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Research description

Seppo K Koskinen, M.D., Ph.D.

Scientific Education and Research Profile

I started my scientific work and education under the supervision of Professor Martti Kormano in 1989. In addition to practical supervision of research projects, his teaching included scientific writing, statistical methods, and planning and conducting scientific projects. Moreover, his profound understanding of integrating research and teaching has had a paramount impact on my scientific thinking. During this period that lasted until 1996, I was able to publish several clinical and basic research papers (see list of publications and my CV). Since the ultimate goal in medical research should always be to benefit the patient, I have combined basic and clinical research. This goal is reflected by the versatility of scientific production. Therefore, the selected papers (see separate list) also include less cited articles describing my experience in various areas besides main research lines.

My first line of research focused on MR imaging of patellofemoral disorders. I joined a young and innovative research group, and during a relatively short period (1990-1993) I produced eight original papers, including five clinical papers that comprise my medical dissertation.  Besides, my research included sports and exercise related injuries and studies of relaxation properties of novel MR contrast agents and tissue specificity of low-field magnetization transfer contrast imaging.

From August 1996 to July 1998 I was a post-doctoral research fellow at Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA under the supervision of Professor Ferenc Jolesz, M.D., the father of MR imaged surgery. The period enabled a deep introduction to MR imaging and image guided interventions and therapy. My main interest was kinematic musculoskeletal imaging using a novel vertically open MR scanner. This was a continuation of my work in Turku University Hospital, where I had started a study kinematic imaging of cervical spine (these two papers were later published). I finished a white paper on musculoskeletal function and published a paper of patellofemoral function in ACL-deficient knees. The studies of MR guided interventions led to review papers and an original paper about a novel method using high-focused ultrasound treatment of synovitis. In addition to these clinically oriented projects, I finished a study on biexponential behavior of T2 relaxation in exercised muscle. This two-year-period is the basis of my wide international contacts and network including USA, Germany, Sweden, and South Africa.

After finishing my radiology training in the summer of 1999, I was almost immediately appointed as an acting radiologist-in chief of a large and busy trauma-musculoskeletal imaging section at the Helsinki University Hospital, and the position was tenured in January 2002. Since then, my research has focused heavily on trauma radiology. Due to the nature of trauma, the research has largely been retrospective. The introduction of multi-slice-CT (MDCT) and well-functioning PACS has helped create a productive research environment even in a busy trauma practice with heavy clinical and administrative workload. Five dissertations have been completed and four are currently in progress. The research is clinically oriented and mainly focuses on diagnostic capabilities of MDCT, dual-energy CT, and MRI in severe chest and extremity trauma. Multiple research projects are being performed in collaboration with various clinical departments. The most recent research is in collaboration with Planmed Inc and was focused on developing a novel cone-beam CT dedicated to extremity imaging. The product went on-sale fall 2011. The recent research at Karolinska Institute is focused on dual-energy CT for polytrauma patients.

In conclusion, I have been very productive in both basic and clinical research as well as clinical and administrative work. 

Academic honours, awards and prizes

The Volvo Award on Low Back Pain Research 1994: Videman T, Sarna S, Battié MC, Koskinen S, Gill K, Paananen H, Gibbons L: The long-term effects of physical loading and exercise lifestyles on back-related symptoms, disability, and spinal pathology.

American Society of Emergency Radiology; Honorary Fellow, 2006

RadioGraphics Editor’s recognition award with special distinction 2015

 

Documents

Publications

Incidence and Imaging Findings of Costal Cartilage Fractures in Patients with Blunt Chest Trauma: A Retrospective Review of 1461 Consecutive Whole-Body CT Examinations for Trauma
Nummela Mt, Bensch Fv, Pyhältö Tt, Koskinen Sk
Radiology 2018;286(2):696-704

Predictors of osteoarthritis following operative treatment of medial tibial plateau fractures
Parkkinen M, Lindahl J, Mäkinen Tj, Koskinen Sk, Mustonen A, Madanat R
Injury 2018;49(2):370-375

Contrast-enhanced ultrasound using sulfur hexafluoride is safe in the pediatric setting
Torres A, Koskinen Sk, Gjertsen H, Fischler B
Acta radiologica (Stockholm, Sweden : 1987) 2017;58(11):1395-1399

CT of facial fracture fixation: an experimental study of artefact reducing methods
Peltola Em, Mäkelä T, Haapamäki V, Suomalainen A, Leikola J, Koskinen Sk, et al
Dento maxillo facial radiology 2017;46(2):20160261-

