Sidinh Luc | Karolinska Institutet

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Articles

Article: NATURE COMMUNICATIONS. 2024;15(1):7966
Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets
Su T-Y; Hauenstein J; Somuncular E; Dumral O; Leonard E; Gustafsson C; Tzortzis E; Forlani A; Johansson A-S; Qian H; Mansson R; Luc S
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2023;12(11):720-726
Combination of CD49b and CD229 Reveals a Subset of Multipotent Progenitors With Short-Term Activity Within the Hematopoietic Stem Cell Compartment
Somuncular E; Su T-Y; Dumral O; Johansson A-S; Luc S
Article: BMC GENOMICS. 2023;24(1):205
T-RHEX-RNAseq - a tagmentation-based, rRNA blocked, random hexamer primed RNAseq method for generating stranded RNAseq libraries directly from very low numbers of lysed cells
Gustafsson C; Hauenstein J; Frengen N; Krstic A; Luc S; Mansson R
Article: STEM CELL REPORTS. 2022;17(7):1546-1560
CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells
Somuncular E; Hauenstein J; Khalkar P; Johansson A-S; Dumral O; Frengen NS; Gustafsson C; Mocci G; Su T-Y; Brouwer H; Trautmann CL; Vanlandewijck M; Orkin SH; Mansson R; Luc S
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:880668
FOXO Dictates Initiation of B Cell Development and Myeloid Restriction in Common Lymphoid Progenitors
Pena-Perez L; Kharazi S; Frengen N; Krstic A; Bouderlique T; Hauenstein J; He M; Somuncular E; Li Wang X; Dahlberg C; Gustafsson C; Johansson A-S; Walfridsson J; Kadri N; Woll P; Kierczak M; Qian H; Westerberg L; Luc S; Mansson R
Journal article: EXPERIMENTAL HEMATOLOGY. 2021;100:s103
3126 – HEMATOPOIETIC STEM CELLS WITH LYMPHOID BIAS ARE MARKED BY CD49B
Somuncular E; Hauenstein J; Khalkar P; Dumral Ö; Johansson A-S; Mocci G; Gustafsson C; Frengen N; Su T-Y; Trautmann C; Brouwer H; Vanlandewijck M; Orkin SH; Månsson R; Luc S
Article: NATURE IMMUNOLOGY. 2016;17(12):1424-1435
Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors
Luis TC; Luc S; Mizukami T; Boukarabila H; Thongjuea S; Woll PS; Azzoni E; Giustacchini A; Lutteropp M; Bouriez-Jones T; Vaidya H; Mead AJ; Atkinson D; Boiers C; Carrelha J; Macaulay IC; Patient R; Geissmann F; Nerlov C; Sandberg R; de Bruijn MFTR; Blackburn CC; Godin I; Jacobsen SEW
Article: BLOOD. 2016;128(19):2338-2342
Strict in vivo specificity of the Bcl11a erythroid enhancer
Smith EC; Luc S; Croney DM; Woodworth MB; Greig LC; Fujiwara Y; Minh N; Sher F; Macklis JD; Bauer DE; Orkin SH
Article: CELL REPORTS. 2016;16(12):3181-3194
Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype
Luc S; Huang J; McEldoon JL; Somuncular E; Li D; Rhodes C; Mamoor S; Hou S; Xu J; Orkin SH
Journal article: BLOOD. 2015;126(23):638
Crispr-Cas9 Saturating Mutagenesis Reveals an Achilles Heel in the BCL11A Erythroid Enhancer for Fetal Hemoglobin Induction (by Genome Editing)
Bauer DE; Canver MC; Smith EC; Sher F; Pinello L; Sanjana NE; Shalem O; Chen DD; Schupp PG; Vinjamur DS; Garcia SP; Luc S; Kurita R; Nakamura Y; Fujiwara Y; Maeda T; Yuan G-C; Lettre G; Zhang F; Orkin SH
Article: NATURE. 2015;527(7577):192-197
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
