Matteo Pedrelli

About me
Publications
Public outreach and news

Research

My research activites focus on the genetic and pharmacological modulation of
lipoprotein composition, size and functions (i.e. for HDL the in vitro
cholesterol efflux capacity as potential atheroprotechive mechanism, and for
LDL the binding to arterial proteoglycans, an atherogenic mechanism). The
main aim is to find a link between changes in lipoprotein metabolism and
cardiovascular diseases.

Articles

Article: ATHEROSCLEROSIS. 2024;394:117545
Modification of lipoprotein metabolism and function driving atherogenesis in diabetes
Luciani L; Pedrelli M; Parini P
Article: FRONTIERS IN PHYSIOLOGY. 2024;15:1371096
The nonvesicular sterol transporter Aster-C plays a minor role in whole body cholesterol balance
Banerjee R; Hohe RC; Cao S; Jung BM; Horak AJ; Ramachandiran I; Massey WJ; Varadharajan V; Zajczenko NI; Burrows AC; Dutta S; Goudarzi M; Mahen K; Carter A; Helsley RN; Gordon SM; Morton RE; Strauch C; Willard B; Gogonea CB; Gogonea V; Pedrelli M; Parini P; Brown JM
Article: SCIENCE ADVANCES. 2023;9(20):eadf2982
Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior
Delbes A-S; Quinones M; Gobet C; Castel J; Denis RGP; Berthelet J; Weger BD; Challet E; Charpagne A; Metairon S; Piccand J; Kraus M; Rohde BH; Bial J; Wilson EM; Vedin L-L; Minniti ME; Pedrelli M; Parini P; Gachon F; Luquet S
Article: NUTRIENTS. 2022;14(24):5364
Plasma Cholesterol- and Body Fat-Lowering Effects of Chicken Protein Hydrolysate and Oil in High-Fat Fed Male Wistar Rats
Aloysius TA; Tillander V; Pedrelli M; Dankel SN; Berge RK; Bjorndal B
Article: CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS. 2022;34(6):322-325
Why are brown bears protected against atherosclerosis even though their plasma cholesterol levels are twice that of humans?
Hurt-Camejo E; Pedrelli M
Article: JOURNAL OF INTERNAL MEDICINE. 2022;292(2):296-307
Soat2 ties cholesterol metabolism to β-oxidation and glucose tolerance in male mice
Pramfalk C; Ahmed O; Pedrelli M; Minniti ME; Luquet S; Denis RG; Olin M; Hardfeldt J; Vedin L-L; Steffensen KR; Ryden M; Hodson L; Eriksson M; Parini P
Article: ENVIRONMENTAL RESEARCH. 2022;208:112626
Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies
Bjorvang RD; Hallberg I; Pikki A; Berglund L; Pedrelli M; Kiviranta H; Rantakokko P; Ruokojarvi P; Lindh CH; Olovsson M; Persson S; Holte J; Sjunnesson Y; Damdimopoulou P
Article: BIOFACTORS. 2022;48(3):707-717
HDL-mediated reduction of cholesterol content inhibits the proliferation of prostate cancer cells induced by LDL: Role of ABCA1 and proteasome inhibition
Ossoli A; Giorgio E; Cetti F; Ruscica M; Rabacchi C; Tarugi P; Parini P; Pedrelli M; Gomaraschi M
Article: ENVIRONMENT INTERNATIONAL. 2021;155:106589
Persistent organic pollutants and the size of ovarian reserve in reproductive-aged women
Bjorvang R; Hassan J; Stefopoulou M; Gemzell-Danielsson K; Pedrelli M; Kiviranta H; Rantakokko P; Ruokojarvi P; Lindh CH; Acharya G; Damdimopoulou P
Article: JOURNAL OF LIPID RESEARCH. 2021;62:100065
Vasculoprotective properties of plasma lipoproteins from brown bears (Ursus arctos)
Pedrelli M; Parini P; Kindberg J; Arnemo JM; Bjorkhem I; Aasa U; Westerstahl M; Walentinsson A; Pavanello C; Turri M; Calabresi L; Oorni K; Camejo G; Frobert O; Hurt-Camejo E
Article: JCI INSIGHT. 2020;5(24):140483
Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease
Cansby E; Caputo M; Gao L; Kulkarni NM; Nerstedt A; Stahlman M; Boren J; Porosk R; Soomets U; Pedrelli M; Parini P; Marschall H-U; Nystrom J; Howell BW; Mahlapuu M
Article: HEPATOLOGY. 2020;72(2):656-670
Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans
Minniti ME; Pedrelli M; Vedin L-L; Delbes A-S; Denis RGP; Oorni K; Sala C; Pirazzini C; Thiagarajan D; Nurmi HJ; Grompe M; Mills K; Garagnani P; Ellis ECS; Strom SC; Luquet SH; Wilson EM; Bial J; Steffensen KR; Parini P
Article: BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2020;1865(6):158659
Generation of new hepatocyte-like in vitro models better resembling human lipid metabolism
Pramfalk C; Jakobsson T; Verzijl CRC; Minniti ME; Obensa C; Ripamonti F; Olin M; Pedrelli M; Eriksson M; Parini P
Article: PLOS ONE. 2020;15(3):e0229322
The PPAR pan-agonist tetradecylthioacetic acid promotes redistribution of plasma cholesterol towards large HDL
Lundasen T; Pedrelli M; Bjorndal B; Rozell B; Kuiper RV; Burri L; Pavanello C; Turri M; Skorve J; Berge RK; Alexson SEH; Tillander V
Article: PLOS ONE. 2020;15(9):e0239284
Lack of RAC1 in macrophages protects against atherosclerosis
Bandaru S; Ala C; Ekstrand M; Akula MK; Pedrelli M; Liu X; Bergstrom G; Haversen L; Boren J; Bergo MO; Akyurek LM
Article: METHODS IN MOLECULAR BIOLOGY. 2020;2164:101-108
Enzymatic Quantification of Liver Lipids After Folch Extraction.
Minniti ME; Ahmed O; Pedrelli M
Article: JOURNAL OF INTERNAL MEDICINE. 2019;286(6):660-675
Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed-forward loop between LXR and autophagy
