Parviz Kokhaei

Publications
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Public outreach and news

Articles

Article: CANCERS. 2024;16(22):3821
A Small Molecule Antagonist of CX3CR1 (KAND567) Inhibited the Tumor Growth-Promoting Effect of Monocytes in Chronic Lymphocytic Leukemia (CLL)
Zhong W; Kokhaei P; Mulder TA; Ghaderi A; Moshfegh A; Lundin J; Palma M; Schultz J; Olin T; Osterborg A; Mellstedt H; Hojjat-Farsangi M
Article: NEW JOURNAL OF CHEMISTRY. 2024;48(15):6977-6996
Design and synthesis of berberine loaded nano-hydroxyapatite/gelatin scaffold for bone cancer treatment
Khajavi S; Bahraminasab M; Arab S; Talebi A; Kokhaei P; Abdoos H
Article: IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY. 2023;22(3):299-311
IL-25 Impact on Malignant B Cells Survival and T Cells Activation in Chronic Lymphocytic Leukemia
Pashaei M; Ghahremanfard F; Doulabi EM; Hemmati M; Pak F; Kokhaei P
Article: PHARMACEUTICS. 2023;15(4):1148
A Small Molecule Targeting the Intracellular Tyrosine Kinase Domain of ROR1 (KAN0441571C) Induced Significant Apoptosis of Non-Small Cell Lung Cancer (NSCLC) Cells
Ghaderi A; Okhovat M-A; Lehto J; De Petris L; Doulabi EM; Kokhaei P; Zhong W; Rassidakis GZ; Drakos E; Moshfegh A; Schultz J; Olin T; Osterborg A; Mellstedt H; Hojjat-Farsangi M
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2023;184(3):291-301
Multistrain Probiotics Supplement Alleviates Asthma Symptoms via Increasing Treg Cells Population: A Randomized, Double-Blind, Placebo-Controlled Trial
Abbasi-Dokht T; Sadrifar S; Forouzandeh S; Malek F; Hemmati M; Kokhaei P; Salek Farrokhi A; Baharlou R
Article: MEDICAL ONCOLOGY. 2022;39(12):217
Anti-tumor effect of berberine on chronic lymphocytic leukemia cells
Abdollahi M; Mohammadlou M; Hemati M; Baharlou R; Doulabi EM; Ghahremanfard F; Sarabi MA; Kokhaei P
Article: IMMUNOLOGICAL INVESTIGATIONS. 2022;51(1):170-181
Genetic Study of Hereditary Angioedema Type I and Type II (First Report from Iranian Patients: Describing Three New Mutations)
Nabilou S; Pak F; Alizadeh Z; Fazlollahi MR; Houshmand M; Ayazi M; Mohammadzadeh I; Bemanian MH; Fayezi A; Nabavi M; Saghafi S; Mohammadian S; Kokhaei P; Moin M; Pourpak Z
Article: JOURNAL OF CLINICAL LABORATORY ANALYSIS. 2022;36(1):e24125
Simultaneous disruption of circulating miR-21 and cytotoxic T lymphocytes (CTLs): Prospective diagnostic and prognostic markers for esophageal squamous cell carcinoma (ESCC)
Samiei H; Ajam F; Gharavi A; Abdolmaleki S; Kokhaei P; Mohammadi S; Memarian A
Article: ACTA NEUROLOGICA BELGICA. 2021;121(6):1685-1692
Kombucha ameliorates experimental autoimmune encephalomyelitis through activation of Treg and Th2 cells
Haghmorad D; Yazdanpanah E; Sadighimoghaddam B; Yousefi B; Sahafi P; Ghorbani N; Rashidy-Pour A; Kokhaei P
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2021;236(7):4966-4972
Thermal inactivation of COVID-19 specimens improves RNA quality and quantity
Hemati M; Soosanabadi M; Ghorashi T; Ghaffari H; Vahedi A; Sabbaghian E; Nejad ZR; Salati A; Danaei N; Kokhaei P
Article: PHYTOTHERAPY RESEARCH. 2021;35(4):2025-2033
Apoptotic effect of berberine via Bcl-2, ROR1, and mir-21 in patients with B-chronic lymphocytic leukemia
Mohammadlou M; Abdollahi M; Hemati M; Baharlou R; Doulabi EM; Pashaei M; Ghahremanfard F; Faranoush M; Kokhaei P
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2021;41(1):76-88
Variable Abnormalities in T and B Cell Subsets in Ataxia Telangiectasia
Moeini Shad T; Yousefi B; Amirifar P; Delavari S; Rae W; Kokhaei P; Abolhassani H; Aghamohammadi A; Yazdani R
