Martin Haraldsson

Publications
Public outreach and news

Articles

Article: ISCIENCE. 2024;27(2):108907
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
Zhang SM; Paulin CBJ; Shu H; Yagu-Capilla M; Michel M; Marttila P; Ortis F; Bwanika HC; Dirks C; Venkatram RP; Wiita E; Jemth A-S; Almlof I; Loseva O; Hormann FM; Koolmeister T; Linde E; Lee S; Llona-Minguez S; Haraldsson M; Axelsson H; Stromberg K; Homan EJ; Scobie M; Lundback T; Helleday T; Rudd SG
Article: METHODS AND APPLICATIONS IN FLUORESCENCE. 2023;11(4):045011
Photo-physical characterization of high triplet yield brominated fluoresceins by transient state (TRAST) spectroscopy
Demirbay B; Baryshnikov G; Haraldsson M; Piguet J; Agren H; Widengren J
Article: BIOCHEMICAL PHARMACOLOGY. 2022;203:115184
Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
Zhang X; Akcan E; Correia M; Rameika N; Kundu S; Stoimenov I; Rendo V; Eriksson AU; Haraldsson M; Globisch D; Sjoblom T
Article: AUTOPHAGY. 2022;18(7):1486-1502
Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy
Giovannucci TA; Salomons FA; Stoy H; Herzog LK; Xu S; Qian W; Merino LG; Gierisch ME; Haraldsson M; Lystad AH; Uvell H; Simonsen A; Gustavsson A-L; Vallin M; Dantuma NP
Article: NATURE CANCER. 2022;3(2):156-172
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Bonagas N; Gustafsson NMS; Henriksson M; Marttila P; Gustafsson R; Wiita E; Borhade S; Green AC; Vallin KSA; Sarno A; Svensson R; Gokturk C; Pham T; Jemth A-S; Loseva O; Cookson V; Kiweler N; Sandberg L; Rasti A; Unterlass JE; Haraldsson M; Andersson Y; Scaletti ER; Bengtsson C; Paulin CBJ; Sanjiv K; Abdurakhmanov E; Pudelko L; Kunz B; Desroses M; Iliev P; Farnegardh K; Kramer A; Garg N; Michel M; Haggblad S; Jarvius M; Kalderen C; Jensen AB; Almlof I; Karsten S; Zhang SM; Haggblad M; Eriksson A; Liu J; Glinghammar B; Nekhotiaeva N; Klingegard F; Koolmeister T; Martens U; Llona-Minguez S; Moulson R; Nordstrom H; Parrow V; Dahllund L; Sjoberg B; Vargas IL; Vo DD; Wannberg J; Knapp S; Krokan HE; Arvidsson PI; Scobie M; Meiser J; Stenmark P; Berglund UW; Homan EJ; Helleday T
Article: CELL DEATH AND DISEASE. 2021;12(10):914
Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound
Giovannucci TA; Salomons FA; Haraldsson M; Elfman LHM; Wickstroem M; Young P; Lundbaeck T; Eirich J; Altun M; Jafari R; Gustavsson A-L; Johnsen JI; Dantuma NP
Article: NEURO-ONCOLOGY ADVANCES. 2021;3(1):vdab152
Glioblastoma cytotoxicity conferred through dual disruption of endolysosomal homeostasis by Vacquinol-1
Kwak D; Hammarstrom LGJ; Haraldsson M; Ernfors P
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2020;63(8):3915-3934
Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
Popova G; Ladds MJGW; Johansson L; Saleh A; Larsson J; Sandberg L; Sahlberg SH; Qian W; Gullberg H; Garg N; Gustavsson A-L; Haraldsson M; Lane D; Yngve U; Lain S
Article: SCIENCE ADVANCES. 2020;6(12):eaax7945
Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death
Busker S; Qian W; Haraldsson M; Espinosa B; Johansson L; Attarha S; Kolosenko I; Liu J; Dagnell M; Grander D; Arner ESJ; Tamm KP; Page BDG
Article: CHEMICAL BIOLOGY AND DRUG DESIGN. 2018;92(1):1255-1271
Identification of inhibitors of Tartrate-resistant acid phosphatase (TRAP/ACP5) activity by small-molecule screening
Reithmeier A; Lundback T; Haraldsson M; Frank M; Ek-Rylander B; Nyholm P-G; Gustavsson A-L; Andersson G
Article: NATURE COMMUNICATIONS. 2018;9(1):1107
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds MJGW; van Leeuwen IMM; Drummond CJ; Chu S; Healy AR; Popova G; Fernandez AP; Mollick T; Darekar S; Sedimbi SK; Nekulova M; Sachweh MCC; Campbell J; Higgins M; Tuck C; Popa M; Safont MM; Gelebart P; Fandalyuk Z; Thompson AM; Svensson R; Gustavsson A-L; Johansson L; Farnegardh K; Yngve U; Saleh A; Haraldsson M; D'Hollander ACA; Franco M; Zhao Y; Hakansson M; Walse B; Larsson K; Peat EM; Pelechano V; Lunec J; Vojtesek B; Carmena M; Earnshaw WC; McCarthy AR; Westwood NJ; Arsenian-Henriksson M; Lane DP; Bhatia R; McCormack E; Lain S
Article: CANCER CELL INTERNATIONAL. 2018;18:147
A drug screening assay on cancer cells chronically adapted to acidosis
Pellegrini P; Serviss JT; Lundback T; Bancaro N; Mazurkiewicz M; Kolosenko I; Yu D; Haraldsson M; D'Arcy P; Linder S; De Milito A
Article: ORGANIC AND BIOMOLECULAR CHEMISTRY. 2017;15(21):4644-4654
High-affinity recognition of the human C-reactive protein independent of phosphocholine
Yang J; Gustavsson A-L; Haraldsson M; Karlsson G; Norberg T; Baltzer L
Article: CANCER RESEARCH. 2017;77(7):1741-1752
Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses
Niklasson M; Maddalo G; Sramkova Z; Mutlu E; Wee S; Sekyrova P; Schmidt L; Fritz N; Dehnisch I; Kyriatzis G; Krafcikova M; Carson BB; Feenstra JM; Marinescu VD; Segerman A; Haraldsson M; Gustavsson A-L; Hammarstrom LGJ; Jensen AJ; Uhrbom L; Altelaar AFM; Linnarsson S; Uhlen P; Trantirek L; Vincent CT; Nelander S; Enger PO; Andang M
Article: PLOS ONE. 2017;12(6):e0178844
Identification of novel small molecules that inhibit STAT3-dependent transcription and function
Kolosenko I; Yu Y; Busker S; Dyczynski M; Liu J; Haraldsson M; Apergi CP; Helleday T; Tamm KP; Page BDG; Grander D
Article: NATURE COMMUNICATIONS. 2016;7:11040
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
Almqvist H; Axelsson H; Jafari R; Dan C; Mateus A; Haraldsson M; Larsson A; Molina DM; Artursson P; Lundback T; Nordlund P
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2015;355(1):108-116
Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C₄ Synthases
Kleinschmidt TK; Haraldsson M; Basavarajappa D; Lundeberg E; Thulasingam M; Ekoff M; Fauland A; Lehmann C; Kahnt AS; Lindbom L; Haeggstrom JZ
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2013;56(16):6457-6466
Structure-Guided Design of Novel Thiazolidine Inhibitors of O-Acetyl Serine Sulfhydrylase from Mycobacterium tuberculosis
Poyraz O; Jeankumar VU; Saxena S; Schnell R; Haraldsson M; Yogeeswari P; Sriram D; Schneider G

