Shane Wright

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About me

Shane C. Wright is a postdoctoral researcher supported by the Swedish
Society for Medical Research at the Department of Physiology and
Pharmacology. He has a background in cell and molecular biology and receptor
pharmacology from the University of Toronto (HBSc), the Université Paris VI
(MSc) and Karolinska Institutet (PhD
supervisor: Prof. Gunnar Schulte).
Shane received postdoctoral training at the Institute for Research in
Immunology and Cancer, Université de Montréal (supervisor: Prof. Michel
Bouvier) and has since returned to Karolinska Institutet as a senior
postdoctoral fellow under the supervision of Prof. Volker Lauschke.
Postdoctoral fellow (Personalized medicine and drug development) – Karolinska Institutet (2020 – Present)
Postdoctoral fellow (Biochemistry and Molecular Medicine) – Université de
Montréal (2019 – 2020)
Doctor of Philosophy (Receptor biology and signaling) – Karolinska
Institutet (2013 – 2019)
Master of Science (Cellular and Molecular Biology) – Université Paris VI
(2010 – 2012)
Honours Bachelor of Science (Life sciences) – University of Toronto
(2005 – 2010)

Research

Shane's research focuses on better understanding the action of drugs on
receptors known as G protein-coupled receptors (GPCRs). Emerging concepts in
receptor pharmacology such as functional selectivity and subcellular
signaling have so far not been explored in the context of drug discovery.
Employing a biosensor-based approach to map signaling events in fine detail
holds great promise for our understanding of drug efficacy and side effects.
Combining these tools with patient-derived material will provide much needed
insight into the individual variability of patients and the potential for
offering better treatments in the future.

Articles

Article: MOLECULAR THERAPY. 2024;32(9):3012-3024
Discovery of a novel inhibitor of macropinocytosis with antiviral activity
Porebski B; Christ W; Corman A; Haraldsson M; Barz M; Lidemalm L; Haggblad M; Ilmain J; Wright SC; Murga M; Schlegel J; Jarvius M; Lapins M; Sezgin E; Bhabha G; Lauschke VM; Carreras-Puigvert J; Lafarga M; Klingstrom J; Huhn D; Fernandez-Capetillo O
Article: MOLECULAR METABOLISM. 2024;85:101931
The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis
Talamonti E; Davegardh J; Kalinovich A; van Beek SMM; Dehvari N; Halleskog C; Bokhari HM; Hutchinson DS; Ham S; Humphrys LJ; Dijon NC; Motso A; Sandstrom A; Zacharewicz E; Mutule I; Suna E; Spura J; Ditrychova K; Stoddart LA; Holliday ND; Wright SC; Lauschke VM; Nielsen S; Scheele C; Cheesman E; Hoeks J; Molenaar P; Summers RJ; Pelcman B; Yakala GK; Bengtsson T
Article: NATURE METABOLISM. 2024;6(7):1268-1281
Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes
Kizilkaya HS; Sorensen KV; Madsen JS; Lindquist P; Douros JD; Bork-Jensen J; Berghella A; Gerlach PA; Gasbjerg LS; Mokrosinski J; Mowery SA; Knerr PJ; Finan B; Campbell JE; D'Alessio DA; Perez-Tilve D; Faas F; Mathiasen S; Rungby J; Sorensen HT; Vaag A; Nielsen JS; Holm J-C; Lauenborg J; Damm P; Pedersen O; Linneberg A; Hartmann B; Holst JJ; Hansen T; Wright SC; Lauschke VM; Grarup N; Hauser AS; Rosenkilde MM
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2024
Altered desensitization and internalization patterns of rodent versus human glucose-dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge
Gasbjerg LS; Rasmussen RS; Dragan A; Lindquist P; Melchiorsen JU; Stepniewski TM; Schiellerup S; Tordrup EK; Gadgaard S; Kizilkaya HS; Willems S; Zhong Y; Wang Y; Wright SC; Lauschke VM; Hartmann B; Holst JJ; Selent J; Rosenkilde MM
Article: SCIENCE SIGNALING. 2024;17(841):eadi4747
Conformation- and activation-based BRET sensors differentially report on GPCR-G protein coupling
Wright SC; Avet C; Gaitonde SA; Muneta-Arrate I; Le Gouill C; Hogue M; Breton B; Koutsilieri S; Alarcia RD; Heroux M; Lauschke VM; Bouvier M
Article: NATURE MICROBIOLOGY. 2024;9(5):1499-1512
Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells
Monteil VM; Wright SC; Dyczynski M; Kellner MJ; Appelberg S; Platzer SW; Ibrahim A; Kwon H; Pittarokoilis I; Mirandola M; Michlits G; Devignot S; Elder E; Abdurahman S; Bereczky S; Bagci B; Youhanna S; Aastrup T; Lauschke VM; Salata C; Elaldi N; Weber F; Monserrat N; Hawman DW; Feldmann H; Horn M; Penninger JM; Mirazimi A
Article: NATURE COMMUNICATIONS. 2023;14(1):6243
GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics
Wright SC; Motso A; Koutsilieri S; Beusch CM; Sabatier P; Berghella A; Blondel-Tepaz E; Mangenot K; Pittarokoilis I; Sismanoglou D-C; Le Gouill C; Olsen JV; Zubarev RA; Lambert NA; Hauser AS; Bouvier M; Lauschke VM
Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2021;2021(3)
Class Frizzled GPCRs in GtoPdb v.2021.3
Arthofer E; Dijksterhuis J; Hot B; Kozielewicz P; Lauth M; Olofsson J; Petersen J; Polonio T; Schulte G; Strakova K; Valnohova J; Wright S
Article: CURRENT OPINION IN STRUCTURAL BIOLOGY. 2021;69:142-149
Illuminating the complexity of GPCR pathway selectivity - advances in biosensor development
Wright SC; Bouvier M
Article: CURRENT OPINION IN PHARMACOLOGY. 2021;59:11-18
Organotypic human ex vivo models for coronavirus disease 2019 research and drug development
Youhanna S; Wright SC; Lauschke VM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(20):e2025846118
BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated Gq activation at early endosomes
Wright SC; Lukasheva V; Le Gouill C; Kobayashi H; Breton B; Mailhot-Larouche S; Blondel-Tepaz E; Vieira NA; Costa-Neto C; Heroux M; Lambert NA; Parreiras-e-Silva LT; Bouvier M
Article: BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH. 2020;1867(12):118849
Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis
Sundqvist M; Holdfeldt A; Wright SC; Moller TC; Siaw E; Jennbacken K; Franzyk H; Bouvier M; Dahlgren C; Forsman H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(35):21723-21730
Agonist-induced formation of unproductive receptor-G₁₂ complexes
Okashah N; Wright SC; Kawakami K; Mathiasen S; Zhou J; Lu S; Javitch JA; Inoue A; Bouvier M; Lambert NA
Article: NATURE COMMUNICATIONS. 2019;10(1):667
A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection
Wright SC; Kozielewicz P; Kowalski-Jahn M; Petersen J; Bowin C-F; Slodkowicz G; Marti-Solano M; Rodriguez D; Hot B; Okashah N; Strakova K; Valnohova J; Babu MM; Lambert NA; Carlsson J; Schulte G
Article: SCIENCE SIGNALING. 2018;11(559):eaar5536
FZD₅ is a Gα_q-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs
Wright SC; Canizal MCA; Benkel T; Simon K; Le Gouill C; Matricon P; Namkung Y; Lukasheva V; Koenig GM; Laporte SA; Carlsson J; Kostenis E; Bouvier M; Schulte G; Hoffmann C
Article: NATURE COMMUNICATIONS. 2017;8(1):226
Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling
Petersen J; Wright SC; Rodriguez D; Matricon P; Lahav N; Vromen A; Friedler A; Stromqvist J; Wennmalm S; Carlsson J; Schulte G

