Sofia Ygberg

Publications
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Public outreach and news

Articles

Article: CHILD NEUROPSYCHOLOGY. 2024;30(6):882-899
Neurocognitive outcome in children and adolescents following infectious encephalitis
Bergman K; Fowler A; Ygberg S; Lovio R; Wickstrom R
Article: HUMAN MUTATION. 2024;2024:1611838-16
Novel Synonymous and Deep Intronic Variants Causing Primary and Secondary Pyruvate Dehydrogenase Complex Deficiency
Bruhn H; Naess K; Ygberg S; Pena-Perez L; Lesko N; Wibom R; Freyer C; Stranneheim H; Wedell A; Wredenberg A
Article: JIMD REPORTS. 2023;64(1):79-89
The Swedish COG6-CDG experience and a comprehensive literature review
Xia Z-J; Ng BG; Jennions E; Blomqvist M; Sandqvist Wiklund A; Hedberg-Oldfors C; Gonzalez CR; Freeze HH; Ygberg S; Eklund EA
Article: BIOMEDICINES. 2022;10(12):3171
A Missense Variant in PDK1 Associated with Severe Neurodevelopmental Delay and Epilepsy
Vaz R; Wincent J; Elfissi N; Rosengren Forsblad K; Pettersson M; Naess K; Wedell A; Wredenberg A; Lindstrand A; Ygberg S
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2022;109(8):1421-1435
Bi-allelic loss-of-function variants in PPFIBP1 cause a neurodevelopmental disorder with microcephaly, epilepsy, and periventricular calcifications
Rosenhahn E; O'Brien TJ; Zaki MS; Sorge I; Wieczorek D; Rostasy K; Vitobello A; Nambot S; Alkuraya FS; Hashem MO; Alhashem A; Tabarki B; Alamri AS; Al Safar AH; Bubshait DK; Alahmady NF; Gleeson JG; Abdel-Hamid MS; Lesko N; Ygberg S; Correia SP; Wredenberg A; Alavi S; Seyedhassani SM; Nasab ME; Hussien H; Omar TEI; Harzallah I; Touraine R; Tajsharghi H; Morsy H; Houlden H; Shahrooei M; Ghavideldarestani M; Abdel-Salam GMH; Torella A; Zanobio M; Terrone G; Brunetti-Pierri N; Omrani A; Hentschel J; Lemke JR; Sticht H; Abou Jamra R; Brown AEX; Maroofian R; Platzer K
Article: FRONTIERS IN PEDIATRICS. 2022;10:940103
Case report: Fatal outcome of pyridoxine-dependent epilepsy presenting as respiratory distress followed by a circulatory collapse
Aquilano G; Linner A; Ygberg S; Stoedberg T; Henckel E
Article: PEDIATRIC RESEARCH. 2022;91(1):204-208
Age-related changes in the inflammatory responses to viral infections in the central nervous system during childhood
Ygberg S; Fowler A; Wickstrom R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2021;297(6):101355
A missense mutation converts the Na⁺,K⁺-ATPase into an ion channel and causes therapy-resistant epilepsy
Ygberg S; Akkuratov EE; Howard RJ; Taylan F; Jans DC; Mahato DR; Katz A; Kinoshita PF; Portal B; Nennesmo I; Lindskog M; Karlish SJD; Andersson M; Lindstrand A; Brismar H; Aperia A
Article: EPILEPSY RESEARCH. 2021;177:106775
Altered cytokine levels in cerebrospinal fluid following ketogenic diet of children with refractory epilepsy
Wickstrom R; Ygberg S; Lindefeldt M; Dahlin M
Article: GENOME MEDICINE. 2021;13(1):40
Integration of whole genome sequencing into a healthcare setting: high diagnostic rates across multiple clinical entities in 3219 rare disease patients
Stranneheim H; Lagerstedt-Robinson K; Magnusson M; Kvarnung M; Nilsson D; Lesko N; Engvall M; Anderlid B-M; Arnell H; Johansson CB; Barbaro M; Bjorck E; Bruhn H; Eisfeldt J; Freyer C; Grigelioniene G; Gustavsson P; Hammarsjo A; Hellstrom-Pigg M; Iwarsson E; Jemt A; Laaksonen M; Enoksson SL; Malmgren H; Naess K; Nordenskjold M; Oscarson M; Pettersson M; Rasi C; Rosenbaum A; Sahlin E; Sardh E; Stodberg T; Tesi B; Tham E; Thonberg H; Tohonen V; von Dobeln U; Vassiliou D; Vonlanthen S; Wikstrom A-C; Wincent J; Winqvist O; Wredenberg A; Ygberg S; Zetterstrom RH; Marits P; Soller MJ; Nordgren A; Wirta V; Lindstrand A; Wedell A
