Sophie Curbo

Publications
CV
Public outreach and news

Articles

Article: JOURNAL OF EDUCATIONAL EVALUATION FOR HEALTH PROFESSIONS. 2023;20:13

Students’ performance of and perspective on an objective structured practical examination for the assessment of preclinical and practical skills in biomedical laboratory science students in Sweden: a 5-year longitudinal study.

Hultgren C; Lindkvist A; Curbo S; Heverin M
Journal article: PLOS ONE. 2023;18(10):e0285242

Long term survival and abnormal liver fat accumulation in mice with specific thymidine kinase 2 deficiency in liver tissue.

Zhao Q; Zhou X; Yan J; Kuiper R; Curbo S; Karlsson A
Article: JOURNAL OF EDUCATIONAL EVALUATION FOR HEALTH PROFESSIONS. 2023;20:32

ChatGPT (GPT-3.5) as an assistant tool in microbial pathogenesis studies in Sweden: a cross-sectional comparative study.

Hultgren C; Lindkvist A; Özenci V; Curbo S
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2022;510:113347

Development of an ELISA displaying similar reactivity with reduced and oxidized human Thioredoxin-1 (Trx1): The plasma level of Trx1 in early onset psychosis disorders.

Lundberg M; Bohman H; Curbo S; Mansouri S; Agartz I; Areström I; Ahlborg N
Article: PLOS ONE. 2022;17(6):e0270418

Mitochondrial dysfunction is associated with lipid metabolism disorder and upregulation of angiotensin-converting enzyme 2.

Zhao Q; Zhou X; Kuiper R; Curbo S; Karlsson A
Article: HUMAN MOLECULAR GENETICS. 2021;30(21):2012-2026

Coordinated pyruvate kinase activity is crucial for metabolic adaptation and cell survival during mitochondrial dysfunction.

Zhou X; Mikaeloff F; Curbo S; Zhao Q; Kuiper R; Végvári Á; Neogi U; Karlsson A
Article: BIOSCIENCE REPORTS. 2020;40(1):BSR20193156

Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy.

Lundberg M; Curbo S; Bohman H; Agartz I; Ögren S-O; Patrone C; Mansouri S
Article: HUMAN MOLECULAR GENETICS. 2019;28(17):2874-2884

Severe mtDNA depletion and dependency on catabolic lipid metabolism in DGUOK knockout mice.

Zhou X; Curbo S; Zhao Q; Krishnan S; Kuiper R; Karlsson A
Article: SCIENTIFIC REPORTS. 2019;9(1):5656

Inhibition of the thioredoxin system by PX-12 (1-methylpropyl 2-imidazolyl disulfide) impedes HIV-1 infection in TZM-bl cells.

Lundberg M; Mattsson Å; Reiser K; Holmgren A; Curbo S
Article: BIOCHEMICAL PHARMACOLOGY. 2018;156:444-450

Metformin downregulates the mitochondrial carrier SLC25A10 in a glucose dependent manner.

Zhao Q; Zhou X; Curbo S; Karlsson A
Article: BMC CANCER. 2018;18(1):559

Inhibition of glutamate oxaloacetate transaminase 1 in cancer cell lines results in altered metabolism with increased dependency of glucose.

Zhou X; Curbo S; Li F; Krishnan S; Karlsson A
Article: PLOS ONE. 2016;11(1):e0147773

The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition.

Reiser K; Mathys L; Curbo S; Pannecouque C; Noppen S; Liekens S; Engman L; Lundberg M; Balzarini J; Karlsson A
Article: ONCOTARGET. 2015;6(11):9271-9283

The mitochondrial carrier SLC25A10 regulates cancer cell growth.

Zhou X; Paredes JA; Krishnan S; Curbo S; Karlsson A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(47):32835-32844

Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances.

Krishnan S; Paredes JA; Zhou X; Kuiper RV; Hultenby K; Curbo S; Karlsson A
Article: PLOS ONE. 2014;9(7):e103554

Methodological aspects of ELISA analysis of thioredoxin 1 in human plasma and cerebrospinal fluid.

