Sam Okret

Publications
CV
Public outreach and news

Articles

Article: CANCERS. 2023;15(4):1298
Sex- and Female Age-Dependent Differences in Gene Expression in Diffuse Large B-Cell Lymphoma-Possible Estrogen Effects
Huang D; Berglund M; Damdimopoulos A; Antonson P; Lindskog C; Enblad G; Amini R-M; Okret S
Article: CANCERS. 2022;14(13):3098
Estrogen Receptor β (ESR2) Transcriptome and Chromatin Binding in a Mantle Cell Lymphoma Tumor Model Reveal the Tumor-Suppressing Mechanisms of Estrogens
Huang D; Huang Z; Indukuri R; Revanna CB; Berglund M; Guan J; Yakimchuk K; Damdimopoulos A; Williams C; Okret S
Article: ENDOCRINE CONNECTIONS. 2018;7(12):1472-1479
Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein
Yakimchuk K; Revanna CB; Huang D; Inzunza J; Okret S
Article: MOLECULAR CANCER THERAPEUTICS. 2018;17(5):1090-1100
p110α Inhibition Overcomes Stromal Cell-Mediated Ibrutinib Resistance in Mantle Cell Lymphoma
Guan J; Huang D; Yakimchuk K; Okret S
Article: LEUKEMIA & LYMPHOMA. 2017;58(2):418-427
Estrogen receptor β1 in diffuse large B-cell lymphoma growth and as a prognostic biomarker
Hasni MS; Berglund M; Yakimchuk K; Guan J; Linderoth J; Amini RM; Enblad G; Okret S
Article: ONCOTARGET. 2016;7(15):20718-20727
Inhibition of estrogen biosynthesis enhances lymphoma growth in mice
Talaber G; Yakimchuk K; Guan J; Inzunza J; Okret S
Article: STEROIDS. 2015;103:58-63
Local glucocorticoid production in the thymus
Talaber G; Jondal M; Okret S
Article: FASEB JOURNAL. 2015;29(6):2526-2534
ACTH controls thymocyte homeostasis independent of glucocorticoids
Talaber G; Tuckermann JP; Okret S
Article: AUTOIMMUNITY. 2015;48(2):117-124
The selective impact of transgenically expressed glucocorticoid receptor on T cells
Yakimchuk K; Chen L; Hasni MS; Okret S; Jondal M
Article: BLOOD. 2014;123(13):2054-2061
Inhibition of lymphoma vascularization and dissemination by estrogen receptor β agonists
Yakimchuk K; Hasni MS; Guan J; Chao MP; Sander B; Okret S
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2013;380(1-2):89-98
Extra-adrenal glucocorticoid synthesis: Immune regulation and aspects on local organ homeostasis
Talaber G; Jondal M; Okret S
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2013;715(1-3):1-9
Mitogen- and stress-activated protein kinase 1 MSK1 regulates glucocorticoid response element promoter activity in a glucocorticoid concentration-dependent manner
Beck IM; Clarisse D; Bougarne N; Okret S; Haegeman G; De Bosscher K
Article: AUTOIMMUNITY. 2012;45(7):510-515
Keratinocyte growth factor (KGF) delays the onset of collagen-induced arthritis
Yakimchuk K; Nandakumar KS; Chen L; Holmdahl R; Okret S; Jondal M
Article: TOXICOLOGICAL SCIENCES. 2012;125(2):488-495
Dickkopf 1 Mediates Glucocorticoid-Induced Changes in Human Neural Progenitor Cell Proliferation and Differentiation
Moors M; Bose R; Johansson-Haque K; Edoff K; Okret S; Ceccatelli S
Article: LEUKEMIA. 2011;25(7):1103-1110
Effect of ligand-activated estrogen receptor β on lymphoma growth in vitro and in vivo
Yakimchuk K; Iravani M; Hasni MS; Rhonnstad P; Nilsson S; Jondal M; Okret S
Article: FASEB JOURNAL. 2010;24(12):5043-5051
Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis
Chen Y; Qiao S; Tuckermann J; Okret S; Jondal M
Article: ENDOCRINOLOGY. 2009;150(9):4163-4169
Thymocyte-Synthesized Glucocorticoids Play a Role in Thymocyte Homeostasis and Are Down-Regulated by Adrenocorticotropic Hormone
Qiao S; Okret S; Jondal M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1793(3):439-446
Inhibition of extracellular signal-regulated kinase (ERK) signaling participates in repression of nuclear factor (NF)-κB activity by glucocorticoids
Bladh L-G; Johansson-Haque K; Rafter I; Nilsson S; Okret S
Article: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2008;41(3-4):239-249
Stimulation of MAPK-phosphatase 1 gene expression by glucocorticoids occurs through a tethering mechanism involving C/EBP
Johansson-Haque K; Palanichamy E; Okret S
Article: EXPERIMENTAL CELL RESEARCH. 2008;314(16):3027-3035
Age-related synthesis of glucocorticoids in thymocytes
Qiao S; Chen L; Okret S; Jondal M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2008;154(6):1318-1326
Ethyl pyruvate modulates acute inflammatory reactions in human endothelial cells in relation to the NF-κB pathway