Article: MICROORGANISMS. 2021;9(2):322
The Kynurenine Pathway is Differentially Activated in Children with Lyme Disease and Tick-Borne Encephalitis
Wickstrom R; Fowler A; Goiny M; Millischer V; Ygberg S; Schwieler L
Article: EPILEPTIC DISORDERS. 2021;23(1):133-142
Post-encephalitic epilepsy in childhood: results from a prospective cohort study
Cooray G; Ygberg S; Fowler A; Wickstrom R
Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2020;39(12):e417-e422
Prospective Evaluation of Childhood Encephalitis Predisposing Factors, Prevention and Outcome
Fowler A; Ygberg S; Svensson E; Bergman K; Cooray G; Wickstrom R
Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2020;39(3):239-243
The Cerebrospinal Fluid Interleukin-6/Interleukin-10 Ratio Differentiates Pediatric Tick-borne Infections
Ygberg S; Fowler A; Bogdanovic G; Wickstrom R
Article: GENOME MEDICINE. 2019;11(1):68
From cytogenetics to cytogenomics: whole-genome sequencing as a first-line test comprehensively captures the diverse spectrum of disease-causing genetic variation underlying intellectual disability
Lindstrand A; Eisfeldt J; Pettersson M; Carvalho CMB; Kvarnung M; Grigelioniene G; Anderlid B-M; Bjerin O; Gustavsson P; Hammarsjo A; Georgii-Hemming P; Iwarsson E; Johansson-Soller M; Lagerstedt-Robinson K; Lieden A; Magnusson M; Martin M; Malmgren H; Nordenskjold M; Norling A; Sahlin E; Stranneheim H; Tham E; Wincent J; Ygberg S; Wedell A; Wirta V; Nordgren A; Lundin J; Nilsson D
Article: BRAIN. 2017;140(10):2610-2622
Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly
Alcantara D; Timms AE; Gripp K; Baker L; Park K; Collins S; Cheng C; Stewart F; Mehta SG; Saggar A; Sztriha L; Zombor M; Caluseriu O; Mesterman R; Van Allen MI; Jacquinet A; Ygberg S; Bernstein JA; Wenger AM; Guturu H; Bejerano G; Gomez-Ospina N; Lehman A; Alfei E; Pantaleoni C; Conti V; Guerrini R; Moog U; Graham JMJ; Hevner R; Dobyns WB; O'Driscoll M; Mirzaa GM
Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2017;36(1):102-108
Assessment of Cytokine and Chemokine Signatures as Potential Biomarkers of Childhood Community-acquired Pneumonia Severity A Nested Cohort Study in India
Saghafian-Hedengren S; Mathew JL; Hagel E; Singhi S; Ray P; Ygberg S; Nilsson A
Article: JOURNAL OF CHILD NEUROLOGY. 2016;31(13):1450-1456
Cytokine and Chemokine Expression in CSF May Differentiate Viral and Autoimmune NMDAR Encephalitis in Children
Ygberg S; Fowler A; Wickstrom R
Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2016;35(9):961-966
Biomarkers in Cerebrospinal Fluid of Children With Tick-borne Encephalitis: Association With Long-term Outcome
Fowler A; Ygberg S; Bogdanovic G; Wickstrom R
Article: ACTA PAEDIATRICA. 2016;105(8):979-982
A ten-year retrospective case series of glucocorticoid treatment of bacterial meningitis in children
Ygberg S; Brauner A; Chambers BJ; Wiklund C; Nilsson A
Article: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY. 2016;20(3):457-461
Biotin and Thiamine Responsive Basal Ganglia Disease - A vital differential diagnosis in infants with severe encephalopathy
Ygberg S; Naess K; Eriksson M; Stranneheim H; Lesko N; Barbaro M; Wibom R; Wang C; Wedell A; Wickstrom R
Article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2016;362:251-257
High-intensity resistance training in multiple sclerosis - An exploratory study of effects on immune markers in blood and cerebrospinal fluid, and on mood, fatigue, health-related quality of life, muscle strength, walking and cognition
