Oscar Horwath

Publications
Grants
CV
Public outreach and news

Selected publications

Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2026
Ribosome dynamics during skeletal muscle repair and regeneration in mice and humans.
Cui M; Edman S; Jude B; Jannig PR; Horwath O; Shorter E; Koopmans PJ; Chambers TL; Jones RG; Nilsson A; Lanner JT; Sejersen T; Pontén E; Murach KA; Schilcher J; von Walden F
Journal article: FASEB JOURNAL. 2026;40(6):e71653
Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction
Horwath O; Edman S; Dayanidhi S; Englund D; Peterson MD; von Walden F
Journal article: DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY. 2026;68(3):343-357
Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy
Edman S; Horwath O; Ponten E; Dayanidhi S; von Walden F
Article: FASEB JOURNAL. 2023;37(3):e22811
Acute hypoxia attenuates resistance exercise-induced ribosome signaling but does not impact satellite cell pool expansion in human skeletal muscle
Horwath O; Nordstrom F; von Walden F; Apro W; Moberg M

Articles

Journal article: EXPERIMENTAL PHYSIOLOGY. 2026
Recent advances in understanding skeletal muscle ageing: Functional, morphological and omics perspectives
Horwath O; Apro W
Journal article: MOLECULAR METABOLISM. 2026;106:102336
Ceramide metabolism in oxidative and glycolytic muscle: Significance for lipid-induced insulin resistance
Euren T; Flockhart M; Strmen T; Zhou X; Horwath O; Apro W; Blackwood SJ; Tischer D; Moberg M; Steneberg P; Edlund H; Katz A; Chorell E
Journal article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2025;193(4):453-463
Use of skeletal muscle fiber composition to assess relationship between amino acid metabolism and insulin sensitivity
Magnusson TE; Blackwood SJ; Tischer D; Strmen T; Ponten M; Edman S; Horwath O; Apro W; Moberg M; Chorell E; Katz A
Journal article: PHYSIOLOGICAL REPORTS. 2025;13(17):e70562
Assessment of different preservation techniques for human skeletal muscle biopsy samples: A comparative method study on freeze-drying, RNAlater, and RNAlater-ICE
Edman S; Engvall A; Eriksson Viklund T; Horwath O; Apro W
Journal article: JOURNAL OF APPLIED PHYSIOLOGY. 2025;139(3):685-697
Divergent strength gains but similar hypertrophy after low-load and high-load resistance exercise training in trained individuals: many roads lead to Rome
Cumming KT; Elvatun IC; Kalenius R; Divljak G; Raastad T; Psilander N; Horwath O
Article: SKELETAL MUSCLE. 2025;15(1):9
Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1-and autophagic signaling in human type I and type II muscle fibers
Horwath O; Cornet L; Stroemlind H; Moberg M; Edman S; Soederlund K; Checa A; Ruas JL; Blomstrand E
Journal article: JOURNAL OF PHYSIOLOGY-LONDON. 2025;603(5):1057-1069
Increased muscle satellite cell content and preserved telomere length in response to combined exercise training in patients with FSHD
Horwath O; Montiel-Rojas D; Ponsot E; Feasson L; Kadi F
Journal article: EXPERIMENTAL PHYSIOLOGY. 2025;110(2):277-292
Ageing leads to selective type II myofibre deterioration and denervation independent of reinnervative capacity in human skeletal muscle
Horwath O; Moberg M; Edman S; Philp A; Apro W
Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2025;16(1):e13613
Anabolic Sensitivity in Healthy, Lean, Older Men Is Associated With Higher Expression of Amino Acid Sensors and mTORC1 Activators Compared to Young
Horwath O; Moberg M; Hodson N; Edman S; Johansson M; Andersson E; van Hall G; Rooyackers O; Philp A; Apro W
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2025;328(1):C20-C26
No detectable loss of myonuclei from human muscle fibers after 6 wk of immobilization following an Achilles tendon rupture
Horwath O; Cumming KT; Eftestol E; Ekblom B; Ackermann P; Raastad T; Gundersen K; Psilander N
Journal article: JOURNAL OF APPLIED PHYSIOLOGY. 2024;137(5):1341-1353
Does one biopsy cut it? Revisiting human muscle fiber type composition variability using repeated biopsies in the vastus lateralis and gastrocnemius medialis
Van de Casteele F; Van Thienen R; Horwath O; Apro W; Van der Stede T; Moberg M; Lievens E; Derave W
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2024;602(17):4171-4193
Muscle memory in humans: evidence for myonuclear permanence and long-term transcriptional regulation after strength training
Cumming KT; Reitzner SM; Hanslien M; Skilnand K; Seynnes OR; Horwath O; Psilander N; Sundberg CJ; Raastad T
Journal article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2024;327(2):e172-e182
Elevated heart rate and decreased muscle endothelial nitric oxide synthase in early development of insulin resistance
Blackwood SJ; Tischer D; van de Ven MPF; Ponten M; Edman S; Horwath O; Apro W; Roja J; Ekblom MM; Moberg M; Katz A
Article: BIO-PROTOCOL. 2023;13(10):e4678
THRIFTY-A High-throughput Single Muscle Fiber Typing Method Based on Immunofluorescence Detection
Edman S; Horwath O; Apro W
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2023;324(5):E390-E401
Insulin resistance after a 3-day fast is associated with an increased capacity of skeletal muscle to oxidize lipids
Blackwood SJ; Horwath O; Moberg M; Ponten M; Apro W; Ekblom MM; Larsen FJ; Katz A
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2022;600(20):4421-4438
THRIFTY: a novel high-throughput method for rapid fibre type identification of isolated skeletal muscle fibres
Horwath O; Edman S; Andersson A; Larsen FJ; Apro W
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2022;107(7):e2729-e2737
Extreme Variations in Muscle Fiber Composition Enable Detection of Insulin Resistance and Excessive Insulin Secretion
Blackwood SJ; Horwath O; Moberg M; Ponten M; Apro W; Ekblom MM; Larsen FJ; Katz A
Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:874748
Molecular Regulators of Muscle Mass and Mitochondrial Remodeling Are Not Influenced by Testosterone Administration in Young Women
Horwath O; Moberg M; Hirschberg AL; Ekblom B; Apro W
Article: ACTA PHYSIOLOGICA. 2022;234(2):e13771
Acute normobaric hypoxia blunts contraction-mediated mTORC1-and JNK-signaling in human skeletal muscle
Moberg M; Apro W; Horwath O; van Hall G; Blackwood SJ; Katz A
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2022;322(1):C49-C62
Changes in plasma concentration of kynurenine following intake of branched-chain amino acids are not caused by alterations in muscle kynurenine metabolism
Jonsson WO; Ponette J; Horwath O; Rydenstam T; Soderlund K; Ekblom B; Azzolini M; Ruas JL; Blomstrand E
Journal article: JOURNAL OF APPLIED PHYSIOLOGY. 2021;131(6):1731-1749
Acute cellular and molecular responses and chronic adaptations to low-load blood flow restriction and high-load resistance exercise in trained individuals
Davids CJ; Naess TC; Moen M; Cumming KT; Horwath O; Psilander N; Ekblom B; Coombes JS; Peake J; Raastad T; Roberts LA
Article: METABOLITES. 2021;11(8):508
Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans
Valente-Silva P; Cervenka I; Ferreira DMS; Correia JC; Edman S; Horwath O; Heng B; Chow S; Jacobs KR; Guillemin GJ; Blomstrand E; Ruas JL
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2021;131(1):158-173
Variability in vastus lateralis fiber type distribution, fiber size, and myonuclear content along and between the legs
Horwath O; Envall H; Roja J; Emanuelsson EB; Sanz G; Ekblom B; Apro W; Moberg M
Article: SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS. 2021;31(2):303-312
Influence of sex and fiber type on the satellite cell pool in human skeletal muscle
Horwath O; Moberg M; Larsen FJ; Philp A; Apro W; Ekblom B
Article: FRONTIERS IN PHYSIOLOGY. 2020;11:585490
Enhanced Skeletal Muscle Oxidative Capacity and Capillary-to-Fiber Ratio Following Moderately Increased Testosterone Exposure in Young Healthy Women
Cardinale DA; Horwath O; Elings-Knutsson J; Helge T; Godhe M; Bermon S; Moberg M; Flockhart M; Larsen FJ; Hirschberg AL; Ekblom B
Journal article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7S):18
Intake Of Essential Amino Acids Stimulates Mtorc1 Signaling And Inhibits Autophagy Following Glycogen-depleted Resistance Exercise
Apró W; Horwath O; Granberg J; Moberg M; Andersson E; Ekblom B
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2020;128(5):1240-1250
Fiber type-specific hypertrophy and increased capillarization in skeletal muscle following testosterone administration in young women
Horwath O; Apro W; Moberg M; Godhe M; Helge T; Ekblom M; Hirschberg AL; Ekblom B
Journal article: JOURNAL OF SCIENCE AND MEDICINE IN SPORT. 2019;22(7):821-826
Isokinetic resistance training combined with eccentric overload improves athletic performance and induces muscle hypertrophy in young ice hockey players
Horwath O; Paulsen G; Esping T; Seynnes O; Olsson MC
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All other publications

Review: JOURNAL OF PHYSIOLOGY-LONDON. 2026
Intramuscular pathways of maladaptation in overtraining syndrome
Shorter E; Horwath O; Barsky ST; von Walden F; Lanner JT
Editorial: JOURNAL OF PHYSIOLOGY-LONDON. 2025
Body composition matters: Preserving muscle and function in the era of GLP-1-based weight loss therapies
Emanuelsson EB; Horwath O
Preprint: BIORXIV. 2025
Comparable Strength and Hypertrophic Adaptations to Low-Load and High-Load Resistance Exercise Training in Trained Individuals: Many Roads Lead to Rome
Cumming KT; Elvatun IC; Kalenius R; Divljak G; Raastad T; Psilander N; Horwath O
Preprint: BIORXIV. 2025
A glucosinolate-rich beverage lowers blood lactate concentrations during submaximal exercise
Vinge F; Tillqvist E; Horwath O; Apró W; Larsen FJ; Sundqvist ML
Preprint: BIORXIV. 2024
Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers
Horwath O; Cornet L; Strömlind H; Moberg M; Edman S; Söderlund K; Checa A; Ruas JL; Blomstrand E
Preprint: BIORXIV. 2024
Anabolic sensitivity in healthy, lean, older men is associated with higher expression of amino acid sensors and mTORC1 activators
Horwath O; Moberg M; Hodson N; Edman S; Johansson M; Andersson E; van Hall G; Rooyackers O; Philp A; Apró W

Grants

Loss of Ribosomal Identity: A Driver of Age-Related Skeletal Muscle Deterioration?
Swedish Society for Medical Research
1 January 2027 - 31 December 2029
Accelerated Aging – A Potential Mechanism Underlying Pathology of Skeletal Muscle in Children with Cerebral Palsy
Stiftelsen Maja & J.P. Åhlén
28 November 2025 - 28 November 2026
Muscle ribosomes in an identity crisis: a driving factor in muscle atrophy and metabolic changes during chronic joint inflammation
KI stiftelsemedel för reumatologiforskning
21 November 2025 - 21 November 2026
Förtidigt åldrande av skelettmuskel hos barn med CP
Folke Bernadotte Stiftelsen
24 October 2025 - 24 October 2026
Is Time Ticking Faster in Skeletal Muscle of Children with CP? Studies on Hallmarks of Premature Aging
Stiftelsen Sunnerdahls Handikappfond
1 October 2025 - 1 October 2026
Förtidigt åldrande – en potentiell förklaringsmekanism bakom muskelpatologi hos barn med CP
Stiftelsen Tornspiran
30 September 2025 - 30 September 2026
Is Time Ticking Faster in Skeletal Muscle of Children with CP? Studies on Hallmarks of Premature Aging
Gustafssonstiftelsen
30 June 2025 - 30 June 2026

Employments

Postdoctoral Researcher, Department of Women's and Children's Health, Karolinska Institutet, 2025-2027

Degrees and Education

PhD, Aging muscle and anabolic resistance: from whole muscle to the single fiber level, Department of Physiology, Nutrition and Biomechanics, The Swedish School of Sport and Health Sciences, 2025

Selected publications

Articles

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