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Corrigendum: NATURE COMMUNICATIONS. 2023;14(1):5019
Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage (vol 14, 5019, 2023)
Ladds MJGW; van Leeuwen IMM; Drummond CJ; Chu S; Healy AR; Popova G; Fernandez AP; Mollick T; Darekar S; Sedimbi SK; Nekulova M; Sachweh MCC; Campbell J; Higgins M; Tuck C; Popa M; Safont MM; Gelebart P; Fandalyuk Z; Thompson AM; Svensson R; Gustavsson A-L; Johansson L; Faernegardh K; Yngve U; Saleh A; Haraldsson M; D'Hollander ACA; Franco M; Zhao Y; Hakansson M; Walse B; Larsson K; Peat EM; Pelechano V; Lunec J; Vojtesek B; Carmena M; Earnshaw WC; McCarthy AR; Westwood NJ; Arsenian-Henriksson M; Lane DP; Bhatia R; McCormack E; Lain S
Corrigendum: NATURE COMMUNICATIONS. 2018;9(1):2071
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds MJGW; van Leeuwen IMM; Drummond CJ; Chu S; Healy AR; Popova G; Fernandez AP; Mollick T; Darekar S; Sedimbi SK; Nekulova M; Sachweh MCC; Campbell J; Higgins M; Tuck C; Popa M; Safont MM; Gelebart P; Fandalyuk Z; Thompson AM; Svensson R; Gustavsson A-L; Johansson L; Farnegardh K; Yngve U; Saleh A; Haraldsson M; D'Hollander ACA; Franco M; Zhao Y; Hakansson M; Walse B; Larsson K; Peat EM; Pelechano V; Lunec J; Vojtesek B; Carmena M; Earnshaw WC; McCarthy AR; Westwood NJ; Arsenian-Henriksson M; Lane DP; Bhatia R; McCormack E; Lain S

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