Noémi van Hul

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Articles

Article: NATURE GENETICS. 2024;56(5):740-742
Understanding liver repair through space and time
Belicova L; Van Hul N; Andersson ER
Article: LIVER INTERNATIONAL. 2024;44(2):541-558
Spatially segregated defects and IGF1-responsiveness of hilar and peripheral biliary organoids from a model of Alagille syndrome
Iqbal A; Van Hul N; Belicova L; Corbat AA; Hankeova S; Andersson ER
Journal article: LIVER INTERNATIONAL. 2024;44(2):i
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Iqbal A; Van Hul N; Belicova L; Corbat AA; Hankeova S; Andersson ER
Journal article: JOURNAL OF HEPATOLOGY. 2023;78:s945
Immune cell incompetence and hepatocyte differentiation defects explain mild fibrosis in a model of Alagille syndrome
Masek J; Filipovic I; Hankeova S; He J; Van Hul NKM; Belicova L; Frontino AM; Jirouskova M; Oliveira D; Turetti F; Cervenka I; Sarnova L; Verboven E; Brabec T; Bjorkstrom N; Gregor M; Dobes J; Andersson E
Journal article: JOURNAL OF HEPATOLOGY. 2023;78:s433
Liver innervation is dysregulated in a mouse model of Alagille syndrome
Verboven E; Van Hul NKM; Hankeova S; Adori C; Ellis E; Fischler B; Andersson E
Journal article: JOURNAL OF HEPATOLOGY. 2023;78:s410-s411
Phenotypic diversity and regeneration in a model of Alagille syndrome recapitulate patient heterogeneity
Sevenants L; Verhulst S; Hildebrandt F; Ankarklev J; van Grunsven L; Van Hul NKM; Andersson E
Journal article: JOURNAL OF HEPATOLOGY. 2023;78:s439
SAT-365 Lineage tracing of hepatic stellate cells with ultrasound-guided in utero nano-injection
He J; Belicova L; De Haan S; Van Hul NKM; Verhulst S; Ratz M; Andersson E
Journal article: JOURNAL OF HEPATOLOGY. 2023;78:s435
SAT-357 IGF1 specifically rescues peripheral intrahepatic biliary organoids from a mouse model of Alagille syndrome
Iqbal A; Van Hul NKM; Belicova L; Corbat A; Hankeova S; Andersson E
Article: EMBO MOLECULAR MEDICINE. 2022;14(12):e15809
Sex differences and risk factors for bleeding in Alagille syndrome
Hankeova S; Van Hul N; Laznovsky J; Verboven E; Mangold K; Hensens N; Adori C; Verhoef E; Zikmund T; Dawit F; Kavkova M; Salplachta J; Sjoqvist M; Johansson BR; Hassan MG; Fredriksson L; Baumgartel K; Bryja V; Lendahl U; Jheon A; Alten F; Fahnehjelm KT; Fischler B; Kaiser J; Andersson ER
Article: NATURE COMMUNICATIONS. 2021;12(1):7046
Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver
Hildebrandt F; Andersson A; Saarenpaa S; Larsson L; Van Hul N; Kanatani S; Masek J; Ellis E; Barragan A; Mollbrink A; Andersson ER; Lundeberg J; Ankarklev J
Article: TRANSGENIC RESEARCH. 2021;30(5):701-707
Severe liver disease resembling PSC in mice with K5-Cre mediated deletion of Kruppel-like factor 5 (Klf5)
Bergstrom A; Gerling M; Van Hul N; Fernandez Moro C; Rozell B; Toftgard R; Sur I
Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2021;(175)
DUCT: Double Resin Casting followed by Micro-Computed Tomography for 3D Liver Analysis
Hankeova S; Salplachta J; Van Hul N; Kavkova M; Iqbal A; Zikmund T; Kaiser J; Andersson ER
Journal article: JOURNAL OF VISUALIZED EXPERIMENTS. 2021;(175)
DUCT: Double Resin Casting followed by Micro-Computed Tomography for 3D Liver Analysis