High intensity focused ultrasound (HIFU) in tumor therapy
Sequeiros Rb, Joronen K, Komar G, Koskinen Sk
Duodecim; laaketieteellinen aikakauskirja 2017;133(2):143-9

Radiocarpal Injuries: Cone Beam Computed Tomography Arthrography, Magnetic Resonance Arthrography, and Arthroscopic Correlation among 21 Patients
Suojarvi N, Haapamaki V, Lindfors N, Koskinen Sk
SCANDINAVIAN JOURNAL OF SURGERY 2017;106(2):173-179

Emergency Imaging: A Practical Guide
Koskinen S
Acta radiologica (Stockholm, Sweden : 1987) 2016;57(10):NP6-

Whole body computed tomography for trauma patients in the Nordic countries 2014: survey shows significant differences and a need for common guidelines
Wiklund E, Koskinen Sk, Linder F, Åslund Pe, Eklöf H
Acta radiologica (Stockholm, Sweden : 1987) 2016;57(6):750-7

Dual-energy computed tomography of cruciate ligament injuries in acute knee trauma
Peltola Ek, Koskinen Sk
Skeletal radiology 2015;44(9):1295-301

[Hips have a hard time in ice hockey goalkeeper's butterfly technique]
Kallio T, Koskinen Sk
Duodecim; laaketieteellinen aikakauskirja 2015;131(17):1554-8

Radiographical measurements for distal intra-articular fractures of the radius using plain radiographs and cone beam computed tomography images
Suojarvi N, Sillat T, Lindfors N, Koskinen Sk
SKELETAL RADIOLOGY 2015;44(12):1769-75

Factors associated with outcome of spinopelvic dissociation treated with lumbopelvic fixation
Lindahl J, Mäkinen Tj, Koskinen Sk, Söderlund T
Injury 2014;45(12):1914-20

FACTORS PREDICTING THE DEVELOPMENT OF EARLY OSTEOARTHRITIS FOLLOWING LATERAL TIBIAL PLATEAU FRACTURES: MID-TERM CLINICAL AND RADIOGRAPHIC OUTCOMES OF 73 OPERATIVELY TREATED PATIENTS
Parkkinen M, Madanat R, Mustonen A, Koskinen Sk, Paavola M, Lindahl J
SCANDINAVIAN JOURNAL OF SURGERY 2014;103(4):256-62

MDCT findings after elbow dislocation: a retrospective study of 140 patients
Sormaala Mj, Sormaala A, Mattila Vm, Koskinen Sk
Skeletal radiology 2014;43(4):507-12

The reverse Segond fracture: not associated with knee dislocation and rarely with posterior cruciate ligament tear
Peltola Ek, Lindahl J, Koskinen Sk
Emergency radiology 2014;21(3):245-9

The spectrum of facial fractures in motor vehicle accidents: an MDCT study of 374 patients
Peltola Em, Koivikko Mp, Koskinen Sk
Emergency radiology 2014;21(2):165-71

The usefulness of MRI and arthroscopy in the diagnosis and treatment of soft-tissue injuries associated with split-depression fractures of the lateral tibial condyle
Parkkinen M, Madanat R, Makinen Tj, Mustonen A, Koskinen Sk, Lindahl J
BONE & JOINT JOURNAL 2014;96B(12):1631-6

[Cone beam computed tomography and its clinical applications]
Suomalainen A, Koskinen Sk
Duodecim; laaketieteellinen aikakauskirja 2013;129(10):1037-43

CT arthrography of the wrist using a novel, mobile, dedicated extremity cone-beam CT (CBCT)
Koskinen Sk, Haapamaki Vv, Salo J, Lindfors Nc, Kortesniemi M, Seppala L, et al
SKELETAL RADIOLOGY 2013;42(5):649-57

Weight-Bearing CT Imaging of the Lower Extremity
Tuominen Ekj, Kankare J, Koskinen Sk, Mattila Kt
AMERICAN JOURNAL OF ROENTGENOLOGY 2013;200(1):146-8

Multidetector Computed Tomography of Spinal Fractures
Bensch Fv, Koivikko Mp, Koskinen Sk
SEMINARS IN ROENTGENOLOGY 2012;47(4):330-41

Osteochondritis dissecans of the humeral capitellum in identical twins
Pudas T, Koskinen Sk, Hiltunen A, Mattila Kt
Acta radiologica short reports 2012;1(7):-

