Pontus Andell

Pontus Andell

Affiliated to Research | Docent
Visiting address: Solnavägen 9, Biomedicum C5, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Molekylär Arbetsfysiologi, 171 77 Stockholm

About me

  • Clinically active cardiologist at Karolinska University Hospital, dedicating 50% of my time to research. My work focuses on identifying high-risk groups for acute myocardial infarction and leading an RCT on stair walking to lower blood pressure and improve cardiovascular health in individuals with hypertension, obesity, and physical inactivity.

Research

    • Epidemiological studies on cardiovascular disease to identify trends and emerging clinical challenges, with a current focus on the interplay between ADHD and CVD, COPD and CVD, and young patients presenting with acute myocardial infarction.
    • Designing pragmatic RCTs evaluating interventions to address emerging cardiovascular challenges, with a particular emphasis on improving lifestyle factors to enhance health outcomes at a scalable, low cost.

Articles

All other publications

Grants

  • Effects of stair walking in individuals with hypertension and increased cardiometabolic risk - a randomized controlled trial
    ALF KI / Region Stockholm
    1 January 2024 - 31 December 2027
  • Effects of stair walking in individuals with hypertension and increased cardiometabolic risk - a randomized controlled trial
    Swedish Heart-Lung Foundation
    1 January 2024 - 31 December 2026
  • Swedish Heart-Lung Foundation
    1 January 2023 - 31 December 2025
    Background: Physical inactivity negatively affects health and is associated with type 2 diabetes, cardiovascular disease, cognitive dysfunction and shorter life span. Despite the growing body of evidence for detrimental effects, the population is increasingly sedentary and currently sitting nine to ten hours per day
    the pattern is seen across all age groups. This harmful development must be mitigated to combat the increasing epidemic of lifestyle-related diseases in society. Stair walking has the potential to incentivize people to be more physically active seamlessly integrated into everyday life. Objectives: To investigate whether six months of daily stair walking (200 stair steps daily) in addition to walking on level ground (75 minutes per week) versus only walking on level ground (150 minutes per week) - in a time-effective manner - confers greater blood pressure reduction as well as greater improvement in aerobic fitness, strength, cardiovascular risk factor control and self-assessed health parameters. Work plan: Study subjects will be screened for inclusion through an online screening tool. Participants are both men and women 40-70 years old with increased cardiometabolic risk defined by hypertension, abdominal obesity and sedentary lifestyle (less than 4000 steps per day). Study subjects (n=400) will be randomized into two groups: 1) daily stair walking plus half the weekly recommended walking on level ground and 2) recommended weekly walking on level ground alone. Activity levels will be monitored regularly. Subjects will be followed for six months. Measured outcomes are blood pressure, aerobic fitness, strength, cardiovascular risk factor control and self-assessed health parameters. Significance: If stair walking is a feasible and time-effective physical activity it could improve individual health through a simplistic training alternative that can be seamlessly integrated into everyday life. It could inform infrastructure planning by ensuring that stairs are readily available and promoted for pedestrians. Healthcare costs could be decreased by keeping vulnerable groups more physically active thus reducing the growing burden of lifestyle-related diseases. Positive findings have population-level scalability and could corroborate the European Society of Cardiology s guidelines on both individual prevention and strong policy suggestions on physical activity when planning/building new landscaping.

Employments

  • Cardiologist, ME Cardiology, Karolinska University Hospital, 2022-
  • Affiliated to Research, Department of Physiology and Pharmacology, Karolinska Institutet, 2025-2028

Degrees and Education

  • Docent, Karolinska Institutet, 2021

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