Niklas Schultz

Publications
Public outreach and news

Articles

Article: NATURE COMMUNICATIONS. 2023;14(1):509
Spatially resolved transcriptomic profiling of degraded and challenging fresh frozen samples
Mirzazadeh R; Andrusivova Z; Larsson L; Newton PT; Galicia LA; Abalo XM; Avijgan M; Kvastad L; Denadai-Souza A; Stakenborg N; Firsova AB; Shamikh A; Jurek A; Schultz N; Nister M; Samakovlis C; Boeckxstaens G; Lundeberg J
Article: NATURE COMMUNICATIONS. 2022;13(1):5475
Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones
Marklund M; Schultz N; Friedrich S; Berglund E; Tarish F; Tanoglidi A; Liu Y; Bergenstrahle L; Erickson A; Helleday T; Lamb AD; Sonnhammer E; Lundeberg J
Article: NATURE. 2022;608(7922):360-367
Spatially resolved clonal copy number alterations in benign and malignant tissue
Erickson A; He M; Berglund E; Marklund M; Mirzazadeh R; Schultz N; Kvastad L; Andersson A; Bergenstrahle L; Bergenstrahle J; Larsson L; Galicia LA; Shamikh A; Basmaci E; De Stahl TD; Rajakumar T; Doultsinos D; Thrane K; Ji AL; Khavari PA; Tarish F; Tanoglidi A; Maaskola J; Colling R; Mirtti T; Hamdy FC; Woodcock DJ; Helleday T; Mills IG; Lamb AD; Lundeberg J
Article: CELL GENOMICS. 2021;1(3):100065
Genome-wide spatial expression profiling in formalin-fixed tissues
Villacampa EG; Larsson L; Mirzazadeh R; Kvastad L; Andersson A; Mollbrink A; Kokaraki G; Monteil V; Schultz N; Appelberg KS; Montserrat N; Zhang H; Penninger JM; Miesbach W; Mirazimi A; Carlson J; Lundeberg J
Article: NATURE COMMUNICATIONS. 2018;9(1):2419
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
Berglund E; Maaskola J; Schultz N; Friedrich S; Marklund M; Bergenstrahle J; Tarish F; Tanoglidi A; Vickovic S; Larsson L; Salmen F; Ogris C; Wallenborg K; Lagergren J; Stahl P; Sonnhammer E; Helleday T; Lundeberg J
Article: NATURE COMMUNICATIONS. 2017;8(1):374
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer
Asim M; Tarish F; Zecchini HI; Sanjiv K; Gelali E; Massie CE; Baridi A; Warren AY; Zhao W; Ogris C; McDuffus L-A; Mascalchi P; Shaw G; Dev H; Wadhwa K; Wijnhoven P; Forment JV; Lyons SR; Lynch AG; O'Neill C; Zecchini VR; Rennie PS; Baniahmad A; Tavare S; Mills IG; Galanty Y; Crosetto N; Schultz N; Neal D; Helleday T
Article: CELL REPORTS. 2016;14(2):298-309
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
Sanjiv K; Hagenkort A; Calderon-Montano JM; Koolmeister T; Reaper PM; Mortusewicz O; Jacques SA; Kuiper RV; Schultz N; Scobie M; Charlton PA; Pollard JR; Berglund UW; Altun M; Helleday T
Article: SCIENCE TRANSLATIONAL MEDICINE. 2015;7(312):312re11
Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair
Tarish FL; Schultz N; Tanoglidi A; Hamberg H; Letocha H; Karaszi K; Hamdy FC; Granfors T; Helleday T
Article: NATURE. 2014;508(7495):215-221
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Gad H; Koolmeister T; Jemth A-S; Eshtad S; Jacques SA; Strom CE; Svensson LM; Schultz N; Lundback T; Einarsdottir BO; Saleh A; Gokturk C; Baranczewski P; Svensson R; Berntsson RP-A; Gustafsson R; Stromberg K; Sanjiv K; Jacques-Cordonnier M-C; Desroses M; Gustavsson A-L; Olofsson R; Johansson F; Homan EJ; Loseva O; Brautigam L; Johansson L; Hoglund A; Hagenkort A; Pham T; Altun M; Gaugaz FZ; Vikingsson S; Evers B; Henriksson M; Vallin KSA; Wallner OA; Hammarstrom LGJ; Wiita E; Almlof I; Kalderen C; Axelsson H; Djureinovic T; Puigvert JC; Haggblad M; Jeppsson F; Martens U; Lundin C; Lundgren B; Granelli I; Jensen AJ; Artursson P; Nilsson JA; Stenmark P; Scobie M; Berglund UW; Helleday T
Article: CLINICAL CANCER RESEARCH. 2013;19(6):1547-1556
Castration Therapy Results in Decreased Ku70 Levels in Prostate Cancer
Al-Ubaidi FLT; Schultz N; Loseva O; Egevad L; Granfors T; Helleday T
Article: CARCINOGENESIS. 2013;34(2):325-330
Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair
Kotova N; Vare D; Schultz N; Meesters DG; Stepnik M; Grawe J; Helleday T; Jenssen D
Article: CARCINOGENESIS. 2012;33(11):2026-2034
Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta
Nicolay NH; Carter R; Hatch SB; Schultz N; Prevo R; McKenna WG; Helleday T; Sharma RA
Article: NUCLEIC ACIDS RESEARCH (NAR). 2012;40(17):8440-8448
CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation
Elvers I; Hagenkort A; Johansson F; Djureinovic T; Lagerqvist A; Schultz N; Stoimenov I; Erixon K; Helleday T
Article: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2012;82(3):1243-1248
CASTRATION THERAPY OF PROSTATE CANCER RESULTS IN DOWNREGULATION OF HIF-1α LEVELS
Al-Ubaidi FLT; Schultz N; Egevad L; Granfors T; Helleday T
Article: DNA REPAIR. 2011;10(9):961-969
CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair
Strom CE; Mortusewicz O; Finch D; Parsons JL; Lagerqvist A; Johansson F; Schultz N; Erixon K; Dianov GL; Helleday T
Article: PLOS ONE. 2011;6(5):e19492
