Martin Enge

Publications
CV
Public outreach and news

Articles

Article: MOLECULAR CANCER. 2024;23(1):180
Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human neuroblastoma
Olsen TK; Otte J; Mei S; Embaie BT; Kameneva P; Cheng H; Gao T; Zachariadis V; Tsea I; Bjorklund A; Kryukov E; Hou Z; Johansson A; Sundstrom E; Martinsson T; Fransson S; Stenman J; Fard SS; Johnsen JI; Kogner P; Adameyko I; Enge M; Kharchenko PV; Baryawno N
Article: JOURNAL OF INFLAMMATION. 2023;20(1):22
Stem cell-derived brainstem mouse astrocytes obtain a neurotoxic phenotype in vitro upon neuroinflammation
Lindblad C; Neumann S; Kolbeinsdottir S; Zachariadis V; Thelin EP; Enge M; Thams S; Brundin L; Svensson M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(26):e2201267119
Single-cell transcriptome and accessible chromatin dynamics during endocrine pancreas development.
Duvall E; Benitez CM; Tellez K; Enge M; Pauerstein PT; Li L; Baek S; Quake SR; Smith JP; Sheffield NC; Kim SK; Arda HE
Article: NATURE COMMUNICATIONS. 2022;13(1):1854
Elastic dosage compensation by X-chromosome upregulation
Lentini A; Cheng H; Noble JC; Papanicolaou N; Coucoravas C; Andrews N; Deng Q; Enge M; Reinius B
Article: JOURNAL OF NEUROINFLAMMATION. 2022;19(1):20
An overlooked subset of Cx3cr1^wt/wt microglia in the Cx3cr1^{CreER-Eyfp/wt} mouse has a repopulation advantage over Cx3cr1^{CreER-Eyfp/wt} microglia following microglial depletion
Zhou K; Han J; Lund H; Boggavarapu NR; Lauschke VM; Goto S; Cheng H; Wang Y; Tachi A; Xie C; Zhu K; Sun Y; Osman AM; Liang D; Han W; Gemzell-Danielsson K; Betsholtz C; Zhang X-M; Zhu C; Enge M; Joseph B; Harris RA; Blomgren K
Article: JOURNAL OF NEUROSCIENCE. 2021;41(40):8441-8459
Spinal Cord Injury Induces Permanent Reprogramming of Microglia into a Disease-Associated State Which Contributes to Functional Recovery
Hakim R; Zachariadis V; Sankavaram SR; Han J; Harris RA; Brundin L; Enge M; Svensson M
Article: NATURE METHODS. 2021;18(8):912-920
An unsupervised method for physical cell interaction profiling of complex tissues
Andrews N; Serviss JT; Geyer N; Andersson AB; Dzwonkowska E; Sutevski I; Heijboer R; Baryawno N; Gerling M; Enge M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(2):e2017849118
Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors
Cui L; Moraga I; Lerbs T; Van Neste C; Wilmes S; Tsutsumi N; Trotman-Grant AC; Gakovic M; Andrews S; Gotlib J; Darmanis S; Enge M; Quake S; Hitchcock IS; Piehler J; Garcia KC; Wernig G
Article: MOLECULAR CELL. 2020;80(3):541-553.e5
A Highly Scalable Method for Joint Whole-Genome Sequencing and Gene-Expression Profiling of Single Cells
Zachariadis V; Cheng H; Andrews N; Enge M
Article: SCIENTIFIC REPORTS. 2019;9(1):5592
Modeling Spatial Correlation of Transcripts with Application to Developing Pancreas
Liu R; Mignardi M; Jones R; Enge M; Kim SK; Quake SR; Zou J
Article: CELL. 2017;171(2):321-330.e14
Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns
Enge M; Arda E; Mignardi M; Beausang J; Bottino R; Kim SK; Quake SR
Article: CELL METABOLISM. 2017;25(3):622-634
Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.
Chakravarthy H; Gu X; Enge M; Dai X; Wang Y; Damond N; Downie C; Liu K; Wang J; Xing Y; Chera S; Thorel F; Quake S; Oberholzer J; MacDonald PE; Herrera PL; Kim SK
Article: NATURE. 2015;527(7578):384-388
DNA-dependent formation of transcription factor pairs alters their binding specificity
Jolma A; Yin Y; Nitta KR; Dave K; Popov A; Taipale M; Enge M; Kivioja T; Morgunova E; Taipale J
Article: NATURE GENETICS. 2015;47(7):818-821
CTCF/cohesin-binding sites are frequently mutated in cancer
Katainen R; Dave K; Pitkanen E; Palin K; Kivioja T; Valimaki N; Gylfe AE; Ristolainen H; Hanninen UA; Cajuso T; Kondelin J; Tanskanen T; Mecklin J-P; Jarvinen H; Renkonen-Sinisalo L; Lepisto A; Kaasinen E; Kilpivaara O; Tuupanen S; Enge M; Taipale J; Aaltonen LA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(23):7285-7290
A survey of human brain transcriptome diversity at the single cell level
Darmanis S; Sloan SA; Zhang Y; Enge M; Caneda C; Shuer LM; Gephart MGH; Barres BA; Quake SR
Article: NATURE COMMUNICATIONS. 2015;6:6178
Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci
Jaeger R; Migliorini G; Henrion M; Kandaswamy R; Speedy HE; Heindl A; Whiffin N; Carnicer MJ; Broome L; Dryden N; Nagano T; Schoenfelder S; Enge M; Yuan Y; Taipale J; Fraser P; Fletcher O; Houlston RS
Article: CELL. 2013;154(4):801-813
Transcription Factor Binding in Human Cells Occurs in Dense Clusters Formed around Cohesin Anchor Sites
Yan J; Enge M; Whitington T; Dave K; Liu J; Sur I; Schmierer B; Jolma A; Kivioja T; Taipale M; Taipale J
Article: CELL. 2013;152(1-2):327-339
DNA-Binding Specificities of Human Transcription Factors
Jolma A; Yan J; Whitington T; Toivonen J; Nitta KR; Rastas P; Morgunova E; Enge M; Taipale M; Wei G; Palin K; Vaquerizas JM; Vincentelli R; Luscombe NM; Hughes TR; Lemaire P; Ukkonen E; Kivioja T; Taipale J
Article: SCIENCE. 2012;338(6112):1360-1363
Mice Lacking a Myc Enhancer That Includes Human SNP rs6983267 Are Resistant to Intestinal Tumors
Sur IK; Hallikas O; Vaharautio A; Yan J; Turunen M; Enge M; Taipale M; Karhu A; Aaltonen LA; Taipale J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(35):29336-29347
Protein Kinase Cα (PKCα) Regulates p53 Localization and Melanoma Cell Survival Downstream of Integrin αv in Three-dimensional Collagen and in Vivo
Smith SD; Enge M; Bao W; Thullberg M; Costa TDF; Olofsson H; Gashi B; Selivanova G; Stromblad S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(48):41600-41615
Inhibition of Glycolytic Enzymes Mediated by Pharmacologically Activated p53 TARGETING WARBURG EFFECT TO FIGHT CANCER
Zawacka-Pankau J; Grinkevich VV; Huenten S; Nikulenkov F; Gluch A; Li H; Enge M; Kel A; Selivanova G
Article: NATURE METHODS. 2011;9(1):72-74
Counting absolute numbers of molecules using unique molecular identifiers
Kivioja T; Vaharautio A; Karlsson K; Bonke M; Enge M; Linnarsson S; Taipale J
Article: SCIENCE. 2011;334(6053):252-255
MED12, the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas
Makinen N; Mehine M; Tolvanen J; Kaasinen E; Li Y; Lehtonen HJ; Gentile M; Yan J; Enge M; Taipale M; Aavikko M; Katainen R; Virolainen E; Bohling T; Koski TA; Launonen V; Sjoberg J; Taipale J; Vahteristo P; Aaltonen LA
Article: CELL CYCLE. 2011;10(19):3346-3358
Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2
Li H; Lakshmikanth T; Garofalo C; Enge M; Spinnler C; Anichini A; Szekely L; Karre K; Carbone E; Selivanova G
Article: EMBO JOURNAL. 2010;29(13):2147-2160
Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo
Wei G-H; Badis G; Berger MF; Kivioja T; Palin K; Enge M; Bonke M; Jolma A; Varjosalo M; Gehrke AR; Yan J; Talukder S; Turunen M; Taipale M; Stunnenberg HG; Ukkonen E; Hughes TR; Bulyk ML; Taipale J
Article: GENOME RESEARCH. 2010;20(6):861-873
Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities
Jolma A; Kivioja T; Toivonen J; Cheng L; Wei G; Enge M; Taipale M; Vaquerizas JM; Yan J; Sillanpaa MJ; Bonke M; Palin K; Talukder S; Hughes TR; Luscombe NM; Ukkonen E; Taipale J
Article: CANCER CELL. 2009;15(5):441-453
Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required for Efficient Apoptosis
Grinkevich VV; Nikulenkov F; Shi Y; Enge M; Bao W; Maljukova A; Gluch A; Kel A; Sangfelt O; Selivanova G
Article: CANCER CELL. 2009;15(3):171-183
MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53
Enge M; Bao W; Hedstrom E; Jackson SP; Moumen A; Selivanova G
Article: EXPERIMENTAL CELL RESEARCH. 2009;315(3):451-461
Tumor-specific induction of apoptosis by a p53-reactivating compound
Hedstrom E; Issaeva N; Enge M; Selivanova G
Article: NATURE MEDICINE. 2004;10(12):1321-1328
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
Issaeva N; Bozko P; Enge M; Protopopova M; Verhoef LGGC; Masucci M; Pramanik A; Selivanova G
Show more

All other publications

Thesis / dissertation: 2009
Dissecting the p53 pathway by means of small molecule-mediated reactivation and computational biology
Enge, Martin

Employments

Principal Researcher, Department of Oncology-Pathology, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2023
Degree Of Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2009

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI