Sophie Petropoulos

Sophie Petropoulos

Principal Researcher
Visiting address: Hälsovägen, Enheten för obstetrik och gynekologi K65, 14186 Stockholm
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLINTEC Obstetrik o gynekologi, 141 52 Huddinge
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About me

  • Sophie Petropoulos, PhD has merged her expertise in the fields of physiology,
    developmental biology, epigenetics and single-cell genomics to gain an
    understanding of early preimplantation development. Her research interests
    focus on how early events such as parental or environmental exposures can
    result in fetal reprogramming, ultimately leading to the onset of disease or
    disorder later in life. Dr. Petropoulos completed her PhD in the
    Department of Physiology, University of Toronto and then joined the
    Department of Pharmacology and Therapeutics at McGill University where she
    specialized in epigenetics. She then moved to the Karolinska Institutet,
    Department of Clinical Science, Intervention and Technology and the Ludwig
    Cancer Research Institute where her studies investigated human
    preimplantation development using single-cell RNA-sequencing.
    *Selected publications from the last 2 years. *
    * Collier AJ*, Panula S*, Schell JP, Chovanec P, Plaza Reyes A, *Petropoulos
    S*, Corcoran AE, Walker R, Douagi I, Lanner F, Rugg-Gunn PJ.
    Comprehensive Cell Surface Protein Profiling Identifies Novel Markers of
    Human Naïve and Primed Pluripotent States. *equal contribution. Cell Stem
    Cell 2017 June 1; 20(6):874-890
    * Hildebrand S, Hultin S, *Petropoulos S*, Subramani A, Cao X, Mpindi J,
    Kalloniemi O, Johansson S, Lanner F*, Holmgren L*. Amotl2 Controls
    Trophectoderm Cell Morphology in Mammalian Blastocysts. *equal
    contribution. Accepted Scientific Reports 2017.
    * Posfai E, *Petropoulos S*, Barros F, Schell JP, Sandber R, Lanner F,
    Rossant J. Position- and Hippo-signaling-dependent plasticity of the
    developing inner cell mass and trophectoderm lineages in the mouse.
    ELife 2017 Feb 22;6. pii: e22906.
    * Bloise E*, *Petropoulos S**, Iqbal M, Kostaki A, Ortiga-Carvalho TM, Gibb
    W, Matthews SG. Acute Effects of Viral Exposure on Disposition of
    P-glycoprotein Substrates in the Fetal Brain. *equal contribution.
    Cellular Physiology and Biochemistry. 2017; 41(3):1044-1050.
    * Jouhilahti EM*, Madissoon E*, Vesterlund L, Töhönen V, Krjutškov K,
    Reyes AP, *Petropoulos S*, Månsson R, Linnarsson S, Burglin T, Lanner F,
    Hovatta O, Katayama S, Kere J. The human PRD-like homeobox gene has a
    central role in embryo genome activation. *equal contribution.
    Development. 2016 Oct 1; 143(19):3459-3469.
    * Chen G, Schell JP, Benitez JA*, *Petropoulos S**, Reinius B, Yilmaz M,
    Alekseenko Z, Shi L, Hedlund E, Lanner F, Sandberg R, Deng Q.
    Single-cell analyses of X-chromosome inactivation dynamics and
    pluripotency gene program during differentiation. *equal contribution.
    Genome Research. 2016 Oct; 26(10):1342-1354.
    * Madissoon E, Jouhilahti EM, Vesterlund L, Töhönen V, Krjutškov K,
    *Petropoulos S*, Einarsdottir E, Linnarsson S, Lanner F, Månsson R,
    Hovatta O, Bürglin TR, Katayama S, Kere J. PRD-like homeodomain
    transcription factors regulate genes involved in human preimplantation
    development. Scientific Reports. 2016 July 14; 6:28995.
    * Cheishvili D, Maayan C, Holzer N, Tsenter J, Lax E, *Petropoulos S*, Razin
    H. Tocotrienol Treatment in Familial Dyautonomia: Open-Label Pilot Study.
    Journal of Molecular Neuroscience. 2016 Jul;59(3):382-91.
    * *Petropoulos S**, Edsgärd D*, Reinus B*, Deng Q, Panula S, Codeluppi S,