Comparison of 1.5T and 3T MRI scanners in evaluation of acute bone stress in the foot
Sormaala Mj, Ruohola Jp, Mattila Vm, Koskinen Sk, Pihlajamaki Hk
BMC MUSCULOSKELETAL DISORDERS 2011;:128-

MDCT findings in sports and recreational accidents
Bensch Fv, Koivikko Mp, Koskinen Sk
ACTA RADIOLOGICA 2011;52(10):1107-12

Multidetector computed tomography evaluation of bony fragments and donor sites in acute patellar dislocation
Peltola Ek, Koskinen Sk
ACTA RADIOLOGICA 2011;52(1):86-90

Musculoskeletal tuberculosis: are you ready to diagnose it?
Koskinen S
ACTA RADIOLOGICA 2011;52(6):591-

Segond Fracture Combined With Tibial Plateau Fracture
Peltola Ek, Mustonen Ao, Lindahl J, Koskinen Sk
AMERICAN JOURNAL OF ROENTGENOLOGY 2011;197(6):W1101-4

Imaging of stab injuries
Koskinen S
ACTA RADIOLOGICA 2010;51(1):3-

Violence-related facial trauma: analysis of multidetector computed tomography findings of 727 patients
Salonen Em, Koivikko Mp, Koskinen Sk
DENTOMAXILLOFACIAL RADIOLOGY 2010;39(2):107-12

Improving the Imaging of Trauma: Is Evidence-Based Imaging the Answer?
Koskinen S
ACTA RADIOLOGICA 2009;50(5):468-

Knee Dislocation in Overweight Patients
Peltola Ek, Lindahl J, Hietaranta H, Koskinen Sk
AMERICAN JOURNAL OF ROENTGENOLOGY 2009;192(1):101-6

Measurement of spinal canal narrowing, interpedicular widening, and vertebral compression in spinal burst fractures: plain radiographs versus multidetector computed tomography
Bensch Fv, Koivikko Mp, Kiuru Mj, Koskinen Sk
SKELETAL RADIOLOGY 2009;38(9):887-93

Postoperative MDCT of Tibial Plateau Fractures
Mustonen Aot, Koivikko Mp, Kiuru Mj, Salo J, Koskinen Sk
AMERICAN JOURNAL OF ROENTGENOLOGY 2009;193(5):1354-60

Acute facial trauma in falling accidents: MDCT analysis of 500 patients
Salonen Em, Koivikko Mp, Koskinen Sk
Emergency radiology 2008;15(4):241-7

MRI of Acute Meniscal Injury Associated with Tibial Plateau Fractures: Prevalence, Type, and Location
Mustonen Aot, Koivikko Mp, Lindahl J, Koskinen Sk
AMERICAN JOURNAL OF ROENTGENOLOGY 2008;191(4):1002-9

MRI of cervical spine injuries complicating ankylosing spondylitis
Koivikko Mp, Koskinen Sk
SKELETAL RADIOLOGY 2008;37(9):813-9

Clinical and mri evaluation of meniscal tears repaired with bioabsorbable arrows
Tielinen L, Lindahl J, Koskinen S, Hirvensalo E
SCANDINAVIAN JOURNAL OF SURGERY 2007;96(3):252-5

Is subcutaneous local anesthesia in shoulder magnetic resonance arthrography necessary?
Koivikko Mp, Koskinen Sk
ACTA RADIOLOGICA 2007;48(7):741-3

Multidetector computed tomography imaging of facial trauma in accidental falls from heights
Salonen Em, Koivikko Mp, Koskinen Sk
ACTA RADIOLOGICA 2007;48(4):449-55

Multidetector computed tomography in acute knee injuries: Assessment of cruciate ligaments with magnetic resonance imaging correlation
Mustonen Aot, Koivikko Mp, Haapamaki Vv, Kiuru Mj, Lamminen Ae, Koskinen Sk
ACTA RADIOLOGICA 2007;48(1):104-11

MRI of menisci repaired with bioabsorbable arrows
Mustonen Aot, Tielinen L, Lindahl J, Hirvensalo E, Kiuru M, Koskinen Sk
SKELETAL RADIOLOGY 2006;35(7):515-21

T-1 rho Dispersion profile of rat tissues in vitro at very low locking fields
Koskinen Sk, Niemi Pt, Kajander Sa, Komu Mes
MAGNETIC RESONANCE IMAGING 2006;24(3):295-9

The incidence and distribution of burst fractures
Bensch Fv, Koivikko Mp, Kiuru Mj, Koskinen Sk
Emergency radiology 2006;12(3):124-9