Canver MC; Smith EC; Sher F; Pinello L; Sanjana NE; Shalem O; Chen DD; Schupp PG; Vinjamur DS; Garcia SP; Luc S; Kurita R; Nakamura Y; Fujiwara Y; Maeda T; Yuan G-C; Zhang F; Orkin SH; Bauer DE
Article: LEUKEMIA. 2015;29(1):38-50
Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lymphoblastic leukemia with MLL rearrangement
Bardini M; Woll PS; Corral L; Luc S; Wittmann L; Ma Z; Lo Nigro L; Basso G; Biondi A; Cazzaniga G; Jacobsen SEW
Article: CELL STEM CELL. 2013;13(5):535-548
Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells
Boiers C; Carrelha J; Lutteropp M; Luc S; Green JCA; Azzoni E; Woll PS; Mead AJ; Hultquist A; Swiers G; Perdiguero EG; Macaulay IC; Melchiori L; Luis TC; Kharazi S; Bouriez-Jones T; Deng Q; Ponten A; Atkinson D; Jensen CT; Sitnicka E; Geissmann F; Godin I; Sandberg R; de Bruijn MFTR; Jacobsen SEW
Article: CELL STEM CELL. 2013;13(4):492-505
Mapping Cellular Hierarchy by Single-Cell Analysis of the Cell Surface Repertoire
Guo G; Luc S; Marco E; Lin T-W; Peng C; Kerenyi MA; Beyaz S; Kim W; Xu J; Das PP; Neff T; Zou K; Yuan G-C; Orkin SH
Article: CELL REPORTS. 2013;3(6):1766-1776
FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors
Mead AJ; Kharazi S; Atkinson D; Macaulay I; Pecquet C; Loughran S; Lutteropp M; Woll P; Chowdhury O; Luc S; Buza-Vidas N; Ferry H; Clark S-A; Goardon N; Vyas P; Constantinescu SN; Sitnicka E; Nerlov C; Jacobsen SEW
Article: ELIFE. 2013;2:e00633
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation
Kerenyi MA; Shao Z; Hsu Y-J; Guo G; Luc S; O'Brien K; Fujiwara Y; Peng C; Nguyen M; Orkin SH
Article: BLOOD. 2012;120(12):2412-2416
Dicer is selectively important for the earliest stages of erythroid development
Buza-Vidas N; Cismasiu VB; Moore S; Mead AJ; Woll PS; Lutteropp M; Melchiori L; Luc S; Bouriez-Jones T; Atkinson D; O'Carroll D; Jacobsen SEW; Nerlov C
Article: NATURE IMMUNOLOGY. 2012;13(4):412-419
The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential
Luc S; Luis TC; Boukarabila H; Macaulay IC; Buza-Vidas N; Bouriez-Jones T; Lutteropp M; Won PS; Loughran SJ; Mead AJ; Hultquist A; Brown J; Mizukami T; Matsuoka S; Ferry H; Anderson K; Duarte S; Atkinson D; Soneji S; Domanski A; Farley A; Sanjuan-Pla A; Carella C; Patient R; de Bruijn M; Enver T; Nerlov C; Blackburn C; Godin I; Jacobsen SEW
Article: EMBO JOURNAL. 2012;31(2):351-365
FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors
Mancini E; Sanjuan-Pla A; Luciani L; Moore S; Grover A; Zay A; Rasmussen KD; Luc S; Bilbao D; O'Carroll D; Jacobsen SE; Nerlov C
Journal article: BLOOD. 2011;118(21):1380
FLT3-ITDs Introduce a Myeloid Differentiation and Transformation Bias to Multipotent Lympho-Myeloid Progenitors
Mead AJ; Kharazi S; Macaulay IC; Atkinson D; Loughran S; Lutteropp M; Woll P; Luc S; Buza-Vidas N; Ferry H; Nerlov C; Sitnicka E; Jacobsen SEW
Journal article: BLOOD. 2011;118(21):2335
The Earliest Thymic T Cell Progenitors Sustain B Cell and Myeloid Lineage Potentials
Luc S; Macaulay IC; Buza-Vidas N; Bouriez-Jones T; Lutteropp M; Woll P; Mead AJ; Boukarabila H; Luis TC; Mizukami T; Matsuoka S; Brown J; Ferry H; Anderson K; Duarte S; Atkinson D; Soneji S; Domanski A; Farley A; Sanjuan-Pla A; Carella C; Patient R; de Bruijn M; Enver T; Nerlov C; Blackburn C; Godin I; Jacobsen SEW
