Peter Swoboda

Publications
CV
Public outreach and news

Articles

Article: BMC BIOLOGY. 2024;22(1):48

Primary cilia promote the differentiation of human neurons through the WNT signaling pathway.

Coschiera A; Yoshihara M; Lauter G; Ezer S; Pucci M; Li H; Kavšek A; Riedel CG; Kere J; Swoboda P
Article: BIOMOLECULAR INTERACTIONS, PT A. 2023;176:27-41

Human LUHMES and NES cells as models for studying primary cilia in neurons.

Coschiera A; Watts ME; Kere J; Tammimies K; Swoboda P
Article: CELL REPORTS. 2022;39(2):110661

The C. elegans regulatory factor X (RFX) DAF-19M module: A shift from general ciliogenesis to cell-specific ciliary and behavioral specialization.

Ahn S; Yang H; Son S; Lee HS; Park D; Yim H; Choi H-J; Swoboda P; Lee J
Article: JOURNAL OF CELL SCIENCE. 2020;133(21):jcs249789

Differentiation of ciliated human midbrain-derived LUHMES neurons.

Lauter G; Coschiera A; Yoshihara M; Sugiaman-Trapman D; Ezer S; Sethurathinam S; Katayama S; Kere J; Swoboda P
Article: REDOX BIOLOGY. 2019;24:101178

Redox-dependent and redox-independent functions of Caenorhabditis elegans thioredoxin 1.

Sanzo-Machuca Á; Monje Moreno JM; Casado-Navarro R; Karakuzu O; Guerrero-Gómez D; Fierro-González JC; Swoboda P; Muñoz MJ; Garsin DA; Pedrajas JR; Barrios A; Miranda-Vizuete A
Article: NATURE COMMUNICATIONS. 2018;9(1):4400

DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity.

Lin X-X; Sen I; Janssens GE; Zhou X; Fonslow BR; Edgar D; Stroustrup N; Swoboda P; Yates JR; Ruvkun G; Riedel CG
Article: BMC GENOMICS. 2018;19(1):181

Characterization of the human RFX transcription factor family by regulatory and target gene analysis.

Sugiaman-Trapman D; Vitezic M; Jouhilahti E-M; Mathelier A; Lauter G; Misra S; Daub CO; Kere J; Swoboda P
Article: GENETICS. 2018;208(3):1083-1097

An Expanded Role for the RFX Transcription Factor DAF-19, with Dual Functions in Ciliated and Nonciliated Neurons.

De Stasio EA; Mueller KP; Bauer RJ; Hurlburt AJ; Bice SA; Scholtz SL; Phirke P; Sugiaman-Trapman D; Stinson LA; Olson HB; Vogel SL; Ek-Vazquez Z; Esemen Y; Korzynski J; Wolfe K; Arbuckle BN; Zhang H; Lombard-Knapp G; Piasecki BP; Swoboda P
Article: FASEB JOURNAL. 2016;30(10):3578-3587

Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs.

Tammimies K; Bieder A; Lauter G; Sugiaman-Trapman D; Torchet R; Hokkanen M-E; Burghoorn J; Castrén E; Kere J; Tapia-Páez I; Swoboda P
Article: GENETICS. 2016;203(1):387-402

TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans.

McCallum KC; Liu B; Fierro-González JC; Swoboda P; Arur S; Miranda-Vizuete A; Garsin DA
Article: JOURNAL OF NEUROSCIENCE. 2016;36(11):3157-3169

Neuropeptidergic Signaling and Active Feeding State Inhibit Nociception in Caenorhabditis elegans.

Ezcurra M; Walker DS; Beets I; Swoboda P; Schafer WR
Article: GENETICS. 2015;200(1):123-134

Cis- and trans-regulatory mechanisms of gene expression in the ASJ sensory neuron of Caenorhabditis elegans.

González-Barrios M; Fierro-González JC; Krpelanova E; Mora-Lorca JA; Pedrajas JR; Peñate X; Chavez S; Swoboda P; Jansen G; Miranda-Vizuete A
Article: CILIA. 2015;4:5

The more we know, the more we have to discover: an exciting future for understanding cilia and ciliopathies.

