Mikael Rhen

Publications
Public outreach and news

Articles

Article: FRONTIERS IN MICROBIOLOGY. 2020;11:26
Nitrate Metabolism Modulates Biosynthesis of Biofilm Components in Uropathogenic Escherichia coli and Acts as a Fitness Factor During Experimental Urinary Tract Infection
Martin-Rodriguez AJ; Rhen M; Melican K; Richter-Dahlfors A
Article: SENSORS AND ACTUATORS, B: CHEMICAL. 2019;297:126703
Electrochemical sensing of bacteria via secreted redox active compounds using conducting polymers
Butina K; Loffler S; Rhen M; Richter-Dahlfors A
Article: FRONTIERS IN MICROBIOLOGY. 2018;9:2941
Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium
Vesto K; Huseby DL; Snygg I; Wang H; Hughes D; Rhen M
Article: NPJ BIOFILMS AND MICROBIOMES. 2017;3:19
Redox-active conducting polymers modulate Salmonella biofilm formation by controlling availability of electron acceptors
Gomez-Carretero S; Libberton B; Svennersten K; Persson K; Jager E; Berggren M; Rhen M; Richter-Dahlfors A
Article: MICROBIAL CELL FACTORIES. 2016;15(1):177
BcsZ inhibits biofilm phenotypes and promotes virulence by blocking cellulose production in Salmonella enterica serovar Typhimurium
Ahmad I; Rouf SF; Sun L; Cimdins A; Shafeeq S; Le Guyon S; Schottkowski M; Rhen M; Romling U
Article: PLOS PATHOGENS. 2016;12(4):e1005528
The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection
Belluz LDB; Guidi R; Pateras IS; Levi L; Mihaljevic B; Rouf SF; Wrande M; Candela M; Turroni S; Nastasi C; Consolandi C; Peano C; Tebaldi T; Viero G; Gorgoulis VG; Krejsgaard T; Rhen M; Frisan T
Article: NPJ BIOFILMS AND MICROBIOMES. 2016;2:16024
Real-time optotracing of curli and cellulose in live Salmonella biofilms using luminescent oligothiophenes
Choong FX; Back M; Fahlen S; Johansson LBG; Melican K; Rhen M; Nilsson KPR; Richter-Dahlfors A
Article: IMMUNOLOGY AND CELL BIOLOGY. 2015;93(6):581-590
CD244 is expressed on dendritic cells and regulates their functions
Georgoudaki A-M; Khodabandeh S; Puiac S; Persson CM; Larsson MK; Lind M; Hammarfjord O; Nabatti TH; Wallin RPA; Yrlid U; Rhen M; Kumar V; Chambers BJ
Article: ENVIRONMENTAL MICROBIOLOGY. 2015;17(4):1310-1320
Dissecting the cyclic di-guanylate monophosphate signalling network regulating motility in Salmonella enterica serovar Typhimurium
Le Guyon S; Simm R; Rehn M; Romling U
Article: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2015;70(2):432-440
Fitness of Salmonella mutants resistant to antimicrobial peptides
Lofton H; Anwar N; Rhen M; Andersson DI
Article: PLOS PATHOGENS. 2014;10(7):e1004270
Independent Bottlenecks Characterize Colonization of Systemic Compartments and Gut Lymphoid Tissue by Salmonella
Lim CH; Voedisch S; Wahl B; Rouf SF; Geffers R; Rhen M; Pabst O
Article: PLOS ONE. 2014;9(8):e106095
Modulation of Biofilm-Formation in Salmonella enterica Serovar Typhimurium by the Periplasmic DsbA/DsbB Oxidoreductase System Requires the GGDEF-EAL Domain Protein STM3615
Anwar N; Rouf SF; Romling U; Rhen M
Article: MOLECULAR MICROBIOLOGY. 2013;90(6):1216-1232
The EAL-like protein STM1697 regulates virulence phenotypes, motility and biofilm formation in Salmonella typhimurium
Ahmad I; Wigren E; Le Guyon S; Vekkeli S; Blanka A; el Mouali Y; Anwar N; Chuah ML; Luensdorf H; Frank R; Rhen M; Liang Z-X; Lindqvist Y; Romling U
Article: CELLULAR MICROBIOLOGY. 2013;15(12):2034-2050