Article: BLOOD. 2011;118(13):3613-3621
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation
Kharazi S; Mead AJ; Mansour A; Hultquist A; Boiers C; Luc S; Buza-Vidas N; Ma Z; Ferry H; Atkinson D; Reckzeh K; Masson K; Cammenga J; Ronnstrand L; Arai F; Suda T; Nerlov C; Sitnicka E; Jacobsen SEW
Article: BLOOD. 2011;118(6):1544-1548
FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells
Buza-Vidas N; Woll P; Hultquist A; Duarte S; Lutteropp M; Bouriez-Jones T; Ferry H; Luc S; Jacobsen SEW
Article: BLOOD. 2011;118(5):1291-1293
GATA3 is redundant for maintenance and self-renewal of hematopoietic stem cells
Buza-Vidas N; Duarte S; Luc S; Bouriez-Jones T; Woll PS; Jacobsen SEW
Article: EPIGENETICS & CHROMATIN. 2011;4(1):9
Generation of bivalent chromatin domains during cell fate decisions
De Gobbi M; Garrick D; Lynch M; Vernimmen D; Hughes JR; Goardon N; Luc S; Lower KM; Sloane-Stanley JA; Pina C; Soneji S; Renella R; Enver T; Taylor S; Jacobsen SEW; Vyas P; Gibbons RJ; Higgs DR
Article: BLOOD. 2011;117(13):3521-3528
Hoxb4-YFP reporter mouse model: a novel tool for tracking HSC development and studying the role of Hoxb4 in hematopoiesis
Hills D; Gribi R; Ure J; Buza-Vidas N; Luc S; Jacobsen SEW; Medvinsky A
Article: CANCER CELL. 2009;16(5):390-400
Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-initiating Cells in C/EBPα Mutant AML
Bereshchenko O; Mancini E; Moore S; Bilbao D; Mansson R; Luc S; Grover A; Jacobsen SEW; Bryder D; Nerlov C
Article: BLOOD. 2008;111(7):3424-3434
Down-regulation of Mpl marks the transition to lymphoid-primed multipotent progenitors with gradual loss of granulocyte-monocyte potential
Luc S; Anderson K; Kharazi S; Buza-Vidas N; Boiers C; Jensen CT; Ma Z; Wittmann L; Jacobsen SEW
Journal article: BLOOD. 2007;110(11):2227
Downregulation of Mpl Marks the Transition to Lymphoid-Primed Multipotent Progenitors with Gradual Loss of Granulocyte-Monocyte Potential.
Luc S; Anderson K; Kharazi S; Buza-Vidas N; Boiers C; Jensen CT; Ma Z; Wittman L; Jacobsen SEW
Article: CURRENT OPINION IN HEMATOLOGY. 2007;14(4):315-321
Delineation of the earliest lineage commitment steps of haematopoietic stem cells: new developments, controversies and major challenges
Buza-Vidas N; Luc S; Jacobsen SEW
Article: IMMUNITY. 2007;26(4):407-419
Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors
Mansson R; Hultquist A; Luc S; Yang L; Anderson K; Kharazi S; Al-Hashmi S; Liuba K; Thoren L; Adolfsson J; Buza-Vidas N; Qian H; Soneji S; Enver T; Sigvardsson M; Jacobsen SEW
Article: GENES & DEVELOPMENT. 2006;20(15):2018-2023
Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK
Buza-Vidas N; Antonchuk J; Qian H; Mansson R; Luc S; Zandi S; Anderson K; Takaki S; Nygren JM; Jensen CT; Jacobsen SEW
Journal article: BLOOD. 2005;106(11):802
Evidence for a Novel Blood Lineage Commitment Pathway from Lympho-Myeloid Hematopoietic Stem Cells.
Jacobsen SEW; Mansson R; Hultquist A; Sigvardsson M; Buza-Vidas N; Thoren L; Liuba K; Luc S; Yang L
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All other publications

