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About me

I am a research group leader of the Vascular Surgery Research Group, Södersjukhuset. We conduct projects in the field of vascular diseases. The group is presented on a web page at the Institution of Clinical Science and Education, Södersjukhuset - SOSVASC. The research has a strong clinical focus including  evaluating the results of both established and new therapies as well as basic science. Much of the clinical research is associated with arteriosclerosis and degenerative vascular disease. The Vascular Section of Surgery, Södersjukhuset, is the second largest clinic in the country and we annually get requests for participation in scientific multicenter studies, both in terms of method development and new treatment. In my role as a research groupleader I focuse on the ongoing PhD projects, my own projects and the multicenter trials we conduct. My main task at Karolinska Institutet, is thus to support the members of the research team, as well as helping them to create the conditions for conducting research. My own research career began with the study of malignant melanoma (PhD2002) but my focus is now on the ongoing vascular projects.

Research description

Ongoing research

1. Methodological aspects on carotid artery intervention

PhD student: Magnus Jonsson, Dep. of Clinical Science and Education, Södersjukhuset, KI

Supervisor: David Lindstrom, Dep. of Molecular Medicine and Surgery (MMK), KI

Co-supervisors: Peter Gillgren,  Dep. of Clinical Science and Education, Södersjukhuset, KI, Anders Wanhainen, Uppsala University

The project plan includes four papers and dissertation is scheduled for spring 2017. I participate in all project papers.

1. Results after 7 years of CAS in South Hospital and CAS in Sweden - single-center and national results.
2. Perioperative stroke risk in acute stenting of carotid stenosis: a population-based national Swedvasc study.
3. Long-term results of CAS - risk of stroke and death within 5 years. 
4. Prediction of shuntneed at carotid endarectomy with NIRS versus stump pressure. Power calculated on 150 patients. 100 patients have been included so far (April 2015).

2. Cutaneous Malignant Melanoma – Body Site in Relation to Prognosis, Sun Exposure and Genetic Factors.

PhD Student: Daniela Gordon, Dep.of Medicine, Solna, KI

Supervisor: Karin Ekström Smedby, Dep.of Medicine, Solna, KI

Co-supervisors: Peter Gillgren, Dep. of Clinical Science and Education, Södersjukhuset, KI, Johan Hansson, Department of Oncology-Pathology, KI

The project plan includes four papers and the dissertation is scheduled for spring 2017. I participate in all project papers.

1. Localization of the sentinel node in melanoma on the trunk and extremities: unusual or multiple drainage does not affect survival.
2. Time trends in incidence of cutaneous melanoma by detailed anatomical location and patterns of ultraviolet radiation exposure – a retrospective population-based study.
3. Effect of Primary Site on Prognosis in Patients with Cutaneous Malignant Melanoma. Data collection is ongoing.
4. Primary Location of Cutaneous Malignant Melanoma in Patients with NRAS / BRAF Mutations. Data collection is ongoing.

 

Other ongoing projects with planned authorship

1. Results of endovascular treatment for aortic disease with visceral branches.

In co-operation with the Radiological department at Södersjukhuset I and PhD-student  Otto Stackelberg (this project is outside his thesis work), will study all consecutive patients treated at our unit. We will evaluate the results of endovascular treatment of patients with complex aortic disease, where treatments have included stenting of the the visceral and/or renal arteries

2. Biomarkers for unstable plaques in arteriosclerotic disease.

There is a lack of reliable methods to predict patients with atherosclerosis, where the plaque, the coating on the inside of the vessel, is unstable and thus about to cause an acute occlusion or occlusion (complete blockage).A better understanding of patients at risk for unstable plaque formation and thereby with an increased risk in the near for cardiac or cerebral infarction would enable more selective treatment. The research project aims to find biomarkers of unstable atherosclerosis and thereby eliminate these shortcomings and tailor treatment. The project is conducted in collaboration with Prof. Ulf Hedins research group at the Dep. of Molecular Medicine and Surgery and has already resulted in a publication where I am co-author.