    Plaza Reyes A, Linnarsson S, Sandberg R‡, Lanner F‡. Single-Cell
    RNA-seq Reveal Lineage Segregation and X-chromosome Inactivation in Human
    Preimplantation Embryos. *, ‡equal contribution. Cell. 2016 May 5;
    165(4):1012-26. doi: 10.1016/j.cell.2016.03.023. [Epub 2016 April 7]
    * *Petropoulos S*, Panula S, Schell JP, Lanner F. Single-Cell RNA
    Sequencing: Revealing human preimplantation development, pluripotency and
    germ cell development. Journal of Internal Medicine. Epub ahead of
    print. April 2016. (Invited Review Article).
    * Zhang H*, Panula S*, *Petropoulos S*, Edsgärd D, Busayavalasa K, Liu L,
    Li X, Risal S, Shen Y, Shao J, Liu M, Li S, Zhang D, Zhang X, Gerner RR,
    Sheikhi M, Damdimopoulou P, Sandberg S, Douagi I, Gustafsson JA, Liu L,
    Lanner F, Hovatta O, § and Liu K§. No DDX4-expressing functional
    oogonial stem cells in adult human and mouse ovaries. * §equal
    contribution. Nature Medicine. 2015 Oct;21(10):1116-8.
    * *Petropoulos S*, Guillemin C, Ergaz Z, Dimov S, Suderman M, Pudim L, Ornoy
    A, Szyf M. Gestational Diabetes Alters Offspring DNA Methylation
    Profiles in Human and Rat: Identification of Key Pathways involved in
    Endocrine System Disorders, Insulin Signaling, Diabetes Signaling and IL-K
    Signaling. Endocrinology. 2015 June; 156(6):2222-38.
    Selected accolades
    Nominated member of AcademiaNet by the Swedish Research Council- Expert
    Database of Outstanding Female Academics in Europe (2017)
    Emil and Wera Cornells Foundation (2017-2018)
    Swedish Society for Medical Research (2017-2020)
    Swedish Research Council, Medicine and Health Starting Grant (2017-2020)
    Karolinska Institute Forskningsstiftelser (2017-2019)
    Karolinska Institute Forskningsstiftelser (2016-2018)
    Society for Reproductive Investigation (SRI) Early Career Grant (2016-2017)
    Karolinska Institute Forskningsstiftelser (2014-2016)
    Developmental Origins of Health and Disease (DOHaD) International Society-
    Top 10 Poster Presentation (2013)
    Mats Sundin Fellow in Human Development (2014-2016)
    59th Annual Society of Gynecologic Investigation poster presentation- Top
    (2%) presentation (2014)
    Canadian Institutes of Health Research Postdoctoral Fellowship (2011-2014)
    Gordon Cressy Student Leadership Award (2008-2009)
    University of Toronto Open Fellowship (2008-2009)
    Canadian Institutes of Health Research Doctoral Research Award (2007-2010)
    GENESIS Advancing Women’s Health (2008)
    Endocrine Trainee Day Award (2008)
    Endocrine Scholars Award (2008)
    Frontier’s in Physiology- Top Oral Presentation (2008)
    Teaching Assistantship Award (2008)
    GENESIS Advancing Women’s Health (2006-2007)
    University of Toronto Open Fellowship (2007)
    Frontier’s in Physiology-Oral Presentation Winner (2007)
    Canadian Institutes of Health Research CGS Masters Award (2005-2006)
    University of Toronto Open Fellowship (2006)
    University of Toronto Open Fellowship (2004)

Research

  • *Embryo, Development, Epigenome, Single-Cell OMICs, Artificial Reproduction,
    Fetal Programming*
    *The Petropoulos lab aims to:*
    1) Investigate how the early ex vivo environment, as occuring during
    Artificial Reproduction, impacts the developmental trajectory of the embryo
    and placenta- potentially programming the developing fetus for disease and
    disorder later in life.
    2) Investigate signaling occuring between the polar side of the human
    embryo and endometrium to shed light on underlying mechanisms of
    implantation. We hope to ultimately establish predictive biomarkers
    associated with successful implantation.

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