; Zocharski P; Cai H; Sinclair JF; Sahi J
Article: PEDIATRICS. 2003;111(6 Pt 1):1262-1267
Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder.
Horslen SP; McCowan TC; Goertzen TC; Warkentin PI; Cai HB; Strom SC; Fox IJ
Article: FEBS JOURNAL. 2003;270(2):230-238
A functional polymorphism at the transcriptional initiation site in beta2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of beta2-glycoprotein I.
Mehdi H; Manzi S; Desai P; Chen Q; Nestlerode C; Bontempo F; Strom SC; Zarnegar R; Kamboh MI
Article: CELL TRANSPLANTATION. 2003;12(8):897-906
In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging.
Wege H; Chui MS; Le HT; Strom SC; Zern MA
Article: LIMNOLOGY AND OCEANOGRAPHY. 2003;48(1):217-229
Chemical defense in the microplankton I:: Feeding and growth rates of heterotrophic protists on the DMS-producing phytoplankter Emiliania huxleyi
Strom S; Wolfe G; Holmes J; Stecher H; Shimeneck C; Lambert S; Moreno E
Article: DRUG METABOLISM AND DISPOSITION. 2002;30(12):1400-1405
Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes.
Kocarek TA; Dahn MS; Cai H; Strom SC; Mercer-Haines NA
Article: MOLECULAR PHARMACOLOGY. 2002;62(3):439-445
Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents.
Schuetz E; Lan L; Yasuda K; Kim R; Kocarek TA; Schuetz J; Strom S
Article: DRUG METABOLISM AND DISPOSITION. 2002;30(9):977-984
Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes.
Wen YH; Sahi J; Urda E; Kulkarni S; Rose K; Zheng X; Sinclair JF; Cai H; Strom SC; Kostrubsky VE
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2002;302(2):475-482
Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes.
Raucy JL; Mueller L; Duan K; Allen SW; Strom S; Lasker JM
Article: GASTROENTEROLOGY. 2002;122(4):1020-1034
Interferon-alpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes.
Radaeva S; Jaruga B; Hong F; Kim W-H; Fan S; Cai H; Strom S; Liu Y; El-Assal O; Gao B
Article: PHARMACOGENETICS AND GENOMICS. 2002;12(2):121-132
Common allelic variants of cytochrome P4503A4 and their prevalence in different populations.
Lamba JK; Lin YS; Thummel K; Daly A; Watkins PB; Strom S; Zhang J; Schuetz EG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(42):39411-39418
Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.
Schuetz EG; Strom S; Yasuda K; Lecureur V; Assem M; Brimer C; Lamba J; Kim RB; Ramachandran V; Komoroski BJ; Venkataramanan R; Cai H; Sinal CJ; Gonzalez FJ; Schuetz JD
Article: PHARMACOGENETICS AND GENOMICS. 2001;11(7):555-572
The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants.
Zhang J; Kuehl P; Green ED; Touchman JW; Watkins PB; Daly A; Hall SD; Maurel P; Relling M; Brimer C; Yasuda K; Wrighton SA; Hancock M; Kim RB; Strom S; Thummel K; Russell CG; Hudson JR; Schuetz EG; Boguski MS
Article: NATURE GENETICS. 2001;27(4):383-391
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.
Kuehl P; Zhang J; Lin Y; Lamba J; Assem M; Schuetz J; Watkins PB; Daly A; Wrighton SA; Hall SD; Maurel P; Relling M; Brimer C; Yasuda K; Venkataramanan R; Strom S; Thummel K; Boguski MS; Schuetz E
Article: DRUG METABOLISM AND DISPOSITION. 2000;28(11):1270-1273
Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures.
Venkataramanan R; Ramachandran V; Komoroski BJ; Zhang S; Schiff PL; Strom SC
Article: DRUG METABOLISM AND DISPOSITION. 2000;28(10):1192-1197
The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures.
Kostrubsky VE; Sinclair JF; Ramachandran V; Venkataramanan R; Wen YH; Kindt E; Galchev V; Rose K; Sinz M; Strom SC
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(36):28083-28092
Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine.
Chang CC; Sakashita N; Ornvold K; Lee O; Chang ET; Dong R; Lin S; Lee CY; Strom SC; Kashyap R; Fung JJ; Farese RV; Patoiseau JF; Delhon A; Chang TY
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;274(1):1-3
Recent advances in human hepatocyte culture systems.