Saliba-Gustafsson P; Pedrelli M; Gertow K; Werngren O; Janas V; Pourteymour S; Baldassarre D; Tremoli E; Veglia F; Rauramaa R; Smit AJ; Giral P; Kurl S; Pirro M; de Faire U; Humphries SE; Hamsten A; Goncalves I; Orho-Melander M; Franco-Cereceda A; Boren J; Eriksson P; Magne J; Parini P; Ehrenborg E; Sirtori CR; Castelnuovo S; Amato M; Frigerio B; Ravani A; Sansaro D; Tedesco C; Bovis F; Discacciati A; Ahl M; Blomgren G; Eriksson MJ; Fahlstadius P; Heinonen M; Nilson L; Cooper J; Acharya J; Huttunen K; Rauramaa E; Pekkarinen H; Penttila IM; Torronen J; van Gessel AI; van Roon AM; Teune GC; Kuipers WD; Bruin M; Nicolai A; Haarsma-Jorritsma P; Mulder DJ; Bilo HJG; Smeets GH; Beaudeux JL; Kahn JF; Carreau V; Kontush A; Karppi J; Nurmi T; Nyyssonen K; Salonen R; Tuomainen TP; Tuomainen J; Kauhanen J; Vaudo G; Alaeddin A; Siepi D; Lupattelli G; Schillaci G
Article: DIGESTIVE AND LIVER DISEASE. 2019;51(7):1016-1022
Genetic depletion of Soat2 diminishes hepatic steatosis via genes regulating de novo lipogenesis and by GLUT2 protein in female mice
Ahmed O; Pramfalk C; Pedrelli M; Olin M; Steffensen KR; Eriksson M; Parini P
Article: BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2019;1864(5):756-762
Effects on hepatic lipid metabolism in human hepatoma cells following overexpression of TGFβ induced factor homeobox 1 or 2
Hardfeldt J; Hodson L; Larsson L; Pedrelli M; Pramfalk C
Article: NATURE COMMUNICATIONS. 2019;10(1):1684
Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα
Liang N; Damdimopoulos A; Goni S; Huang Z; Vedin L-L; Jakobsson T; Giudici M; Ahmed O; Pedrelli M; Barilla S; Alzaid F; Mendoza A; Schroder T; Kuiper R; Parini P; Hollenberg A; Lefebvre P; Francque S; Van Gaal L; Staels B; Venteclef N; Treuter E; Fan R
Article: BIOLOGY OF SEX DIFFERENCES. 2019;10(1):11
Sex-specific lipid molecular signatures in obesity-associated metabolic dysfunctions revealed by lipidomic characterization in ob/ob mouse
Gonzalez-Granillo M; Helguero LA; Alves E; Archer A; Savva C; Pedrelli M; Ahmed O; Li X; Domingues MR; Parini P; Gustafsson J-A; Korach-Andre M
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2019;479:147-158
ERβ activation in obesity improves whole body metabolism via adipose tissue function and enhanced mitochondria biogenesis
Gonzalez-Granillo M; Savva C; Li X; Fitch M; Pedrelli M; Hellerstein M; Parini P; Korach-Andre M; Gustafsson J-A
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2018;38(8):1723-1737
STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia
Cansby E; Magnusson E; Nunez-Duran E; Amrutkar M; Pedrelli M; Parini P; Hoffmann J; Stahlman M; Howell BW; Marschall H-U; Boren J; Mahlapuu M
Article: PLOS ONE. 2014;9(4):e93552
Hepatic ACAT2 Knock Down Increases ABCA1 and Modifies HDL Metabolism in Mice
Pedrelli M; Davoodpour P; Degirolamo C; Gomaraschi M; Graham M; Ossoli A; Larsson L; Calabresi L; Gustafsson J-A; Steffensen KR; Eriksson M; Parini P
Article: MOLECULAR ENDOCRINOLOGY. 2012;26(12):1980-1990
Fasting-Induced FGF21 Is Repressed by LXR Activation via Recruitment of an HDAC3 Corepressor Complex in Mice
Archer A; Venteclef N; Mode A; Pedrelli M; Gabbi C; Clement K; Parini P; Gustafsson J-A; Korach-Andre M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2011;164(6):1642-1651
The thienotriazolodiazepine Ro 11-1464 increases plasma apoA-I and promotes reverse cholesterol transport in human apoA-I transgenic mice
Zanotti I; Maugeais C; Pedrelli M; Gomaraschi M; Salgam P; Calabresi L; Bernini F; Kempen H
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2011;301(1):E210-E222
Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice
Korach-Andre M; Archer A; Gabbi C; Barros RP; Pedrelli M; Steffensen KR; Pettersson AT; Laurencikiene J; Parini P; Gustafsson J-A
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2011;31(1):74-80
Macrophage, But Not Systemic, Apolipoprotein E Is Necessary for Macrophage Reverse Cholesterol Transport In Vivo
Zanotti I; Pedrelli M; Poti F; Stomeo G; Gomaraschi M; Calabresi L; Bernini F
Article: WORLD JOURNAL OF GASTROENTEROLOGY. 2010;16(47):5958-5964
Thyroid hormones and thyroid hormone receptors: Effects of thyromimetics on reverse cholesterol transport
Pedrelli M; Pramfalk C; Parini P
Article: PHARMACOLOGICAL RESEARCH. 2010;62(3):265-270
Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages
Costa S; Zimetti F; Pedrelli M; Cremonesi G; Bernini F
Article: ATHEROSCLEROSIS. 2009;204(1):141-146
Functional LCAT is not required for macrophage cholesterol efflux to human serum
Calabresi L; Favari E; Moleri E; Adorni MP; Pedrelli M; Costa S; Jessup W; Gelissen IC; Kovanen PT; Bernini F; Franceschini G
Article: JOURNAL OF LIPID RESEARCH. 2008;49(5):954-960
The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential
Zanotti I; Poti F; Pedrelli M; Favari E; Moleri E; Franceschini G; Calabresi L; Bernini F
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All other publications

