Robert van Domselaar

Robert van Domselaar

Research Specialist
Visiting address: I73, Karolinska Universitetssjukhuset Huddinge, 14186 Stockholm
Postal address: H7 Medicin, Huddinge, H7 CIM-CID Sönnerborg, 171 77 Stockholm
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About me

  • I received my PhD training in medical biology from the Department of Pathology, University Medical Center Utrecht, and the Utrecht University, in
    The Netherlands. I obtained my doctoral degree in 2012 on how cytotoxic lymphocytes can control cytomegalovirus infections.
    Currently, I am Team Leader for "Team Viral immunopathogenesis/ Antiviral Therapy" within Anders Sönnerborg's group: https://ki.se/en/medh/anders-sonnerborgs-group-translational-research-on-human-microbial-infections-and-its

    Education:
    2007 - 2012 *PhD degree in Life Sciences, *University Medical Center Utrecht & Utrecht University, The Netherlands (/Fields of expertise: Immunology, Microbiology, Molecular/Cell Biology)/
    2005 - 2007 *MSc degree in Biomedical Sciences, *Utrecht University, The Netherlands
    2002 - 2005 *BSc degree in Biomedical Sciences, *Utrecht University, The Netherlands

Research

  • My main research focus is on the immunological mechanisms by which cytotoxic lymphocytes can control HIV-1 infection and to find ways to exploit or boost these mechanisms for an improved HIV-1 control. Currently, I am investigating how NK cells could be utilized in a shock-and-kill strategy.

    *Publications*
    Ceña-Diez R, Narayanan A, Ray S, van de Klundert M, Rodriguez JE, Nilvebrant J, Nygren PA, Végvári Á, *van Domselaar R*, Sönnerborg A. (2023)
    /Naturally occurring dipeptide from elite controllers with dual anti-HIV-1 mechanism./ *Int. J. Antimicrob. Agents.* 2023 Mar 15;106792

    Furtado Milão J, Love L, Gourgi G, Derhaschnig L, Svensson JP, Sönnerborg A, *van Domselaar R*. (2022) /Natural killer cells induce HIV-1 latency
    reversal after treatment with pan-caspase inhibitors./ *Front Immunol.* 2022 Dec 6;13:1067767 (PMID: 36561752)

    Saccon E, Mikaeloff F, Figueras Ivern P, Végvári Á, Sönnerborg A, Neogi U, *van Domselaar R*. (2021) /Cytotoxic lymphocytes target HIV-1 Gag through granzyme M-mediated cleavage./* Front Immunol. *2021* *Apr 19;12:669347. (PMID: 33953729)

    Sperk M, *van Domselaar R*, Rodriguez JE, Mikaeloff F, Sá Vinhas B, Saccon E, Sönnerborg A, Singh K, Gupta S, Végvári Á, Neogi U. (2020) /Utility of
    Proteomics in Emerging and Re-Emerging Infectious Diseases Caused by RNA Viruses./ *J Proteome Res.* 2020 Nov 6;19(11):4259-4274. (PMID: 33095583)

    *van Domselaar R*, Njenda DT, Rao R, Sönnerborg A, Singh K, Neogi U. (2019) /HIV-1 Subtype C with PYxE Insertion Has Enhanced Binding of Gag-p6 to Host Cell Protein ALIX and Increased Replication Fitness./ *J Virol.* 2019 Apr 17;93(9):e00077-19 (PMID: 30760577)

    Sperk M, *van Domselaar R*, Neogi U. (2018) /Immune Checkpoints as the Immune System Regulators and Potential Biomarkers in HIV-1 Infection./ *Int J Mol Sci.* 2018 Jul 9;19(7):2000. (PMID: 29987244)

    Zhang W, Ambikan AT, Sperk M, *van Domselaar R*, Nowak P, Noyan K, Russom A, Sönnerborg A, Neogi U. (2018) /Transcriptomics and Targeted Proteomics Analysis to Gain Insights Into the Immune-control Mechanisms of HIV-1 Infected Elite Controllers./ *EBioMedicine.* 2018 Jan;27:40-50 (PMID: 29269040)

    van de Ven RAH, de Groot JS, Park D, *van Domselaar R*, de Jong D, Szuhai K, van der Wall E, Rueda OM, Ali HR, Caldas C, van Diest PJ, Hetzer MW, Sahai E, Derksen PWB. (2016) /p120-catenin prevents multinucleation through spatial control of MKLP1-dependent RhoA activity during cytokinesis./ *Nat Commun.* 2016 Dec 22;7:13874 (PMID: 28004812)

    de Groot JS, Moelans CB, Elias SG, Fackler MJ, *van Domselaar R*, Suijkerbuijk KPM, Witkamp AJ, Sukumar S, van Diest PJ, van der Wall E. (2016)
    /DNA promoter hypermethylation in nipple fluid: a potential tool for early breast cancer detection./ *Oncotarget*.* *2016* *Apr 26;7(17):24778-91 (PMID: 27028854)

    Bovenschen N, Spijkers SNM, Wensink AC, Schellens IMM, *van Domselaar R*, van Baarle D. (2014) /Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation./ *Clin Immunol. *2014* *Jan;150(1):1-11 (PMID: 24316590)

    *van Domselaar R*, de Poot SAH, Remmerswaal EBM, Lai KW, ten Berge IJM, Bovenschen N. (2013) /Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication./ *Cell Death Diff. *2013* *Mar;20(3):419-29 (PMID: 23099853)

    *van Domselaar R*, Quadir R, van der Made AM, Broekhuizen R, Bovenschen N. (2012) /All human granzymes target hnRNP K that is essential for tumor cell viability./* J Biol Chem. *2012 Jun 29;287(27):22854-64 (PMID: 22582387)

    *van Domselaar R*, Bovenschen N. (2011) /Cell death-independent functions of granzymes: hit viruses where it hurts./ *Rev Med Virol.* 2011 Sep;21(5):301-314 (PMID: 21714121)

    *van Domselaar R*, Philippen LE, Quadir R, Wiertz EJHJ, Kummer JA, Bovenschen N. (2010) /Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71./ *J Immunol.* 2010 Dec 15;185(12):7605-13 (PMID: 21059895)

    *van Domselaar R*, de Poot SAH, Bovenschen N. (2010) /Proteomic profiling of proteases: tools for granzyme degradomics./ *Exp Rev Proteomics.* 2010 Jun;7(3):347-359 (PMID: 20536307)

    Rooijakkers SHM, Wu J, Ruyken M, *van Domselaar R*, Planken KL, Tzekou A, Ricklin D, Lambris JD, Janssen BJC, van Strijp JAG, Gros P. (2009)
    /Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor./ *Nat Immunol.* 2009 Jul;10(7):721-7 (PMID: 19503103)

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