Sam Okret

Publications
CV
Public outreach and news

Articles

Article: CANCERS. 2023;15(4):1298

Sex- and Female Age-Dependent Differences in Gene Expression in Diffuse Large B-Cell Lymphoma-Possible Estrogen Effects.

Huang D; Berglund M; Damdimopoulos A; Antonson P; Lindskog C; Enblad G; Amini R-M; Okret S
Article: CANCERS. 2022;14(13):3098

Estrogen Receptor β (ESR2) Transcriptome and Chromatin Binding in a Mantle Cell Lymphoma Tumor Model Reveal the Tumor-Suppressing Mechanisms of Estrogens.

Huang D; Huang Z; Indukuri R; Bangalore Revanna C; Berglund M; Guan J; Yakimchuk K; Damdimopoulos A; Williams C; Okret S
Article: ENDOCRINE CONNECTIONS. 2018;7(12):1472-1479

Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein.

Yakimchuk K; Bangalore Revanna C; Huang D; Inzunza J; Okret S
Article: MOLECULAR CANCER THERAPEUTICS. 2018;17(5):1090-1100

p110α Inhibition Overcomes Stromal Cell-Mediated Ibrutinib Resistance in Mantle Cell Lymphoma.

Guan J; Huang D; Yakimchuk K; Okret S
Article: LEUKEMIA & LYMPHOMA. 2017;58(2):418-427

Estrogen receptor β1 in diffuse large B-cell lymphoma growth and as a prognostic biomarker.

Hasni MS; Berglund M; Yakimchuk K; Guan J; Linderoth J; Amini RM; Enblad G; Okret S
Article: ONCOTARGET. 2016;7(15):20718-20727

Inhibition of estrogen biosynthesis enhances lymphoma growth in mice.

Talaber G; Yakimchuk K; Guan J; Inzunza J; Okret S
Article: STEROIDS. 2015;103:58-63

Local glucocorticoid production in the thymus.

Talaber G; Jondal M; Okret S
Article: FASEB JOURNAL. 2015;29(6):2526-2534

ACTH controls thymocyte homeostasis independent of glucocorticoids.

Talaber G; Tuckermann JP; Okret S
Article: AUTOIMMUNITY. 2015;48(2):117-124

The selective impact of transgenically expressed glucocorticoid receptor on T cells.

Yakimchuk K; Chen L; Hasni MS; Okret S; Jondal M
Article: BLOOD. 2014;123(13):2054-2061

Inhibition of lymphoma vascularization and dissemination by estrogen receptor β agonists.

Yakimchuk K; Hasni MS; Guan J; Chao MP; Sander B; Okret S
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2013;380(1-2):89-98

Extra-adrenal glucocorticoid synthesis: immune regulation and aspects on local organ homeostasis.

Talabér G; Jondal M; Okret S
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2013;715(1-3):1-9

Mitogen- and stress-activated protein kinase 1 MSK1 regulates glucocorticoid response element promoter activity in a glucocorticoid concentration-dependent manner.

Beck IM; Clarisse D; Bougarne N; Okret S; Haegeman G; De Bosscher K
Article: AUTOIMMUNITY. 2012;45(7):510-515

Keratinocyte growth factor (KGF) delays the onset of collagen-induced arthritis.

Yakimchuk K; Nandakumar KS; Chen L; Holmdahl R; Okret S; Jondal M
Article: TOXICOLOGICAL SCIENCES. 2012;125(2):488-495

Dickkopf 1 mediates glucocorticoid-induced changes in human neural progenitor cell proliferation and differentiation.

Moors M; Bose R; Johansson-Haque K; Edoff K; Okret S; Ceccatelli S
Article: LEUKEMIA. 2011;25(7):1103-1110

Effect of ligand-activated estrogen receptor β on lymphoma growth in vitro and in vivo.

Yakimchuk K; Iravani M; Hasni MS; Rhönnstad P; Nilsson S; Jondal M; Okret S
Article: FASEB JOURNAL. 2010;24(12):5043-5051

Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis.

Chen Y; Qiao S; Tuckermann J; Okret S; Jondal M
Article: ENDOCRINOLOGY. 2009;150(9):4163-4169

Thymocyte-synthesized glucocorticoids play a role in thymocyte homeostasis and are down-regulated by adrenocorticotropic hormone.

Qiao S; Okret S; Jondal M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1793(3):439-446

Inhibition of extracellular signal-regulated kinase (ERK) signaling participates in repression of nuclear factor (NF)-kappaB activity by glucocorticoids.

Bladh L-G; Johansson-Haque K; Rafter I; Nilsson S; Okret S
Article: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2008;41(4):239-249

Stimulation of MAPK-phosphatase 1 gene expression by glucocorticoids occurs through a tethering mechanism involving C/EBP.