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2020;235(12):9424-9431
Evaluating the mechanism underlying antitumor effect of interleukin 27 on B cells of chronic lymphocytic leukemia patients
Manouchehri-Doulabi E; Abbaspour S; Rostami S; Faranoush M; Ghahramanfard F; Pak F; Barati M; Kokhaei P; Momtazi-Borojeni AA
Article: BIOMEDICINES. 2020;8(6):E170-170
ROR1 is Expressed in Diffuse Large B-Cell Lymphoma (DLBCL) and a Small Molecule Inhibitor of ROR1 (KAN0441571C) Induced Apoptosis of Lymphoma Cells
Ghaderi A; Daneshmanesh AH; Moshfegh A; Kokhaei P; Vagberg J; Schultz J; Olin T; Harrysson S; Smedby KE; Drakos E; Rassidakis GZ; Osterborg A; Mellstedt H; Hojjat-Farsangi M
Article: JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 2020;40(3):139-144
Evaluation of Interleukin 25 and Interleukin 25 Receptor Expression in Peripheral Blood Mononuclear Cells of Breast Cancer Patients and Normal Subjects
Barati M; Sinaeian M; Shokrollahi Barough M; Pak F; Semnani V; Kokhaei P; Momtazi-Borojeni AA
Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2020;82:106350
IL-27 impact on NK cells activity: Implication for a robust anti-tumor response in chronic lymphocytic leukemia
Hemati M; Nejad ZR; Shokri M-R; Ghahremanfard F; Mohammadkhani MM; Kokhaei P
Article: PATHOLOGY AND ONCOLOGY RESEARCH. 2019;25(4):1467-1475
CRP and LOX-1: a Mechanism for Increasing the Tumorigenic Potential of Colorectal Cancer Carcinoma Cell Line
Ghazi-Khanloosani M; Bandegi AR; Kokhaei P; Barati M; Pakdel A
Article: IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY. 2019;18(4):379-392
In Vitro Evaluation of CMV Specific CD8+T Cells Function in CMV plus Colorectal Cancer Patients Compared to Healthy Controls
Ardakani MS; Pak F; Kokhaei P; Fazeli MS; Shakiba Y; Yazdi SMT; Abbasian A; Nourizadeh M
Article: IMMUNOLOGIC RESEARCH. 2019;67(2-3):212-222
Dysregulation of helper T lymphocytes in esophageal squamous cell carcinoma (ESCC) patients is highly associated with aberrant production of miR-21
Samiei H; Sadighi-Moghaddam B; Mohammadi S; Gharavi A; Abdolmaleki S; Khosravi A; Kokhaei P; Bazzazi H; Memarian A
Article: INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY. 2019;13(1):12-17
The State of Peripheral Blood Natural Killer Cells and Cytotoxicity in Women with Recurrent Pregnancy Loss and Unexplained Infertility
Azargoon A; Mirrasouli Y; Barough MS; Barati M; Kokhaei P
Article: LEUKEMIA. 2018;32(10):2291-2295
First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells
Hojjat-Farsangi M; Daneshmanesh AH; Khan AS; Shetye J; Mozaffari F; Kharaziha P; Rathje L-S; Kokhaei P; Hansson L; Vagberg J; Bystrom S; Olsson E; Lofberg C; Norstrom C; Schultz J; Norin M; Olin T; Osterborg A; Mellstedt H; Moshfegh A
Article: ANTI-CANCER DRUGS. 2018;29(9):847-853
RITA induces apoptosis in p53-null K562 leukemia cells by inhibiting STAT5, Akt, and NF-κB signaling pathways
Mobaraki RN; Karimi M; Alikarami F; Farhadi E; Amini A; Bashash D; Paridar M; Kokhaei P; Rezvani MR; Kazemi A; Safa M
Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2018;62:109-113
Neutralizing antibody production against Rebif® and ReciGen® in Relapsing-Remitting Multiple Sclerosis (RRMS) patients and its association with patient's disability
Barough MS; Ashtari F; Akhavi MS; Asghari N; Mosayebi G; Mirmohammadkhani M; Kokhaei N; Bahraminia F; Ajami A; Kokhaei P
Article: BIOMEDICINE & PHARMACOTHERAPY. 2018;98:793-800
Anti-inflammatory and anti-tumor effects of α-l-guluronic acid (G2013) on cancer-related inflammation in a murine breast cancer model.