[Acute development of flatfoot in connection with fluoroquinolone therapy]
Harve H, Michelsson O, Hoikka V, Koskinen Sk, Harilainen A
Duodecim; laaketieteellinen aikakauskirja 2005;121(1):79-83

Acute knee trauma: Analysis of multidetector computed tomography findings and comparison with conventional radiography
Mustonen Aot, Koskinen Sk, Kiuru Mj
ACTA RADIOLOGICA 2005;46(8):866-74

Diagnostic value of pelvic radiography in the initial trauma series in blunt trauma
Their Mea, Bensch Fv, Koskinen Sk, Handolin L, Kiuru Mj
EUROPEAN RADIOLOGY 2005;15(8):1533-7

Evaluation of flexion/extension of the upper cervical spine in patients with rheumatoid arthritis: an MRI study with a dedicated positioning device compared to conventional radiographs
Karhu Jo, Parkkola Rk, Koskinen Sk
ACTA RADIOLOGICA 2005;46(1):55-66

Magnetic resonance imaging of microneurovascular free muscle flaps in facial reanimation
Yla-kotola Tm, Kauhanen Msc, Koskinen Sk, Asko-seljavaara Sl
BRITISH JOURNAL OF PLASTIC SURGERY 2005;58(1):22-7

Multidetector computed tomography in acute joint fractures
Haapamaki Vv, Kiuru Mj, Mustonen Ao, Koskinen Sk
ACTA RADIOLOGICA 2005;46(6):587-98

Ankle and foot injuries: Analysis of MDCT findings
Haapamaki Vv, Kiuru Mj, Koskinen Sk
AMERICAN JOURNAL OF ROENTGENOLOGY 2004;183(3):615-22

Cortical activation during a spatiotemporal tactile comparison task
Numminen J, Schurmann M, Hiltunen J, Joensuu R, Jousmaki V, Koskinen Sk, et al
NEUROIMAGE 2004;22(2):815-21

Detection of intracranial aneurysms with two-dimensional and three-dimensional multislice helical computed tomographic angiography
Kangasniemi M, Makela T, Koskinen S, Porras M, Poussa K, Hernesniemi J
NEUROSURGERY 2004;54(2):336-40

Factors associated with nonunion in conservatively-treated type-II fractures of the odontoid process
Koivikko Mp, Kiuru Mj, Koskinen Sk, Myllynen P, Santavirta S, Kivisaari L
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME 2004;86B(8):1146-51

Lisfranc fracture-dislocation in patents with multiple trauma diagnosis with multidetector computed tomography
Haapamaki V, Kiuru M, Koskinen S
FOOT & ANKLE INTERNATIONAL 2004;25(9):614-9

[Magnetic arthrography]
Koskinen Sk, Niemi P, Kiuru Mj, Mattila Kt
Duodecim; laaketieteellinen aikakauskirja 2004;120(20):2441-51

Multidetector computed tomography diagnosis of adult elbow fractures
Haapamaki Vv, Kiuru Mj, Koskinen Sk
ACTA RADIOLOGICA 2004;45(1):65-70

Multidetector computed tomography of cervical spine fractures in ankylosing spondylitis
Koivikko Mp, Kiuru Mj, Koskinen Sk
ACTA RADIOLOGICA 2004;45(7):751-9

Multidetector CT in shoulder fractures
Haapamaki Vv, Kiuru Mj, Koskinen Sk
Emergency radiology 2004;11(2):89-94

Radicular lower extremity pain as the first symptom of primary hyperparathyroidism
Mustonen Aot, Kiuru Mj, Stahls A, Bohling T, Kivioja A, Koskinen Sk
SKELETAL RADIOLOGY 2004;33(8):467-72

Reconstruction of soft tissue after complicated calcaneal fractures
Koski Ea, Kuokkanen Hom, Koskinen Sk, Tukiainen Ej
SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY 2004;38(5):284-7

Spine fractures in falling accidents: analysis of multidetector CT findings
Bensch Fv, Kiuru Mj, Koivikko Mp, Koskinen Sk
EUROPEAN RADIOLOGY 2004;14(4):618-24

Wrist injuries; diagnosis with multidetector CT
Kiuru Mj, Haapamaki Vv, Koivikko Mp, Koskinen Sk
Emergency radiology 2004;10(4):182-5

Serious horse-riding accidents: imaging findings and evaluation with multi-slice CT
Kiuru Mj, Koivikko Mp, Koskinen Sk
Emergency radiology 2002;9(4):213-8