Johansson A-S; Johansson-Haque K; Okret S; Palmblad J
Article: BIOCHEMICAL PHARMACOLOGY. 2005;70(4):545-551
Effects of ethanol on cytokine generation and NFκB activity in human lung epithelial cell
Johansson ASM; Lidén J; Okret S; Palmblad JEW
Article: ENDOCRINOLOGY. 2005;146(6):2501-2507
Conditional expression of a glucocorticoid receptor transgene in thymocytes reveals a role for thymic-derived glucocorticoids in thymopoiesis in vivo
Pazirandeh A; Jondal M; Okret S
Article: MOLECULAR PHARMACOLOGY. 2005;67(3):815-826
Identification of endogenous glucocorticoid repressed genes differentially regulated by a glucocorticoid receptor mutant able to separate between nuclear factor-κB and activator protein-1 repression
Bladh LG; Lidén J; Dahlman-Wright K; Reimers M; Nilsson S; Okret S
Article: MOLECULAR ENDOCRINOLOGY. 2005;19(3):632-643
Identification of target genes involved in the antiproliferative effect of glucocorticoids reveals a role for nuclear factor-κB repression
Bladh LG; Lidén J; Pazirandeh A; Rafter I; Dahlman-Wright K; Nilsson S; Okret S
Article: TRENDS IN IMMUNOLOGY. 2004;25(11):595-600
Different roles for glucocorticoids in thymocyte homeostasis?
Jondal M; Pazirandeh A; Okret S
Article: ENDOCRINOLOGY. 2004;145(5):2392-2401
Glucocorticoids delay age-associated thymic involution through directly affecting the thymocytes
Pazirandeh A; Jondal M; Okret S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(26):15619-15624
p57^Kip2 cooperates with Nurr1 in developing dopamine cells
Joseph B; Wallén-Mackenzie Å; Benoit G; Murata T; Joodmardi E; Okret S; Perlmann T
Article: RESPIRATORY MEDICINE. 2003;97(8):882-892
Organic dust activates NF-κB in lung epithelial cells
Lidén J; Ek A; Palmberg L; Okret S; Larsson K
Article: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2003;30(3):359-368
Identification of a functional glucocorticoid response element in the promoter of the cylcin-dependant kinase inhibitor p57^Kip2
Alheim K; Corness J; Samuelsson MKR; Bladh LG; Murata T; Nilsson T; Okret S
Article: BIOCHEMICAL JOURNAL. 2003;370(Pt 3):1087-1095
Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor interaction with the homoeodomain protein Pbx1
Subramaniam N; Campión J; Rafter I; Okret S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;296(3):702-709
A pro-apoptotic effect of the CDK inhibitor p57 ^Kip2 on staurosporine-induced apoptosis in HeLa cells
Samuelsson MKR; Pazirandeh A; Okret S
Article: FASEB JOURNAL. 2002;16(3):727-729
Effects of altered glucocorticoid sensitivity in the T-cell lineage on thymocyte and T-cell homeostasis
Pazirandeh A; Xue YT; Prestegaard T; Jondal M; Okret S
Article: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. 2002;25(3):229-235
Central and peripheral glucocorticoid receptor function in abdominal obesity
Ljung T; Ottosson M; Ahlberg AC; Edén S; Odén B; Okret S; Brönnegård M; Stierna P; Björntorp P
Article: MOLECULAR AND CELLULAR BIOLOGY. 2001;21(9):3266-3279
Expression level-dependent contribution of glucocorticoid receptor domains for functional interaction with STAT5
Doppler W; Windegger M; Soratroi C; Tomasi J; Lechner J; Rusconi S; Cato ACB; Almlof T; Liden J; Okret S; Gustafsson J; Richard-Foy H; Starr DB; Klocker H; Edwards D; Geymayer S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(45):34841-34844
Type 1 11β-hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets
Davani B; Khan A; Hult M; Mårtensson E; Okret SE; Efendic S; Jörnvall H; Oppermann UCT
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;276(1):189-196
Glucocorticoid resistance in thymocytes from mice expressing a T cell receptor transgene
Pazirandeh A; Xue YT; Okret S; Jondal M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;273(3):1008-1014
Glucocorticoid effects on NF-κB binding in the transcription of the ICAM-1 gene
Liden J; Rafter I; Truss M; Gustafsson J; Okret S
Article: MOLECULAR ENDOCRINOLOGY. 1999;13(11):1811-1822
p57^Kip2, a glucocorticoid-induced inhibitor of cell cycle progression in HeLa cells
Samuelsson MKR; Pazirandeh A; Davani B; Okret S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(25):18121-18127
Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids
Subramaniam N; Treuter E; Okret S
Article: FASEB JOURNAL. 1999;13(8):893-901