Transcription Inhibition by DRB Potentiates Recombinational Repair of UV Lesions in Mammalian Cells
Stoimenov I; Schultz N; Gottipati P; Helleday T
Article: MUTATION RESEARCH - FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2011;706(1-2):1-6
Transcription inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) causes DNA damage and triggers homologous recombination repair in mammalian cells
Stoimenov I; Gottipati P; Schultz N; Helleday T
Article: JOURNAL OF MOLECULAR BIOLOGY. 2010;402(1):70-82
Methylated DNA Causes a Physical Block to Replication Forks Independently of Damage Signalling, O⁶-Methylguanine or DNA Single-Strand Breaks and Results in DNA Damage
Groth P; Auslander S; Majumder MM; Schultz N; Johansson F; Petermann E; Helleday T
Article: THE FASEB JOURNAL. 2010;24(8):2795-2803
Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans.
Waluk DP; Schultz N; Hunt MC
Article: CANCER RESEARCH. 2010;70(13):5389-5398
Poly(ADP-Ribose) Polymerase Is Hyperactivated in Homologous Recombination-Defective Cells
Gottipati P; Vischioni B; Schultz N; Solomons J; Bryant HE; Djureinovic T; Issaeva N; Sleeth K; Sharma RA; Helleday T
Article: MOLECULAR CELL. 2010;37(4):492-502
Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
Petermann E; Luis Orta M; Issaeva N; Schultz N; Helleday T
Article: NUCLEIC ACIDS RESEARCH (NAR). 2009;37(19):6400-6413
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links
Al-Minawi AZ; Lee Y-F; Hakansson D; Johansson F; Lundin C; Saleh-Gohari N; Schultz N; Jenssen D; Bryant HE; Meuth M; Hinz JM; Helleday T
Article: EMBO JOURNAL. 2009;28(17):2601-2615
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
Bryant HE; Petermann E; Schultz N; Jemth A-S; Loseva O; Issaeva N; Johansson F; Fernandez S; McGlynn P; Helleday T
Article: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2007;83(5):319-329
Kinetics and dose-response of residual 53BP1/gamma-H2AX foci: co-localization, relationship with DSB repair and clonogenic survival.
Marková E; Schultz N; Belyaev IY
Article: CYTOGENETIC AND GENOME RESEARCH. 2007;116(1-2):38-45
RAD51C (RAD51L2) is involved in maintaining centrosome number in mitosis
Lindh AR; Schultz N; Saleh-Gohari N; Helleday T
Article: HUMAN MOLECULAR GENETICS. 2006;15(7):1217-1224
Mitotic defects in XRCC3 variants T241M and D213N and their relation to cancer susceptibility
Lindh AR; Rafii S; Schultz N; Cox A; Helleday T
Article: CELL CYCLE. 2005;4(9):1176-1178
Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy
Helleday T; Bryant HE; Schultz N
Article: MOLECULAR AND CELLULAR BIOLOGY. 2005;25(16):7158-7169
Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks
Saleh-Gohari N; Bryant HE; Schultz N; Parker KA; Cassel TN; Helleday T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(18):6455-6460
Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro.
Mellroth P; Karlsson J; Håkansson J; Schultz N; Goldman WE; Steiner H
Article: NATURE. 2005;434(7035):913-917
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Bryant HE; Schultz N; Thomas HD; Parker KM; Flower D; Lopez E; Kyle S; Meuth M; Curtin NJ; Helleday T
Article: ONCOGENE. 2004;23(13):2324-2329
p53 protects from replication-associated DNA double-strand breaks in mammalian cells
Kumari A; Schultz N; Helleday T
Article: NUCLEIC ACIDS RESEARCH (NAR). 2003;31(17):4959-4964
Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
Schultz N; Lopez E; Saleh-Gohari N; Helleday T
Article: JOURNAL OF MOLECULAR BIOLOGY. 2003;328(3):521-535
RAD51 is involved in repair of damage associated with DNA replication in mammalian cells
Lundin C; Schultz N; Arnaudeau C; Mohindra A; Hansen LT; Helleday T
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(16):5869-5878
Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells
Lundin C; Erixon K; Arnaudeau C; Schultz N; Jenssen D; Meuth M; Helleday T
Article: CELL MOTILITY AND THE CYTOSKELETON. 2001;50(2):69-88
Spindle positioning in fibroblasts supports an astral microtubule length dependent force generation at the basal membrane.
Schultz N; Onfelt A
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2000;126(2):97-123
Sensitivity of cytokinesis to hydrophobic interactions. Chemical induction of bi-and multinucleated cells.
Schultz N; Onfelt A
Article: MUTATION RESEARCH - FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 1996;353(1-2):11-46
The detection and evaluation of aneugenic chemicals.
Parry JM; Parry EM; Bourner R; Doherty A; Ellard S; O'Donovan J; Hoebee B; de Stoppelaar JM; Mohn GR; Onfelt A; Renglin A; Schultz N; Söderpalm-Berndes C; Jensen KG; Kirsch-Volders M; Elhajouji A; Van Hummelen P; Degrassi F; Antoccia A; Cimini D; Izzo M; Tanzarella C; Adler ID; Kliesch U; Hess P
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