Si Min Zhang | Karolinska Institutet

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Articles

Article: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 2024;:1-6
The N-terminal SAM domain of the dNTPase SAMHD1 is not required for inhibition by small molecule TH6342
Dirks C; Bwanika HC; Jemth A-S; Zhang SM; Rudd SG
Article: ISCIENCE. 2024;27(2):108907
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
Zhang SM; Paulin CBJ; Shu H; Yagu-Capilla M; Michel M; Marttila P; Ortis F; Bwanika HC; Dirks C; Venkatram RP; Wiita E; Jemth A-S; Almlof I; Loseva O; Hormann FM; Koolmeister T; Linde E; Lee S; Llona-Minguez S; Haraldsson M; Axelsson H; Stromberg K; Homan EJ; Scobie M; Lundback T; Helleday T; Rudd SG
Article: NATURE CANCER. 2022;3(2):156-172
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Bonagas N; Gustafsson NMS; Henriksson M; Marttila P; Gustafsson R; Wiita E; Borhade S; Green AC; Vallin KSA; Sarno A; Svensson R; Gokturk C; Pham T; Jemth A-S; Loseva O; Cookson V; Kiweler N; Sandberg L; Rasti A; Unterlass JE; Haraldsson M; Andersson Y; Scaletti ER; Bengtsson C; Paulin CBJ; Sanjiv K; Abdurakhmanov E; Pudelko L; Kunz B; Desroses M; Iliev P; Farnegardh K; Kramer A; Garg N; Michel M; Haggblad S; Jarvius M; Kalderen C; Jensen AB; Almlof I; Karsten S; Zhang SM; Haggblad M; Eriksson A; Liu J; Glinghammar B; Nekhotiaeva N; Klingegard F; Koolmeister T; Martens U; Llona-Minguez S; Moulson R; Nordstrom H; Parrow V; Dahllund L; Sjoberg B; Vargas IL; Vo DD; Wannberg J; Knapp S; Krokan HE; Arvidsson PI; Scobie M; Meiser J; Stenmark P; Berglund UW; Homan EJ; Helleday T
Article: CELL CHEMICAL BIOLOGY. 2021;28(12):1693-1702.e6
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
Zhang SM; Rehling D; Jemth A-S; Throup A; Landazuri N; Almlof I; Gottmann M; Valerie NCK; Borhade SR; Wakchaure P; Page BDG; Desroses M; Homan EJ; Scobie M; Rudd SG; Berglund UW; Soderberg-Naucler C; Stenmark P; Helleday T
Article: CELL DEATH & DISEASE. 2021;12(7):709
Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells
Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
Article: BMC RESEARCH NOTES. 2021;14(1):27
Drug synergy scoring using minimal dose response matrices
Makela P; Zhang SM; Rudd SG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2021;296:100568
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity
Rehling D; Zhang SM; Jemth A-S; Koolmeister T; Throup A; Wallner O; Scaletti E; Moriyama T; Nishii R; Davies J; Desroses M; Rudd SG; Scobie M; Homan E; Berglund UW; Yang JJ; Helleday T; Stenmark P
Article: NATURE CHEMICAL BIOLOGY. 2020;16(10):1120-1128
Development of a chemical probe against NUDT15
Zhang SM; Desroses M; Hagenkort A; Valerie NCK; Rehling D; Carter M; Wallner O; Koolmeister T; Throup A; Jemth A-S; Almlof I; Loseva O; Lundback T; Axelsson H; Regmi S; Sarno A; Kraemer A; Pudelko L; Brautigam L; Rasti A; Gottmann M; Wiita E; Kutzner J; Schaller T; Kalderen C; Cazares-Korner A; Page BDG; Krimpenfort R; Eshtad S; Altun M; Rudd SG; Knapp S; Scobie M; Homan EJ; Berglund UW; Stenmark P; Helleday T
Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy
Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CBJ; Sandhow L; Kutzner J; Myrberg IH; Bunten SS; Axelsson H; Zhang SM; Rasti A; Makela P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtio J; Rassidakis GZ; Tamm KP; Warpman-Berglund U; Heyman M; Grander D; Lehmann S; Lundback T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2018;101:103-112
Identification and application of self-binding zipper-like sequences in SARS-CoV spike protein
Zhang SM; Liao Y; Neo TL; Lu Y; Liu DX; Vahlne A; Tam JP
Article: BIOCHEMISTRY. 2015;54(9):1819-1830
Tryptophan-Dependent Membrane Interaction and Heteromerization with the Internal Fusion Peptide by the Membrane Proximal External Region of SARS-CoV Spike Protein
Liao Y; Zhang SM; Neo TL; Tam JP
Article: PLOS ONE. 2015;10(7):e0134851
Membrane-Active Sequences within gp41 Membrane Proximal External Region (MPER) Modulate MPER-Containing Peptidyl Fusion Inhibitor Activity and the Biosynthesis of HIV-1 Structural Proteins
Zhang SM; Jejcic A; Tam JP; Vahlne A