Kierkegaard M; Lundberg IE; Olsson T; Johansson S; Ygberg S; Opava C; Holmqvist LW; Piehl F
Article: JOURNAL OF GLOBAL HEALTH. 2015;5(2):050418-232
Etiology of community acquired pneumonia among children in India: prospective, cohort study
Mathew JL; Singhi S; Ray P; Hagel E; Saghafian-Hedengren S; Bansal A; Ygberg S; Sodhi KS; Kumar BVR; Nilsson A
Article: MBIO. 2012;4(1):e00535-e00512
Pilus Adhesin RrgA Interacts with Complement Receptor 3, Thereby Affecting Macrophage Function and Systemic Pneumococcal Disease
Orrskog S; Rounioja S; Spadafina T; Gallotta M; Norman M; Hentrich K; Falker S; Ygberg-Eriksson S; Hasenberg M; Johansson B; Uotila LM; Gahmberg CG; Barocchi M; Gunzer M; Normark S; Henriques-Normark B
Article: JOURNAL OF BACTERIOLOGY. 2009;191(22):6918-6927
Thioredoxin 1 Participates in the Activity of the Salmonella enterica Serovar Typhimurium Pathogenicity Island 2 Type III Secretion System
Negrea A; Bjur E; Puiac S; Ygberg SE; Aslund F; Rhen M
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2007;51(8):2867-2876
Salicylidene acylhydrazides that affect type III protein secretion in Salmonella enterica serovar Typhimurium
Negrea A; Bjur E; Ygberg SE; Elofsson M; Wolf-Watz H; Rhen M
Article: AMERICAN JOURNAL OF PATHOLOGY. 2007;170(1):227-239
FasL and TRAIL induce epidermal apoptosis and skin ulceration upon exposure to Leishmania major
Eidsmo L; Fluur C; Rethi B; Ygberg SE; Ruffin N; De Milito A; Akuffo H; Chiodi F
Article: INFECTION AND IMMUNITY. 2006;74(9):5140-5151
Thioredoxin 1 promotes intracellular replication and virulence of Salmonella enterica serovar Typhimurium
Bjur E; Eriksson-Ygberg S; Aslund F; Rhen M
Article: MICROBES AND INFECTION. 2006;8(7):1826-1838
The O-antigen affects replication of Salmonella enterica serovar Typhimurium in murine macrophage-like J774-A.1 cells through modulation of host cell nitric oxide production
Bjur E; Eriksson-Ygberg S; Rhen M
Article: INFECTION AND IMMUNITY. 2006;74(2):1243-1254
Polynucleotide phosphorylase negatively controls spv virulence gene expression in Salmonella enterica
Ygberg SE; Clements MO; Rytkönen A; Thompson A; Holden DW; Hinton JCD; Rhen M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(34):12112-12116
Bacterial genome size reduction by experimental evolution
Nilsson AI; Koskiniemi S; Eriksson S; Kugelberg E; Hinton JCD; Andersson DI
Article: CELLULAR MICROBIOLOGY. 2005;7(1):147-155
Components of the peptidoglycan-recycling pathway modulate invasion and intracellular survival of Salmonella enterica serovar Typhimurium
Folkesson A; Eriksson S; Andersson M; Park JT; Normark S
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2003;47(12):3743-3749
Fusidic acid-resistant mutants of Salmonella enterica serovar typhimurium with low fitness in vivo are defective in RpoS induction
Macvanin M; Björkman J; Eriksson S; Rhen M; Andersson DI; Hughes D
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2003;58(5):493-502
Nitric oxide produced by murine dendritic cells is cytotoxic for intracellular Salmonella enterica sv. Typhimurium
Eriksson S; Chambers BJ; Rhen M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(13):8784-8789
Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica
Clements MO; Eriksson S; Thompson A; Lucchini S; Hinton JCD; Normark S; Rhen M
Article: CELLULAR MICROBIOLOGY. 2000;2(3):239-250
Salmonella typhimurium mutants that downregulate phagocyte nitric oxide production
Eriksson S; Björkman J; Borg S; Syk A; Pettersson S; Andersson DI; Rhen M
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All other publications