Hosseini F; Mahdian-Shakib A; Jadidi-Niaragh F; Enderami SE; Mohammadi H; Hemmatzadeh M; Mohammed HA; Anissian A; Kokhaei P; Mirshafiey A; Hassannia H
Article: PLOS ONE. 2018;13(2):e0192839
Autologous T cells expressing the oncogenic transcription factor KLF6-SV1 prevent apoptosis of chronic lymphocytic leukemia cells
Kokhaei P; Hojjat-Farsangi M; Mozaffari F; Moshfegh A; Pak F; Rashidy-Pour A; Palma M; Hansson L; Osterborg A; Mellstedt H
Article: CANCER MEDICINE. 2017;6(3):640-650
Targeting of crosstalk between tumor and tumor microenvironment by β-D mannuronic acid (M2000) in murine breast cancer model
Hosseini F; Hassannia H; Mahdian-Shakib A; Jadidi-Niaragh F; Enderami SE; Fattahi M; Anissian A; Mirshafiey A; Kokhaei P
Article: BIOMEDICINE & PHARMACOTHERAPY. 2017;86:41-47
Suppression of protein tyrosine phosphatase PTPN22 gene induces apoptosis in T-cell leukemia cell line (Jurkat) through the AKT and ERK pathways
Baghbani E; Baradaran B; Pak F; Mohammadnejad L; Shanehbandi D; Mansoori B; Khaze V; Montazami N; Mohammadi A; Kokhaei P
Article: TRANSPLANT IMMUNOLOGY. 2016;39:25-29
Evaluation of interleukin 12 and CD56+lymphocyte cells in pediatric hematopoietic stem cell transplantation for early diagnosis of acute graft versus host disease
Tootoonchian R; Pak F; Ardekani AM; Sehati N; Abedi-Valugerdi M; Kokhaei P
Article: TUMOR BIOLOGY. 2016;37(9):11947-11957
Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia
Khan AS; Hojjat-Farsangi M; Daneshmanesh AH; Hansson L; Kokhaei P; Osterborg A; Mellstedt H; Moshfegh A
Article: TURKISH JOURNAL OF MEDICAL SCIENCES. 2016;46(4):1135-1143
ILP-2 modeling and virtual screening of an FDA-approved library: a possible anticancer therapy
Khalili S; Mohammadpour H; Shokrollahi Barough M; Kokhaei P
Article: IRANIAN JOURNAL OF CANCER PREVENTION. 2015;8(6):e4193
Apoptosis/Necrosis Induction by Ultraviolet, in ER Positive and ER Negative Breast Cancer Cell Lines.
Shokrollahi Barough M; Hasanzadeh H; Barati M; Pak F; Kokhaei P; Rezaei-Tavirani M
Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2014;22(1):273-276
Cimetidine effects on the immunosuppression induced by burn injury
Kokhaei P; Barough MS; Hassan ZM
Article: OPEN VETERINARY JOURNAL. 2014;4(1):4-8
Comparison of effects of age and sex on serum protein electrophoretic pattern in one-humped camels (Camelus dromedarius) in Semnan, Iran.
Ahmadi-Hamedani M; Ghazvinian K; Kokhaei P; Barati M; Mahdavi A
Article: EXPERIMENTAL HEMATOLOGY. 2013;41(7):615-626
Telomere length and expression of human telomerase reverse transcriptase splice variants in chronic lymphocytic leukemia
Palma M; Parker A; Hojjat-Farsangi M; Forster J; Kokhaei P; Hansson L; Osterborg A; Mellstedt H
Article: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2013;62(1):51-63
T cells from indolent CLL patients prevent apoptosis of leukemic B cells in vitro and have altered gene expression profile
Kiaii S; Kokhaei P; Mozaffari F; Rossmann E; Pak F; Moshfegh A; Palma M; Hansson L; Mashayekhi K; Hojjat-Farsangi M; Osterborg A; Choudhury A; Mellstedt H
Article: PLOS ONE. 2013;8(6):e67601
A Proline/Arginine-Rich End Leucine-Rich Repeat Protein (PRELP) Variant Is Uniquely Expressed in Chronic Lymphocytic Leukemia Cells
Mikaelsson E; Osterborg A; Jeddi-Tehrani M; Kokhaei P; Ostadkarampour M; Hadavi R; Gholamin M; Akhondi M; Shokri F; Rabbani H; Mellstedt H
Article: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2012;61(6):865-879
Vaccination with dendritic cells loaded with tumor apoptotic bodies (Apo-DC) in patients with chronic lymphocytic leukemia: effects of various adjuvants and definition of immune response criteria
Palma M; Hansson L; Choudhury A; Nasman-Glaser B; Eriksson I; Adamson L; Rossmann E; Widen K; Horvath R; Kokhaei P; Vertuani S; Mellstedt H; Osterborg A
Article: MEDICAL ONCOLOGY. 2011;28:S660-S666
Immune responses regulation following antitumor dendritic cell-based prophylactic, concurrent, and therapeutic vaccination
Samadi-Foroushani M; Vahabpour R; Memarnejadian A; Namdar A; Khamisabadi M; Sadat SM; Asgarian-Omran H; Azadmanesh K; Kokhaei P; Aghasadeghi MR; Hadjati J
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2010;151(4):327-335
Silencing of ROR1 and FMOD with siRNA results in apoptosis of CLL cells
Choudhury A; Derkow K; Daneshmanesh AH; Mikaelsson E; Kiaii S; Kokhaei P; Osterborg A; Mellstedt H
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2010;37(6):1599-1606
FcγR polymorphisms and clinical outcome in colorectal cancer patients receiving passive or active antibody treatment
Wang B; Kokhaei P; Mellstedt H; Liljefors M
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2009;69(6):529-536
Generation of a Dendritic Cell-based Vaccine in Chronic Lymphocytic Leukaemia Using CliniMACS Platform for Large-scale Production
Adamson L; Palma M; Choudhury A; Eriksson I; Nasman-Glaser B; Hansson M; Hansson L; Kokhaei P; Osterborg A; Mellstedt H
Article: CELLULAR IMMUNOLOGY. 2009;257(1-2):23-31
Autologous dendritic cells loaded with apoptotic tumor cells induce T cell-mediated immune responses against breast cancer in vitro.
Delirezh N; Moazzeni SM; Shokri F; Shokrgozar MA; Atri M; Kokhaei P
Article: INFECTIOUS AGENTS AND CANCER. 2008;3:10
Human herpesvirus-8 (HHV-8) sero-detection and HIV association in Kaposi's sarcoma (KS), non-KS tumors and non-neoplastic conditions.