Runge D; Michalopoulos GK; Strom SC; Runge DM
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;273(1):333-341
Induction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypical inducers in human hepatocytes.
Runge D; Köhler C; Kostrubsky VE; Jäger D; Lehmann T; Runge DM; May U; Stolz DB; Strom SC; Fleig WE; Michalopoulos GK
Article: CLINICAL NUCLEAR MEDICINE. 2000;25(6):447-450
Use of indium-111-labeled hepatocytes to determine the biodistribution of transplanted hepatocytes through portal vein infusion.
Bohnen NI; Charron M; Reyes J; Rubinstein W; Strom SC; Swanson D; Towbin R
Article: NATURE MEDICINE. 2000;6(5):564-567
Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand.
Jo M; Kim TH; Seol DW; Esplen JE; Dorko K; Billiar TR; Strom SC
Article: DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT. 2000;125(13):397-400
[Hepatocyte transplantation. Possibilities for use and examples of practical clinical application].
Runge D; Fleig WE; Michalopoulos GK; Strom SC; Runge DM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(12):8806-8811
Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells.
Jo M; Stolz DB; Esplen JE; Dorko K; Michalopoulos GK; Strom SC
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;269(1):46-53
Serum-free, long-term cultures of human hepatocytes: maintenance of cell morphology, transcription factors, and liver-specific functions.
Runge D; Runge DM; Jäger D; Lubecki KA; Beer Stolz D; Karathanasis S; Kietzmann T; Strom SC; Jungermann K; Fleig WE; Michalopoulos GK
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1999;265(2):376-381
STAT 1alpha/1beta, STAT 3 and STAT 5: expression and association with c-MET and EGF-receptor in long-term cultures of human hepatocytes.
Runge DM; Runge D; Foth H; Strom SC; Michalopoulos GK
Article: DRUG METABOLISM AND DISPOSITION. 1999;27(10):1194-1199
Troglitazone increases cytochrome P-450 3A protein and activity in primary cultures of human hepatocytes.
Ramachandran V; Kostrubsky VE; Komoroski BJ; Zhang S; Dorko K; Esplen JE; Strom SC; Venkataramanan R
Article: JOURNAL OF HEPATOLOGY. 1999;31(3):435-442
CD14 expression and production by human hepatocytes.
Su GL; Dorko K; Strom SC; Nüssler AK; Wang SC
Article: DRUG METABOLISM AND DISPOSITION. 1999;27(8):887-894
The use of human hepatocyte cultures to study the induction of cytochrome P-450.
Kostrubsky VE; Ramachandran V; Venkataramanan R; Dorko K; Esplen JE; Zhang S; Sinclair JF; Wrighton SA; Strom SC
Article: IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL. 1999;35(4):190-197
Isolation and characterization of a human hepatic epithelial-like cell line (AKN-1) from a normal liver.
Nussler AK; Vergani G; Gollin SM; Dorko K; Morris SM; Demetris AJ; Nomoto M; Beger HG; Strom SC
Article: JOURNAL OF HEPATOLOGY. 1999;30(2):265-274
Epidermal growth factor- and hepatocyte growth factor-receptor activity in serum-free cultures of human hepatocytes.
Runge DM; Runge D; Dorko K; Pisarov LA; Leckel K; Kostrubsky VE; Thomas D; Strom SC; Michalopoulos GK
Article: HEPATOLOGY. 1999;29(1):90-100
Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor.
Michalopoulos GK; Bowen WC; Zajac VF; Beer-Stolz D; Watkins S; Kostrubsky V; Strom SC
Article: METHODS IN MOLECULAR MEDICINE. 1999;19:495-500
Primary human hepatocyte culture for the study of HCV.
O' Connell JF; Cox S; Buontempo P; Skelton A; Pisarov LA; Dorko K; Strom SC
Article: DRUG METABOLISM AND DISPOSITION. 1998;26(11):1063-1068
Alterations of the catalytic activities of drug-metabolizing enzymes in cultures of human liver slices.
VandenBranden M; Wrighton SA; Ekins S; Gillespie JS; Binkley SN; Ring BJ; Gadberry MG; Mullins DC; Strom SC; Jensen CB
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1998;355(2):131-136
Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes.