Paracrine glucocorticoid activity produced by mouse thymic epithelial cells
Pazirandeh A; Xue YT; Rafter I; Sjövall J; Jondal M; Okret S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(36):23567-23574
Glucocorticoids repress transcription from a negative glucocorticoid response element recognized by two homeodomain-containing proteins, Pbx and Oct-1
Subramaniam N; Cairns W; Okret S
Article: TRENDS IN BIOCHEMICAL SCIENCES. 1998;23(7):233-235
Cross-talk between steroids and NF-κB:: what language?
Dumont A; Hehner SP; Schmitz ML; Gustafsson J; Lidén J; Okret S; Van der Saag PT; Wissink S; Van der Burg B; Herrlich P; Haegeman G; De Bosscher K; Fiers W
Article: DIABETOLOGIA. 1998;41(6):634-639
Increased glucocorticoid sensitivity in islet beta-cells:: effects on glucose 6-phosphatase, glucose cycling and insulin release
Ling ZC; Khan A; Delauny F; Davani B; Östenson CG; Gustafsson J; Okret S; Landau BR; Efendic S
Article: JOURNAL OF CLINICAL INVESTIGATION. 1997;100(8):2094-2098
Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids
Delaunay F; Khan A; Cintra A; Davani B; Ling ZC; Andersson A; Ostenson CG; Gustafsson JA; Efendic S; Okret S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(34):21467-21472
A new function for the C-terminal zinc finger of the glucocorticoid receptor - Repression of RelA transactivation
Liden J; Delaunay F; Rafter I; Gustafsson JA; Okret S
Article: DNA AND CELL BIOLOGY. 1997;16(2):153-163
Studies on the mechanism of glucocorticoid-mediated repression from a negative glucocorticoid response element from the bovine prolactin gene
Subramaniam N; Cairns W; Okret S
Article: FEBS JOURNAL. 1996;242(3):839-845
Glucocorticoid receptor lacking the tau 1 transactivation domain ss a gene-specific regulator of the wild-type glucocorticoid-receptor activity
Delaunay F; Liden J; Gustafsson JA; Okret S
Article: CARCINOGENESIS. 1996;17(3):421-426
Increased c-fos mRNA and binding to the AP-1 recognition sequence accompanies the proliferative response to deoxycholate of HT29 cells
Matheson H; Branting C; Rafter I; Okret S; Rafter J
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(2):428-434
Inhibition of I-A(d)-, but not D-b-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice
Xue YT; Murdjeva M; Okret S; McConkey D; Kiuossis D; Jondal M
Article: JOURNAL OF IMMUNOLOGY. 1995;155(10):4525-4528
FUNCTIONAL GLUCOCORTICOID RECEPTOR EXPRESSION IS REQUIRED FOR CAMP-MEDIATED APOPTOSIS IN A HUMAN LEUKEMIC T-CELL LINE
KIEFER J; OKRET S; JONDAL M; MCCONKEY DJ
Article: MOLECULAR ENDOCRINOLOGY. 1995;9(4):401-412
NEGATIVE CROSS-TALK BETWEEN RELA AND THE GLUCOCORTICOID RECEPTOR - A POSSIBLE MECHANISM FOR THE ANTIINFLAMMATORY ACTION OF GLUCOCORTICOIDS
CALDENHOVEN E; LIDEN J; WISSINK S; VANDESTOLPE A; RAAIJMAKERS J; KOENDERMAN L; OKRET S; GUSTAFSSON JA; VANDERSAAG PT
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Review: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2013;375(1-2):121-129
Estrogen receptor α and β in the normal immune system and in lymphoid malignancies
Yakimchuk K; Jondal M; Okret S
Meeting abstract: JOURNAL OF INVESTIGATIVE MEDICINE. 2004;52(2):S403
Effects of ethanol on cytokine generation and nuclear factor κB activity in human lung epithelial cell.
Johansson AS; Liden J; Okret S; Palmblad J
Published conference paper: DIABETES. 2004;53:S51-S59
Aged transgenic mice with increased glucocorticoid sensitivity in pancreatic β-cells develop diabetes
Davani B; Portwood N; Bryzgalova G; Reimer MK; Heiden T; Östenson CG; Okret S; Ahren B; Efendic S; Khan A
Letter: TRENDS IN IMMUNOLOGY. 2001;22(4):185-186
A role for glucocorticoids in the thymus?
Jondal M; Pazirandeh A; Okret S
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 1997;8(4):152-157
Nuclear factor-kappa B repression in antiinflammation and immunosuppression by glucocorticoids
vanderBurg B; Liden J; Okret S; Delaunay F; Wissink S; vanderSaag PT; Gustafsson JA
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 1995;200:67-79
Thymocyte apoptosis by glucocorticoids and cAMP.
Jondal M; Xue Y; McConkey DJ; Okret S

Employments

Professor Emeritus/Emerita, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2026
Professor Emeritus/Emerita, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2026

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