Preprint: BIORXIV. 2023
Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets
Somuncular E; Hauenstein J; Su T-Y; Dumral Ö; Gustafsson C; Tzortzis E; Forlani A; Johansson A-S; Månsson R; Luc S
Preprint: BIORXIV. 2023
The combination of CD49b and CD229 reveals a subset of multipotent progenitors with short-term activity within the hematopoietic stem cell compartment
Somuncular E; Su T-Y; Dumral Ö; Johansson A-S; Luc S
Preprint: BIORXIV. 2022
T-RHEX-RNAseq – A tagmentation-based, rRNA blocked, random hexamer primed RNAseq method for generating stranded RNAseq libraries directly from very low numbers of lysed cells
Gustafsson C; Hauenstein J; Frengen N; Krstic A; Luc S; Månsson R
Preprint: BIORXIV. 2022
FOXO dictate initiation of B cell development and myeloid restriction in common lymphoid progenitors
Peña-Pérez L; Kharazi S; Frengen N; Krstic A; Bouderlique T; Hauenstein J; He M; Somuncular E; Li Wang X; Dahlberg C; Gustafsson C; Johansson A-S; Walfridsson J; Kadri N; Woll P; Kierczak M; Qian H; Westerberg L; Luc S; Månsson R
Conference publication: EXPERIMENTAL HEMATOLOGY. 2021;100:S103
HEMATOPOIETIC STEM CELLS WITH LYMPHOID BIAS ARE MARKED BY CD49B
Somuncular E; Hauenstein J; Khalkar P; Dumral Ö; Johansson A-S; Mocci G; Gustafsson C; Frengen N; Su T-Y; Trautmann C; Brouwer H; Vanlandewijck M; Orkin SH; Mansson R; Luc S
Conference publication: EXPERIMENTAL HEMATOLOGY. 2017;53:S113-S114
EMBRYONIC THYMOPOIESIS IS INITIATED BY AN IMMUNE-RESTRICTED LYMPHO-MYELOID PROGENITOR, INDEPENDENTLY OF NOTCH SIGNALING
Luis T; Luc S; Mizukami T; Boukarabila H; Thongjuea S; Woll P; Azzoni E; Giustacchini A; Lutteropp M; Bouriez-Jones T; Vaidya H; Mead A; Atkinson D; Boiers C; Carrelha J; Macaulay I; Patient R; Geissmann F; Nerlov C; Sandberg R; De Bruijn M; Blackburn C; Godin I; Jacobsen SE
Conference publication: EXPERIMENTAL HEMATOLOGY. 2016;44(9):S65
EMBRYONIC THYMOPOIESIS IS INITIATED BY AN IMMUNE-RESTRICTED LYMPHO-MYELOID PROGENITOR INDEPENDENTLY OF NOTCH SIGNALING
Luis TC; Luc S; Mizukami T; Boukarabila H; Thongjuea S; Woll P; Azzoni E; Lutteropp M; Bouriez-Jones T; Vaidya H; Mead A; Atkinson D; Boeiers C; Carrelha J; Macaulay L; Patient R; Nerlov C; Sandberg R; de Bruijn M; Blackburn CC; Godin I; Jacobsen SE
Conference publication: EXPERIMENTAL HEMATOLOGY. 2013;41(8):S13
ESTABLISHMENT OF LYMPHO-MYELOID RESTRICTED PROGENITORS PRIOR TO THE EMERGENCE OF DEFINITIVE HEMATOPOIETIC STEM CELLS
Boiers C; Lutteropp M; Luc S; Woll P; Mead A; Hultquist A; Carrelha J; Macaulay I; Swiers G; Melchiori L; Luis T; Kharazi S; Bouriez-Jones T; Deng Q; Ponten A; Jensen C; Sitnicka E; Sandberg R; de Bruijn M; Jacobsen SE
Editorial comment: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(29):11670-11671
Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells
Luc S; Orkin SH
Review: SEMINARS IN IMMUNOLOGY. 2008;20(4):213-220
Delineating the cellular pathways of hematopoietic lineage commitment
Luc S; Buza-Vidas N; Jacobsen SEW
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2007;1106:89-94
Biological and molecular evidence for existence of lymphoid-primed multipotent progenitors
Luc S; Buza-Vidas N; Jacobsen SEW

Grants

Luc, Sidinh – The differential leukemic development from lineage-biased hematopoietic stem cells
Swedish Cancer Society
1 January 2021
Epigenetic regulation of blood stem cells in normal blood development and in leukemia development
Swedish Cancer Society
1 January 2018
Epigenetic control of lineage-biased hematopoietic stem cells
Swedish Research Council
1 January 2017 - 31 December 2020
Epigenetic regulation of blood stem cells in normal blood development and in leukemia development
Swedish Cancer Society
1 January 2017

Employments

Researcher, Department of Laboratory Medicine, Karolinska Institutet, 2025-
Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2021-2025
Assistant Professor, Department of Medicine, Huddinge, Karolinska Institutet, 2017-2021

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