Lundberg M; Curbo S; Reiser K; Masterman T; Braesch-Andersen S; Areström I; Ahlborg N
Article: ANTIOXIDANTS & REDOX SIGNALING. 2013;18(7):795-799

Is trichloroacetic acid an insufficient sample quencher of redox reactions?

Curbo S; Reiser K; Rundlöf A-K; Karlsson A; Lundberg M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(7):5072-5079

Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency.

Krishnan S; Zhou X; Paredes JA; Kuiper RV; Curbo S; Karlsson A
Article: PLOS ONE. 2013;8(3):e58843

Thymidine kinase 2 deficiency-induced mtDNA depletion in mouse liver leads to defect β-oxidation.

Zhou X; Kannisto K; Curbo S; von Döbeln U; Hultenby K; Isetun S; Gåfvels M; Karlsson A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;390(4):1272-1277

Regulation of interleukin-4 signaling by extracellular reduction of intramolecular disulfides.

Curbo S; Gaudin R; Carlsten M; Malmberg K-J; Troye-Blomberg M; Ahlborg N; Karlsson A; Johansson M; Lundberg M
Article: EXPERIMENTAL CELL RESEARCH. 2009;315(15):2539-2543

Acute cytotoxicity of arabinofuranosyl nucleoside analogs is not dependent on mitochondrial DNA.

Curbo S; Johansson M; Balzarini J; Lewis LD; Karlsson A
Article: GENOMICS. 2006;87(3):410-416

Human mitochondrial pyrophosphatase: cDNA cloning and analysis of the gene in patients with mtDNA depletion syndromes.

Curbo S; Lagier-Tourenne C; Carrozzo R; Palenzuela L; Lucioli S; Hirano M; Santorelli F; Arenas J; Karlsson A; Johansson M
Journal article: CHEMINFORM. 2005;36(12):no

5‐Fluoro‐2′‐deoxyuridine Has Effects on Mitochondria in CEM T‐Lymphoblast Cells

Curbo S; Johansson M; Karlsson A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;311(2):440-445

The Drosophila melanogaster UMP-CMP kinase cDNA encodes an N-terminal mitochondrial import signal.

Curbo S; Amiri M; Foroogh F; Johansson M; Karlsson A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;307(4):942-947

Effects of 9-beta-D-arabinofuranosylguanine on mitochondria in CEM T-lymphoblast leukemia cells.

Curbo S; Zhivotovsky B; Johansson M; Karlsson A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2001;285(1):40-45

Dual mechanisms of 9-beta-D-arabinofuranosylguanine resistance in CEM T-lymphoblast leukemia cells.

Curbo S; Zhu C; Johansson M; Balzarini J; Karlsson A
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All other publications

Conference publication: MITOCHONDRION. 2012;12(5):561-562

Thymidine kinase 2 deficiency-induced mtDNA depletion in liver leads to defect β-oxidation and insufficient supply of ketone bodies and glucose for brain function

Curbo S; Curbo S; Zhou X; Kannisto K; von Dobeln U; Hultenby K; Isetun S; Gafvels M; Karlsson A
Book chapter: DEOXYNUCLEOSIDE ANALOGS IN CANCER THERAPY: CANCER DRUG DISCOVERY AND DEVELOPMENT. 2007;p. 215-224

9-β-D-Arabinofuranosylguanine

Curbo S; Karlsson A
Review: REVIEWS ON RECENT CLINICAL TRIALS. 2006;1(3):185-192

Nelarabine: a new purine analog in the treatment of hematologic malignancies.

Curbo S; Karlsson A
Published conference paper: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 2004;23(8-9):1495-1498

5-Fluoro-2'-deoxyuridine has effects on mitochondria in CEM T-lymphoblast cells.

Curbo S; Johansson M; Karlsson A

Employments

Assistant Senior Lecturer, Department of Laboratory Medicine, Karolinska Institutet, 2022-

Degrees and Education

Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2004

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