Johansson-Haque K; Palanichamy E; Okret S
Article: EXPERIMENTAL CELL RESEARCH. 2008;314(16):3027-3035

Age-related synthesis of glucocorticoids in thymocytes.

Qiao S; Chen L; Okret S; Jondal M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2008;154(6):1318-1326

Ethyl pyruvate modulates acute inflammatory reactions in human endothelial cells in relation to the NF-kappaB pathway.

Johansson A-S; Johansson-Haque K; Okret S; Palmblad J
Article: BIOCHEMICAL PHARMACOLOGY. 2005;70(4):545-551

Effects of ethanol on cytokine generation and NFkappaB activity in human lung epithelial cell.

Johansson A-SM; Lidén J; Okret S; Palmblad JEW
Article: ENDOCRINOLOGY. 2005;146(6):2501-2507

Conditional expression of a glucocorticoid receptor transgene in thymocytes reveals a role for thymic-derived glucocorticoids in thymopoiesis in vivo.

Pazirandeh A; Jondal M; Okret S
Article: MOLECULAR PHARMACOLOGY. 2005;67(3):815-826

Identification of endogenous glucocorticoid repressed genes differentially regulated by a glucocorticoid receptor mutant able to separate between nuclear factor-kappaB and activator protein-1 repression.

Bladh L-G; Lidén J; Dahlman-Wright K; Reimers M; Nilsson S; Okret S
Article: MOLECULAR ENDOCRINOLOGY. 2005;19(3):632-643

Identification of target genes involved in the antiproliferative effect of glucocorticoids reveals a role for nuclear factor-(kappa)B repression.

Bladh L-G; Lidén J; Pazirandeh A; Rafter I; Dahlman-Wright K; Nilsson S; Okret S
Article: TRENDS IN IMMUNOLOGY. 2004;25(11):595-600

Different roles for glucocorticoids in thymocyte homeostasis?

Jondal M; Pazirandeh A; Okret S
Article: ENDOCRINOLOGY. 2004;145(5):2392-2401

Glucocorticoids delay age-associated thymic involution through directly affecting the thymocytes.

Pazirandeh A; Jondal M; Okret S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(26):15619-15624

p57(Kip2) cooperates with Nurr1 in developing dopamine cells.

Joseph B; Wallén-Mackenzie A; Benoit G; Murata T; Joodmardi E; Okret S; Perlmann T
Article: RESPIRATORY MEDICINE. 2003;97(8):882-892

Organic dust activates NF-kappaB in lung epithelial cells.

Lidén J; Ek A; Palmberg L; Okret S; Larsson K
Article: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2003;30(3):359-368

Identification of a functional glucocorticoid response element in the promoter of the cyclin-dependent kinase inhibitor p57Kip2.

Alheim K; Corness J; Samuelsson MKR; Bladh L-G; Murata T; Nilsson T; Okret S
Article: BIOCHEMICAL JOURNAL. 2003;370(Pt 3):1087-1095

Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor interaction with the homoeodomain protein Pbx1.

Subramaniam N; Campión J; Rafter I; Okret S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;296(3):702-709

A pro-apoptotic effect of the CDK inhibitor p57(Kip2) on staurosporine-induced apoptosis in HeLa cells.

Samuelsson MKR; Pazirandeh A; Okret S
Article: FASEB JOURNAL. 2002;16(7):727-729

Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis.

Pazirandeh A; Xue Y; Prestegaard T; Jondal M; Okret S
Article: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. 2002;25(3):229-235

Central and peripheral glucocorticoid receptor function in abdominal obesity.

Ljung T; Ottosson M; Ahlberg AC; Edén S; Odén B; Okret S; Brönnegård M; Stierna P; Björntorp P
Article: MOLECULAR AND CELLULAR BIOLOGY. 2001;21(9):3266-3279

Expression level-dependent contribution of glucocorticoid receptor domains for functional interaction with STAT5.

Doppler W; Windegger M; Soratroi C; Tomasi J; Lechner J; Rusconi S; Cato AC; Almlöf T; Liden J; Okret S; Gustafsson JA; Richard-Foy H; Starr DB; Klocker H; Edwards D; Geymayer S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(45):34841-34844

Type 1 11beta -hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets.

Davani B; Khan A; Hult M; Mårtensson E; Okret S; Efendic S; Jörnvall H; Oppermann UC
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;276(1):189-196

Glucocorticoid resistance in thymocytes from mice expressing a T cell receptor transgene.

Pazirandeh A; Xue Y; Okret S; Jondal M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;273(3):1008-1014

Glucocorticoid effects on NF-kappaB binding in the transcription of the ICAM-1 gene.

Liden J; Rafter I; Truss M; Gustafsson JA; Okret S
Article: MOLECULAR ENDOCRINOLOGY. 1999;13(11):1811-1822

p57Kip2, a glucocorticoid-induced inhibitor of cell cycle progression in HeLa cells.

