Meng Xie

Meng Xie

Principal Researcher
Visiting address: Blickagången 16, 14152 141 52
Postal address: H7 Medicin, Huddinge, H7 CeRM Johansson Xie, 171 77 Stockholm
Part of:

About me

  • Research Grants
    (1) Swedish Research Council (Vetenskapsrådet), Starting Grant
    (2) Stiftelsen Frimurare Barnhuset I Stockholm Foundation
    (3) Ulla and Gustaf af Uggla Foundation on arthropathic diseases
    (4) Foundation for Rheumatology Research from Karolinska Institutet
    (5) Loo and Han Osterman Foundation from Karolinska Institutet
    (6) Alex and Eva Foundation from Karolinska Institutet
    (7）European Molecular Biology Organization, Long-Term Fellowship


    Publications:

    (1) Li Y, Zhang H, Ibáñez CF*, Xie M*. Characterization of subcutaneous and visceral de-differentiated fat cells. Mol Metab. 2025 Jan 28;93:102105. * Corresponding authors

    (2) Hu D, Zhang H, Liu Z, Ibáñez CF, Tie C, Xie M*. Sphingomyelin Is Involved in Regulating UCP1-Mediated Non-Shivering Thermogenesis. Journal of Lipid Research. 2024 May 8:100559. doi: 10.1016/j.jlr.2024.100559. * Corresponding author

    (3) Xie M, Kaiser M, Gershtein Y, Schnyder D, Deviatiiarov R, Gazizova G, Shagimardanova E, Zikmund T, Kerckhofs G, Ivashkin E, Batkovskyte D, Newton PT, Andersson O, Fried K, Gusev O, Zeberg H, Kaiser J, Adameyko I, Chagin AS. The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling. Nature Communications. 2024 Mar 26;15(1):2367. doi: 10.1038/s41467-024-46030-3.
    (4) Zhang H, Li Y, Ibáñez CF*,  Xie M*. Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion. Elife. 2024 Mar 12;13:RP93151. doi: 10.7554/eLife.93151. * Corresponding authors 
    (5) Tangseefa P, Jin H, Zhang H,  Xie M, Ibáñez CF. Human ACVR1C missense variants that correlate with altered body fat distribution produce metabolic alterations of graded severity in knock-in mutant mice. Molecular Metabolism. 2024 Mar;81:101890. doi: 10.1016/j.molmet.2024.101890.
    (6) Xie M, Chagin AS. The epiphyseal secondary ossification center: Evolution, development and function. Bone. 2020 Oct 19:115701. doi: 10.1016/j.bone.2020.115701.
    (7) Xie M, Gol'din P, Herdina AN, Estefa J, Medvedeva EV, Li L, Newton PT, Kotova S, Shavkuta B, Saxena A, Shumate LT, Metscher BD, Großschmidt K, Nishimori S, Akovantseva A, Usanova AP, Kurenkova AD, Kumar A, Arregui IL, Tafforeau P, Fried K, Carlström M, Simon A, Gasser C, Kronenberg HM, Bastepe M, Cooper KL, Timashev P, Sanchez S, Adameyko I, Eriksson A, Chagin AS. Secondary ossification center induces and protects growth plate structure. Elife. 2020 Oct 16;9:e55212. doi: 10.7554/eLife.55212.
    (8) Zhang Y, Kameneva P, Annusver K, Kasper M, Chagin AS, Adameyko I*,  Xie M*. Cruciate ligament, patellar tendon and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds. Developmental Dynamics. 2020 Jun;249(6):711-722. doi: 10.1002/dvdy.158. * Corresponding authors
    (9) Zhang Y, Annusver K, Sunadome K, Kameneva P, Edwards S, Kasper M, Chagin AS, Adameyko I*,  Xie M*. Epiphyseal cartilage formation involves differential dynamics of various cellular populations during embryogenesis. Frontiers in Cell and Developmental Biology. 2020 Mar 5;8:122. doi: 10.3389/fcell.2020.00122. eCollection 2020. *Corresponding authors
    (10) Xie M, Kamenev D, Kaucka M, Kastriti ME, Zhou B, Artemov AV, Storer M, Fried K, Adameyko I, Dyachuk V, Chagin AS. Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish. PNAS. 2019 Jul 23;116(30):15068-15073. doi: 10.1073/pnas.1900038116.
    (11) Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M,  Xie M, Sun X, Sandhow L, Artemov AV, Ivashkin E, Suter S, Dyachuk V, El Shahawy M, Gritli-Linde A, Bouderlique T, Petersen J, Mollbrink A, Lundeberg J, Enikolopov G, Qian H, Fried K, Kasper M, Hedlund E, Adameyko I, Sävendahl L, Chagin AS. A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate. Nature. 2019 Mar;567(7747):234-238. doi: 10.1038/s41586-019-0989-6.
    (12) Xie M, Li JP. Heparan sulfate proteoglycan - A common receptor for diverse cytokines. Cellular Signaling. 2019 Feb;54:115-121. doi: 10.1016/j.cellsig.2018.11.022.
    (13) Kaucka M, Petersen J, Tesarova M, Szarowska B, Kastriti ME,  Xie M, Kicheva A, Annusver K, Kasper M, Symmons O, Pan L, Spitz F, Kaiser J, Hovorakova M, Zikmund T, Sunadome K, Matise MP, Wang H, Marklund U, Abdo H, Ernfors P, Maire P, Wurmser M, Chagin AS, Fried K, Adameyko I. Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage. Elife. 2018 Jun 13;7. pii: e34465. doi: 10.7554/eLife.34465.
    (14) Newton PT,  Xie M, Medvedeva EV, Sävendahl L, Chagin AS. Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered. Bone Reports. 2018 Feb 24;8:64-71. doi: 10.1016/j.bonr.2018.02.006.
    (15) Li L, Newton PT, Bouderlique T, Sejnohova M, Zikmund T, Kozhemyakina E,  Xie M, Krivanek J, Kaiser J, Qian H, Dyachuk V, Lassar AB, Warman ML, Barenius B, Adameyko I, Chagin AS. Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice. FASEB Journal 2017 Mar;31(3):1067-1084. doi: 10.1096/fj.201600918R.
    (16) Kaucka M, Ivashkin E, Gyllborg D, Zikmund T, Tesarova M, Kaiser J,  Xie M, Petersen J, Pachnis V, Nicolis SK, Yu T, Sharpe P, Arenas E, Brismar H, Blom H, Clevers H, Suter U, Chagin AS, Fried K, Hellander A, Adameyko I. Analysis of neural crest-derived clones reveals novel aspects of facial development. Science Advances 2016 Aug 3;2(8):e1600060. doi: 10.1126/sciadv.1600060.
    (17) Xie M and Roy R. AMP-Activated Kinase Regulates Lipid Droplet Localization and Stability of Adipose Triglyceride Lipase in C. elegans Dauer Larvae. PLoS One. 2015 Jun 22;10(6):e0130480. doi: 10.1371/journal.pone.0130480.
    (18) Xie M and Roy R. The Causative Gene in Chanarian-Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans. PLoS Genetics. 2015 Jun 17;11(6):e1005284. doi: 10.1371/journal.pgen.1005284.