Hankeova S; Salplachta J; Van Hul N; Kavkova M; Iqbal A; Zikmund T; Kaiser J; Andersson ER
Article: SCIENCE SIGNALING. 2021;14(688):eaay9185
Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation
Minnis-Lyons SE; Ferreira-Gonzalez S; Aleksieva N; Man TY; Gadd VL; Williams MJ; Guest RV; Lu W-Y; Dwyer BJ; Jamieson T; Nixon C; Van Hul N; Lemaigre FP; McCafferty J; Leclercq IA; Sansom OJ; Boulter L; Forbes SJ
Article: GASTROENTEROLOGY. 2021;160(6):2103-2118
Protective Functions of ZO-2/Tjp2 Expressed in Hepatocytes and Cholangiocytes Against Liver Injury and Cholestasis
Xu J; Kausalya PJ; Van Hul N; Caldez MJ; Xu S; Ong AGM; Woo WL; Ali SM; Kaldis P; Hunziker W
Article: ELIFE. 2021;10:e60916
DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome
Hankeova S; Salplachta J; Zikmund T; Kavkova M; Van Hul N; Brinek A; Smekalova V; Laznovsky J; Dawit F; Jaros J; Bryja V; Lendahl U; Ellis E; Nemeth A; Fischler B; Hannezo E; Kaiser J; Andersson ER
Article: PLOS GENETICS. 2020;16(11):e1009084
Loss of hepatocyte cell division leads to liver inflammation and fibrosis
Dewhurst MR; Ow JR; Zafer G; van Hul NKM; Wollmann H; Bisteau X; Brough D; Choi H; Kaldis P
Article: NATURE MATERIALS. 2020;19(9):1026-1035
Biomimetic niches reveal the minimal cues to trigger apical lumen formation in single hepatocytes
Zhang Y; De Mets R; Monzel C; Acharya V; Toh P; Chin JFL; Van Hul N; Ng IC; Yu H; Ng SS; Rashid ST; Viasnoff V
Journal article: JOURNAL OF HEPATOLOGY. 2020;73:s113-s114
AS168 Impaired hepatocyte cell division induces progenitor cell activation and emergence of bi-phenotypic hepatocytes
Zafer G; Ow JR; Dewhurst M; Van Hul NKM; Caldez M; Goh C; Fu NY; Kaldis P
Journal article: JOURNAL OF HEPATOLOGY. 2020;73:s244
THU208 Targeting the embryonic liver with ultrasound-guided in utero nano-injection to manipulate gene expression during liver development and hematopoiesis
He J; Van Hul NKM; Mašek J; Björkström N; Andersson E
Journal article: JOURNAL OF HEPATOLOGY. 2020;73:s43
AS058 Double resin casting micro computed tomography (CT) reveals biliary and vascular pathology in tandem in a mouse model for alagille syndrome
Hankeova S; Salplachta J; Zikmund T; Kavkova M; Van Hul NKM; Brinek A; Smekalova V; Laznovsky J; Jaros J; Bryja V; Lendahl U; Ellis E; Hannezo E; Kaiser J; Andersson E
Article: JOURNAL OF INTERNAL MEDICINE. 2020;287(5):534-545
Regulation of bile acid metabolism in biliary atresia: reduction of FGF19 by Kasai portoenterostomy and possible relation to early outcome
Johansson H; Svensson JF; Almstrom M; Van Hui N; Rudling M; Angelin B; Nowak G; Fischler B; Ellis E
Article: AMERICAN JOURNAL OF PATHOLOGY. 2019;189(8):1569-1581
Invasive Ductular Reaction Operates Hepatobiliary Junctions upon Hepatocellular Injury in Rodents and Humans
Clerbaux L-A; Manco R; Van Hul N; Bouzin C; Sciarra A; Sempoux C; Theise ND; Leclercq IA
Article: ONCOGENE. 2019;38(7):998-1018
Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality
Szmyd R; Niska-Blakie J; Diril MK; Nunes PR; Tzelepis K; Lacroix A; van Hul N; Deng L-W; Matos J; Dreesen O; Bisteau X; Kaldis P
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1981:203-236
Mouse Models for Diseases in the Cholangiocyte Lineage.
