Meng Xie

Meng Xie

Principal Researcher
Visiting address: Blickagången 16, 14152 141 52
Postal address: H7 Medicin, Huddinge, H7 BioNut Johansson Xie, 171 77 Stockholm

About me

  • Research Grants
    (1) Swedish Research Council (Vetenskapsrådet), Starting Grant
    (2) Stiftelsen Frimurare Barnhuset I Stockholm Foundation
    (3) Ulla and Gustaf af Uggla Foundation on arthropathic diseases
    (4) Foundation for Rheumatology Research from Karolinska Institutet
    (5) Loo and Han Osterman Foundation from Karolinska Institutet
    (6) Alex and Eva Foundation from Karolinska Institutet
    (7)European Molecular Biology Organization, Long-Term Fellowship
    Selected Publications:
    1) *Xie M*, Gol'din P, Herdina AN, Estefa J, Medvedeva EV, Li L, Newton PT,
    Kotova S, Shavkuta B, Saxena A, Shumate LT, Metscher BD, Großschmidt K,
    Nishimori S, Akovantseva A, Usanova AP, Kurenkova AD, Kumar A, Arregui
    IL, Tafforeau P, Fried K, Carlström M, Simon A, Gasser C, Kronenberg HM,
    Bastepe M, Cooper KL, Timashev P, Sanchez S, Adameyko I, Eriksson A,
    Chagin AS. Secondary ossification center induces and protects growth
    plate structure. Elife. 2020 Oct 16
  • 9:e55212. doi: 10.7554/eLife.55212.
    2) *Xie M*, Chagin AS. The epiphyseal secondary ossification center:
    Evolution, development and function. /Bone/. 2020 Oct 19:115701. doi:
    3) Zhang Y, Annusver K, Sunadome K, Kameneva K, Edwards S, Kasper M, Chagin
    AS, Adameyko I*, *Xie M**. Epiphyseal cartilage formation involves
    differential dynamics of various cellular populations during
    embryogenesis. /Frontiers in Cell and Developmental Biology/. 2020 Mar
  • 8:122. doi: 10.3389/fcell.2020.00122. eCollection 2020. **Corresponding
    authors *
    4) Zhang Y, Kameneva P, Annusver K, Kasper M, Chagin AS, Adameyko I*, *Xie
    M**. Cruciate ligament, patellar tendon and patella formation involves
    differential cellular sources and dynamics as joint cavitation proceeds.
    /Developmental Dynamics/. 2020 Jun
  • 249(6):711-722. doi: 10.1002/dvdy.158.
    ** Corresponding authors*
    5) *Xie M*, Kamenev D, Kaucka M, Kastriti ME, Zhou B, Artemov AV, Storer M,
    Fried K, Adameyko I, Dyachuk V, Chagin AS. Schwann cell precursors
    contribute to skeletal formation during embryonic development in mice and
    zebrafish. /Proc Natl Acad Sci U S A. /2019 Jul 23
  • 116(30):15068-15073.
    doi: 10.1073/pnas.1900038116.
    6) *Xie M*, Li JP. Heparan sulfate proteoglycan - A common receptor for
    diverse cytokines. /Cell Signal/. 2019 Feb
  • 54:115-121. doi:
    7) *Xie M** *and Roy R. AMP-Activated Kinase Regulates Lipid Droplet
    Localization and Stability of Adipose Triglyceride Lipase in C. elegans
    Dauer Larvae. /PLoS One/. 2015 Jun 22
  • 10(6):e0130480. doi:
    8) *Xie M** *and Roy R. The Causative Gene in Chanarian-Dorfman Syndrome
    Regulates Lipid Droplet Homeostasis in C. elegans. /PLoS Genetics/. 2015
    Jun 17
  • 11(6):e1005284. doi: 10.1371/journal.pgen.1005284.
    9) *Xie M* and Roy R. Increased Levels of Hydrogen Peroxide Induce a
    HIF-1-dependent Remodelling of Lipid Metabolism in C. elegans. /Cell
    Metabolism/.* *2012 Sep 5
  • 16(3):322-35.
    10) *Xie M*, Alonso H and Roujeinikova A. An Improved Procedure for the
    Purification of Catalytically Active Alkane Hydroxylase from
    /Pseudomonas putida GPo1/. /Appl Biochem Biotechnol/. 2011
  • 165(3-4):823-3.
    2023 - present
    Principal Researcher - Karolinska Institutet
    2021 - present
    Assistant Professor - Peking University, China
    2015 - 2020
    Postdoctoral Fellow - Karolinska Institutet, Sweden
    2009 - 2014
    Doctor of Philosophy in Biology – McGill University, Montréal, Canada
    2007 - 2008
    Master of Philosophy in Biomolecular Science - University of Manchester,
    Manchester, UK.
    2003 - 2007
    Bachelor of Science in Pharmacology with Industrial Experience - University
    of Manchester, Manchester, UK.


  • My interest is to understand the cellular dynamics that drive the formation
    of different components of the intervertebral discs during embryonic
    development, and the plasticity of adipose tissue in response to
    environmental changes. We mainly use single cell/nucleus RNA sequencing
    methods combined with genetic lineage tracing to tackle these scientific
    questions. Our findings will innovate the current research frontier in the
    fields of developmental and metabolic biology and inspire the develop of
    novel treatment strategy against spine-related and metabolic disorders.


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