Shaohua Xie
Principal Researcher
| Docent
E-mail: shaohua.xie@ki.se
Visiting address: Nobels väg 7, 17165 Solna
Postal address: K1 Molekylär medicin och kirurgi, K1 MMK Övre GI-kirurgi, 171 77 Stockholm
About me
- Shaohua Xie is Principal Researcher and /Docent /in Cancer Epidemiology
working in the research group of Upper Gastrointestinal Surgery, Department
of Molecular Medicine and Surgery.
Shaohua Xie is member of the Reference Group for International Affairs of
Karolinska Institutet and has been mainly involved in alumni activities.
*Grants*
Cancerfonden (Swedish Cancer Society), 2020-2022, 1 800 000 SEK (Principle
investigator)
Clinical Scientist Training Programme (CSTP), 2018-2022, 1 280 000 SEK (Main
applicant as a PhD supervisor)
Ihred Fund, the Swedish Society of Medicine, 2016-2020, 505 000 SEK
(Principle investigator)
Ruth and Richard Julin Foundation, 2016-2021, 700 000 SEK (Principle
investigator)
KI Research Foundation Grant, 2016-2020, 132 200 SEK (Principle
investigator)
Research environment grant within register-based research, Swedish Research
Council, 2019 - 2023, 13 000 000 SEK (Co-investigator)
Cancer Research UK, 2018 - 2020, 161, 138 GBP (Co-investigator)
China - Sweden Network Grant for Research Collaboration, the Swedish Research
Council, 2016 - 2017, 700 000 SEK (Co-investigator)
National Natural Science Foundation of China, 2011 - 2013, 370, 000 CNY - 2012
- 2013, 160, 000 CNY - 2014 - 2017, 700, 000 CNY (Co-investigator)
*Other Awards*
Tongji Medical College Overseas Alumni Association - Sehngquan Zou
Outstanding Clinical
Junior Research Award (2020)
Global Scholarship Program for Research Excellence - CNOOC Grants and trained
at Harvard School of Public Health in 2012, 30 000 HKD
Research Postgraduate Students' Research / Conference Grant, The Jockey Club
School of Public Health and Primary Care, The Chinese University of Hong
Kong, 2009-2013 , 40 000 HKD
2013 PhD in Public Health, The Chinese University of Hong Kong, Hong
Kong SAR, China
*Thesis title: *Domestic Incense Burning and the Risk of Nasopharyngeal
Carcinoma: A Case-Referent Study among Hong Kong Chinese
*Supervisors:* Prof. Ignatius Tak-sun Yu (main supervisor) & - Prof. Shelly
Lap-Ah Tse
2007 Bachelor of Medicine in Preventive Medicine (major), Huazhong
University of Science and Technology, Wuhan, China
2007 Bachelor of Arts in English (minor), Huazhong University of
Science and Technology, Wuhan, China
*Other trainings*
2020.11 - 2021.06 Professional Certificate in
Pharmacoepidemiology & - Pharmacovigilance, London School of Hygiene &
- Tropical
Medicine
2012.03 - 2012.06 Visiting Scientist at Harvard School of Public
Health, Boston, USA (Hosted by Prof. Alex Chensheng Lu)
2009.04 Yale - China CDC Workshop on
Environmental Epidemiology, Suzhou, China
Research
- My research interests focus on cancer epidemiology. I am currently
working on the epidemiology of upper gastrointestinal cancers, particularly
that of esophageal adenocarcinoma.
I am also interested in the epidemiology of other types of cancers
and environmental health issues.
*Trends and Disparities in Oesophageal and Gastric Cancers*
I have been interested in the time trends and disparities across regions and
social groups in oesophageal and gastric cancers. We have assessed the time
trends in the incidence of these cancer in Sweden and in other parts of the
world (*/Cancer Epidemol/* 2016, 2017 - */Int J Cancer/* 2017
- */Clin
Epidemiol/* 2018 - */Acta Oncol/* 2018). We have reviewed existing literature
on the social group disparities in the incidence and prognosis of oesophageal
cancer (*/United European Gastroenterol J/* 2018). Our recent study found
considerable geographic disparities in the incidence and tumour stage
distribution of oesophageal cancer in Sweden (*/Scand J Gastroenterol/*
2020). We also finished quantitative analyses of the racial/ethnic
disparities in the incidence of oesophageal and gastric cancers in the United
States, using a panel of health disparity measures (*/Am J Epidemiol/*
2017 - */ Cancer Res Treat/* 2019).
