Stefan Holzhauser

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About me

Studies on targeted therapy against human papillomavirus (HPV) positive and
negative head and neck cancer, especially on tonsillar and base of tongue
squamous cell carcinoma cell lines.

Articles

Article: ORAL ONCOLOGY. 2024;151:106749

Human papillomavirus (HPV) load is higher in HPVDNA/p16 positive than in HPVDNA positive/p16 negative oropharyngeal squamous cell carcinoma but does not differ significantly between various subsites or correlate to survival.

Zupancic M; Kostopoulou ON; Holzhauser S; Lukoseviciute M; Jylhä C; Marklund L; Näsman A; Sivars L; Dalianis T
Article: ACTA ONCOLOGICA. 2023;62(12):1649-1652

Prevalence of human papillomavirus (HPV) types 16 and 18 in cervical cancer in Stockholm, Sweden during 2019-2023 compared to 2003-2008.

Sivars L; Holzhauser S; Ramqvist T; Tham E; Hellman K; Dalianis T
Article: ONCOLOGY REPORTS. 2023;50(3):166

Efficacy of combined targeted therapy with PI3K and CDK4/6 or PARP and WEE1 inhibitors in neuroblastoma cell lines.

Lukoseviciute M; Holzhauser S; Pappa E; Mandal T; Dalianis T; Kostopoulou ON
Article: ONCOLOGY REPORTS. 2023;49(6):125

Combination of PARP and WEE1 inhibitors in vitro: Potential for use in the treatment of SHH medulloblastoma.

Lukoseviciute M; Theodosopoulou A; Holzhauser S; Dalianis T; Kostopoulou ON
Article: CANCERS. 2023;15(7):1954

High Levels of FGF11 Correlate with Poor Survival in Patients with Human Papillomavirus (HPV)-Positive Oropharyngeal Squamous Cell Carcinoma.

Flon CHD; Haeggblom L; Holzhauser S; Kostopoulou ON; Zupancic M; Dalianis T; Munck-Wikland E; Marklund L; Näsman A
Article: CANCERS. 2022;15(1):93

Targeted Therapy with PI3K, PARP, and WEE1 Inhibitors and Radiotherapy in HPV Positive and Negative Tonsillar Squamous Cell Carcinoma Cell Lines Reveals Synergy while Effects with APR-246 Are Limited.

Byskata K; Lukoseviciute M; Tuti F; Zupancic M; Kostopoulou ON; Holzhauser S; Dalianis T
Article: GYNECOLOGIC ONCOLOGY. 2022;167(1):107-114

Circulating cell-free tumor human papillomavirus DNA is a promising biomarker in cervical cancer.

Sivars L; Hellman K; Crona Guterstam Y; Holzhauser S; Nordenskjöld M; Falconer H; Palsdottir K; Tham E
Article: VIRUSES-BASEL. 2022;14(7):1372

Targeted Therapy of HPV Positive and Negative Tonsillar Squamous Cell Carcinoma Cell Lines Reveals Synergy between CDK4/6, PI3K and Sometimes FGFR Inhibitors, but Rarely between PARP and WEE1 Inhibitors.

Kostopoulou ON; Zupancic M; Pont M; Papin E; Lukoseviciute M; Mikelarena BA; Holzhauser S; Dalianis T
Article: VIRUSES-BASEL. 2022;14(5):1040

Analysis of Human Papillomavirus (HPV) and Polyomaviruses (HPyVs) in Adenoid Cystic Carcinoma (AdCC) of the Head and Neck Region Reveals Three HPV-Positive Cases with Adenoid Cystic-like Features.

Zupancic M; Holzhauser S; Cheng L; Ramqvist T; Du J; Friesland S; Näsman A; Dalianis T
Article: CANCERS. 2021;14(1):77

Whole-Exome Sequencing of HPV Positive Tonsillar and Base of Tongue Squamous Cell Carcinomas Reveals a Global Mutational Pattern along with Relapse-Specific Somatic Variants.

Ährlund-Richter A; Holzhauser S; Dalianis T; Näsman A; Mints M
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2021;58(2):211-225

Effects of PI3K and FGFR inhibitors alone and in combination, and with/without cytostatics in childhood neuroblastoma cell lines.

Holzhauser S; Lukoseviciute M; Papachristofi C; Vasilopoulou C; Herold N; Wickström M; Kostopoulou ON; Dalianis T
Article: ACTA OTO-LARYNGOLOGICA. 2021;141(1):89-94

The value of p16 and HPV DNA in non-tonsillar, non-base of tongue oropharyngeal cancer.

