Meng Xie
Principal Researcher
E-mail: meng.xie@ki.se
Visiting address: Blickagången 16, 14152 141 52
Postal address: H7 Medicin, Huddinge, H7 BioNut Johansson Xie, 171 77 Stockholm
About me
- Research Grants
(1) Swedish Research Council (Vetenskapsrådet), Starting Grant
(2) Stiftelsen Frimurare Barnhuset I Stockholm Foundation
(3) Ulla and Gustaf af Uggla Foundation on arthropathic diseases
(4) Foundation for Rheumatology Research from Karolinska Institutet
(5) Loo and Han Osterman Foundation from Karolinska Institutet
(6) Alex and Eva Foundation from Karolinska Institutet
(7)European Molecular Biology Organization, Long-Term Fellowship
Selected Publications:
1) *Xie M*, Gol'din P, Herdina AN, Estefa J, Medvedeva EV, Li L, Newton PT,
Kotova S, Shavkuta B, Saxena A, Shumate LT, Metscher BD, Großschmidt K,
Nishimori S, Akovantseva A, Usanova AP, Kurenkova AD, Kumar A, Arregui
IL, Tafforeau P, Fried K, Carlström M, Simon A, Gasser C, Kronenberg HM,
Bastepe M, Cooper KL, Timashev P, Sanchez S, Adameyko I, Eriksson A,
Chagin AS. Secondary ossification center induces and protects growth
plate structure. Elife. 2020 Oct 16 - 9:e55212. doi: 10.7554/eLife.55212.
2) *Xie M*, Chagin AS. The epiphyseal secondary ossification center:
Evolution, development and function. /Bone/. 2020 Oct 19:115701. doi:
10.1016/j.bone.2020.115701.
3) Zhang Y, Annusver K, Sunadome K, Kameneva K, Edwards S, Kasper M, Chagin
AS, Adameyko I*, *Xie M**. Epiphyseal cartilage formation involves
differential dynamics of various cellular populations during
embryogenesis. /Frontiers in Cell and Developmental Biology/. 2020 Mar
5 - 8:122. doi: 10.3389/fcell.2020.00122. eCollection 2020. **Corresponding
authors *
4) Zhang Y, Kameneva P, Annusver K, Kasper M, Chagin AS, Adameyko I*, *Xie
M**. Cruciate ligament, patellar tendon and patella formation involves
differential cellular sources and dynamics as joint cavitation proceeds.
/Developmental Dynamics/. 2020 Jun - 249(6):711-722. doi: 10.1002/dvdy.158.
** Corresponding authors*
5) *Xie M*, Kamenev D, Kaucka M, Kastriti ME, Zhou B, Artemov AV, Storer M,
Fried K, Adameyko I, Dyachuk V, Chagin AS. Schwann cell precursors
contribute to skeletal formation during embryonic development in mice and
zebrafish. /Proc Natl Acad Sci U S A. /2019 Jul 23 - 116(30):15068-15073.
doi: 10.1073/pnas.1900038116.
6) *Xie M*, Li JP. Heparan sulfate proteoglycan - A common receptor for
diverse cytokines. /Cell Signal/. 2019 Feb - 54:115-121. doi:
10.1016/j.cellsig.2018.11.022.
7) *Xie M** *and Roy R. AMP-Activated Kinase Regulates Lipid Droplet
Localization and Stability of Adipose Triglyceride Lipase in C. elegans
Dauer Larvae. /PLoS One/. 2015 Jun 22 - 10(6):e0130480. doi:
10.1371/journal.pone.0130480.
8) *Xie M** *and Roy R. The Causative Gene in Chanarian-Dorfman Syndrome
Regulates Lipid Droplet Homeostasis in C. elegans. /PLoS Genetics/. 2015
Jun 17 - 11(6):e1005284. doi: 10.1371/journal.pgen.1005284.
9) *Xie M* and Roy R. Increased Levels of Hydrogen Peroxide Induce a
HIF-1-dependent Remodelling of Lipid Metabolism in C. elegans. /Cell
Metabolism/.* *2012 Sep 5 - 16(3):322-35.
10) *Xie M*, Alonso H and Roujeinikova A. An Improved Procedure for the
Purification of Catalytically Active Alkane Hydroxylase from
/Pseudomonas putida GPo1/. /Appl Biochem Biotechnol/. 2011
Oct - 165(3-4):823-3.
2023 - present
Principal Researcher - Karolinska Institutet
2021 - present
Assistant Professor - Peking University, China
2015 - 2020
Postdoctoral Fellow - Karolinska Institutet, Sweden
2009 - 2014
Doctor of Philosophy in Biology – McGill University, Montréal, Canada
2007 - 2008
Master of Philosophy in Biomolecular Science - University of Manchester,
Manchester, UK.
2003 - 2007
Bachelor of Science in Pharmacology with Industrial Experience - University
of Manchester, Manchester, UK.
Research
- My interest is to understand the cellular dynamics that drive the formation
of different components of the intervertebral discs during embryonic
development, and the plasticity of adipose tissue in response to
environmental changes. We mainly use single cell/nucleus RNA sequencing
methods combined with genetic lineage tracing to tackle these scientific
questions. Our findings will innovate the current research frontier in the
fields of developmental and metabolic biology and inspire the develop of
novel treatment strategy against spine-related and metabolic disorders.
Articles
- Article: JOURNAL OF LIPID RESEARCH. 2024;65(6):100559
- Article: NATURE COMMUNICATIONS. 2024;15(1):2367
- Journal article: ELIFE. 2024;13
- Article: ELIFE. 2024;13:RP93151
- Article: MOLECULAR METABOLISM. 2024;81:101890
- Article: BONE. 2021;142:115701
- Article: ELIFE. 2020;9:e55212
- Journal article: BONE REPORTS. 2020;13:100663
- Journal article: BONE REPORTS. 2020;13:100466
- Journal article: BONE REPORTS. 2020;13:100468
- Article: DEVELOPMENTAL DYNAMICS. 2020;249(6):711-722
- Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:122
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(30):15068-15073
- Article: NATURE. 2019;567(7747):234-238
- Article: CELLULAR SIGNALLING. 2019;54:115-121
- Article: ELIFE. 2018;7:e34465
- Article: FASEB JOURNAL. 2017;31(3):1067-1084
- Article: SCIENCE ADVANCES. 2016;2(8):e1600060
- Article: PLOS GENETICS. 2015;11(6):e1005284
- Article: PLOS ONE. 2015;10(6):e0130480
- Article: JOURNAL OF THE ROYAL SOCIETY INTERFACE. 2013;10(79):20120717
- Article: CELL METABOLISM. 2012;16(3):322-335
- Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2011;67(Pt 12):1009-1016
- Article: APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY. 2011;165(3-4):823-831
- Show more
All other publications
- Preprint: RESEARCH SQUARE. 2023
- Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2023;38:140
- Preprint: BIORXIV. 2019
- Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2018;33:367
- Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2017;32:S328
Grants
- Swedish Research Council1 January 2022 - 31 December 2025