Editorial comment: STEM CELLS TRANSLATIONAL MEDICINE. 2024;13(6):505-514
Human In Vitro Models of Neuroenergetics and Neurometabolic Disturbances: Current Advances and Clinical Perspectives
Rogal J; Zamproni LN; Nikolakopoulou P; Ygberg S; Wedell A; Wredenberg A; Herland A
Other: CLINICAL CASE REPORTS. 2022;10(6):e5989
Expanding the phenotype of the recurrent truncating eIF2γ pathogenic variant p.(Ile465Serfs*4) identified in two brothers with MEHMO syndrome
Ygberg S; Lindstrand A
Review: ACTA PAEDIATRICA. 2021;110(12):3153-3160
Clinical guidance for diagnosis and management of suspected Pediatric Acute-onset Neuropsychiatric Syndrome in the Nordic countries
Pfeiffer HCV; Wickstrom R; Skov L; Sorensen CB; Sandvig I; Gjone IH; Ygberg S; de Visscher C; Idring Nordstrom S; Herner LB; Hesselmark E; Hedderly T; Lim M; Debes NM
Letter: ACTA PAEDIATRICA. 2021;110(12):3390-3391
Authors' reply regarding "On diagnosing and treating PANS/PANDAS: Questions from a patient support group"
Pfeiffer HCV; De Visscher C; Gjone IH; Ygberg S; Herner LB; Hesselmark E; Idring Nordstrom S; Sandvig I; Skov L; Sorensen CB; Lim M; Wickstrom R; Hedderly T; Debes NM
Review: ACTA PAEDIATRICA. 2012;101(2):120-127
The developing immune system - from foetus to toddler
Ygberg S; Nilsson A
Review: CELLULAR MICROBIOLOGY. 2008;10(4):958-984
During infection of epithelial cells Salmonella enterica serovar Typhimurium undergoes a time-dependent transcriptional adaptation that results in simultaneous expression of three type 3 secretion systems
Hautefort I; Thompson A; Eriksson-Ygberg S; Parker ML; Lucchini S; Danino V; Bongaerts RJM; Ahmad N; Rhen M; Hinton JCD
Review: CURRENT OPINION IN MICROBIOLOGY. 2004;7(3):277-282
Benefits and pitfalls of using microarrays to monitor bacterial gene expression during infection
Hinton JCD; Hautefort I; Eriksson S; Thompson A; Rhen M
Review: MOLECULAR MICROBIOLOGY. 2003;47(1):103-118
Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica
Eriksson S; Lucchini S; Thompson A; Rhen M; Hinton JCD
Published conference paper: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 2002;357(1423):887-893
Low-temperature sensors in bacteria
Eriksson S; Hurme R; Rhen M
Review: ANNALS OF MEDICINE. 2001;33(3):178-185
Virulence gene regulation in Salmonella enterica
Clements M; Eriksson S; Tezcan-Merdol D; Hinton JCD; Rhen M
Review: CURRENT OPINION IN MICROBIOLOGY. 2000;3(1):60-64
Bacterial adaptation to host innate immunity responses
Rhen M; Eriksson S; Pettersson S
Published conference paper: IMMUNOLOGY LETTERS. 1999;68(2-3):247-249
Novel Salmonella typhimurium properties in host-parasite interactions
Borg S; Björkman J; Eriksson S; Syk A; Andersson DI; Schesser K; Rhen M; Pettersson S; French NS

Employments

Affiliated to Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2024-2025

Degrees and Education

University Medical Degree, Karolinska Institutet, 2009
Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2003

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