Benmerah A; Durand B; Giles RH; Harris T; Kohl L; Laclef C; Meilhac SM; Mitchison HM; Pedersen LB; Roepman R; Swoboda P; Ueffing M; Bastin P
Article: PLOS ONE. 2015;10(2):e0116702

ABCE1 is a highly conserved RNA silencing suppressor.

Kärblane K; Gerassimenko J; Nigul L; Piirsoo A; Smialowska A; Vinkel K; Kylsten P; Ekwall K; Swoboda P; Truve E; Sarmiento C
Article: AGING-US. 2014;6(11):975-991

Iron promotes protein insolubility and aging in C. elegans.

Klang IM; Schilling B; Sorensen DJ; Sahu AK; Kapahi P; Andersen JK; Swoboda P; Killilea DW; Gibson BW; Lithgow GJ
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2014;73:328-336

Protective effects of the thioredoxin and glutaredoxin systems in dopamine-induced cell death.

Arodin L; Miranda-Vizuete A; Swoboda P; Fernandes AP
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2014;68(100):205-219

Functional characterization of thioredoxin 3 (TRX-3), a Caenorhabditis elegans intestine-specific thioredoxin.

Jiménez-Hidalgo M; Kurz CL; Pedrajas JR; Naranjo-Galindo FJ; González-Barrios M; Cabello J; Sáez AG; Lozano E; Button EL; Veal EA; Fierro-González JC; Swoboda P; Miranda-Vizuete A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2014;444(2):254-259

RNAi mediates post-transcriptional repression of gene expression in fission yeast Schizosaccharomyces pombe.

Smialowska A; Djupedal I; Wang J; Kylsten P; Swoboda P; Ekwall K
Article: DEVELOPMENTAL BIOLOGY. 2012;368(2):415-426

The in vivo dissection of direct RFX-target gene promoters in C. elegans reveals a novel cis-regulatory element, the C-box.

Burghoorn J; Piasecki BP; Crona F; Phirke P; Jeppsson KE; Swoboda P
Article: ANTIOXIDANTS & REDOX SIGNALING. 2012;16(12):1384-1400

The characterization of the Caenorhabditis elegans mitochondrial thioredoxin system uncovers an unexpected protective role of thioredoxin reductase 2 in β-amyloid peptide toxicity.

Cacho-Valadez B; Muñoz-Lobato F; Pedrajas JR; Cabello J; Fierro-González JC; Navas P; Swoboda P; Link CD; Miranda-Vizuete A
Article: CURRENT BIOLOGY. 2011;21(20):1685-1694

The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans.

O'Hagan R; Piasecki BP; Silva M; Phirke P; Nguyen KCQ; Hall DH; Swoboda P; Barr MM
Article: DEVELOPMENTAL BIOLOGY. 2011;357(1):235-247

Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport.

Phirke P; Efimenko E; Mohan S; Burghoorn J; Crona F; Bakhoum MW; Trieb M; Schuske K; Jorgensen EM; Piasecki BP; Leroux MR; Swoboda P
Article: SCIENCE. 2011;332(6032):930-936

Comparative functional genomics of the fission yeasts.

Rhind N; Chen Z; Yassour M; Thompson DA; Haas BJ; Habib N; Wapinski I; Roy S; Lin MF; Heiman DI; Young SK; Furuya K; Guo Y; Pidoux A; Chen HM; Robbertse B; Goldberg JM; Aoki K; Bayne EH; Berlin AM; Desjardins CA; Dobbs E; Dukaj L; Fan L; FitzGerald MG; French C; Gujja S; Hansen K; Keifenheim D; Levin JZ; Mosher RA; Müller CA; Pfiffner J; Priest M; Russ C; Smialowska A; Swoboda P; Sykes SM; Vaughn M; Vengrova S; Yoder R; Zeng Q; Allshire R; Baulcombe D; Birren BW; Brown W; Ekwall K; Kellis M; Leatherwood J; Levin H; Margalit H; Martienssen R; Nieduszynski CA; Spatafora JW; Friedman N; Dalgaard JZ; Baumann P; Niki H; Regev A; Nusbaum C
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;406(3):478-482

The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans.

