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Research description

Cancer Cell Biology

We study the role of cell-matrix interactions and Pak4 in cancer progression, including in cancer cell migration and senescence.

Publications

Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions
Spiess M, Hernandez-varas P, Oddone A, Olofsson H, Blom H, Waithe D, et al
The Journal of cell biology 2018;217(6):1929-1940

Inflammation-Sensitive Myosin-X Functionally Supports Leukocyte Extravasation by Cdc42-Mediated ICAM-1-Rich Endothelial Filopodia Formation
Kroon J, Schaefer A, Van Rijssel J, Hoogenboezem M, Van Alphen F, Hordijk P, et al
Journal of immunology (Baltimore, Md. : 1950) 2018;200(5):1790-1801

Using Systems Microscopy to Understand the Emergence of Cell Migration from Cell Organization
Strömblad S, Lock Jg
Methods in molecular biology (Clifton, N.J.) 2018;1749():119-134

Identification of the PAK4 interactome reveals PAK4 phosphorylation of N-WASP and promotion of Arp2/3-dependent actin polymerization
Zhao M, Spiess M, Johansson Hj, Olofsson H, Hu J, Lehtiö J, et al
Oncotarget 2017;8(44):77061-77074

Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development
Zhao M, Rabieifar P, Costa Tdf, Zhuang T, Minden A, Löhr M, et al
Scientific reports 2017;7(1):7031-

An analysis toolbox to explore mesenchymal migration heterogeneity reveals adaptive switching between distinct modes
Shafqat-abbasi H, Kowalewski Jm, Kiss A, Gong X, Hernandez-varas P, Berge U, et al
eLife 2016;5():e11384-

RING finger protein 31 promotes p53 degradation in breast cancer cells
Zhu J, Zhao C, Zhuang T, Jonsson P, Sinha I, Williams C, et al
Oncogene 2016;35(15):1955-64

A plastic relationship between vinculin-mediated tension and adhesion complex area defines adhesion size and lifetime
Hernández-varas P, Berge U, Lock Jg, Strömblad S
Nature communications 2015;6():7524-

Disentangling Membrane Dynamics and Cell Migration; Differential Influences of F-actin and Cell-Matrix Adhesions
Kowalewski Jm, Shafqat-abbasi H, Jafari-mamaghani M, Endrias Ganebo B, Gong X, Strömblad S, et al
PloS one 2015;10(8):e0135204-

Non-monotonic cellular responses to heterogeneity in talin protein expression-level
Kiss A, Gong X, Kowalewski Jm, Shafqat-abbasi H, Strömblad S, Lock Jg
Integrative biology : quantitative biosciences from nano to macro 2015;7(10):1171-85

p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells
Zhuang T, Zhu J, Li Z, Lorent J, Zhao C, Dahlman-wright K, et al
Oncotarget 2015;6(41):43853-68

Early B cell factor 1 regulates adipocyte morphology and lipolysis in white adipose tissue
Gao H, Mejhert N, Fretz Ja, Arner E, Lorente-cebrián S, Ehrlund A, et al
Cell metabolism 2014;19(6):981-92

Plasticity in the macromolecular-scale causal networks of cell migration
Lock Jg, Mamaghani Mj, Shafqat-abbasi H, Gong X, Tyrcha J, Strömblad S
PloS one 2014;9(2):e90593-

The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferation
Zhu J, Zhao C, Kharman-biz A, Zhuang T, Jonsson P, Liang N, et al
Oncogene 2014;33(34):4340-51

A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells
Gao Jc, Khan Aa, Shimokawa T, Zhan J, Stromblad S, Fang Wg, et al
FEBS LETTERS 2013;587(6):631-8

Cell to extracellular matrix interactions and their reciprocal nature in cancer
Van Dijk M, Goransson Sa, Stromblad S
EXPERIMENTAL CELL RESEARCH 2013;319(11):1663-70

Molecular networks of DYX1C1 gene show connection to neuronal migration genes and cytoskeletal proteins
Tammimies K, Vitezic M, Matsson H, Le Guyader S, Bürglin Tr, Ohman T, et al
Biological psychiatry 2013;73(6):583-90

Verification of cell viability in bioengineered tissues and organs before clinical transplantation
Jungebluth P, Haag Jc, Lim Ml, Lemon G, Sjöqvist S, Gustafsson Y, et al
Biomaterials 2013;34(16):4057-67