Hammarstedt L; Holzhauser S; Zupancic M; Kapoulitsa F; Ursu RG; Ramqvist T; Haeggblom L; Näsman A; Dalianis T; Marklund L
Article: FRONTIERS IN ONCOLOGY. 2021;11:748657

Targeting PI3K, FGFR, CDK4/6 Signaling Pathways Together With Cytostatics and Radiotherapy in Two Medulloblastoma Cell Lines.

Lukoseviciute M; Maier H; Poulou-Sidiropoulou E; Rosendahl E; Holzhauser S; Dalianis T; Kostopoulou ON
Article: FRONTIERS IN ONCOLOGY. 2021;11:640490

Targeted Therapy With PI3K and FGFR Inhibitors on Human Papillomavirus Positive and Negative Tonsillar and Base of Tongue Cancer Lines With and Without Corresponding Mutations.

Holzhauser S; Wild N; Zupancic M; Ursu RG; Bersani C; Näsman A; Kostopoulou ON; Dalianis T
Article: EUROPEAN JOURNAL OF CANCER. 2020;139:192-200

Survival of patients with oropharyngeal squamous cell carcinomas (OPSCC) in relation to TNM 8 - Risk of incorrect downstaging of HPV-mediated non-tonsillar, non-base of tongue carcinomas.

Marklund L; Holzhauser S; de Flon C; Zupancic M; Landin D; Kolev A; Haeggblom L; Munck-Wikland E; Hammarstedt-Nordenvall L; Dalianis T; Näsman A
Article: ONCOLOGY REPORTS. 2020;44(4):1717-1726

Sensitivity of human papillomavirus‑positive and ‑negative oropharyngeal cancer cell lines to ionizing irradiation.

Holzhauser S; Pirotte E; Jones J; Owens D; Al-Hussaini A; Giles P; Evans M; Man S; Powell N
Article: ANTICANCER RESEARCH. 2020;40(1):53-66

Targeting Fibroblast Growth Factor Receptor (FGFR) and Phosphoinositide 3-kinase (PI3K) Signaling Pathways in Medulloblastoma Cell Lines.

Holzhauser S; Lukoseviciute M; Andonova T; Ursu RG; Dalianis T; Wickström M; Kostopoulou ON
Article: ONCOLOGY LETTERS. 2019;18(6):6249-6260

In vitro antitumor effects of FGFR and PI3K inhibitors on human papillomavirus positive and negative tonsillar and base of tongue cancer cell lines.

Holzhauser S; Kostopoulou ON; Ohmayer A; Lange BKA; Ramqvist T; Andonova T; Bersani C; Wickström M; Dalianis T
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2019;55(6):1372-1384

Analyses of FGFR3 and PIK3CA mutations in neuroblastomas and the effects of the corresponding inhibitors on neuroblastoma cell lines.

Kostopoulou ON; Holzhauser S; Lange BKA; Ohmayer A; Andonova T; Bersani C; Wickström M; Dalianis T
Article: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2019;41(6):1583-1590

Changes in incidence and prevalence of human papillomavirus in tonsillar and base of tongue cancer during 2000-2016 in the Stockholm region and Sweden.

Haeggblom L; Attoff T; Yu J; Holzhauser S; Vlastos A; Mirzae L; Ährlund-Richter A; Munck-Wikland E; Marklund L; Hammarstedt-Nordenvall L; Ye W; Ramqvist T; Näsman A; Dalianis T
Article: PLOS ONE. 2018;13(12):e0207934

Sensitivity to inhibition of DNA repair by Olaparib in novel oropharyngeal cancer cell lines infected with Human Papillomavirus.

Pirotte EF; Holzhauser S; Owens D; Quine S; Al-Hussaini A; Christian AD; Giles PJ; Man ST; Evans M; Powell NG
Article: EUROPEAN JOURNAL OF CANCER. 2015;51(1):55-61

Incidence of human papillomavirus positive tonsillar and base of tongue carcinoma: a stabilisation of an epidemic of viral induced carcinoma?

Näsman A; Nordfors C; Holzhauser S; Vlastos A; Tertipis N; Hammar U; Hammarstedt-Nordenvall L; Marklund L; Munck-Wikland E; Ramqvist T; Bottai M; Dalianis T
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Review: ANTICANCER RESEARCH. 2023;43(9):3829-3839

New Approaches Towards Targeted Therapy for Childhood Neuroblastoma.

Dalianis T; Lukoseviciute M; Holzhauser S; Kostopoulou ON
Review: VIRUSES-BASEL. 2021;13(5):910

Prognostic Markers and Driver Genes and Options for Targeted Therapy in Human-Papillomavirus-Positive Tonsillar and Base-of-Tongue Squamous Cell Carcinoma.

Näsman A; Holzhauser S; Kostopoulou ON; Zupancic M; Ährlund-Richter A; Du J; Dalianis T

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