Salmonella enterica delivers its genotoxin through outer membrane vesicles secreted from infected cells
Guidi R; Levi L; Rouf SF; Puiac S; Rhen M; Frisan T
Article: MICROBIOLOGY (UNITED KINGDOM). 2013;159(Pt 7):1447-1458
Biotin sulfoxide reductase contributes to oxidative stress tolerance and virulence in Salmonella enterica serovar Typhimurium
Denkel LA; Rhen M; Bange F-C
Article: PLOS ONE. 2013;8(7):e70147
Pathoadaptive Mutations in Salmonella enterica Isolated after Serial Passage in Mice
Koskiniemi S; Gibbons HS; Sandegren L; Anwar N; Ouellette G; Broomall S; Karavis M; McGregor P; Liem A; Fochler E; McNew L; Rosenzweig CN; Rhen M; Skowronski EW; Andersson DI
Article: PLOS ONE. 2013;8(6):e64948
Oxidoreductases that Act as Conditional Virulence Suppressors in Salmonella enterica Serovar Typhimurium
Anwar N; Sem XH; Rhen M
Article: CELLULAR MICROBIOLOGY. 2012;14(10):1584-1599
Modulation of Caenorhabditis elegans infection sensitivity by the LIN-7 cell junction protein
Sem X; Kreisberg JF; Kawli T; Tan M-W; Rhen M; Tan P
Article: PLOS ONE. 2012;7(9):e45417
Pathogenicity of Salmonella enterica in Caenorhabditis elegans Relies on Disseminated Oxidative Stress in the Infected Host
Sem X; Rhen M
Article: FEMS MICROBIOLOGY LETTERS. 2011;325(1):56-63
Genetic analysis of the pnp-deaD genetic region reveals membrane lipoprotein NlpI as an independent participant in cold acclimatization of Salmonella enterica serovar Typhimurium
Rouf SF; Anwar N; Clements MO; Rhen M
Article: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 2011;38(5):409-416
Small-molecular virulence inhibitors show divergent and immunomodulatory effects in infection models of Salmonella enterica serovar Typhimurium
Puiac S; Sem X; Negrea A; Rhen M
Article: FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY. 2011;61(2):168-178
Helicobacter pylori defines local immune response through interaction with dendritic cells
Andres S; Schmidt H-MA; Mitchell H; Rhen M; Maeurer M; Engstrand L
Article: BMC GENOMICS. 2011;12:123
Comparative tissue transcriptomics reveal prompt inter-organ communication in response to local bacterial kidney infection
Boekel J; Kallskog O; Ryden-Aulin M; Rhen M; Richter-Dahlfors A
Article: JOURNAL OF BACTERIOLOGY. 2011;193(2):580-582
Opposing Contributions of Polynucleotide Phosphorylase and the Membrane Protein NlpI to Biofilm Formation by Salmonella enterica Serovar Typhimurium
Rouf SF; Ahmad I; Anwar N; Vodnala SK; Kader A; Romling U; Rhen M
Article: PLOS ONE. 2011;6(11):e26974
Methionine Sulfoxide Reductases Are Essential for Virulence of Salmonella Typhimurium
Denkel LA; Horst SA; Rouf SF; Kitowski V; Bohm OM; Rhen M; Jager T; Bange F-C
Article: JOURNAL OF BACTERIOLOGY. 2010;192(11):2929-2932
Thiol Peroxidase Protects Salmonella enterica from Hydrogen Peroxide Stress In Vitro and Facilitates Intracellular Growth
Horst SA; Jaeger T; Denkel LA; Rouf SF; Rhen M; Bange F-C
Article: ENVIRONMENTAL MICROBIOLOGY. 2010;12(1):40-53
Cyclic di-GMP signalling controls virulence properties of Salmonella enterica serovar Typhimurium at the mucosal lining
Lamprokostopoulou A; Monteiro C; Rhen M; Romling U
Article: JOURNAL OF BACTERIOLOGY. 2009;191(22):6918-6927
Thioredoxin 1 Participates in the Activity of the Salmonella enterica Serovar Typhimurium Pathogenicity Island 2 Type III Secretion System