Kostrubsky VE; Lewis LD; Strom SC; Wood SG; Schuetz EG; Schuetz JD; Sinclair PR; Wrighton SA; Sinclair JF
Article: PHARMACOGENETICS AND GENOMICS. 1998;8(2):137-155
Human cytochrome P450 3A (CYP3A) mediated midazolam metabolism: the effect of assay conditions and regioselective stimulation by alpha-naphthoflavone, terfenadine and testosterone.
Mäenpää J; Hall SD; Ring BJ; Strom SC; Wrighton SA
Article: UROLOGY. 1997;49(6):981-988
A simple method for the isolation and culture of epithelial and stromal cells from benign and neoplastic prostates.
Krill D; Shuman M; Thompson MT; Becich MJ; Strom SC
Article: MOLECULAR CARCINOGENESIS. 1997;18(4):244-255
Modifications of the hepatocyte growth factor/c-met pathway by constitutive expression of transforming growth factor-alpha in rat liver epithelial cells.
Presnell SC; Stolz DB; Mars WM; Jo M; Michalopoulos GK; Strom SC
Article: TRANSPLANTATION. 1997;63(4):559-569
Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure.
Strom SC; Fisher RA; Thompson MT; Sanyal AJ; Cole PE; Ham JM; Posner MP
Article: JOURNAL OF CELL BIOLOGY. 1996;132(6):1133-1149
Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium.
Block GD; Locker J; Bowen WC; Petersen BE; Katyal S; Strom SC; Riley T; Howard TA; Michalopoulos GK
Article: MOLECULAR PHARMACOLOGY. 1996;49(1):63-72
Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.
Schuetz JD; Schuetz EG; Thottassery JV; Guzelian PS; Strom S; Sun D
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 1995;165(2):261-272
Induction of P-glycoprotein mRNA by protein synthesis inhibition is not controlled by a transcriptional repressor protein in rat and human liver cells.
Schuetz JD; Strom SC; Schuetz EG
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1995;322(2):516-520
Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes.
Kostrubsky VE; Strom SC; Wood SG; Wrighton SA; Sinclair PR; Sinclair JF
Article: MOLECULAR CARCINOGENESIS. 1995;13(4):233-244
Investigation of the cooperative effects of transforming growth factor alpha and c-myc overexpression in rat liver epithelial cells.
Presnell SC; Thompson MT; Strom SC
Article: DRUG METABOLISM AND DISPOSITION. 1995;23(3):415-421
Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes.
Kocarek TA; Schuetz EG; Strom SC; Fisher RA; Guzelian PS
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Published conference paper: JOURNAL OF INHERITED METABOLIC DISEASE. 2019;42(6):1054-1063
A liver-humanized mouse model of carbamoyl phosphate synthetase 1-deficiency
Srinivasan RC; Zabulica M; Hammarstedt C; Wu T; Gramignoli R; Kannisto K; Ellis E; Karadagi A; Fingerhut R; Allegri G; Rufenacht V; Thony B; Haberle J; Nuoffer J-M; Strom SC
Review: CURRENT PROTOCOLS IN TOXICOLOGY / EDITORIAL BOARD, MAHIN D. MAINES (EDITOR-IN-CHIEF) ... [ET AL.]. 2016;67:14.13.1-14.13.27
The Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver Diseases.