3. Procedural risk in acute carotid endarterectomy

In recent years, our Vascular section of surgery at Södersjukhuset have treated more patients with carotid stenosis than any other hospital in the country. I have been invited to a collaboration with the Dep. of Molecular and Clinical Medicine, Wallenberg Laboratory at Sahlgrenska University Hospital, Gothenburg. The project aims to identify risk factors for early surgery for symptomatic carotid stenosis  The Gothenburg-group has already published a well cited article on the subject; Risk of early recurrent stroke in symptomatic carotid stenosis. The study shall also constitute one paper in the PhD-student Sofia Strömberg's thesis.

4. Natural History of Peripheral Arterial Disease

Frederick Sartipy M.D., has a PhD project. In collaboration with Dr Birgitta Sigvant, Karlstad's Central Hospital, and Professor Eric Wahlberg at Linköping University' Sartipy will study quality of life, disease panorama and death in patients with PAD. Sigvant holds a PhD in the subject and a large cohort of patients is in our database already.

5. Cellular mechanisms for instability in arteriosclerotic plaques

In collaboration with Professor Johan Frostegårds group at the Unit of Immunology and Chronic Disease at KI, we will study cellular mechanisms in unstable arteriosclerotic plaques in the carotid and femoral artery. I will take active part as well as PhD Johnny Steuer. 2-3 publications are planned.

6. We plan to investigate diagnoses in vascular surgery in patients subjected to pelvic radiotherapy. The project is a collaboration with Åsa Hallqvist Everhov, Jonas Malmstedt and Karin Ekström Smedby.

7. We study the results after treatment for primary trmbosis of the subclavian vein. This is a project in collaboration with Carl-Magnus Wahlgren and Jonas Malmstedt along with a medical student (Sara Lindblom)

8. I am co-principle investigator for the Basil-2 trial. A randomized multi-centre trial from University of Birmingham. The objective is to find out if a "vein by-pass first" or a "best endovascular first" revascularisation strategy is best, in terms of either clinical or cost-effectiviness, for severe limb ischemia due to infra-popliteal disease.

 

Members of the vascular research team

Post-doc

Johnny Steuer (PhD)

Jonas Malmstedt (PhD)

Anneli Linné (PhD)

PhD students

Magnus Jonsson (MD)

Christian Smedberg (MD)

Sayid Zommorodi (MD)

Eva Torbjörnsson (NT)

Sara Haile (NT)

Sartipy Fredrik (MD)

Andreas Älgå (MD)

 

 

External students with KI-SÖS projects

 

Otto Stackelberg (MD)

 

Seven selected publications

2-cm versus 4-cm excision margins for primary cutaneous melanoma thicker than 2 mm: a randomized, multicentre trial. Gillgren P, Drzewiecki KT, Niin M, Gullestad, HP, Hellborg H, Mansson-Brahme, E, Ingvar C, Call Borg U. Lancet. 2011 Nov 5; 378 (9803): 1635-42.

Peri-procedural risk with the Urgent Carotid Artery Stenting: A Population-based Study Swedvasc. Jonsson M, Gillgren P, Wanhainen A, Acosta S, Lindstrom D. Eur J Vasc Endovasc Surg. 2015 February 28. PII: S1078-5884 (15) 00045-3. doi: 10.1016/j.ejvs.2015.01.007.

Outcome After Seven Years of carotid artery stenting and endarectomi in Sweden - single center and the national results. Lindstrom D, Jonsson M, Formgren J, Delle M, Rosfors S, Gillgren P. Eur J Vasc Endovasc Surg. 2012 May;43(5):499-503.

Profiling of atherosclerotic lesions by Gene and tissue microarrays Reveals PCSK6 as a novel protease in unstable carotid atherosclerosis. Perisic L, Hedin E, Razuvaev A, Lengquist M, Osterholm C, Folkersen L, Gillgren P , Paulsson-Berne G, Ponten F, Odeberg J, Hedin U. Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2432-43.

Sentinel node location in trunk and extremity melanomas: uncommon or multiple lymph drainage does not affect survival. Gordon D, Smedby KE, Schultz I, Olsson H, Ingvar C, Hansson J, Gillgren P . Ann Surg Oncol. 2014 Oct;21(11):3386-94.

The role of procalcitonin in postimplantation syndrome after EVAR: a pilot study. The role of procalcitonin in postimplantation syndrome after EVAR: a pilot study. Sartipy F, Lindström D, Gillgren P , Ternhag A. Ann Vasc Surg. 2014 May;28(4):866-73.