Fierro-González JC; González-Barrios M; Miranda-Vizuete A; Swoboda P
Article: EMBO JOURNAL. 2011;30(6):1110-1122

Food sensitizes C. elegans avoidance behaviours through acute dopamine signalling.

Ezcurra M; Tanizawa Y; Swoboda P; Schafer WR
Article: PLOS ONE. 2011;6(1):e16561

The thioredoxin TRX-1 modulates the function of the insulin-like neuropeptide DAF-28 during dauer formation in Caenorhabditis elegans.

Fierro-González JC; Cornils A; Alcedo J; Miranda-Vizuete A; Swoboda P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(3):1064-1069

Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans.

Stenvall J; Fierro-González JC; Swoboda P; Saamarthy K; Cheng Q; Cacho-Valadez B; Arnér ESJ; Persson OP; Miranda-Vizuete A; Tuck S
Article: PLOS ONE. 2011;6(6):e20580

Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons.

Massinen S; Hokkanen M-E; Matsson H; Tammimies K; Tapia-Páez I; Dahlström-Heuser V; Kuja-Panula J; Burghoorn J; Jeppsson KE; Swoboda P; Peyrard-Janvid M; Toftgård R; Castrén E; Kere J
Article: PLOS ONE. 2011;6(6):e20995

The retrograde IFT machinery of C. elegans cilia: two IFT dynein complexes?

Hao L; Efimenko E; Swoboda P; Scholey JM
Article: GENETICS. 2010;186(3):969-U328

Genetics of extracellular matrix remodeling during organ growth using the Caenorhabditis elegans pharynx model.

Jafari G; Burghoorn J; Kawano T; Mathew M; Mörck C; Axäng C; Ailion M; Thomas JH; Culotti JG; Swoboda P; Pilon M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(29):12969-12974

Regulatory Factor X (RFX)-mediated transcriptional rewiring of ciliary genes in animals.

Piasecki BP; Burghoorn J; Swoboda P
Article: JOURNAL OF CELL SCIENCE. 2010;123(Pt 12):2076-2083

Dauer pheromone and G-protein signaling modulate the coordination of intraflagellar transport kinesin motor proteins in C. elegans.

Burghoorn J; Dekkers MPJ; Rademakers S; de Jong T; Willemsen R; Swoboda P; Jansen G
Article: GENETICS. 2009;183(2):595-3SI

Worms with a single functional sensory cilium generate proper neuron-specific behavioral output.

Senti G; Ezcurra M; Löbner J; Schafer WR; Swoboda P
Article: MOLECULAR BIOLOGY OF THE CELL. 2008;19(12):5517-5528

Distinct isoforms of the RFX transcription factor DAF-19 regulate ciliogenesis and maintenance of synaptic activity.

Senti G; Swoboda P
Article: PLOS GENETICS. 2008;4(3):e1000044

An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes.

Li C; Inglis PN; Leitch CC; Efimenko E; Zaghloul NA; Mok CA; Davis EE; Bialas NJ; Healey MP; Héon E; Zhen M; Swoboda P; Katsanis N; Leroux MR
Article: GENOME BIOLOGY. 2007;8(9):r195

Identification of novel regulatory factor X (RFX) target genes by comparative genomics in Drosophila species.

Laurençon A; Dubruille R; Efimenko E; Grenier G; Bissett R; Cortier E; Rolland V; Swoboda P; Durand B
Article: MOLECULAR BIOLOGY OF THE CELL. 2006;17(11):4801-4811

Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the intraflagellar transport machinery in sensory cilia.

Efimenko E; Blacque OE; Ou G; Haycraft CJ; Yoder BK; Scholey JM; Leroux MR; Swoboda P
Article: FEBS LETTERS. 2006;580(2):484-490

Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons.