Negrea A; Bjur E; Puiac S; Ygberg SE; Aslund F; Rhen M
Article: INFECTION AND IMMUNITY. 2009;77(8):3170-3180
Mesenteric Lymph Nodes Confine Dendritic Cell-Mediated Dissemination of Salmonella enterica Serovar Typhimurium and Limit Systemic Disease in Mice
Voedisch S; Koenecke C; David S; Herbrand H; Foerster R; Rhen M; Pabst O
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2009;53(6):2298-2305
Genetic Analysis of Colistin Resistance in Salmonella enterica Serovar Typhimurium
Sun S; Negrea A; Rhen M; Andersson DI
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2009;53(6):2402-2409
Omeprazole Antagonizes Virulence and Inflammation in Salmonella enterica-Infected RAW264.7 Cells
Puiac S; Negrea A; Richter-Dahlfors A; Plant L; Rhen M
Article: ENVIRONMENTAL MICROBIOLOGY. 2009;11(6):1348-1357
High abundance of virulence gene homologues in marine bacteria
Persson OP; Pinhassi J; Riemann L; Marklund B-I; Rhen M; Normark S; Gonzalez JM; Hagstrom A
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2008;52(8):2734-2741
Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2
Pranting M; Negrea A; Rhen M; Andersson DI
Article: INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY. 2008;298(3-4):263-278
Activation of pro-matrix metalloproteinase-9 and degradation of gelatin by the surface protease PgtE of Salmonella enterica serovar Typhimurium
Ramu P; Lobo LA; Kukkonen M; Bjur E; Suomalainen M; Raukola H; Miettinen M; Julkunen I; Holst O; Rhen M; Korhonen TK; Lahteenmaki K
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2007;51(8):2867-2876
Salicylidene acylhydrazides that affect type III protein secretion in Salmonella enterica serovar Typhimurium
Negrea A; Bjur E; Ygberg SE; Elofsson M; Wolf-Watz H; Rhen M
Article: INFECTION AND IMMUNITY. 2006;74(9):5140-5151
Thioredoxin 1 promotes intracellular replication and virulence of Salmonella enterica serovar Typhimurium
Bjur E; Eriksson-Ygberg S; Aslund F; Rhen M
Article: MICROBES AND INFECTION. 2006;8(7):1826-1838
The O-antigen affects replication of Salmonella enterica serovar Typhimurium in murine macrophage-like J774-A.1 cells through modulation of host cell nitric oxide production
Bjur E; Eriksson-Ygberg S; Rhen M
Article: INFECTION AND IMMUNITY. 2006;74(2):1243-1254
Polynucleotide phosphorylase negatively controls spv virulence gene expression in Salmonella enterica
Ygberg SE; Clements MO; Rytkönen A; Thompson A; Holden DW; Hinton JCD; Rhen M
Article: INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY. 2005;295(4):201-212
Salmonella enterica SpvB-mediated ADP-ribosylation as an activator for host cell actin degradation
Tezcan-Merdol D; Engstrand L; Rhen M
Article: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2004;70(6):3706-3714
Uptake and replication of Salmonella enterica in Acanthamoeba rhysodes
Tezcan-Merdol D; Ljungström M; Winiecka-Krusnell J; Linder E; Engstrand L; Rhen M
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2003;47(12):3743-3749
Fusidic acid-resistant mutants of Salmonella enterica serovar typhimurium with low fitness in vivo are defective in RpoS induction
Macvanin M; Björkman J; Eriksson S; Rhen M; Andersson DI; Hughes D
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2003;58(5):493-502