Publications

Haemodialysis access thrombosis: Outcomes after surgical thrombectomy versus catheter-directed thrombolytic infusion
Koraen-smith L, Krasun M, Bottai M, Hedin U, Wahlgren Cm, Gillgren P
The journal of vascular access 2018;():1129729818761277-

IgM antibodies against phosphorylcholine promote polarization of T regulatory cells from patients with atherosclerotic plaques, systemic lupus erythematosus and healthy donors
Sun J, Lundström Sl, Zhang B, Zubarev Ra, Steuer J, Gillgren P, et al
Atherosclerosis 2018;268():36-48

Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage
Matic Lp, Jesus Iglesias M, Vesterlund M, Lengquist M, Hong Mg, Saieed S, et al
JACC. Basic to translational science 2018;3(4):464-480

Aortic Graft Infections after Emergency and Non-Emergency Reconstruction: Incidence, Treatment, and Long-Term Outcome
Pettersson J, Daryapeyma A, Gillgren P, Hultgren R
Surgical infections 2017;18(3):303-310

Choices of Stent and Cerebral Protection in the Ongoing ACST-2 Trial: A Descriptive Study
Acst-2 Collaborative Group, De Waard Dd, Halliday A, De Borst Gj, Bulbulia R, Huibers A, et al
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2017;53(5):617-625

Induction of Dendritic Cell-Mediated Activation of T Cells From Atherosclerotic Plaques by Human Heat Shock Protein 60
Rahman M, Steuer J, Gillgren P, Hayderi A, Liu A, Frostegård J
Journal of the American Heart Association 2017;6(11):-

Near Infrared Spectroscopy as a Predictor for Shunt Requirement During Carotid Endarterectomy
Jonsson M, Lindström D, Wanhainen A, Djavani Gidlund K, Gillgren P
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2017;53(6):783-791

Primary tumor sites in relation to ultraviolet radiation exposure and skin visibility correlate with survival in cutaneous melanoma
Gordon D, Hansson J, Eloranta S, Gordon M, Gillgren P, Smedby Ke
International journal of cancer 2017;141(7):1345-1354

Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease
Euclid Trial Steering Committee And Investigators, Hiatt Wr, Fowkes Fg, Heizer G, Berger Js, Baumgartner I, et al
The New England journal of medicine 2017;376(1):32-40

Long-Term Outcome After Carotid Artery Stenting: A Population-Based Matched Cohort Study
Jonsson M, Lindström D, Gillgren P, Wanhainen A, Malmstedt J
Stroke 2016;47(8):2083-9

Nationwide Study of the Treatment of Mycotic Abdominal Aortic Aneurysms Comparing Open and Endovascular Repair
Swedish Collaborator Group For Mycotic Abdominal Aortic Aneurysms*, Sörelius K, Wanhainen A, Furebring M, Björck M, Gillgren P, et al
Circulation 2016;134(23):1822-1832

Safety of Intra-arterial Catheter Directed Thrombolysis: Does Level of Care Matter?
Koraen-smith L, Wängberg M, Montán C, Gillgren P, Wahlgren Cm
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2016;51(5):718-23

Peri-procedural Risk with Urgent Carotid Artery Stenting: A Population based Swedvasc Study
Jonsson M, Gillgren P, Wanhainen A, Acosta S, Lindström D
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2015;49(5):506-12

Risk Factors For Stroke, Myocardial Infarction, or Death Following Carotid Endarterectomy: Results From the International Carotid Stenting Study
Icss Investigators, Doig D, Turner El, Dobson J, Featherstone Rl, De Borst Gj, et al
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2015;50(6):688-94

The Impact of Stent Graft Material on the Inflammatory Response After EVAR
Sartipy F, Lindström D, Gillgren P, Ternhag A
Vascular and endovascular surgery 2015;49(3-4):79-83

Time trends in incidence of cutaneous melanoma by detailed anatomical location and patterns of ultraviolet radiation exposure: a retrospective population-based study
Gordon D, Gillgren P, Eloranta S, Olsson H, Gordon M, Hansson J, et al
Melanoma research 2015;25(4):348-56

Sentinel node location in trunk and extremity melanomas: uncommon or multiple lymph drainage does not affect survival
Gordon D, Smedby Ke, Schultz I, Olsson H, Ingvar C, Hansson J, et al
Annals of surgical oncology 2014;21(11):3386-94