Van Hul N; Lendahl U; Andersson ER
Article: FRONTIERS IN MEDICINE. 2019;6:179
IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis
Czepukojc B; Abuhaliema A; Barghash A; Tierling S; Nass N; Simon Y; Koerbel C; Cadenas C; van Hul N; Sachinidis A; Hengstler JG; Helms V; Laschke MW; Walter J; Haybaeck J; Leclercq I; Kiemer AK; Kessler SM
Article: DEVELOPMENTAL CELL. 2018;47(4):425-438.e5
Metabolic Remodeling during Liver Regeneration
Caldez MJ; Van Hul N; Koh HWL; Teo XQ; Fan JJ; Tan PY; Dewhurst MR; Too PG; Talib SZA; Chiang BE; Stunkel W; Yu H; Lee P; Fuhrer T; Choi H; Bjorklund M; Kaldis P
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2017;101(3):391-403
CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays
Windpassinger C; Piard J; Bonnard C; Alfadhel M; Lim S; Bisteau X; Blouin S; Ali NB; Ng AYJ; Lu H; Tohari S; Talib SZA; van Hul N; Caldez MJ; Van Maldergem L; Yigit G; Kayserili H; Youssef SA; Coppola V; de Bruin A; Tessarollo L; Choi H; Rupp V; Roetzer K; Roschger P; Klaushofer K; Altmueller J; Roy S; Venkatesh B; Ganger R; Grill F; Ben Chehida F; Wollnik B; Altunoglu U; Al Kaissi A; Reversade B; Kaldis P
Article: PLOS ONE. 2016;11(9):e0162286
Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies
Best J; Verhulst S; Syn W-K; Lagaisse K; van Hul N; Heindryckx F; Sowa J-P; Peeters L; Van Vlierberghe H; Leclercq IA; Canbay A; Dolle L; van Grunsven LA
Article: CELL TRANSPLANTATION. 2015;24(12):2557-2571
Hepatic Stellate Cells Improve Engraftment of Human Primary Hepatocytes: A Preclinical Transplantation Study in an Animal Model
Dusabineza A-C; Najimi M; van Hul N; Legry V; Dung NK; van Grunsven LA; Sokal E; Leclercq IA
Article: GASTROENTEROLOGY. 2012;143(6):1564-1575.e7
Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice
Espanol-Suner R; Carpentier R; Van Hul N; Legry V; Achouri Y; Cordi S; Jacquemin P; Lemaigre F; Leclercq IA
Article: LABORATORY INVESTIGATION. 2012;92(1):72-81
Participation of liver progenitor cells in liver regeneration: lack of evidence in the AAF/PH rat model
Dusabineza A-C; Van Hul NK; Abarca-Quinones J; Starkel P; Najimi M; Leclercq IA
Article: AMERICAN JOURNAL OF PATHOLOGY. 2011;179(4):1839-1850
Kupffer Cells Influence Parenchymal Invasion and Phenotypic Orientation, but Not the Proliferation, of Liver Progenitor Cells in a Murine Model of Liver Injury
Van Hul N; Lanthier N; Suner RE; Quinones JA; van Rooijen N; Leclercq I
Article: GASTROENTEROLOGY. 2011;141(4):1432-1438.e4
Embryonic Ductal Plate Cells Give Rise to Cholangiocytes, Periportal Hepatocytes, and Adult Liver Progenitor Cells
Carpentier R; Suner RE; van Hul N; Kopp JL; Beaudry J-B; Cordi S; Antoniou A; Raynaud P; Lepreux S; Jacquemin P; Leclercq IA; Sander M; Lemaigre FP
Article: HEPATOLOGY. 2009;49(5):1625-1635
Relation Between Liver Progenitor Cell Expansion and Extracellular Matrix Deposition in a CDE-Induced Murine Model of Chronic Liver Injury
Van Hul NKM; Abarca-Quinones J; Sempoux C; Horsmans Y; Leclercq IA
Article: LABORATORY INVESTIGATION. 2006;86(11):1161-1171
Defective hepatic regeneration after partial hepatectomy in leptin-deficient mice is not rescued by exogenous leptin.
Leclercq IA; Vansteenberghe M; Lebrun VB; VanHul NK; Abarca-Quinones J; Sempoux CL; Picard C; Stärkel P; Horsmans YL
Article: GENOMICS. 2005;85(5):574-581
Distribution of human β-defensin polymorphisms in various control and cystic fibrosis populations
Vankeerberghen A; Scudiero O; De Boeck K; Macek M; Pignatti PF; Van Hul N; Nuytten H; Salvatore F; Castaldo G; Zemkova D; Vavrova V; Cassiman JJ; Cuppens H
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Preprint: BIORXIV. 2023