Nitric oxide produced by murine dendritic cells is cytotoxic for intracellular Salmonella enterica sv. Typhimurium
Eriksson S; Chambers BJ; Rhen M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(13):8784-8789
Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica
Clements MO; Eriksson S; Thompson A; Lucchini S; Hinton JCD; Normark S; Rhen M
Article: MOLECULAR MICROBIOLOGY. 2001;39(3):606-619
Actin is ADP-ribosylated by the Salmonella enterica virulence-associated protein SpvB
Tezcan-Merdol D; Nyman T; Lindberg U; Haag F; Koch-Nolte F; Rhen M
Article: JOURNAL OF BACTERIOLOGY. 2001;183(2):512-519
The gaf fimbrial gene cluster of Escherichia coli expresses a full-size and a truncated soluble adhesin protein
Tanskanen J; Saarela S; Tankka S; Kalkkinen N; Rhen M; Korhonen TK; Westerlund-Wikström B
Article: MOLECULAR MICROBIOLOGY. 2000;37(5):1106-1115
The spvB gene-product of the Salmonella enterica virulence plasmid is a mono(ABP-ribosyl)transferase
Otto H; Tezcan-Merdol D; Girisch R; Haag F; Rhen M; Koch-Nolte F
Article: CELLULAR MICROBIOLOGY. 2000;2(3):239-250
Salmonella typhimurium mutants that downregulate phagocyte nitric oxide production
Eriksson S; Björkman J; Borg S; Syk A; Pettersson S; Andersson DI; Rhen M
Article: INFECTION AND IMMUNITY. 1998;66(10):4965-4970
Identification of two laminin-binding fimbriae, the type 1 fimbria of Salmonella enterica serovar typhimurium and the G fimbria of Escherichia coli, as plasminogen receptors
Kukkonen M; Saarela S; Lähteenmäki K; Hynönen U; Westerlund-Wikström B; Rhen M; Korhonen TK
Article: NATURE MEDICINE. 1998;4(3):298-302
Activation of the contact-phase system on bacterial surfaces -: a clue to serious complications in infectious diseases
Herwald H; Mörgelin M; Olsén A; Rhen M; Dahlbäck B; Müller-Esterl W; Björck L
Article: INFECTION AND IMMUNITY. 1997;65(12):5320-5325
Expression of thin aggregative fimbriae promotes interaction of Salmonella typhimurium SR-11 with mouse small intestinal epithelial cells
Sukupolvi S; Lorenz RG; Gordon JI; Bian Z; Pfeifer JD; Normark SJ; Rhen M
Article: CELL. 1997;90(1):55-64
A proteinaceous gene regulatory thermometer in Salmonella
Hurme R; Berndt KD; Normark SJ; Rhen M
Article: INFECTION AND IMMUNITY. 1997;65(2):838-842
Development of a murine model of chronic Salmonella infection
Sukupolvi S; Edelstein A; Rhen M; Normark SJ; Pfeifer JD
Article: INFECTION AND IMMUNITY. 1996;64(7):2857-2860
The GafD protein of the G (F17) fimbrial complex confers adhesiveness of Escherichia coli to laminin
Saarela S; WesterlundWikstrom B; Rhen M; Korhonen TK
Article: FEMS MICROBIOLOGY LETTERS. 1996;139(2-3):121-126
Salmonella typhimurium cob mutants are not hyper-virulent
Bjorkman J; Rhen M; Andersson DI
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(21):12626-12631
DNA binding exerted by a bacterial gene regulator with an extensive coiled-coil domain
Hurme R; Berndt KD; Namork E; Rhen M
Article: JOURNAL OF BACTERIOLOGY. 1995;177(6):1477-1484
The Escherichia coli G-fimbrial lectin protein participates both in fimbrial biogenesis and in recognition of the receptor N-acetyl-D-glucosamine.
Saarela S; Taira S; Nurmiaho-Lassila EL; Makkonen A; Rhen M
Article: MOLECULAR GENETICS AND GENOMICS. 1995;246(4):437-444
Evidence for functional polymorphism of the spvR gene regulating virulence gene expression in Salmonella.