*The Mysterious Male Predominance in Oesophageal Adenocarcinoma*
Oesophageal adenocarcinoma is characterised by a marked and enigmatic sex
difference in incidence, with the male-to-female incidence ratio as high as
8-to-1 in Northern America and 6-to-1 in Europe. Sex hormonal factors may
play a role in the development of this cancer. I have summarised the existing
evidence on this topic in my review article (*/Clin Gastroenterol Hepatol/*
2016). My research has been focused on disentangling this mysterious male
predominance in oesophageal adenocarcinoma and the role of sex hormonal
exposures, with different epidemiological approaches. Particularly, in a
case-control study nested in a prospective Norwegian cohort and a
meta-analysis of existing studies, we found a decreased risk of oesophageal
adenocarcinoma associated with higher testosterone levels in men (*/Am J
Gastroenterol/* 2020). Our Mendelian randomisation analysis revealed causal
effects of follicle-stimulating hormone and luteinising hormone on the risk
of oesophageal adenocarcinoma (*/Clin Gastroenterol Hepatol/* 2020).
*Diabetes and Metformin Use in Relation to Oesophageal and Gastric Cancers*
Diabetes and common anti-diabetes medications may influence the risk and
prognosis of cancer. We are particularly interested in the role of diabetes
and use the first-line anti-diabetes drug metformin in oesophageal and
gastric cancers. We have examined the association how diabetes influence the
risk and prognosis of gastric adenocarcinoma in population-based cohorts in
Sweden (*/Br J Surg/* 2018 - */Br J Cancer/* 2019). To investigate common
medications in relation to cancer risk and other health outcomes, we have
established a nationwide cohort of 8.4 million users of selected common
medications, using data from several health data registers in Sweden */(BMJ
Open/* 2019). We have found that metformin use may decrease risk of
oesophageal squamous cell carcinoma but not gastric cancer (*/Br J Cancer/*
2019 - */Am J Gastroenterol/* 2020).
*Precision Prevention of Oesophageal Cancer*
Oesophageal cancer carries a poor prognosis, with an overall 5-year survival
below 15-20%. Upper endoscopy is increasingly utilized for detection of the
premalignant conditions which might improve survival. However, a universal
screening strategy is not feasible given the considerable costs and risk of
complications, and the low incidence of oesophageal cancer. Identifying a
limited group of individuals at high absolute risk of oesophageal cancer for
endoscopic screening would be more favourable. We have been developing and
validating risk prediction models for oesophageal cancer based on information
on a panel of readily identifiable risk factors, and evaluating the
feasibility of targeted screening based on individual risk assessment (*/Int
J Cancer/* 2016 - */Epidemiology/* 2017
- */Am J Gastroenterol/* 2018
- */Clin
Gastroenterol Hepatol/* 2018 - */Gastrointest Endosc/* 2018
*/Gastroenterology/* 2019- */Am J Gastroenterol /*2020.). We have also
developed a model predicting long-term survival in patients who have
undergone oesophageal cancer surgery (*/Ann Surg/* 2021).
Successful prevention of oesophageal cancer is dependent on availability of
effective preventive measures or interventions. In a systematic review and
meta-analysis of 52 studies, we have found that smoking cessation
time-dependently decreases risk of oesophageal squamous cell carcinoma, but
has limited influence on the risk of oesophageal adenocarcinoma (*/J Natl
Cancer Inst /*2017).
"*Oesophageal Adenocarcinoma Risk Assessment Tool*" and "*Prediction of
survival after esophageal cancer surgery*" are available through the links on
the left.
Teaching
- *Supervision*
I am currently main supervisor of a PhD student, Sirus Rabbani, in our
research group.
I was co-supervisor of two PhD candidate, Drs. Jiaojiao Zheng and Qiaoli
Wang, who successfully defended her thesis in 2021 and 2020, respectively, at
Karolinska Institutet.
*I warmly welcome medical and master students to carry out their degree
projects with me. *Medical students who worked with me have authored
publications in scientific journals, including Am J Gastroenterol and Am J
Epidemiol.
