Reza Zandi Shafagh

Reza Zandi Shafagh

Research Specialist
Visiting address: Solnavägen 9, Biomedicum, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Individanpassad medicin och läkemedelsutveckling, 171 77 Stockholm
Part of:

About me

  • Ph.D in Micro and Nanosystems
    Head of Biofabrication and Tissue Engineering core Facility (Biofab)
    Reza is a research specialist and currently the head of Biofabrication and
    Tissue Engineering core Facility (Biofab) [1] at the Department of Physiology
    and Pharmacology [2 [3], karolinska institutet [4] (KI). He holds Ph.D
    degree in Micro and Nanosystems from Royal Institute of Technology
    [5](KTH), Micro and Nanosystems department [6] (MST), Stockholm,
    Sweden.
    Reza's expertise lies in nanoengineering, microfluidics, lab-on-a-chip, and
    biomicroelectromechanical systems (BioMEMS) for biomedical applications. More
    specifically during his Ph.D studies, he made the following contributions:
    * Establishing novel micro-and nanofabrication methods (micro and nano
    reaction injection molding- μRIM and NanoRIM), as well as implementing
    the standard ones (Electron beam lithography and Nanoimprint lithography),
    for high-resolution structuring of polymer materials (down to 20 nm) and
    scalable manufacturing of microfluidic devices.
    * Introducing facile back-end processing techniques, including direct
    bonding and sealing, 3D surface energy patterning, and seamless
    integration of microfluidic devices and sensors.
    * Presenting high-resolution protein patterning techniques.
    * Developing ultrasensitive biosensing methods.
    He was also previously involved in three European IMI and EU FP7 projects ,
    "RAPP-ID [7]" and "Norosensor [8]" and "POSITIVE [9]":
    * Within the framework of the RAPP-ID [10] project, the research
    included technologies for rapid and ultrasensitive detection of Influenza
    virus directly from human breath.
    * Within the framework of the Norosensor [11] project, the research
    included technologies for the rapid and ultrasensitive detection of
    Norovirus in ambient air.
    * POSITIVE [12]project aimed at the diagnosis of food allergies
    via porous silicon-based lab-on-a-chip devices.
    Reza is currently the head of Biofabrication and Tissue Engineering core
    Facility (Biofab) [13] at KI. Biofab aims to bridge the gap between
    engineering and biology at Karolinska Institutet and provide common grounds
    with respect to suitable material of use of modular design and tunable
    structures for biomedical purposes.
    [1] https://ki.se/en/fyfa/biofabrication-and-tissue-engineering-biofab-facility
    [2] https://ki.se/en/fyfa/department-of-physiology-and-pharmacology
    [3] https://ki.se/en/fyfa/department-of-physiology-and-pharmacology?_ga=2.197737199.1739688656.1584358795-1051791297.1578605044
    [4] https://ki.se/
    [5] https://www.kth.se/
    [6] https://www.kth.se/mst
    [7] https://www.imi.europa.eu/projects-results/project-factsheets/rapp-id
    [8] https://cordis.europa.eu/project/rcn/110979/factsheet/en
    [9] https://www.kth.se/mst/research/micro-and-nanofluidi/projects/previous-projects/positive-1.66472
    [10] https://www.imi.europa.eu/projects-results/project-factsheets/rapp-id
    [11] https://cordis.europa.eu/project/rcn/110979/factsheet/en
    [12] https://www.kth.se/mst/research/micro-and-nanofluidi/projects/previous-projects/positive-1.66472
    [13] https://ki.se/en/fyfa/biofabrication-and-tissue-engineering-biofab-facility

Research

  • * *Microphysiological systems to mimic organ-to-organ
    crosstalk*: Microphysiological systems, also coined as Organ-on-a-Chip
    devices, offer exciting possibilities to bioengineer tissue-tissue
    interaction for disease modeling or drug development purposes.
    Reza's research interest lies in developing suitable materials and
    engineering solutions in the noted research field.
    * *Mechanobiological control of human cells using
    bioinspired nanostructures*: Development of suitable platforms for 3D
    cell culture and manipulation of different cell behaviors on a broad range
    of nanotopographies to alter mechanosensing of human cells are some
    other examples of the intended research efforts.

Articles

All other publications

Grants

  • KI core-facility grant
    1 January 2022 - 1 January 2024
  • An “on-chip” platform for 3D cell co-culture, tissue-tissue interaction and “in-situ” drug screening
    TORE NILSON'S FOUNDATION FOR MEDICAL RESEARCH
    1 January 2021 - 1 January 2022

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