Mwakigonja AR; Pyakurel P; Kokhaei P; Pak F; Lema LK; Kaaya EE; Biberfeld P
Article: ANNALS OF ONCOLOGY. 2008;19(6):1172-1179
Idiotype vaccination in patients with myeloma reduced circulating myeloma cells (CMC)
Abdalla AO; Kokhaei P; Hansson L; Mellstedt H; Osterborg A
Article: EUROPEAN JOURNAL OF CANCER. 2007;43(12):1877-1882
Kaposi's sarcoma herpesvirus load in biopsies of cutaneous and oral Kaposi's sarcoma lesions
Pak F; Mwakigonja AR; Kokhaei P; Hosseinzadeh N; Pyakurel P; Kaaya E; Bogdanovic G; Selivanova G; Biberfeld P
Article: CLINICAL CANCER RESEARCH. 2007;13(12):3536-3544
Expression of erythropoietin receptor and in vitro functional effects of epoetins in B-cell malignancies
Kokhaei P; Abdalla AO; Hansson L; Mikaelsson E; Kubbies M; Haselbeck A; Jernberg-Wiklund H; Mellstedt H; Osterborg A
Article: EXPERIMENTAL HEMATOLOGY. 2007;35(2):297-304
Telomerase (hTERT 611-626) serves as a tumor antigen in B-cell chronic lymphocytic leukemia and generates spontaneously antileukemic, cytotoxic T cells
Kokhaei P; Palma M; Hansson L; Osterborg A; Mellstedt H; Choudhury A
Article: CYTOTHERAPY. 2006;8(4):318-326
Generation of DC-based vaccine for therapy of B-CLL patients.: Comparison of two methods for enriching monocytic precursors
Kokhaei P; Adamson L; Palma M; Osterborg A; Pisa P; Choudhury A; Mellstedt H
Article: MEDICAL ONCOLOGY. 2006;23(2):273-282
Dendritic cells, pulsed with lysate of allogeneic tumor cells, are capable of stimulating MHC-restricted antigen-specific antitumor T cells
Mahdian R; Kokhaei P; Najar HM; Derkow K; Choudhury A; Mellstedt H
Article: JOURNAL OF CUTANEOUS PATHOLOGY. 2005;32(1):21-27
HHV-8/KSHV during the development of Kaposi's sarcoma: evaluation by polymerase chain reaction and immunohistochemistry
Pak F; Pyakural P; Kokhaei P; Kaaya E; Pourfathollah AA; Selivanova G; Biberfeld P
Article: LEUKEMIA. 2004;18(11):1810-1815
Apoptotic tumor cells are superior to tumor cell lysate, and tumor cell RNA in induction of autologous T cell response in B-CLL
Kokhaei P; Choudhury A; Mahdian R; Lundin J; Moshfegh A; Österborg A; Mellstedt H
Article: JOURNAL OF CLINICAL MICROBIOLOGY. 2004;42(11):5394-5396
Association between a high BK virus load in urine samples of patients with graft-versus-host disease and development of hemorrhagic cystitis after hematopoietic stem cell transplantation
Bogdanovic G; Priftakis P; Giraud G; Kuzniar M; Ferraldeschi R; Kokhaei P; Mellstedt H; Remberger M; Ljungman P; Winiarski J; Dalianis T
Article: LEUKEMIA. 2003;17(5):894-899
Dendritic cells loaded with apoptotic tumour cells induce a stronger T-cell response than dendritic cell-tumour hybrids in B-CLL
Kokhaei P; Rezvany MR; Virving L; Choudhury A; Rabbani H; Österborg A; Mellstedt H
Article: JOURNAL OF CLINICAL VIROLOGY. 2003;26(1):71-77
BK virus (BKV) quantification in urine samples of bone marrow transplanted patients is helpful for diagnosis of hemorrhagic cystitis, although wide individual variations exist
Priftakis P; Bogdanovic G; Kokhaei P; Mellstedt H; Dalianis T
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Review: MEDICAL GAS RESEARCH. 2022;12(2):33-40
Potential therapeutic effect of oxygen-ozone in controlling of COVID-19 disease
Yousefi B; Banihashemian S; Feyzabadi Z; Hasanpour S; Kokhaei P; Abdolshahi A; Emadi A; Eslami M
