Rafael Cena Diez

Publications
CV
Public outreach and news

Articles

Article: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2024;14:1334126
Broad synergistic antiviral efficacy between a novel elite controller-derived dipeptide and antiretrovirals against drug-resistant HIV-1
Giammarino F; Sonnerborg A; Cena-Diez R
Article: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 2023;61(5):106792
Naturally occurring dipeptide from elite controllers with dual anti-HIV-1 mechanism
Cena-Diez R; Narayanan A; Ray S; van de Klundert M; Rodriguez JE; Nilvebrant J; Nygren P-A; Vegvari A; van Domselaar R; Sonnerborg A
Article: ADVANCED SCIENCE. 2022;9(32):e2203898
Synthetic Mucin Gels with Self-Healing Properties Augment Lubricity and Inhibit HIV-1 and HSV-2 Transmission
Kretschmer M; Cena-Diez R; Butnarasu C; Silveira V; Dobryden I; Visentin S; Berglund P; Sonnerborg A; Lieleg O; Crouzier T; Yan H
Article: VIRUSES-BASEL. 2022;14(10):2099
Molecular Epidemiology of HIV-1 in Eastern Europe and Russia
van de Klundert MAA; Antonova A; Di Teodoro G; Diez RC; Chkhartishvili N; Heger E; Kuznetsova A; Lebedev A; Narayanan A; Ozhmegova E; Pronin A; Shemshura A; Tumanov A; Pfeifer N; Kaiser R; Saladini F; Zazzi M; Incardona F; Bobkova M; Sonnerborg A
Article: INFECTIOUS DISEASES AND THERAPY. 2022;11(3):1103-1116
Novel Naturally Occurring Dipeptides and Single-Stranded Oligonucleotide Act as Entry Inhibitors and Exhibit a Strong Synergistic Anti-HIV-1 Profile
Cena-Diez R; Singh K; Spetz A-L; Sonnerborg A
Article: BIOMEDICINES. 2022;10(5):982
Characterization of the Upper Respiratory Bacterial Microbiome in Critically Ill COVID-19 Patients
Bai X; Narayanan A; Skagerberg M; Cena-Diez R; Giske CG; Stralin K; Sonnerborg A
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(5):2565
Safety of G2-S16 Polyanionic Carbosilane Dendrimer as Possible HIV-1 Vaginal Microbicide
Martin-Moreno A; Cena-Diez R; Serramia MJ; Jimenez JL; Gomez-Ramirez R; Munoz-Fernandez M
Article: JOURNAL OF VIROLOGY. 2021;95(18):e0047921-10.1128/jvi.00421
Fecal Metabolome Signature in the HIV-1 Elite Control Phenotype: Enrichment of Dipeptides Acts as an HIV-1 Antagonist but a Prevotella Agonist
Sperk M; Ambikan AT; Ray S; Singh K; Mikaeloff F; Diez RC; Narayanan A; Vesterbacka J; Nowak P; Sonnerborg A; Neogi U
Article: POLYMERS. 2021;13(13):2141
Role of G2-S16 Polyanionic Carbosilane Dendrimer in the Prevention of Respiratory Syncytial Virus Infection In Vitro and In Vivo in Mice
Rodriguez-Izquierdo I; Cena-Diez R; Serramia MJ; Rodriguez-Fernandez R; Martinez I; Munoz-Fernandez M
Article: PHARMACEUTICS. 2020;12(6):E515-515
Cationic Dendrimer G2-S16 Inhibits Herpes Simplex Type 2 Infection and Protects Mice Vaginal Microbiome
Guerrero-Beltran C; Garcia-Heredia I; Cena-Diez R; Rodriguez-Izquierdo I; Jesus Serramia M; Martinez-Hernandez F; Lluesma-Gomez M; Martinez-Garcia M; Angeles Munoz-Fernandez M
Article: RSC ADVANCES. 2020;10(34):20083-20088
New synthetic procedure for the antiviral sulfonate carbosilane dendrimer G2-S16 and its fluorescein-labelled derivative for biological studies
Gutierrez-Ulloa C; Pena-Gonzalez CE; Barrios-Gumiel A; Cena-Diez R; Jesus Serramia-Lobera M; Angeles Munoz-Fernandez M; Javier de la Mata F; Sanchez-Nieves J; Gomez R
Article: NANOSCALE. 2019;11(19):9679-9690
New anionic poly(alkylideneamine) dendrimers as microbicide agents against HIV-1 infection