Taira S; Heiskanen P; Hurme R; Heikkilä H; Riikonen P; Rhen M
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Review: JOURNAL OF INNATE IMMUNITY. 2019;11(3):216-226
Salmonella and Reactive Oxygen Species: A Love-Hate Relationship
Rhen M
Corrigendum: FRONTIERS IN MICROBIOLOGY. 2019;10:386
Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium (vol 9, 2941, 2018)
Vesto K; Huseby DL; Snygg I; Wang H; Hughes D; Rhen M
Corrigendum: NPJ BIOFILMS AND MICROBIOMES. 2018;4:19
Redox-active conducting polymers modulate Salmonella biofilm formation by controlling availability of electron acceptors (vol 3, 19, 2017)
Gomez-Carretero S; Libberton B; Svennersten K; Persson K; Jager E; Berggren M; Rhen M; Richter-Dahlfors A
Corrigendum: ENVIRONMENTAL MICROBIOLOGY. 2015;17(11):4818
Dissecting the cyclic di-guanylate monophosphate signalling network regulating motility in Salmonella enterica serovar Typhimurium (vol 17, pg 1310, 2014)
Le Guyon S; Simm R; Rhen M; Romling U
Review: FUTURE MICROBIOLOGY. 2014;9(11):1261-1282
Regulation of biofilm formation in Salmonella enterica serovar Typhimurium
Simm R; Ahmad I; Rhen M; Le Guyon S; Romling U
Review: CURRENT OPINION IN MICROBIOLOGY. 2012;15(1):15-22
Tissue microbiology provides a coherent picture of infection
Richter-Dahlfors A; Rhen M; Udekwu K
Review: CELLULAR MICROBIOLOGY. 2008;10(4):958-984
During infection of epithelial cells Salmonella enterica serovar Typhimurium undergoes a time-dependent transcriptional adaptation that results in simultaneous expression of three type 3 secretion systems
Hautefort I; Thompson A; Eriksson-Ygberg S; Parker ML; Lucchini S; Danino V; Bongaerts RJM; Ahmad N; Rhen M; Hinton JCD
Review: INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY. 2005;294(8):487-502
Hierarchical gene regulators adapt Salmonella enterica to its host milieus
Rhen M; Dorman CJ
Review: CONTRIBUTIONS TO MICROBIOLOGY. 2005;12:67-89
Fimbriae, pili, flagella and bacterial virulence.
Jonson A-B; Normark S; Rhen M
Review: CURRENT OPINION IN MICROBIOLOGY. 2004;7(3):277-282
Benefits and pitfalls of using microarrays to monitor bacterial gene expression during infection
Hinton JCD; Hautefort I; Eriksson S; Thompson A; Rhen M
Review: TRENDS IN MICROBIOLOGY. 2003;11(2):80-86
The basis of persistent bacterial infections
Rhen M; Eriksson S; Clements M; Bergström S; Normark SJ
Review: MOLECULAR MICROBIOLOGY. 2003;47(1):103-118
Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica
Eriksson S; Lucchini S; Thompson A; Rhen M; Hinton JCD
Review: NATURE IMMUNOLOGY. 2002;3(11):1033-1040
Bacterial strategies for overcoming host innate and adaptive immune responses
Hornef MW; Wick MJ; Rhen M; Normark S
Published conference paper: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON. BIOLOGICAL SCIENCES. 2002;357(1423):887-893
Low-temperature sensors in bacteria
Eriksson S; Hurme R; Rhen M
Review: ANNALS OF MEDICINE. 2001;33(3):178-185
Virulence gene regulation in Salmonella enterica
Clements M; Eriksson S; Tezcan-Merdol D; Hinton JCD; Rhen M
Review: TRENDS IN MICROBIOLOGY. 2001;9(1):4-5
The best defense is a good offense -: Salmonella deploys an ADP-ribosylating toxin:: Response
Koch-Nolte F; Haag F; Lindberg U; Rhen M
Review: CURRENT OPINION IN MICROBIOLOGY. 2000;3(1):60-64
Bacterial adaptation to host innate immunity responses
Rhen M; Eriksson S; Pettersson S
Published conference paper: IMMUNOLOGY LETTERS. 1999;68(2-3):247-249
Novel Salmonella typhimurium properties in host-parasite interactions
Borg S; Björkman J; Eriksson S; Syk A; Andersson DI; Schesser K; Rhen M; Pettersson S; French NS
Review: MOLECULAR MICROBIOLOGY. 1998;30(1):1-6
Temperature sensing in bacterial gene regulation - what it all boils down to
Hurme R; Rhen M
Addendum: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(29):17592
DNA binding exerted by a bacterial gene regulator with an extensive coiled-coil domain (vol 271, pg 12626, 1996)
Hurme R; Berndt KD; Namork E; Rhen M

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