Ninib Baryawno

Ninib Baryawno

Principal Researcher | Docent
Visiting address: Widerströmska huset, Tomtebodavägen 18A, 17177 Stockholm
Postal address: K6 Kvinnors och barns hälsa, K6 Barnonkologi och barnkirurgi Baryawno, 171 77 Stockholm
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About me

  • The lab focus is to solve problems that limit the ability of cancer therapy 

  • to be used more effectively against deadly forms of pediatric cancers and 
  • adult cancers.

     

  • Dr Ninib Baryawno received his PhD diploma at Karolinska Institutet under the supervision of associate professor John Inge Johnsen and professor Per 

  • Kogner. His thesis work focused on developing novel therapeutics based on 
  • better biological understanding of the childhood brain tumor medulloblastoma. 
  • A disorder of development, arising mostly in the cerebellum during 
  • embryogenesis and is largely dictated by events in stem cell regulatory 
  • signaling pathways. His research was published as a thesis “New Potential 
  • Targets in Medulloblastoma Therapy – Studies on Cellular Mechanisms and 
  • Mediators”, and defended in February 2010. It was the interest in stem cell based approaches to disease that brought Dr 
  • Baryawno together with professor David Scadden at Harvard University and 
  • Massachusetts General Hospital in 2011. Dr Baryawno was a postdoctoral fellow 
  • in the Scadden lab until 2017 where he applied single-cell RNA-sequencing to 
  • study how the hematopoietic stem cell niche supports the outgrowth of murine 
  • leukemia and human bone metastases.

     

  • Dr Baryawno became Assistant professor at Karolinska Institutet in January 2018.

     

  • Research training:

    • 2001-2005, Biomedicine program, Karolinska Institutet.
    • 2005-2010, PhD training, Karolinska Institutet.
    • 2011-2017, Postdoc fellowship, Harvard University/Massachusetts General Hospital.
    • 2018, Assistant pProfessor, Karolinska Institutet.
    • 2023, Associate Professor (Docent), Karolinska Institutet.
    • 2023, Group leader, Karolinska Institutet.

Research

  • The lab's focus is to solve problems that limit the ability of cancer therapy to be used more effectively against deadly forms of pediatric cancers and adult cancers. We focus our research on pediatric tumors of the nervous system such as neuroblastoma and medulloblastoma, and bone metastases from different tumor origins.

     

  • Our research is balanced by a commitment to the value of basic and translational research. This effort is based on the integrated approach of single-cell technologies, computational modeling, and functional preclinical testing, directed at understanding the role of the tumor microenvironment in cancer development, tumor cell dissemination, and cancer resistance.

     

  • Read more about our work here at 

  • http://baryawnolab.com/.

    Research expertise:

    • Childhood cancer (neuroblastoma, medulloblastoma)
    • Metastatic cancer (neuroblastoma, prostate cancer, renal cell carcinoma)
    • Tumor microenvironment (stroma, immune cells)
    • Basic and translational
    • Single-cell omics
    • Preclinical modeling (organoids/tumoroids, animals)

Teaching

  • Teaching at Karolinska Institutet, lectures and seminars:

    • Pediatric oncology course 2017, 2021 (graduates, 13h)
    • Medical Medicine – Oncology 2019, 2020, 2021, 2022 and current (undergraduates, 75 hours)
    • Tumor Biology Course 2018 (undergraduates/graduates
    • 20 hours, )
    • Advanced Course in Tumor Biology 2018 (graduates, 1h)
    • Vascular Cell Biology Course 2019 (graduates, 1h)
    • Regenerative Medicine (undergraduates, 1h)

Articles

All other publications

Employments

  • Principal Researcher, Department of Women's and Children's Health, Karolinska Institutet, 2022-

Degrees and Education

  • Docent, Karolinska Institutet, 2023
  • Degree Of Doctor Of Philosophy, Department of Women's and Children's Health, Karolinska Institutet, 2010
  • Master Of Medical Science, Karolinska Institutet, 2007

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