Maciel D; Guerrero-Beltran C; Cena-Diez R; Tomas H; Angeles Munoz-Fernandez M; Rodrigues J
Article: INTERNATIONAL JOURNAL OF NANOMEDICINE. 2019;14:2371-2380
G1-S4 or G2-S16 carbosilane dendrimer in combination with Platycodin D as a promising vaginal microbicide candidate with contraceptive activity
Cena-Diez R; Martin-Moreno A; Javier de la Mata F; Gomez-Ramirez R; Munoz E; Ardoys M; Angeles Munoz-Fernandez M
Journal article: PLOS ONE. 2018;13(4):e0195744
Evaluation of the fusion inhibitor P3 peptide as a potential microbicide to prevent HIV transmission in women
Bartolo I; Diniz AR; Borrego P; Ferreira JP; Bronze MR; Barroso H; Pinto R; Cardoso C; Pinto JF; Cena Diaz R; Garcia Broncano P; Angel Munoz-Fernandez M; Taveira N
Article: NANOSCALE. 2017;9(44):17263-17273
Carbosilane dendrons with fatty acids at the core as a new potential microbicide against HSV-2/HIV-1 co-infection
Guerrero-Beltran C; Cena-Diez R; Sepulveda-Crespo D; De la Mata J; Gomez R; Leal M; Munoz-Fernandez MA; Jimenez JL
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2017;811:155-163
Efficacy of carbosilane dendrimers with an antiretroviral combination against HIV-1 in the presence of semen-derived enhancer of viral infection
Garcia-Broncano P; Cena-Diez R; de la Mata FJ; Gomez R; Resino S; Angeles Munoz-Fernandez M
Article: NANOSCALE. 2017;9(27):9732-9742
G2-S16 dendrimer as a candidate for a microbicide to prevent HIV-1 infection in women
Cena-Diez R; Garica-Broncano P; Javier de la Mata F; Gomez R; Resino S; Angeles Munoz-Fernandez M
Article: MEDICINAL RESEARCH REVIEWS. 2017;37(1):149-179
Mechanistic Studies of Viral Entry: An Overview of Dendrimer-Based Microbicides As Entry Inhibitors Against Both HIV and HSV-2 Overlapped Infections
Sepulveda-Crespo D; Cena-Diez R; Luis Jimenez J; Angeles Munoz-Fernandez M
Article: INTERNATIONAL JOURNAL OF NANOMEDICINE. 2016;11:2443-2450
Efficacy of HIV antiviral polyanionic carbosilane dendrimer G2-S16 in the presence of semen
Cena-Diez R; Garcia-Broncano P; Javier de la Mata F; Gomez R; Angeles Munoz-Fernandez M
Article: INTERNATIONAL JOURNAL OF NANOMEDICINE. 2016;11:2147-2162
Prevention of vaginal and rectal herpes simplex virus type 2 transmission in mice: mechanism of antiviral action
Cena-Diez R; Vacas-Cordoba E; Garcia-Broncano P; de la Mata FJ; Gomez R; Maly M; Angeles Munoz-Fernandez M
Journal article: RSC ADVANCES. 2016;6(52):46755-46764
Dendrimeric based microbicides against sexual transmitted infections associated to heparan sulfate
Cena-Diez R; Sepulveda-Crespo D; Maly M; Angeles Munoz-Fernandez M
Journal article: JOURNAL OF CRITICAL CARE. 2014;29(2):307-309
Transcriptomic evidence of impaired immunoglobulin G production in fatal septic shock
Almansa R; Tamayo E; Heredia M; Gutierrez S; Ruiz P; Alvarez E; Gomez-Sanchez E; Andaluz-Ojeda D; Cena R; Rico L; Iglesias V; Ignacio Gomez-Herreras J; Bermejo-Martin JF
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Review: DRUG RESISTANCE UPDATES. 2023;68:100955
Synergistic antiviral activity against drug-resistant HIV-1 by naturally occurring dipeptide and A single-stranded oligonucleotide
Cena-Diez R; Spetz A-L; Sonnerborg A

Employments

Affiliated to Research, Department of Medicine, Huddinge, Karolinska Institutet, 2025-2028
Research Specialist, Department of Medicine, Huddinge, Karolinska Institutet, 2023-2025

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