Mike Aoun

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About me

"If you really want to hear about it, the first thing you'll probably want to
know is where I was born, and what my lousy childhood was like, and how my
parents were occupied and all before they had me, and all that David
Copperfield kind of crap, but I don't feel like going into it, if you want to
know the truth."
-/Salinger/
PhD in *Immunology *at Karolinska Institute
M.Sc in *Immunology and Immunotherapies* at Pierre et Marie Curie
University-Paris 6
B.Sc in *Biology* at Lebanese American University-LAU

Research

Understanding the role of the innate immune system and B cells in regulating
rheumatoid arthritis

Selected publications

Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2023;220(11):e20230101
Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice.
Aoun M; Coelho A; Krämer A; Saxena A; Sabatier P; Beusch CM; Lönnblom E; Geng M; Do N-N; Xu Z; Zhang J; He Y; Romero Castillo L; Abolhassani H; Xu B; Viljanen J; Rorbach J; Fernandez Lahore G; Gjertsson I; Kastbom A; Sjöwall C; Kihlberg J; Zubarev RA; Burkhardt H; Holmdahl R

Articles

Article: CHEMBIOCHEM. 2024;25(9):e202400026
Stereoselective Synthesis of the Gal-α-(1→3)-Gal-β-(1→3)-GlcNAc Trisaccharide: a new Ligand for DCAR and Mincle C-Type Lectin Receptors
Tricomi J; Aoun M; Xu B; Holmdahl R; Richichi B
Article: JCI INSIGHT. 2023;8(17):e167656
Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations
Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Adori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; Mcinerney G; Murrell B; Aoun M; Baeckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Hedestam GBK; Dopico XC; Rorbach J
Article: NATURE COMMUNICATIONS. 2023;14(1):691
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis
He Y; Ge C; Moreno-Giro A; Xu B; Beusch CM; Sandor K; Su J; Cheng L; Lonnblom E; Lundqvist C; Slot LM; Tong D; Urbonaviciute V; Liang B; Li T; Lahore GF; Aoun M; Malmstrom V; Rispens T; Ernfors P; Svensson CI; Scherer HU; Toes REM; Gjertsson I; Ekwall O; Zubarev RA; Holmdahl R
Article: ANTIOXIDANTS. 2021;11(1):12
Glycan Activation of Clec4b Induces Reactive Oxygen Species Protecting against Neutrophilia and Arthritis
Aoun M; Cai X; Xu B; Lahore GF; Bonner MY; He Y; Backdahl L; Holmdahl R
Article: NATURE COMMUNICATIONS. 2021;12(1):6558
An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation
Sabatier P; Beusch CM; Saei AA; Aoun M; Moruzzi N; Coelho A; Leijten N; Nordenskjold M; Micke P; Maltseva D; Tonevitsky AG; Millischer V; Villaescusa JC; Kadekar S; Gaetani M; Altynbekova K; Kel A; Berggren P-O; Simonson O; Grinnemo K-H; Holmdahl R; Rodin S; Zubarev RA
Article: NATURE COMMUNICATIONS. 2021;12(1):5565
Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases
Lahore GF; Forster M; Johannesson M; Sabatier P; Lonnblom E; Aoun M; He Y; Nandakumar KS; Zubarev RA; Holmdahl R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(40):24986-24997
Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases
Lahore GF; Raposo B; Lagerquist M; Ohlsson C; Sabatier P; Xu B; Aoun M; James J; Cai X; Zubarev RA; Nandakumar KS; Holmdahl R
Article: PLOS GENETICS. 2020;16(6):e1008788
Identification of Clec4b as a novel regulator of bystander activation of auto-reactive T cells and autoimmune disease
Backdahl L; Aoun M; Norin U; Holmdahl R
Article: BONE MARROW TRANSPLANTATION. 2015;50(6):858-864
Evaluation of pretransplant influenza vaccination in hematopoietic SCT: a randomized prospective study
Ambati A; Boas LSV; Ljungman P; Testa L; de Oliveira JF; Aoun M; Colturato V; Maeurer M; Machado CM

All other publications

Review: ANNALS OF THE RHEUMATIC DISEASES. 2024;83(5):550-555
Shift in perspective: autoimmunity protecting against rheumatoid arthritis
He Y; Aoun M; Xu Z; Holmdahl R
Preprint: MEDRXIV. 2021
Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses
Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Àdori M; Sheward D; Teifel S; Liu Y; Harris R; Murrell B; Mcinerney G; Aoun M; Bäckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Karlsson Hedestam G; Dopico XC; Rorbach J
Thesis / dissertation: 2021
Positional cloning of polymorphic loci that control autoreactive T cells
Aoun, Mike
Preprint: RESEARCH SQUARE. 2021
Polymorphic estrogen receptor binding site causes CD2-dependent sex bias in the susceptibility to autoimmune diseases
Lahore GF; Förster M; Johannesson M; Sabatier P; Lönnblom E; Aoun M; He Y; Nandakumar K; Zubarev R; Holmdahl R
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):324
Non-coding variants promote vitamin D receptor expression in activated T cells and protect from GPI-induced arthritis
Fernandez-Lahore G; Raposo B; Marquina C; Aoun M; Lagerquist M; Holmdahl R
Conference publication: BONE MARROW TRANSPLANTATION. 2014;49:S330
PRE-TRANSPLANT DONOR AND RECIPIENT INFLUENZA VACCINATION ENHANCES SERO-RESPONSE RATES IN THE FIRST SIX MONTHS AFTER HSCT
Ambati A; Testa L; Ljungman P; Boas LSV; Aoun M; Maeurer M; Machado C

Employments

Postdoctoral Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2022-2025

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2021

About me

Research

Selected publications

Articles

All other publications

Employments

Degrees and Education

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