Host-Pathogen Interactions in thePlasmodium-Infected Mouse Liver at Spatial and Single-Cell Resolution
Hildebrandt F; Urrutia-Iturritza M; Zwicker C; Vanneste B; Hul NV; Semle E; Pascini T; Saarenpää S; He M; Andersson E; Scott C; Vega-Rodriguez J; Lundeberg J; Ankarklev J
Conference publication: JOURNAL OF HEPATOLOGY. 2023;78:S439
Lineage tracing of hepatic stellate cells with ultrasound-guided in utero nano-injection
He J; Belicova L; De Haan S; Van Hul NKM; Verhulst S; Ratz M; Andersson E
Conference publication: JOURNAL OF HEPATOLOGY. 2023;78:S435
IGF1 specifically rescues peripheral intrahepatic biliary organoids from a mouse model of Alagille syndrome
Iqbal A; Van Hul NKM; Belicova L; Corbat A; Hankeova S; Andersson E
Preprint: BIORXIV. 2022
Jag1 Insufficiency Disrupts Neonatal T Cell Differentiation and Impairs Hepatocyte Maturation, Leading to Altered Liver Fibrosis
Mašek J; Filipovic I; Hul NV; Belicová L; Jiroušková M; Oliveira D; Frontino AM; Hankeova S; He J; Turetti F; Iqbal A; Červenka I; Sarnová L; Verboven E; Brabec T; Björkström N; Gregor M; Dobeš J; Andersson E
Preprint: BIORXIV. 2021
Bleeding in patients and mice with Alagille syndrome: sex differences and risk factors
Hankeova S; Van Hul N; Laznovsky J; Hensen N; Verhoef E; Zikmund T; Dawit F; Kavkova M; Salplachta J; Li L; Sjöqvist M; Johansson BR; Hassan M; Bryja V; Lendahl U; Jheon A; Wang JS; Alten F; Fahnehjelm KT; Fischler B; Kaiser J; Andersson ER
Preprint: BIORXIV. 2021
Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the liver
Hildebrandt F; Andersson A; Saarenpää S; Larsson L; Van Hul N; Kanatani S; Masek J; Ellis E; Barragan A; Mollbrink A; Andersson ER; Lundeberg J; Ankarklev J
Corrigendum: ONCOGENE. 2020;39(9):2030
Correction: Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality.
Szmyd R; Niska-Blakie J; Diril MK; Nunes PR; Tzelepis K; Lacroix A; van Hul N; Deng L-W; Matos J; Dreesen O; Bisteau X; Kaldis P
Conference publication: JOURNAL OF HEPATOLOGY. 2020;73:S244
Targeting the embryonic liver with ultrasound-guided in utero nano-injection to manipulate gene expression during liver development and hematopoiesis
He J; Van Hul NKM; Masek J; Bjorkstrom N; Andersson E
Conference publication: JOURNAL OF HEPATOLOGY. 2020;73:S43
Double resin casting micro computed tomography (CT) reveals biliary and vascular pathology in tandem in a mouse model for alagille syndrome
Hankeova S; Salplachta J; Zikmund T; Kavkova M; Van Hul NKM; Brinek A; Smekalova V; Laznovsky J; Jaros J; Bryja V; Lendahl U; Ellis E; Hannezo E; Kaiser J; Andersson E
Conference publication: JOURNAL OF HEPATOLOGY. 2020;73:S113-S114
Impaired hepatocyte cell division induces progenitor cell activation and emergence of bi-phenotypic hepatocytes
Zafer G; Ow JR; Dewhurst M; Van Hul NKM; Caldez M; Goh C; Fu NY; Kaldis P
Preprint: BIORXIV. 2019
Protective functions of ZO-2/Tjp2 expressed in hepatocytes and cholangiocytes against liver injury and cholestasis
Xu J; Kausalya J; Van Hul N; Caldez M; Xu S; Min Ong AG; Woo WL; Ali SM; Kaldis P; Hunziker W
Preprint: BIORXIV. 2019
DoUble resin casting micro computed tomography (DUCT) reveals biliary and vascular pathology in a mouse model of Alagille syndrome
Hankeova S; Salplachta J; Zikmund T; Kavkova M; Van Hul N; Brinek A; Smekalova V; Laznovsky J; Jaros J; Bryja V; Lendahl U; Ellis E; Hannezo E; Kaiser J; Andersson ER
Preprint: BIORXIV. 2019
Autonomous induction of hepatic polarity to construct single cell liver
Zhang Y; de Mets R; Monzel C; Toh P; Van Hul N; Ng SS; Rashid ST; Viasnoff V
Meeting abstract: JOURNAL OF HEPATOLOGY. 2017;66(1):s6
