Shi Yong Neo

About me
Publications
CV
Public outreach and news

About me

I am a postdoctoral fellow working in the Singapore Immunology Network which is a research institute within the Agency for Science, Technology and Research (A*STAR). Since 2021 after graduating from Karolinska Institute, I continue to hold an affiliated research appointment to work closely with like-minded immune oncologists and foster cross-institutional collaborations

Education
Doctoral degree in Medical Sciences, Karolinska Institute, Sweden
Bachelors with First class honours in Biological Sciences, Nanyang
Technological University, Singapore

Research

Mapping Immune Landscape across multiple solid tumours including Sarcoma,
breast cancer, renal cell carcinoma, hepatocellular carcinoma and ovarian
cancer.
Development of Patient-derived organoid models for immune and metabolism
studies

Articles

Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(747):eadi2952
Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis
Neo SY; Tong L; Chong J; Liu Y; Jing X; Oliveira MMS; Chen Y; Chen Z; Lee K; Burduli N; Chen X; Gao J; Ma R; Lim JP; Huo J; Xu S; Alici E; Wickstrom SL; Haglund F; Hartman J; Wagner AK; Cao Y; Kiessling R; Lam KP; Westerberg LS; Lundqvist A
Article: JOURNAL OF EXPERIMENTAL AND CLINICAL CANCER RESEARCH. 2024;43(1):13
Natural killer cells drive 4-1BBL positive uveal melanoma towards EMT and metastatic disease
Neo SY; Oliveira MMS; Tong L; Chen Y; Chen Z; Cismas S; Burduli N; Malmerfelt A; Teo JKH; Lam K-P; Alici E; Girnita L; Wagner AK; Westerberg LS; Lundqvist A
Article: ONCOIMMUNOLOGY. 2023;12(1):2175517
CD25^bright NK cells display superior function and metabolic activity under regulatory T cell-mediated suppression
Chen Z; Tong L; Neo SY; Li S; Gao J; Schlisio S; Lundqvist A
Journal article: MOLECULAR CANCER RESEARCH. 2023;21(12):1288-1302
Competing Engagement of β-arrestin Isoforms Balances IGF1R/p53 Signaling and Controls Melanoma Cell Chemotherapeutic Responsiveness
Cismas S; Pasca S; Crudden C; Drakensjo IT; Suleymanova N; Zhang S; Gebhard B; Song D; Neo S; Shibano T; Smith TJ; Calin GA; Girnita A; Girnita L
Journal article: AGING. 2023;15(13):6380-6399
DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway.
Sun C; Wen K; Zhang B; Dong Y; Chen C; Neo S-Y; Leng B; Gao T-T; Wu J
Journal article: BIOLOGY. 2023;12(4):597
Mitochondrial Dysfunction in CD4+ T Effector Memory RA+ Cells.
Strickland M; Lee S; Neo SY; Balachander A; Low I; Mustafah S; Goh WI; Wright GD; Larbi A; Pender SLF
Journal article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2023;11(4):e006434
Harnessing novel strategies and cell types to overcome immune tolerance during adoptive cell therapy in cancer
Neo SY; Xu S; Chong J; Lam K-P; Wu J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(1):e2209856120
Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction
Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Min ATH; Lovrot J; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
Journal article: FRONTIERS IN PHARMACOLOGY. 2023;14:1163160
Unravelling the role of obesity and lipids during tumor progression
Zhao J; Lee K; Toh HC; Lam KP; Neo SY
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(10):e005308
Tumor MHC class I expression alters cancer-associated myelopoiesis driven by host NK cells
Neo SY; Jing X; Tong L; Tong D; Gao J; Chen Z; De Los Santos MC; Burduli N; Ferreira SDS; Wagner AK; Alici E; Rolny C; Cao Y; Lundqvist A
Article: JOURNAL OF EXPERIMENTAL AND CLINICAL CANCER RESEARCH. 2022;41(1):173
GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma
Fang Z; Zhang N; Yuan X; Xing X; Li X; Qin X; Liu Z; Neo S; Liu C; Kong F; Bjorkholm M; Fan Y; Xu D