Samuelsson MK; Pazirandeh A; Davani B; Okret S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(25):18121-18127

Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids.

Subramaniam N; Treuter E; Okret S
Article: FASEB JOURNAL. 1999;13(8):893-901

Paracrine glucocorticoid activity produced by mouse thymic epithelial cells.

Pazirandeh A; Xue Y; Rafter I; Sjövall J; Jondal M; Okret S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(36):23567-23574

Glucocorticoids repress transcription from a negative glucocorticoid response element recognized by two homeodomain-containing proteins, Pbx and Oct-1.

Subramaniam N; Cairns W; Okret S
Article: TRENDS IN BIOCHEMICAL SCIENCES. 1998;23(7):233-235

Cross-talk between steroids and NF-kappa B: what language?

Dumont A; Hehner SP; Schmitz ML; Gustafsson JA; Lidén J; Okret S; van der Saag PT; Wissink S; van der Burg B; Herrlich P; Haegeman G; De Bosscher K; Fiers W
Article: DIABETOLOGIA. 1998;41(6):634-639

Increased glucocorticoid sensitivity in islet beta-cells: effects on glucose 6-phosphatase, glucose cycling and insulin release.

Ling ZC; Khan A; Delauny F; Davani B; Ostenson CG; Gustafsson JA; Okret S; Landau BR; Efendic S
Article: JOURNAL OF CLINICAL INVESTIGATION. 1997;100(8):2094-2098

Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids.

Delaunay F; Khan A; Cintra A; Davani B; Ling ZC; Andersson A; Ostenson CG; Gustafsson J; Efendic S; Okret S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(34):21467-21472

A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation.

Liden J; Delaunay F; Rafter I; Gustafsson J; Okret S
Article: DNA AND CELL BIOLOGY. 1997;16(2):153-163

Studies on the mechanism of glucocorticoid-mediated repression from a negative glucocorticoid response element from the bovine prolactin gene.

Subramaniam N; Cairns W; Okret S
Article: FEBS JOURNAL. 1996;242(3):839-845

Glucocorticoid receptor lacking the tau 1 transactivation domain is a gene-specific regulator of the wild-type glucocorticoid-receptor activity.

Delaunay F; Liden J; Gustafsson JA; Okret S
Article: CARCINOGENESIS. 1996;17(3):421-426

Increased c-fos mRNA and binding to the AP-1 recognition sequence accompanies the proliferative response to deoxycholate of HT29 cells.

Matheson H; Branting C; Rafter I; Okret S; Rafter J
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(2):428-434

Inhibition of I-Ad-, but not Db-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice.

Xue Y; Murdjeva M; Okret S; McConkey D; Kiuossis D; Jondal M
Article: JOURNAL OF IMMUNOLOGY. 1995;155(10):4525-4528

Functional glucocorticoid receptor expression is required for cAMP-mediated apoptosis in a human leukemic T cell line.

Kiefer J; Okret S; Jondal M; McConkey DJ
Article: MOLECULAR ENDOCRINOLOGY. 1995;9(4):401-412

Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids.

Caldenhoven E; Liden J; Wissink S; Van de Stolpe A; Raaijmakers J; Koenderman L; Okret S; Gustafsson JA; Van der Saag PT
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Review: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2013;375(1-2):121-129

Estrogen receptor α and β in the normal immune system and in lymphoid malignancies.

Yakimchuk K; Jondal M; Okret S
Meeting abstract: JOURNAL OF INVESTIGATIVE MEDICINE. 2004;52(2):S403

Effects of ethanol on cytokine generation and nuclear factor κB activity in human lung epithelial cell.

Johansson AS; Liden J; Okret S; Palmblad J
Published conference paper: DIABETES. 2004;53 Suppl 1:S51-S59

Aged transgenic mice with increased glucocorticoid sensitivity in pancreatic beta-cells develop diabetes.

Davani B; Portwood N; Bryzgalova G; Reimer MK; Heiden T; Ostenson C-G; Okret S; Ahren B; Efendic S; Khan A
Letter: TRENDS IN IMMUNOLOGY. 2001;22(4):185-186

A role for glucocorticoids in the thymus?

Jondal M; Pazirandeh A; Okret S
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 1997;8(4):152-157

Nuclear factor-kappa B repression in antiinflammation and immunosuppression by glucocorticoids.

van der Burg B; Liden J; Okret S; Delaunay F; Wissink S; van der Saag PT; Gustafsson JA
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 1995;200:67-79

Thymocyte apoptosis by glucocorticoids and cAMP.

Jondal M; Xue Y; McConkey DJ; Okret S

Employments

Professor Emeritus/Emerita, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2026
Professor Emeritus/Emerita, Department of Biosciences and Nutrition, Karolinska Institutet, 2023-2026

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