Hansel MC; Davila JC; Vosough M; Gramignoli R; Skvorak KJ; Dorko K; Marongiu F; Blake W; Strom SC
Review: INTERNATIONAL JOURNAL OF SURGERY. 2015;23(Pt B):273-279
Current status of hepatocyte xenotransplantation
Meier RPH; Navarro-Alvarez N; Morel P; Schuurman H-J; Strom S; Buhler LH
Review: EUROPEAN SURGICAL RESEARCH. 2015;54(3-4):162-177
Clinical Hepatocyte Transplantation: Practical Limits and Possible Solutions
Gramignoli R; Vosough M; Kannisto K; Srinivasan RC; Strom SC
Corrigendum: DRUG METABOLISM AND DISPOSITION. 2014;42(5):917
Genetic Variation in Aldo-Keto Reductase 1D1 (AKR1D1) Affects the Expression and Activity of Multiple Cytochrome P450s (vol 41, 1538, 2013)
Chaudhry AS; Thirumaran RK; Yasuda K; Yang X; Fan Y; Strom SC; Schuetz EG
Review: GASTROENTEROLOGY. 2013;145(6):1209-1214
Mice With Human Livers
Grompe M; Strom S
Review: JOURNAL OF INTERNAL MEDICINE. 2012;272(3):201-223
Hepatocyte transplantation for inherited metabolic diseases of the liver
Jorns C; Ellis EC; Nowak G; Fischler B; Nemeth A; Strom SC; Ericzon BG
Review: CELL TRANSPLANTATION. 2012;21(1):1-10
Improving the Techniques for Human Hepatocyte Transplantation: Report From a Consensus Meeting in London
Puppi J; Strom SC; Hughes RD; Bansal S; Castell JV; Dagher I; Ellis ECS; Nowak G; Ericzon B-G; Fox IJ; Jose Gomez-Lechon M; Guha C; Gupta S; Mitry RR; Ohashi K; Ott M; Reid LM; Roy-Chowdhury J; Sokal E; Weber A; Dhawan A
Review: STEM CELLS AND DEVELOPMENT. 2010;19(2):143-154
Toward cell therapy using placenta-derived cells: disease mechanisms, cell biology, preclinical studies, and regulatory aspects at the round table.
Parolini O; Alviano F; Bergwerf I; Boraschi D; De Bari C; De Waele P; Dominici M; Evangelista M; Falk W; Hennerbichler S; Hess DC; Lanzoni G; Liu B; Marongiu F; McGuckin C; Mohr S; Nolli ML; Ofir R; Ponsaerts P; Romagnoli L; Solomon A; Soncini M; Strom S; Surbek D; Venkatachalam S; Wolbank S; Zeisberger S; Zeitlin A; Zisch A; Borlongan CV
Review: METHODS IN MOLECULAR BIOLOGY. 2010;640:525-534
Human hepatocyte transplantation.
Dhawan A; Strom SC; Sokal E; Fox IJ
Review: METHODS IN MOLECULAR BIOLOGY. 2010;640:491-509
Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity.
Strom SC; Davila J; Grompe M
Review: CRITICAL REVIEWS IN BIOMEDICAL ENGINEERING. 2009;37(4-5):377-398
Embryonic and induced pluripotent stem cells as a model for liver disease.
Yagi H; Tafaleng E; Nagaya M; Hansel MC; Strom SC; Fox IJ; Soto-Gutierrez A
Review: METHODS IN MOLECULAR BIOLOGY. 2009;481:155-168
Production of hepatocyte-like cells from human amnion.
Miki T; Marongiu F; Ellis ECS; Dorko K; Mitamura K; Ranade A; Gramignoli R; Davila J; Strom SC
Editorial comment: GASTROENTEROLOGY. 2008;134(3):878-881
To be or not to be: generation of hepatocytes from cells outside the liver.
Fox IJ; Strom SC
Review: STEM CELLS. 2008;26(2):300-311
Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells.
Parolini O; Alviano F; Bagnara GP; Bilic G; Bühring H-J; Evangelista M; Hennerbichler S; Liu B; Magatti M; Mao N; Miki T; Marongiu F; Nakajima H; Nikaido T; Portmann-Lanz CB; Sankar V; Soncini M; Stadler G; Surbek D; Takahashi TA; Redl H; Sakuragawa N; Wolbank S; Zeisberger S; Zisch A; Strom SC
Published conference paper: DRUG METABOLISM AND DISPOSITION. 2007;35(2):228-233
Effects of green tea compounds on irinotecan metabolism.
Mirkov S; Komoroski BJ; Ramírez J; Graber AY; Ratain MJ; Strom SC; Innocenti F
Review: TRANSPLANTATION. 2006;82(4):441-449
Human hepatocyte transplantation: worldwide results.
Fisher RA; Strom SC
Review: JOURNAL OF HEPATOLOGY. 2006;45(1):144-159
Present status and perspectives of cell-based therapies for liver diseases
Nussler A; Konig S; Ott M; Sokal E; Christ B; Thasler W; Brulport M; Gabelein G; Schormann W; Schulze M; Ellis E; Kraemer M; Nocken F; Fleig W; Manns M; Strom SC; Hengstler JG
Published conference paper: TRANSPLANTATION PROCEEDINGS. 2006;38(4):1179-1180
Historical aspects of hepatocyte transplantation.