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(5):e004592
A_2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
Tay AHM; Prieto-Diaz R; Neo S; Tong L; Chen X; Carannante V; Onfelt B; Hartman J; Haglund F; Majellaro M; Azuaje J; Garcia-Mera X; Brea JM; Loza MI; Jespers W; Gutierrez-de-Teran H; Sotelo E; Lundqvist A
Article: CANCERS. 2022;14(6):1385
Downregulation and Hypermethylation of GABPB1 Is Associated with Aggressive Thyroid Cancer Features
Xing X; Mu N; Yuan X; Wang N; Juhlin CC; Straat K; Larsson C; Neo SY; Xu D
Article: CANCERS. 2021;13(5):1175
CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma
Su Y; Tsagkozis P; Papakonstantinou A; Tobin NP; Gultekin O; Malmerfelt A; Ingelshed K; Neo SY; Lundquist J; Chaabane W; Nisancioglu MH; Leiss LW; Ostman A; Bergh J; Sedimbi S; Lehti K; Lundqvist A; Stragliotto CL; Haglund F; Ehnman M
Article: EMBO REPORTS. 2021;22(3):e51329
Phosphodiesterase 4A confers resistance to PGE2-mediated suppression in CD25⁺/CD54⁺ NK cells
Chen Z; Yang Y; Neo SY; Shi H; Chen Y; Wagner AK; Larsson K; Tong L; Jakobsson P-J; Alici E; Wu J; Cao Y; Wang K; Liu LL; Mao Y; Sarhan D; Lundqvist A
Journal article: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES. 2021;17(14):3968-3980
Long non-coding RNA MEG3 promotes cisplatin- induced nephrotoxicity through regulating AKT/TSC/ mTOR-mediated
Jing X; Han J; Zhang J; Chen Y; Yuan J; Wang J; Neo S; Li S; Yu X; Wu J
Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(10):5508-5522
Thioredoxin activity confers resistance against oxidative stress in tumor-infiltrating NK cells
Yang Y; Neo SY; Chen Z; Cui W; Chen Y; Guo M; Wang Y; Xu H; Kurzay A; Alici E; Holmgren L; Haglund F; Wang K; Lundqvist A
Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(3):1185-1198
CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment
Neo SY; Yang Y; Record J; Ma R; Chen X; Chen Z; Tobin NP; Blake E; Seitz C; Thomas R; Wagner AK; Andersson J; de Boniface J; Bergh J; Murray S; Alici E; Childs R; Johansson M; Westerberg LS; Haglund F; Hartman J; Lundqvist A
Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2020;1231:45-51
The Multifaceted Roles of CXCL9 Within the Tumor Microenvironment
Neo SY; Lundqvist A
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1913:49-65
Immune Monitoring of Cancer Patients by Multi-color Flow Cytometry.
Neo SY; O'Reilly A; Pico de Coaña Y
Article: BMC GENOMICS. 2016;17:452
Local transmission and global dissemination of New Delhi Metallo-Beta-Lactamase (NDM): a whole genome analysis
Khong WX; Xia E; Marimuthu K; Xu W; Teo Y-Y; Tan EL; Neo S; Krishnan PU; Ang BSP; Lye DCB; Chow ALP; Ong RT-H; Ng OT
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All other publications

Letter: CANCER COMMUNICATIONS. 2023;43(7):855-859
Renal cell carcinoma escapes NK cell-mediated immune surveillance through the downregulation of DNAM-1
Tong L; Kremer V; Neo SY; Liu Y; Chen Y; Wagner AK; Yang Y; Chen Z; Seitz C; Tobin NP; Ligtenberg MA; Alici E; Chen X; Haglund F; Seliger B; Harmenberg U; Colon E; Plogell A-HS; Liu LL; Lundqvist A
Thesis / dissertation: 2021
Uniquely NK cells : the multifaceted roles of the natural killers
Neo, Shiyong
Review: CANCER AND METASTASIS REVIEWS. 2012;31(3-4):763-778
Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment
Ito K; Stannard K; Gabutero E; Clark AM; Neo S-Y; Onturk S; Blanchard H; Ralph SJ

Employments

Affiliated to Research, Department of Oncology-Pathology, Karolinska Institutet, 2022-2025

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Oncology-Pathology, Karolinska Institutet, 2021

About me

Research

Articles

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Degrees and Education

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