All other publications

Preprint: BIORXIV. 2023
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1viaa comprehensive screening funnel
Zhang SM; Paulin CBJ; Michel M; Marttila P; Yagüe-Capilla M; Bwanika HC; Shu H; Vekatram RP; Wiita E; Jemth A-S; Almlöf I; Loseva O; Ortis F; Dirks C; Koolmeister T; Linde E; Lee S; Llona-Minguez S; Haraldsson M; Strömberg K; Homan E; Scobie M; Lundbäck T; Helleday T; Rudd S
Preprint: BIORXIV. 2022
Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM
Valerie NCK; Sanjiv K; Mortusewicz O; Zhang SM; Alam S; Pires M; Stigsdotter H; Rasti A; Langelier M-F; Langelier M-F; Rehling D; Throup A; Desroses M; Onireti J; Wakchaure P; Almlöf I; Boström J; Bevc L; Benzi G; Stenmark P; Pascal J; Helleday T; Page BDG; Altun M
Corrigendum: CELL DEATH & DISEASE. 2022;13(8):672
Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells (vol 12, 709, 2021)
Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
Preprint: BIORXIV. 2020
Drug synergy scoring using minimal dose response matrices
Mäkelä P; Zhang SM; Rudd S
Preprint: BIORXIV. 2020
SAMHD1 promotes oncogene-induced replication stress
Zhang SM; Calderón-Montaño J; Rudd S
Thesis / dissertation: 2015
Interaction-mediating sequences within class I viral fusion glycoproteins : their roles in viral infection and in applications
Zhang, Simin

Selected grants

Targeting host nucleotide metabolism for personalized antimetabolite therapies
Åke Wibergs Stiftelse
1 January 2023

Grants

Stiftelsen Clas Groschinskys Minnesfond
1 January 2024
Targeting host nucleotide metabolism for personalized antimetabolite therapies
Stiftelsen Lars Hiertas Minne
1 January 2023
Stiftelsen Clas Groschinskys Minnesfond
1 January 2023
Exploiting nucleotide metabolism for improved leukemia therapy
Felix Mindus contribution to Leukemia Research
1 January 2022
Targeting nucleotide-sanitizing enzymes to improve antiviral therapies
KI Foundation for Virus Research
1 January 2022
Overcoming drug resistance in acute leukaemias with SAMHD1 inhibitors
Dr Åke Olsson Foundation for Hematological Research
1 January 2022
Understanding and exploiting drug resistance in cancer among elderly - targeting nucleotide-metabolizing enzymes SAMHD1 and NUDT15
Loo and Hans Osterman Foundation for Medical Research
1 January 2022
Targeting host nucleotide metabolism for personalized antimetabolite therapies
Åke Wibergs Stiftelse
1 January 2022
Understanding and exploiting drug resistance in cancer - targeting the dNTPase SAMHD1
KID - partial funding to doctoral students at Karolinska Institutet
1 January 2021
Targeting nucleotide-sanitizing enzymes to improve treatment of hematological malignancies
Felix Mindus contribution to Leukemia Research
1 January 2020
Targeting nucleotide-sanitizing enzymes to improve antiviral therapies
KI Foundation for Virus Research
1 January 2020
Targeting nucleotide-sanitizing enzymes to improve treatment of hematological malignancies
Felix Mindus contribution to Leukemia Research
1 January 2019

Employments

Research Specialist, Department of Oncology-Pathology, Karolinska Institutet, 2023-
Postdoctoral Researcher, Department of Oncology-Pathology, Karolinska Institutet, 2019-2023

Degrees and Education

Doctor Of Philosophy, Biomedical Science, Interaction-mediating sequences within Class I viral fusion glycoproteins: their roles in viral infection and in applications, School of Biological Sciences, Nanyang Technological University, 2016
Degree Of Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2015

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