Ductular reactions provide a structural biliary network to preserve bile drainage in the CDE-model of hepatocellular chronic liver injury
Clerbaux L-A; Manco R; Van Hul N; Espanol-Suner R; Bouzin C; Sempoux C; Theise N; Leclercq I
Meeting abstract: JOURNAL OF HEPATOLOGY. 2016;64:s203
FUELING CELLULAR DIVISION DURING LIVER REGENERATION: CDK1 REGULATES ENERGY METABOLISM BY DIRECTING THE FLUX OF PYRUVATE
Caldez M; Van Hul N; Teo XQ; Fuhrer T; Fan JJ; Tan PY; Stunkel W; Yu H; Bjorklund M; Sauer U; Lee P; Kaldis P
Meeting abstract: JOURNAL OF HEPATOLOGY. 2016;64:s638-s639
COMBINED DELETION OF HEPATIC ZO-1 AND ZO-2 INDUCES LOSS OF BILE DUCTS
Xu J; Van Hul N; Caldez M; Dewhurst M; Kaldis P; Hunziker W
Meeting abstract: JOURNAL OF HEPATOLOGY. 2016;64:s350
CDK1 KNOCK OUT GIANT HEPATOCYTES INDUCE LIVER PROGENITOR CELLS
Van Hul N; Caldez M; Kaldis P
Meeting abstract: JOURNAL OF HEPATOLOGY. 2015;62:s469
CELL CYCLE REGULATION IS DELAYED IN A MODEL OF LIVER REGENERATION AFTER SERIAL PARTIAL HEPATECTOMY
Caldez M; Van Hul N; Kaldis P
Meeting abstract: JOURNAL OF HEPATOLOGY. 2015;62:s465-s466
DELETION OF Cdk1 IN THE LIVER INDUCES CHANGES IN PYRUVATE METABOLISM
Caldez M; Teo XQ; Van Hul N; Lee P; Kaldis P
Meeting abstract: JOURNAL OF HEPATOLOGY. 2015;62:s407
THE INSULINE-LIKE GROWTH FACTOR 2 (IGF2) MRNA BINDING PROTEIN (IMP) P62 PROMOTES CIRRHOSIS-LINKED HEPATOCARCINOGENESIS
Kessler SM; Czepukojc B; Engel K; Van Hul N; Haybaeck J; Leclercq I; Kiemer AK
Conference publication: HEPATOLOGY. 2015;62:545A
Notch and Wnt control ductular reactions via the Igf1 axis
Minnis-Lyons SE; Boulter LG; Man TY; Williams MJ; Guest RV; Lu W-Y; Van Hul N; Leclercq IA; Sansom OJ; Forbes SJ
Meeting abstract: JOURNAL OF HEPATOLOGY. 2014;60(1):S101
ROLE OF TUMOR NECROSIS FACTOR-α DURING THE DUCTULAR REACTION IN MOUSE MODELS OF LIVER INJURY
Best J; Verhulst S; Van Hul N; Syn W-K; Heindryckx F; Van Vlierberghe H; Reynaert H; Leclercq IA; van Grunsven LA; Dolle L
Conference publication: HEPATOLOGY. 2013;58:1004A
Discrepancies between widely used mouse models of liver progenitor cells: a comparative study between CDE- and DDC-induced chronic liver injuries
Van Hul N; Espanol-Suner R; Sempoux C; Dolle L; van Grunsven LA; Lemaigre F; Leclercq IA
Conference publication: HEPATOLOGY. 2013;58:375A
Hepatic stellate cells improve survival and engraftment of hepatocytes after transplantation
Dusabineza A-C; Van Hul N; Legry V; Khuu DN; Sokal EM; van Grunsven LA; Najimi M; Leclercq IA
Meeting abstract: JOURNAL OF HEPATOLOGY. 2012;56:s28
ADULT LIVER PROGENITOR CELLS DIFFERENTIATE TOWARD MATURE HEPATOCYTES AFTER CDE DIET-INDUCED INJURY
Suner RE; Carpentier R; Van Hul N; Lemaigre F; Leclercq I
Conference publication: HEPATOLOGY. 2010;52(4):971A
KUPFFER CELLS CONDITION MIGRATION AND PHENOTYPIC ORIENTATION BUT NOT THE PROLIFERATION OF LIVER PROGENITOR CELLS IN A MURINE MODEL OF LIVER INJURY
Van Hul N; Lanthier N; Suner RE; Abarca-Quinones J; Leclercq IA
Meeting abstract: JOURNAL OF HEPATOLOGY. 2009;50:s314
RELATION BETWEEN LIVER PROGENITOR CELL EXPANSION AND EXTRACELLULAR MATRIX DEPOSITION IN A CDE INDUCED MURINE MODEL OF CHRONIC LIVER INJURY
Van Hul N; Abarca-Quinones J; Sempoux C; Horsmans Y; Leclercq I
Review: JOURNAL OF HEPATOLOGY. 2007;47(1):142-156
Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms and consequences
Leclercq IA; Morais ADS; Schroyen B; Van Hul N; Geerts A
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Affiliated to Research, Department of Cell and Molecular Biology, Karolinska Institutet, 2024-2025
Researcher, Department of Cell and Molecular Biology, Karolinska Institutet, 2020-2024

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