The role of procalcitonin in postimplantation syndrome after EVAR: a pilot study
Sartipy F, Lindström D, Gillgren P, Ternhag A
Annals of vascular surgery 2014;28(4):866-73

Effect of white-matter lesions on the risk of periprocedural stroke after carotid artery stenting versus endarterectomy in the International Carotid Stenting Study (ICSS): a prespecified analysis of data from a randomised trial
Icss Investigators, Ederle J, Davagnanam I, Van Der Worp Hb, Venables Gs, Lyrer Pa, et al
The Lancet. Neurology 2013;12(9):866-872

Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis
Perisic L, Hedin E, Razuvaev A, Lengquist M, Osterholm C, Folkersen L, et al
Arteriosclerosis, thrombosis, and vascular biology 2013;33(10):2432-43

Status Update and Interim Results from the Asymptomatic Carotid Surgery Trial-2 (ACST-2)
Acst-2 Collaborative Grp, Halliday A, Bulbulia R, Gray W, Naughten A, Den Hartog A, et al
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY 2013;46(5):510-8

Outcome After 7 Years of Carotid Artery Stenting and Endarterectomy in Sweden - Single Centre and National Results
Lindstrom D, Jonsson M, Formgren J, Delle M, Rosfors S, Gillgren P
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY 2012;43(5):499-503

2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: a randomised, multicentre trial
Gillgren P, Drzewiecki Kt, Niin M, Gullestad Hp, Hellborg H, Mansson-brahme E, et al
LANCET 2011;378(9803):1635-42

Outcome After Nitinol Stenting in the Superficial Femoral and Popliteal Artery in an Elderly Population
Gillgren P, Pettersson H, Fernstrom J, Falkenberg M, Delle M, Konrad P, et al
ANNALS OF VASCULAR SURGERY 2011;25(6):758-65

Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial
Int Carotid Stenting Study, Ederle J, Dobson J, Featherstone Rl, Bonati Lh, Van Der Worp Hb, et al
LANCET 2010;375(9719):985-97

General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial
Gala Trial Collaborative Grp, Lewis Sc, Warlow Cp, Bodenham Ar, Colam B, Rothwell Pm, et al
LANCET 2008;372(9656):2132-42

The risk for cutaneous malignant melanoma, melanoma in situ and intraocular malignant melanoma in relation to tobacco use and body mass index
Odenbro A, Gillgren P, Bellocco R, Boffetta P, Hakansson N, Adami J
BRITISH JOURNAL OF DERMATOLOGY 2007;156(1):99-105

Effect of primary site on prognosis in patients with cutaneous malignant melanoma. A study using a new model to analyse anatomical locations
Gillgren P, Brattstrom G, Frisell J, Persson Jo, Ringborg U, Hansson J
MELANOMA RESEARCH 2005;15(2):125-32

Body site of cutaneous malignant melanoma - a study on patients with hereditary and multiple sporadic tumours
Gillgren P, Brattstrom G, Frisell J, Palmgren J, Ringborg U, Hansson J
MELANOMA RESEARCH 2003;13(3):279-86

A new computerized methodology to analyse tumour site in relation to phenotypic traits and epidemiological characteristics of cutaneous malignant melanoma
Gillgren P, Brattstrom G, Martensson Ed, Frisell J, Palmgren J, Ringborg U, et al
BRITISH JOURNAL OF DERMATOLOGY 2002;146(6):1023-30

A prospective population-based study of cutaneous malignant melanoma of the head and neck
Gillgren P, Mansson-brahme E, Frisell J, Johansson H, Larsson O, Ringborg U
LARYNGOSCOPE 2000;110(9):1498-504

Epidemiological characteristics of cutaneous malignant melanoma of the head and neck - A population-based study
Gillgren P, Mansson-brahme E, Frisell J, Johansson H, Larsson O, Ringborg U
ACTA ONCOLOGICA 1999;38(8):1069-74

RESULTS OF RECTOCELE REPAIR - A PROSPECTIVE-STUDY
Mellgren A, Anzen B, Nilsson By, Johansson C, Dolk A, Gillgren P, et al
DISEASES OF THE COLON & RECTUM 1995;38(1):7-13

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