    (19) Xie M and Roy R. Increased Levels of Hydrogen Peroxide Induce a HIF-1-dependent Remodelling of Lipid Metabolism in C. elegans. Cell Metabolism. 2012 Sep 5;16(3):322-35.
    (20) Andrew D, Xie M, Bottomley S, Wilce M and Roujeinikova A. Design, purification and characterization of the soluble variant of the integral membrane protein MotB for structural studies. Journal of the Royal Society Interface. 2013 Feb 6;10(79):20120717.
    (21) O’Neil J,  Xie M, Hijnen M and Roujeinikova. Role of the MotB linker in the assembly and activation of the bacterial flagellar motor. Acta Crystallographica Section D. 2011 Dec;67(Pt 12):1009-16.
    (22) Xie M, Alonso H and Roujeinikova A. An Improved Procedure for the Purification of Catalytically Active Alkane Hydroxylase from Pseudomonas putida GPo1. Applied Biochemistry and Biotechnology. 2011 Oct;165(3-4):823-3.


    2023 - present
    Principal Researcher - Karolinska Institutet
    2021 - present
    Research Assistant Professor - Peking University, China
    2015 - 2020
    Postdoctoral Fellow - Karolinska Institutet, Sweden
    2009 - 2014
    Doctor of Philosophy in Biology – McGill University, Montréal, Canada
    2007 - 2008
    Master of Philosophy in Biomolecular Science - University of Manchester,
    Manchester, UK.
    2003 - 2007
    Bachelor of Science in Pharmacology with Industrial Experience - University
    of Manchester, Manchester, UK.

Research

  • My interest is to understand the cellular dynamics that drive the formation
    of different components of the intervertebral discs during embryonic
    development, and the plasticity of adipose tissue in response to
    environmental changes. We mainly use single cell/nucleus RNA sequencing
    methods combined with genetic lineage tracing to tackle these scientific
    questions. Our findings will innovate the current research frontier in the
    fields of developmental and metabolic biology and inspire the develop of
    novel treatment strategy against spine-related and metabolic disorders.

Articles

All other publications

Grants

  • Swedish Research Council
    1 January 2022 - 31 December 2025
    Purpose of the proposed study is to elucidate the cellular and molecular mechanisms that drive and regulate formation of the spinal cord and vertebral column during embryogenesis using mouse and zebrafish models. The project has two specific aims, focusing on the cellular and molecular aspects, respectively. Regarding the time plan, first year will be dedicated to animal strain generation and establishment of optimal experimental conditions. Second and third year will be focused on performing the proposed experiments and data collection. Fourth year will mainly involve data analysis and publication. Scientific methods include but not limited to multi-colored clonal lineage tracing, in vitro and in vivo live imaging, single-cell RNA-sequencing and related analysis, CRISPR-mediated genome editing and micro-CT analysis etc. Accomplishment of the studies will not only uncover the basic principles behind mesodermal and ectodermal tissue patterning and molecular clues for neural tube/neural crest, notochord and mesenchymal cell differentiation
    but also improve our understanding of the fundamental mechanisms underlying spinal cord and vertebral column formation. Both achievements will innovate the current research frontier in the field of developmental biology and neuroscience. Findings from the proposed research will establish a solid scientific basis for the development of novel therapeutic, surgical and regenerative approaches against all kinds of spine-related disorders.

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