Bruzzone P; Strom SC
Published conference paper: LIFE SCIENCES. 2006;78(18):2105-2115
In vitro and in vivo assessment of herb drug interactions.
Venkataramanan R; Komoroski B; Strom S
Review: TOXICOLOGY IN VITRO. 2006;20(2):135-153
In vitro methods in human drug biotransformation research: implications for cancer chemotherapy.
Hariparsad N; Sane RS; Strom SC; Desai PB
Published conference paper: CELL TRANSPLANTATION. 2006;15:S105-S110
Hepatocyte transplantation: Clinical experience and potential for future use
Strom SC; Bruzzone P; Cai HB; Ellis E; Lehmann T; Mitamura K; Miki T
Editorial comment: LIVER TRANSPLANTATION. 2006;12(1):16-18
Bigger may not be better when it comes to hepatocytes
Strom SC; Call HB; Ellis E; Mitamura K; Miki T
Published conference paper: PHARMACEUTICAL RESEARCH. 2005;22(12):2007-2015
Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats.
Tian H; Ou J; Strom SC; Venkataramanan R
Published conference paper: DRUG METABOLISM AND DISPOSITION. 2005;33(3):329-335
Pharmacokinetics of tacrolimus and mycophenolic acid are altered, but recover at different times during hepatic regeneration in rats.
Tian H; Ou J; Strom SC; Venkataramanan R
Published conference paper: TOXICOLOGICAL SCIENCES. 2004;79(2):214-223
Use and application of stem cells in toxicology.
Davila JC; Cezar GG; Thiede M; Strom S; Miki T; Trosko J
Editorial comment: GASTROENTEROLOGY. 2003;124(2):568-571
Hepatocyte transplantation: new possibilities for therapy.
Strom S; Fisher R
Editorial comment: NATURE MEDICINE. 2001;7(5):536-537
Promiscuous regulator of xenobiotic removal.
Schuetz E; Strom S
Other: CELL TRANSPLANTATION. 2001;10(2):123
Memorial to Dr. Hugo Osvaldo Jauregui 1934 - 2000.
Strom S
Published conference paper: TRANSPLANTATION. 2000;69(2):303-307
Defining hepatocellular chimerism in a liver failure patient bridged with hepatocyte infusion.
Fisher RA; Bu D; Thompson M; Tisnado J; Prasad U; Sterling R; Posner M; Strom S
Review: SEMINARS IN LIVER DISEASE. 1999;19(1):39-48
Hepatocyte transplantation for the treatment of human disease.
Strom SC; Chowdhury JR; Fox IJ
Editorial comment: PEDIATRICS. 1998;102(3 Pt 1):647-648
Human hepatocyte transplantation: gene therapy and more?
Chowdhury JR; Chowdhury NR; Strom SC; Kaufman SS; Horslen S; Fox IJ
Published conference paper: NEW ENGLAND JOURNAL OF MEDICINE. 1998;338(20):1422-1426
Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation.
Fox IJ; Chowdhury JR; Kaufman SS; Goertzen TC; Chowdhury NR; Warkentin PI; Dorko K; Sauter BV; Strom SC
Published conference paper: TRANSPLANTATION PROCEEDINGS. 1997;29(4):2103-2106
Transplantation of human hepatocytes.
Strom SC; Fisher RA; Rubinstein WS; Barranger JA; Towbin RB; Charron M; Mieles L; Pisarov LA; Dorko K; Thompson MT; Reyes J
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 1996;272:388-401
Use of human hepatocytes to study P450 gene induction.
Strom SC; Pisarov LA; Dorko K; Thompson MT; Schuetz JD; Schuetz EG
Published conference paper: TRANSPLANTATION PROCEEDINGS. 1995;27(6):3269
Short exposure to hepatocyte growth factor stimulates adult human pancreatic beta-cell proliferation.
Karatzas T; Strumph P; Ionelle J; Strom S; Michalopoulos G; Fung JJ; Carroll PB
Other: MOLECULAR CARCINOGENESIS. 1995;12(2):61-65
Phenotypic variability in induction of P-glycoprotein mRNA by aromatic hydrocarbons in primary human hepatocytes.
Schuetz EG; Schuetz JD; Thompson MT; Fisher RA; Madariage JR; Strom SC
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