Review: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2022;132:998-1009
The role of the host microbiome in autism and neurodegenerative disorders and effect of epigenetic procedures in the brain functions
Yousefi B; Kokhaei P; Mehranfar F; Bahar A; Abdolshahi A; Emadi A; Eslami M
Review: JOURNAL OF CELLULAR PHYSIOLOGY. 2019;234(12):21770-21784
Epigenetic changes in gastric cancer induction by Helicobacter pylori
Yousefi B; Mohammadlou M; Abdollahi M; Farrokhi AS; Karbalaei M; Keikha M; Kokhaei P; Valizadeh S; Rezaiemanesh A; Arabkari V; Eslami M
Review: JOURNAL OF CELLULAR PHYSIOLOGY. 2019;234(9):14800-14811
Current information on the association of Helicobacter pylori with autophagy and gastric cancer
Eslami M; Yousefi B; kokhaei P; Arabkari V; Ghasemian A
Review: JOURNAL OF CELLULAR PHYSIOLOGY. 2019;234(10):17127-17143
Importance of probiotics in the prevention and treatment of colorectal cancer
Eslami M; Yousefi B; Kokhaei P; Hemati M; Nejad ZR; Arabkari V; Namdar A
Review: JOURNAL OF CELLULAR PHYSIOLOGY. 2019;234(6):8008-8018
Probiotics importance and their immunomodulatory properties
Yousefi B; Eslami M; Ghasemian A; Kokhaei P; Farrokhi AS; Darabi N
Review: COMPARATIVE IMMUNOLOGY, MICROBIOLOGY AND INFECTIOUS DISEASES. 2019;64:99-108
Are probiotics useful for therapy of Helicobacter pylori diseases?
Eslami M; Yousefi B; Kokhaei P; Moghadas AJ; Moghadam BS; Arabkari V; Niazi Z
Review: JOURNAL OF DRUG TARGETING. 2016;24(5):373-385
Ibrutinib-A double-edge sword in cancer and autoimmune disorders.
Kokhaei P; Jadidi-Niaragh F; Sotoodeh Jahromi A; Osterborg A; Mellstedt H; Hojjat-Farsangi M
Published conference paper: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2008;57(11):1705-1710
Development of a dendritic cell-based vaccine for chronic lymphocytic leukemia
Palma M; Adamson L; Hansson L; Kokhaei P; Rezvany R; Mellstedt H; Oesterborg A; Choudhury A
Published conference paper: ANNALS OF ONCOLOGY. 2006;17:X144-X154
The biology and treatment of chronic lymphocytic leukemia
Palma M; Kokhaei P; Lundin J; Choudhury A; Mellstedt H; Osterborg A
Thesis / dissertation: 2006
Preclinical therapeutic vaccination strategies in malignancies with focus on B-cell chronic lymphocytic leukemia
Kokhaei, Parviz
Review: ADVANCES IN CANCER RESEARCH. 2006;95:147-202
Clinical results of vaccine therapy for cancer: Learning from history for improving the future
Choudhury A; Mosolits S; Kokhaei P; Hansson L; Palma M; Mellstedt H
Published conference paper: ANNALS OF ONCOLOGY. 2005;16:ii113-ii123
Biology and treatment of chronic lymphocytic leukemia
Kokhaei P; Palma A; Mellstedt H; Choudhury A
Meeting abstract: BLOOD. 2004;104(11):288B
Comparison of antigen-loading strategies for DC-based immunotherapy of B-CLL.
Mellstedt H; Kokhaei P; Osterborg A; Choudhury A
Meeting abstract: BLOOD. 2004;104(11):54A
Downregulating the fibromodulin gene by short interfering RNA causes B-CLL cell death.
Choudhury A; Derkow K; Mikaelsson E; Kokhaei P; Österborg A; Rabbani H; Mellstedt H

Employments

Affiliated to Research, Department of Oncology-Pathology, Karolinska Institutet, 2023-2026

Degrees and Education

Doctor Of Philosophy, Department of Oncology-Pathology, Karolinska Institutet, 2006

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