Miranda-Vizuete A; Fierro González JC; Gahmon G; Burghoorn J; Navas P; Swoboda P
Article: GENOME BIOLOGY. 2006;7(12):r126

Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomics.

Chen N; Mah A; Blacque OE; Chu J; Phgora K; Bakhoum MW; Newbury CRH; Khattra J; Chan S; Go A; Efimenko E; Johnsen R; Phirke P; Swoboda P; Marra M; Moerman DG; Leroux MR; Baillie DL; Stein LD
Article: JOURNAL OF CELL SCIENCE. 2005;118(Pt 23):5575-5587

The C. elegans homologs of nephrocystin-1 and nephrocystin-4 are cilia transition zone proteins involved in chemosensory perception.

Winkelbauer ME; Schafer JC; Haycraft CJ; Swoboda P; Yoder BK
Article: CURRENT BIOLOGY. 2005;15(10):935-941

Functional genomics of the cilium, a sensory organelle.

Blacque OE; Perens EA; Boroevich KA; Inglis PN; Li C; Warner A; Khattra J; Holt RA; Ou G; Mah AK; McKay SJ; Huang P; Swoboda P; Jones SJM; Marra MA; Baillie DL; Moerman DG; Shaham S; Leroux MR
Article: DEVELOPMENT. 2005;132(8):1923-1934

Analysis of xbx genes in C. elegans.

Efimenko E; Bubb K; Mak HY; Holzman T; Leroux MR; Ruvkun G; Thomas JH; Swoboda P
Article: MOLECULAR BIOLOGY OF THE CELL. 2003;14(5):2057-2070

XBX-1 encodes a dynein light intermediate chain required for retrograde intraflagellar transport and cilia assembly in Caenorhabditis elegans.

Schafer JC; Haycraft CJ; Thomas JH; Yoder BK; Swoboda P
Article: DEVELOPMENT. 2002;129(23):5487-5498

Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.

Dubruille R; Laurençon A; Vandaele C; Shishido E; Coulon-Bublex M; Swoboda P; Couble P; Kernan M; Durand B
Article: DEVELOPMENT. 2001;128(9):1493-1505

The C. elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms.

Haycraft CJ; Swoboda P; Taulman PD; Thomas JH; Yoder BK
Article: MOLECULAR CELL. 2000;5(3):411-421

The RFX-type transcription factor DAF-19 regulates sensory neuron cilium formation in C. elegans.

Swoboda P; Adler HT; Thomas JH
Article: PLANT MOLECULAR BIOLOGY. 1995;28(2):281-292

Somatic intrachromosomal homologous recombination events in populations of plant siblings.

Puchta H; Swoboda P; Gal S; Blot M; Hohn B
Article: PLANT JOURNAL. 1995;7(2):203-210

INDUCTION OF INTRACHROMOSOMAL HOMOLOGOUS RECOMBINATION IN WHOLE PLANTS

PUCHTA H; SWOBODA P; HOHN B
Show more

All other publications

Review: DEVELOPMENT. 2014;141(7):1427-1441

Switching on cilia: transcriptional networks regulating ciliogenesis.

Choksi SP; Lauter G; Swoboda P; Roy S
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2013;525:327-350

Finding ciliary genes: a computational approach.

Henriksson J; Piasecki BP; Lend K; Bürglin TR; Swoboda P
Meeting abstract: MECHANISMS OF DEVELOPMENT. 2009;126:S17

Worms with only a single cilium S.: per animal

Swoboda P
Editorial comment: GENOME BIOLOGY. 2008;9(6):312

Caenorhabditis elegans comes of age.

Ceron J; Swoboda P

Employments

Principal Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2024-
Principal Researcher, Department of Biosciences and Nutrition, Karolinska Institutet, 2024-2024
Principal Researcher, Department of Biosciences and Nutrition, Karolinska Institutet, 2022-2024

Degrees and Education

Docent, Karolinska Institutet, 2018

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI