I am a microbiologist specialized in human microbiota research and its implications in health and disease. I am especially interested in how the gut and skin microbiota affect disease development through different mechanisms. My current research focuses on the effect of environmental microbial biodiversity on allergy development. Additionally I am studying how the skin microbiota is related to atopic dermatitis and psoriasis.
For my PhD research I studied the human intestinal microbe Akkermansia muciniphila, which promotes beneficial interactions in the gut. Currently the most convincing evidence of its beneficial effect on health comes from studies linking A. muciniphila to metabolic disorders, such as diabetes and obesity. My PhD thesis focused on characterizing the metabolic pathways, outer membrane proteome and host immune response of this bacterium.
- Ph.D. in Microbiology from Wageningen University, the Netherlands, 2015
- M.Sc. in Food Development from the University of Turku, Finland, 2009
- B.Sc. in Health Biosciences from the University of Turku, 2008
PhD-thesis: Host interactions and substrate utilization of the gut symbiont Akkermansia muciniphila (available electronically at edepot.wur.nl/354248)
Impact of environmental biodiversity on human microbiota and allergy responses
This project aims at connecting human living environment, commensal microbiota, and health, with respect to chronic inflammatory disorders. The work builds around the biodiversity hypothesis of allergic disease, proposing that contact with environmental biodiversity is important for the education of the immune system in early life, in turn affecting the risk of allergy later in life. Exposure to a diverse environmental microbiota can take place in multiple ways and it is not clear how and when should this exposure occur to ensure that the immune system receives sufficient educational signalling from bacteria.
The project is performed in collaboration with the University of Helsinki: The research group of Lasse Ruokolainen at the Department of Biosciences and the the research group of Harri Alenius at the Department of Bacteriology and Immunology.
Composition and activity of the skin microbiome in atopic dermatitis
This project continues on the work of the EU-project MAARS (Microbes in Allergy and Autoimmunity Related to the Skin), which explores the nature and duration of microbial stimuli and associated changes in the epithelial barrier leading to the development of skin-related allergy and autoimmunity. Atopic dermatitis and psoriasis serve as models for investigation of the programming of the immune system towards an allergic or autoimmune inflammation. The aim of the study is to identify microbe-host-interaction networks involved in the development and persistence of atopic dermatitis and psoriasis. The project will pave the way for progress in prevention, new diagnostic strategies and treatment options for allergy and autoimmunity related skin diseases.