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Research description

Research area/interest: Chemical Biology of nucleic acids, non-B-DNA structures in gene regulation, structure-specific nucleic acid binding of small molecules

Publications

Oligonucleotide Binding to Non-B-DNA in MYC
Umek T, Sollander K, Bergquist H, Wengel J, Lundin Ke, Smith Cie, et al
Molecules (Basel, Switzerland) 2019;24(5):-

Oligonucleotide⁻Palladacycle Conjugates as Splice-Correcting Agents
Hande M, Saher O, Lundin Ke, Smith Cie, Zain R, Lönnberg T
Molecules (Basel, Switzerland) 2019;24(6):-

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study
Xu Y, Gissberg O, Pabon-martinez Yv, Wengel J, Lundin Ke, Smith Cie, et al
PloS one 2019;14(2):e0211651-

Therapeutic Oligonucleotides: State of the Art
Smith Cie, Zain R
Annual review of pharmacology and toxicology 2019;59():605-630

Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity
Saher O, Rocha Csj, Zaghloul Em, Wiklander Opb, Zamolo S, Heitz M, et al
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2018;132():29-40

Translocation-generated ITK-FER and ITK-SYK fusions induce STAT3 phosphorylation and CD69 expression
Fathi Nn, Mohammad Dk, Görgens A, Andaloussi Se, Zain R, Nore Bf, et al
Biochemical and biophysical research communications 2018;504(4):749-752

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression
Zaghloul Em, Gissberg O, Moreno Pmd, Siggens L, Hällbrink M, Jørgensen As, et al
Nucleic acids research 2017;45(9):5153-5169

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures
Pabon-martinez Yv, Xu Y, Villa A, Lundin Ke, Geny S, Nguyen Ch, et al
Scientific reports 2017;7(1):11043-

Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies
Hartono Yd, Pabon-martinez Yv, Uyar A, Wengel J, Lundin Ke, Zain R, et al
ACS omega 2017;2(5):2165-2177

Clamping of RNA with PNA enables targeting of microRNA
Ghidini A, Bergquist H, Murtola M, Punga T, Zain R, Strömberg R
Organic & biomolecular chemistry 2016;14(23):5210-3

Delivery, Effect on Cell Viability, and Plasticity of Modified Aptamer Constructs
Gissberg O, Zaghloul Em, Lundin Ke, Nguyen Ch, Landras-guetta C, Wengel J, et al
Nucleic acid therapeutics 2016;26(3):183-9

Disruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)n Repeats by PNA or LNA Targeting
Bergquist H, Rocha Cs, Álvarez-asencio R, Nguyen Ch, Rutland Mw, Smith Ci, et al
PloS one 2016;11(11):e0165788-

Four Novel Splice-Switch Reporter Cell Lines: Distinct Impact of Oligonucleotide Chemistry and Delivery Vector on Biological Activity
Rocha Cs, Lundin Ke, Behlke Ma, Zain R, El Andaloussi S, Smith Ci
Nucleic acid therapeutics 2016;26(6):381-391

Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes
Geny S, Moreno Pm, Krzywkowski T, Gissberg O, Andersen Nk, Isse Aj, et al
Nucleic acids research 2016;44(5):2007-19

A distinct triplex DNA unwinding activity of ChlR1 helicase
Guo M, Hundseth K, Ding H, Vidhyasagar V, Inoue A, Nguyen Ch, et al
The Journal of biological chemistry 2015;290(8):5174-89

Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA
Moreno Pm, Geny S, Pabon Yv, Bergquist H, Zaghloul Em, Rocha Cs, et al
Nucleic acids research 2013;41(5):3257-73

Structure-specific recognition of Friedreich's ataxia (GAA)n repeats by benzoquinoquinoxaline derivatives
Bergquist H, Nikravesh A, Fernández Rd, Larsson V, Nguyen Ch, Good L, et al
Chembiochem : a European journal of chemical biology 2009;10(16):2629-37

Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect
Nikravesh A, Dryselius R, Faridani Or, Goh S, Sadeghizadeh M, Behmanesh M, et al
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(8):1537-42

Benzoquinoquinoxaline derivatives stabilize and cleave H-DNA and repress transcription downstream of a triplex-forming sequence
Amiri H, Nekhotiaeva N, Sun Js, Nguyen Ch, Grierson Ds, Good L, et al
Journal of molecular biology 2005;351(4):776-83

Triple-helix directed cleavage of double-stranded DNA by benzoquinoquinoxaline-1,10-phenanthroline conjugates
Zaid A, Sun Js, Nguyen Ch, Bisagni E, Garestier T, Grierson Ds, et al
CHEMBIOCHEM 2004;5(11):1550-7

Do natural DNA triple-helical structures occur and function in vivo?
Zain R, Sun Js
CELLULAR AND MOLECULAR LIFE SCIENCES 2003;60(5):862-70

Optimization of triple-helix-directed DNA cleavage by benzoquinoquinoxaline-ethylenediaminetetraacetic acid conjugates
Zain R, Polverari D, Nguyen Ch, Blouquit Y, Bisagni E, Garestier T, et al
CHEMBIOCHEM 2003;4(9):856-62

Design of a triple-helix-specific cleaving reagent
Zain R, Marchand C, Sun J, Nguyen Ch, Bisagni E, Garestier T, et al
Chemistry & biology 1999;6(11):771-7

Studies on nucleoside H-phosphonothioates as synthons in the synthesis of oligonucleotide analogues
Zain R, Bollmark M, Stawinski J
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 1997;16(7-9):1661-1662

Studies on nucleoside phosphonates and their derivatives. A progress report
Bollmark M, Kers A, Kers I, Szabo T, Zain R, Stawinski J
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 1997;16(5-6):679-684

A new entry to nucleoside phosphorofluoridate and nucleoside phosphorofluoridothioate diesters
Bollmark M, Zain R, Stawinski J
TETRAHEDRON LETTERS 1996;37(20):3537-3540

Efficient method for the preparation of nucleoside phosphorofluoridates and nucleoside phosphorofluoridothioates
Bollmark M, Zain R, Stawinski J
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS 1996;:S68-S71

Nucleoside H-phosphonates .16. P-31 NMR studies on the transformation of nucleoside H-phosphonate monoesters into a monofunctional tervalent intermediate, nucleoside acyl silyl phosphite
Zain R, Stawinski J
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 1996;:795-799

Nucleoside H-phosphonates .17. Synthetic and P-31 NMR studies on the preparation of dinucleoside H-phosphonothioates
Zain R, Stawinski J
JOURNAL OF ORGANIC CHEMISTRY 1996;61(19):6617-6622

Nucleoside phosphonates. Development of synthetic methods and reagents
Kers A, Kers I, Kraszewski A, Sobkowski M, Szabo T, Thelin M, et al
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 1996;15(1-3):361-378

CONVERSION OF NUCLEOSIDE H-PHOSPHONATE MONOESTERS TO THE CORRESPONDING H-PHOSPHONOTHIOATES - P-31 NMR-STUDIES
Stawinski J, Zain R
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 1995;14(3-5):711-714

Nucleoside H-phosphonates .15. Preparation of nucleoside H-phosphonothioate monoesters from the corresponding nucleoside H-phosphonates
Zain R, Stromberg R, Stawinski J
JOURNAL OF ORGANIC CHEMISTRY 1995;60(25):8241-8244

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