*Courses*
Study design in clinical research (KI PhD course 2980, previously 1794)
Articles
-
Article: GASTROENTEROLOGY. 2024;167(3):485-492.e3
-
Article: ANNALS OF SURGICAL ONCOLOGY. 2024;:1-10
-
Article: CANCER MEDICINE. 2023;12(21):20544-20553
-
Article: JOURNAL OF GASTROENTEROLOGY. 2023;58(8):734-740
-
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2023;58(5):453-459
-
Article: ACTA ONCOLOGICA. 2023;62(5):438-443
-
Article: INTERNATIONAL JOURNAL OF SURGERY. 2023;109(5):1141-1148
-
Article: SCIENTIFIC REPORTS. 2023;13(1):6955
-
Article: JOURNAL OF GASTROENTEROLOGY. 2022;57(12):942-951
-
Article: CARDIOVASCULAR DRUGS AND THERAPY. 2022;36(6):1121-1128
-
Article: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY. 2022;34(11):1116-1120
-
Article: BRITISH JOURNAL OF CANCER. 2022;127(5):892-897
-
Article: GASTRIC CANCER. 2022;25(3):652-658
-
Article: BRITISH JOURNAL OF CANCER. 2022;126(1):129-133
-
Article: BRITISH JOURNAL OF CANCER. 2021;125(2):277-283
-
Article: ANNALS OF SURGERY. 2021;273(5):933-939
-
Article: BMJ OPEN. 2021;11(4):e042762
-
Article: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2021;116(4):683-691
-
Article: INTERNATIONAL JOURNAL OF CANCER. 2021;148(4):905-913
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Article: CANCERS. 2021;13(1):E141-141
-
Article: BMC GASTROENTEROLOGY. 2020;20(1):418
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Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2020;18(12):2701-2709.e3
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Article: CANCER SCIENCE. 2020;111(7):2451-2459
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Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2020;55(3):258-264
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Article: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2020;115(2):216-223
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Article: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2020;115(1):73-78
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Article: BRITISH JOURNAL OF CANCER. 2019;121(10):877-882
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Article: MICROORGANISMS. 2019;7(10):E461-461
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Article: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2019;50(2):159-166
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Article: BRITISH JOURNAL OF CANCER. 2019;120(12):1147-1152
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Article: CANCER RESEARCH AND TREATMENT. 2019;51(2):519-529
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Article: GASTROINTESTINAL ENDOSCOPY. 2019;89(4):726-732.e2
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Article: BMJ OPEN. 2019;9(1):e023155
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Article: GASTROENTEROLOGY. 2019;156(1):43-45
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Article: BRITISH JOURNAL OF SURGERY. 2018;105(13):1799-1806
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Article: BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY. 2018;36-37:3-8
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Article: ACTA ONCOLOGICA. 2018;57(9):1173-1178
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Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2018;16(8):1229-1236.e4
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Article: CANCER COMMUNICATIONS. 2018;38(1):42-10
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Article: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2018;113(6):829-835
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Article: GASTROENTEROLOGY. 2018;154(2):390-405
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Article: CLINICAL EPIDEMIOLOGY. 2018;10:717-728
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Article: PLOS ONE. 2018;13(5):e0196989
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Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2017;186(12):1341-1351
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Article: INTERNATIONAL JOURNAL OF CANCER. 2017;141(10):1981-1986
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Article: ONCOTARGET. 2017;8(40):68131-68137
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Article: ONCOTARGET. 2017;8(31):51800-51809
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Article: INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH. 2017;90(5):443-449
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Article: ONCOTARGET. 2017;8(21):34727-34735
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Article: SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH. 2017;43(3):226-233
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Article: CANCER EPIDEMIOLOGY. 2017;47:114-117
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Article: STEROIDS. 2017;118:47-54
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Article: INTERNATIONAL JOURNAL OF CANCER. 2017;140(3):636-645
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Article: CANCER EPIDEMIOLOGY. 2016;44:71-76
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Article: ONCOTARGET. 2016;7(25):38876-38883
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Article: INTERNATIONAL JOURNAL OF CANCER. 2016;138(12):2813-2819
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Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2016;14(3):338-347.e1
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Article: TRAFFIC INJURY PREVENTION. 2016;17(1):39-43
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Article: CANCER CAUSES & CONTROL. 2015;26(6):913-921
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Article: BMC CANCER. 2014;14:975
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Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2014;55(9):751-756
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Article: OBESITY REVIEWS. 2014;15(9):709-720
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Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2014;122(7):741-746
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Article: INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH. 2013;86(4):431-440
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Article: ENVIRONMENT INTERNATIONAL. 2013;54:134-140
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Article: ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2013;47(4):2018-2025
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Article: EUROPEAN JOURNAL OF CANCER. 2013;49(1):150-155
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Article: ACCIDENT ANALYSIS AND PREVENTION. 2012;48:457-463
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Article: CANCER EPIDEMIOLOGY. 2012;36(1):8-10
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Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2012;416:105-110
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Article: ENVIRONMENTAL RESEARCH. 2011;111(2):295-300
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Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2010;51(3):229-235
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Article: TOXICOLOGY LETTERS. 2009;189(2):91-95
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Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2009;675(1-2):71-76
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Article: LIFE SCIENCE JOURNAL. 2009;6(2):33-39
- Show more
All other publications
-
Editorial comment: ANNALS OF SURGICAL ONCOLOGY. 2024;:1-2
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Review: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2023;32(7):936-946
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Corrigendum: BRITISH JOURNAL OF CANCER. 2022;126(7):1109
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Review: BRITISH JOURNAL OF CANCER. 2022;126(7):1100-1107
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Letter: ALLERGY. 2021;76(5):1559-1562
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Review: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2020;29(11):2109-2118
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Review: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2018;1434(1):227-238
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Review: UNITED EUROPEAN GASTROENTEROLOGY JOURNAL. 2018;6(3):343-348
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Review: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2017;109(12):djx115
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Review: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2017;26(9):1381-1390
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Review: BRITISH JOURNAL OF SURGERY. 2017;104(9):1131-1140
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Review: DRUG SAFETY. 2017;40(4):285-292
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Letter: EPIDEMIOLOGY. 2017;28(2):e11-e12
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Letter: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION. 2015;15(24):11001
Employments
- Principal Researcher, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2020
Supervisor
- Jiaojiao Zheng, Diabetes, metformin and gastric adenocarcinoma, 2017