Review: AGEING RESEARCH REVIEWS. 2024;94:102194
Lipid droplets, autophagy, and ageing: A cell-specific tale
Maestri A; Garagnani P; Pedrelli M; Hagberg CE; Parini P; Ehrenborg E
Review: ANTIOXIDANTS. 2022;11(8):1541
The Prognostic Value of Derivatives-Reactive Oxygen Metabolites (d-ROMs) for Cardiovascular Disease Events and Mortality: A Review
Pigazzani F; Gorni D; Dyar KA; Pedrelli M; Kennedy G; Costantino G; Bruno A; Mackenzie I; MacDonald TM; Tietge UJF; George J
Meeting abstract: ATHEROSCLEROSIS. 2016;252:E237
WORKSHOP 2.1: LIPOPROTEINS AND EXTRACELLULAR MATRIX. INCREASED LIPOPROTEIN BINDING TO ARTERIAL PROTEOGLYCANS AND NORMAL MACROPHAGE CHOLESTEROL EFFLUX CAPACITY DEFINE THE PRO-ATHEROGENIC FEATURE OF CKD DYSLIPIDEMIA
Pedrelli M; Stenvinkel P; Minniti ME; Emma K; Dikkers A; Ebtehaj S; Gomaraschi M; Barany P; Qureshi AR; Camejo G; Lindholm B; Oorni K; Tietge U; Calabresi L; Hurt-Camejo E; Parini P
Review: BIOLOGY. 2015;4(1):104-132
Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism.
Gnocchi D; Pedrelli M; Hurt-Camejo E; Parini P
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2011;1812(8):929-937
Role of thyroid receptor β in lipid metabolism
Pramfalk C; Pedrelli M; Parini P
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):39
THE INHIBITION OF HEPATIC ACYL COENZYME A:CHOLESTEROL ACYLTRANSFERASE (ACAT) 2 POSITIVELY AFFECTS HDL METABOLISM AND FUNCTIONALITY IN MICE
Pedrelli M; Davoodpour P; Degirolamo C; Gomaraschi M; Larsson L; Rudel LL; Calabresi L; Gustafsson JA; Steffensen K; Eriksson M; Parini P

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