Focal adhesion disassembly is regulated by a RIAM to MEK-1 pathway
Colo Gp, Hernandez-varas P, Lock J, Bartolome Ra, Arellano-sanchez N, Stromblad S, et al
JOURNAL OF CELL SCIENCE 2012;125(22):5338-52

Protein kinase Cα (PKCα) regulates p53 localization and melanoma cell survival downstream of integrin αv in three-dimensional collagen and in vivo
Smith Sd, Enge M, Bao W, Thullberg M, Costa Td, Olofsson H, et al
The Journal of biological chemistry 2012;287(35):29336-47

FUNCTIONAL CHARACTERIZATION OF HUMAN KINDLIN-2 CORE PROMOTER IDENTIFIES A KEY ROLE OF SP1 IN KINDLIN-2 TRANSCRIPTIONAL REGULATION
Khan Aa, Shimokawa T, Stromblad S, Zhang Hq
CELLULAR & MOLECULAR BIOLOGY LETTERS 2011;16(4):638-51

PRIMA-1(Met)/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo
Bao Wj, Chen M, Zhao X, Kumar R, Spinnler C, Thullberg M, et al
CELL CYCLE 2011;10(2):301-7

Rap1-GTP-interacting Adaptor Molecule (RIAM) Protein Controls Invasion and Growth of Melanoma Cells
Hernandez-varas P, Colo Gp, Bartolome Ra, Paterson A, Medrano-fernandez I, Arellano-sanchez N, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2011;286(21):18492-504

Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study
Jungebluth P, Alici E, Baiguera S, Le Blanc K, Blomberg P, Bozoky B, et al
LANCET 2011;378(9808):1997-2004

Integrin-mediated Cell Attachment Induces a PAK4-dependent Feedback Loop Regulating Cell Adhesion through Modified Integrin alpha v beta 5 Clustering and Turnover
Li Zl, Lock Jg, Olofsson H, Kowalewski Jm, Teller S, Liu Yj, et al
MOLECULAR BIOLOGY OF THE CELL 2010;21(19):3317-29

Kindlin-2 controls sensitivity of prostate cancer cells to cisplatin-induced cell death
Gong Xw, An Zw, Wang Yl, Guan Lz, Fang Wg, Stromblad S, et al
CANCER LETTERS 2010;299(1):54-62

Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration
An Zw, Dobra K, Lock Jg, Stromblad S, Hjerpe A, Zhang Hq
INTERNATIONAL JOURNAL OF CANCER 2010;127(9):1999-2008

p21-activated Kinase 4 Phosphorylation of Integrin beta 5 Ser-759 and Ser-762 Regulates Cell Migration
Li Zl, Zhang Hq, Lundin L, Thullberg M, Liu Yj, Wang Yl, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2010;285(31):23699-710

p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients
Siu Mky, Chan Hy, Kong Dsh, Wong Esy, Wong Ogw, Ngan Hys, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010;107(43):18622-7

PtdIns(3,4,5)P-3 is a regulator of myosin-X localization and filopodia formation
Plantard L, Arjonen A, Lock Jg, Nurani G, Ivaska J, Stromblad S
JOURNAL OF CELL SCIENCE 2010;123(20):3525-34

Systems microscopy: An emerging strategy for the life sciences
Lock Jg, Stromblad S
EXPERIMENTAL CELL RESEARCH 2010;316(8):1438-44

WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies
Mahmoudi S, Henriksson S, Weibrecht I, Smith S, Soderberg O, Stromblad S, et al
PLOS BIOLOGY 2010;8(11):e1000521-

Anchorage-independent cytokinesis as part of oncogenic transformation?
Thullberg M, Stromblad S
CELL CYCLE 2008;7(8):984-8

Cell-matrix adhesion complexes: Master control machinery of cell migration
Lock Jg, Wehrle-haller B, Stromblad S
SEMINARS IN CANCER BIOLOGY 2008;18(1):65-76

Oncogenic H-Ras V12 promotes anchorage-independent cytokinesis in human fibroblasts
Thullberg M, Gad A, Le Guyader S, Stromblad S
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007;104(51):20338-43

Single fluorescent protein-based Ca2+ sensors with increased dynamic range
Souslova Ea, Belousov Vv, Lock Jg, Stromblad S, Kasparov S, Bolshakov Ap, et al
BMC BIOTECHNOLOGY 2007;:37-