All other publications

Preprint: BIORXIV. 2024
Downregulation of NR4A3 during inactivity alters glucose metabolism and impairs translation in human skeletal muscle
Smith JAB; Gabriel B; Abdelmoez A; Savikj M; Wright S; Koutsilieri S; Barrès R; Lauschke V; Krook A; Zierath J; Pillon N
Preprint: BIORXIV. 2023
Discovery of a novel inhibitor of macropinocytosis with antiviral activity
Porebski B; Christ W; Corman A; Haraldsson M; Barz M; Lidemalm L; Häggblad M; Ilmain J; Wright S; Murga M; Shlegel J; Sezgin E; Bhabha G; Lauschke V; Lafarga M; Klingström J; Huhn D; Fernandez-Capetillo O
Editorial comment: JOURNAL OF PHYSIOLOGY. 2023;601(8):1317-1318
Rewiring of catecholamine-induced calcium signalling is an early event in non-alcoholic fatty liver disease
Wright SC; Lauschke VM
Letter: CELL RESEARCH. 2021;31(12):1311-1314
Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G_s
Xu L; Chen B; Schihada H; Wright SC; Turku A; Wu Y; Han G-W; Kowalski-Jahn M; Kozielewicz P; Bowin C-F; Zhang X; Li C; Bouvier M; Schulte G; Xu F
Preprint: BIORXIV. 2020
Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis
Sundqvist M; Holdfeldt A; Wright S; Møller T; Siaw E; Jennbacken K; Franzyk H; Bouvier M; Dahlgren C; Forsman H
Thesis / dissertation: 2018
Activation mechanisms of Class F receptors
Wright, Shane Christopher
Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2018;39(9):828-842
Frizzleds as GPCRs - More Conventional Than We Thought!
Schulte G; Wright SC

Employments

Postdoctoral Researcher, Department of Physiology and Pharmacology, Karolinska Institutet, 2021-2024

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Physiology and Pharmacology, Karolinska Institutet, 2019

About me

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Articles

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