Dynamic lateral patellar tilt in the anterior cruciate ligament-deficient knee - A magnetic resonance imaging analysis
Steiner Me, Koskinen Sk, Winalski Cs, Martin Sd, Haymen M
AMERICAN JOURNAL OF SPORTS MEDICINE 2001;29(5):593-9

Factors associated with hip joint rotation in former elite athletes
Kettunen Ja, Kujala Um, Raty H, Videman T, Sarna S, Impivaara O, et al
BRITISH JOURNAL OF SPORTS MEDICINE 2000;34(1):44-8

Interventional and intraoperative magnetic resonance imaging
Kettenbach J, Kacher Df, Koskinen Sk, Silverman Sg, Nabavi A, Gering D, et al
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING 2000;:661-90

Associations of isometric and isoinertial trunk muscle strength measurements and lumbar paraspinal muscle cross-sectional areas
Raty Hp, Kujala U, Videman T, Koskinen Sk, Karppi Sl, Sarna S
JOURNAL OF SPINAL DISORDERS 1999;12(3):266-70

[Interventional magnetic resonance imaging]
Koskinen Sk
Duodecim; laaketieteellinen aikakauskirja 1999;115(9):1011-9

Kinematic magnetic resonance imaging of the upper cervical spine using a novel positioning device
Karhu Jo, Parkkola Rk, Komu Mes, Kormano Mj, Koskinen Sk
SPINE 1999;24(19):2046-56

Magnetic resonance imaging-guided focused ultrasound synovectomy
Foldes K, Hynynen K, Shortkroff S, Winalski Cs, Collucci V, Koskinen Sk, et al
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 1999;28(4):233-7

Medial tibial pain: A dynamic contrast-enhanced MRI study
Mattila Kt, Komu Mes, Dahlstrom S, Koskinen Sk, Heikkila J
MAGNETIC RESONANCE IMAGING 1999;17(7):947-54

T-1 rho dispersion of rat tissues in vitro
Koskinen Sk, Virta Am, Niemi Pt, Kajander Sa, Komu Mes
MAGNETIC RESONANCE IMAGING 1999;17(7):1043-7

Effect of Elmslie-Trillat and Roux-Goldthwait procedures on patellofemoral relationships and symptoms in patients with patellar dislocations
Koskinen Sk, Rantanen Jp, Nelimarkka Oi, Kujala Um
The American journal of knee surgery 1998;11(3):167-73

Glomus tumor of the trachea
Koskinen Sk, Niemi Pt, Ekfors To, Sipila J, Valavaara R, Dean Pb
EUROPEAN RADIOLOGY 1998;8(3):364-6

Incidence and clinical significance of bone bruises after supination injury of the ankle - A double-blind, prospective study
Alanen V, Taimela S, Kinnunen J, Koskinen Sk, Karaharju E
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME 1998;80B(3):513-5

Composition, clinical suitability and future prospects of a 0.5-T MR system for interventional use
Kettenbach J, Silverman Sg, Schwartz Rb, Hsu L, Koskinen Sk, Kikinis R, et al
RADIOLOGE 1997;37(10):825-34

Magnetization transfer and spin lock MR imaging of patellar cartilage degeneration at 0.1 T
Koskinen Sk, Ylaoutinen H, Aho Hj, Komu Mes
ACTA RADIOLOGICA 1997;38(6):1071-5

Orthopedic and interventional applications at low field MRI with horizontally open configuration - A review
Koskinen Sk, Parkkola Rk, Karhu J, Komu Mes, Kormano Mj
RADIOLOGE 1997;37(10):819-24

Stress fracture of the ulnar diaphysis in a recreational golfer
Koskinen Sk, Mattila Kt, Alanen Am, Aro Ht
CLINICAL JOURNAL OF SPORT MEDICINE 1997;7(1):63-5

STRESS-FRACTURES IN ATHLETES AND MILITARY RECRUITS - A REVIEW
Orava S, Hulkko A, Koskinen S, Taimela S
ORTHOPADE 1995;24(5):457-66

THE LONG-TERM EFFECTS OF PHYSICAL LOADING AND EXERCISE LIFE-STYLES ON BACK-RELATED SYMPTOMS, DISABILITY, AND SPINAL PATHOLOGY AMONG MEN
Videman T, Sama S, Battie Mc, Koskinen S, Gill K, Paananen H, et al
SPINE 1995;20(6):699-709

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