The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity
Thullberg M, Gad A, Beeser A, Chernoff J, Stromblad S
ONCOGENE 2007;26(12):1820-8

Integrin alpha v-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen
Bao Wj, Stromblad S
JOURNAL OF CELL BIOLOGY 2004;167(4):745-56

Myosin-X provides a motor-based link between integrins and the cytoskeleton
Zhang Hq, Berg Js, Li Zl, Wang Yl, Lang P, Sousa Ad, et al
NATURE CELL BIOLOGY 2004;6(6):523-31

Recombinant CD44-HABD is a novel and potent direct angiogenesis inhibitor enforcing endothelial cell-specific growth inhibition independently of hyaluronic acid binding
Pall T, Gad A, Kasak L, Drews M, Stromblad S, Kogerman P
ONCOGENE 2004;23(47):7874-81

Retinoblastoma susceptibility gene product (pRb) and p107 functionally separate the requirements for serum and anchorage in the cell cycle G(1)-phase
Gad A, Thullberg M, Dannenberg Jh, Riele Ht, Stromblad S
JOURNAL OF BIOLOGICAL CHEMISTRY 2004;279(14):13640-4

Cell attachment to the extracellular matrix induces proteasomal degradation of p21(CIP1) via Cdc42/Rac1 signaling
Bao Wj, Thullberg M, Zhang Hq, Onischenko A, Stromblad S
MOLECULAR AND CELLULAR BIOLOGY 2002;22(13):4587-97

Loss of p53 compensates for alpha(v)-integrin function in retinal neovascularization
Stromblad S, Fotedar A, Brickner H, Theesfeld C, De Diaz Ea, Friedlander M, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277(16):13371-4

P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration
Zhang Hq, Li Zl, Viklund Ek, Stromblad S
JOURNAL OF CELL BIOLOGY 2002;158(7):1287-97

Use of an Immobilized Monoclonal Antibody to Examine Integrin alpha5beta1 Signaling Independent of Cell Spreading
Bao W, Strömblad S
Biological procedures online 2002;4():81-87

RANTES promotes growth and survival of human first-trimester forebrain astrocytes
Bakhiet M, Tjernlund A, Mousa A, Gad A, Stromblad S, Kuziel Wa, et al
NATURE CELL BIOLOGY 2001;3(2):150-7

Integrin alpha(V)beta(3) promotes M21 melanoma growth in human skin by regulating tumor cell survival
Petitclerc E, Stromblad S, Von Schalscha Tl, Mitjans F, Piulats J, Montgomery Amp, et al
CANCER RESEARCH 1999;59(11):2724-30

Integrin alpha v beta 3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis
Eliceiri Bp, Klemke R, Stromblad S, Cheresh Da
JOURNAL OF CELL BIOLOGY 1998;140(5):1255-63

Cell adhesion and angiogenesis
Stromblad S, Cheresh Da
TRENDS IN CELL BIOLOGY 1996;6(12):462-8

Integrins, angiogenesis and vascular cell survival
Stromblad S, Cheresh Da
CHEMISTRY & BIOLOGY 1996;3(11):881-5

Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3
Brooks Pc, Stromblad S, Sanders Lc, Vonschalscha Tl, Aimes Rt, Stetlerstevenson Wg, et al
CELL 1996;85(5):683-93

Requirement of receptor-bound urokinase-type plasminogen activator for integrin alpha v beta 5-directed cell migration
Yebra M, Parry Gcn, Stromblad S, Mackman N, Rosenberg S, Mueller Bm, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 1996;271(46):29393-9

Suppression of p53 activity and p21(WAF1/CIP1) expression by vascular cell integrin alpha v beta 3 during angiogenesis
Stromblad S, Becker Jc, Yebra M, Brooks Pc, Cheresh Da
JOURNAL OF CLINICAL INVESTIGATION 1996;98(2):426-33

ANTIINTEGRIN ALPHA-V-BETA-3 BLOCKS HUMAN BREAST-CANCER GROWTH AND ANGIOGENESIS IN HUMAN SKIN
Brooks Pc, Stromblad S, Klemke R, Visscher D, Sarkar Fh, Cheresh Da
JOURNAL OF CLINICAL INVESTIGATION 1995;96(4):1815-22

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