Marie Jeansson
About me
Please have a look at www.jeanssonlab.com for more information about our work!
Research
I am a associate professor in vascular biology with a long-standing interest in how blood vessels in the kidney contribute to both health and disease. Over the years, I have combined methods ranging from electron microscopy and in vivo models of glomerular injury to modern single-cell and spatial transcriptomics. These approaches allow me to map the heterogeneity of endothelial cells in health and in conditions such as diabetic nephropathy. I am particularly interested in how molecular pathways such as Tie2/angiopoietin signalling and endothelial–podocyte cross-talk can be targeted to preserve capillary integrity, slow chronic kidney disease progression, and ultimately protect patients from kidney failure.
My translational ambition is to move beyond understanding mechanisms toward developing new treatments. I am the co-founder and CEO of Sang Biotech AB, a Swedish biotech company that builds on my laboratory’s discoveries to create therapies for kidney and cardiovascular diseases. At Sang Biotech, we aim to translate insights about endothelial injury and repair into drug candidates that strengthen the vasculature and restore function. My work stands at the interface of basic vascular biology and clinical nephrology. By bridging these fields, I hope to redefine kidney disease as a disorder of the entire vascular niche and to contribute to therapies that address the root causes of organ damage, not only its symptoms.
Articles
- Journal article: NATURE. 2025;641(8062):465-475
- Article: VASCULAR PHARMACOLOGY. 2024;157:107434
- Article: NATURE COMMUNICATIONS. 2024;15(1):7643
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(8):4320
- Article: NATURE COMMUNICATIONS. 2021;12(1):2141
- Article: CIRCULATION RESEARCH. 2021;128(4):e46-e62
- Article: PLOS ONE. 2018;13(1):e0189433
- Article: BMC CANCER. 2017;17(1):539
- Article: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2017;114:186-193
- Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2014;25(11):2459-2470
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(10):4320-4324
- Article: JOURNAL OF PATHOLOGY. 2013;230(1):95-106
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2013;304(1):F120-F126
- Article: PLOS ONE. 2012;7(11):e50996
- Article: DIABETES. 2012;61(11):2958-2966
- Article: CELL. 2012;151(2):384-399
- Article: DEVELOPMENTAL BIOLOGY. 2012;367(1):40-54
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2011;121(6):2278-2289
- Article: CELL METABOLISM. 2010;12(4):329-340
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2009;119(4):943-953
- Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2009;20(1):114-122
- Article: DIABETOLOGIA. 2006;49(9):2200-2209
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2006;539(3):184-191
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2006;290(1):F111-F116
- Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2003;14(7):1756-1765
- Show more
All other publications
- Preprint: BIORXIV. 2025
- Conference publication: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2024;39:gfae069-0742-2114
- Conference publication: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2024;39:I1216
- Conference publication: JOURNAL OF VASCULAR RESEARCH. 2023;60(SUPP1):48
- Conference publication: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2022;33(11S):587
- Conference publication: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2022;33(11):587
- Conference publication: ACTA PHYSIOLOGICA. 2022;236:333
- Conference publication: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2021;32(10S):55
- Conference publication: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2021;32(10S):240-241
- Conference publication: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2021;32(10):240-241
- Conference publication: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2021;32(10):55
- Conference publication: JOURNAL OF VASCULAR RESEARCH. 2021;58:5
- Conference publication: JOURNAL OF VASCULAR RESEARCH. 2021;58:3
- Conference publication: ANNALS OF ONCOLOGY. 2017;28:ii12
- Review: ANNUAL REVIEW OF PHYSIOLOGY. 2016;78:437-461
- Review: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 2011;20(3):258-262
- Review: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 2009;18(4):331-335
Grants
- Angiopoietin-2 and Lipocalin-2 as causal factors of endothelial dysfunction and diabetic complicationsEXODIAB1 April 2025 - 31 March 2026
- Therapeutic intervention to slow progression of chronic kidney diseaseKnut och Alice Wallenbergs Stiftelse1 January 2025 - 31 December 2026
- Therapeutic intervention to slow progression of chronic kidney diseaseNovo Nordisk Foundation1 January 2024 - 31 December 2024
- European Foundation for the Study of Diabetes1 January 2024 - 31 December 2024
- Angiopoietin-2 and renal microthrombosis in COVID-19The Swedish Kidney Foundation1 January 2023 - 31 December 2023
- Angiopoietin-2 and renal microthrombosis in COVID-19The Swedish Kidney Foundation1 January 2022 - 31 December 2022
- Angiopoietins in fibrosisMagn. Bergwalls Stiftelse1 March 2015 - 29 February 2016
- The Angiopoietin/Tek System in Fibrotic DiseaseIGPs medel till Unga Forskare1 January 2015 - 31 December 2015
- Angiopoietin/Tek in fibrosisMagn. Bergwalls Stiftelse1 March 2014 - 28 February 2015
- The Angiopoietin/Tek system in fibrosisÅke Wiberg1 March 2014 - 28 February 2015
- Swedish Research Council1 January 2013 - 31 December 2015
- Discovery of new therapeutic targets in human disease through animal modelsVenture Sinai Women1 August 2012 - 31 July 2013
- Endothelial cell glycocalyx and vascular endothelia growth factor-A (VEGF-A) in the renal glomerular barrierWenner-Gren Stiftelserna1 January 2008 - 31 December 2008
- Growth Factor Signaling in Renal DiseaseSwedish Research Council1 January 2008 - 31 December 2008
- The glomerular barrier and the endothelial cell glycocalyWenner-Gren Stiftelserna1 January 2007 - 31 December 2007
Employments
- Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2018-
- Associate Professor, Vascular biology, Immunology, Genetics, and Pathology, Uppsala University, 2017-2018
- Assistant Professor, Vascular biology/Kidney disease, Immunologi, Genetic, and Pathology, Uppsala University, 2013-2017
- Postdoctoral Fellow, Lunenfeld-Tanenbaum Research Institute, 2006-2013
Degrees and Education
- Associate Professor, Vascular biology, Immunology, genetics, and Pathology, Uppsala University, 2017
- PhD, Renal Physiology, Aspects of the glomerular barrier in healthy and diabetic kidneys, Neuroscience and Physiology, University of Gothenburg, 2005
- Master degree, Linnaeus University, 2001
Leadership and responsibility assignments
- Academic Mentor postdoctoral fellow, Roche Innovation Center, 2018-2020
Supervision
- Amanda Marks, 2023-
- Yuyang Miao, 2021-
- Krishnapriya Loganathan, 2018
- Yang Zhang, Organ-specific mechanisms of vascular development in the mesentery, 2018
- Maria Ascencion Globisch, Inflammation and immunothrombosis in cerebral cavernous malformations, novel molecular targets for the treatment of an incurable disease, 2023
Committee work
- Member, American Society of Nephrology's PhD committee, American Society of Nephrology, 2016-2018
- Member, Committee for Equal Opportunities, Immunology, Genetics, and Pathology, Uppsala University, 2015-2018
- Member, Committee for Common Instruments, Immunology, Genetics, and pathology, Uppsala University, 2014-2018
Visiting research fellowships
- Postdoctoral Fellowship, Mount Sinai Hospital, 2006-2013
- Postdoctoral fellow, University of Gothenburg, 2005-2006
Thesis evaluation
- Milena Petkova, Examination board member, Immunology, Genetics, and Pathology, Uppsala University, Cell-autonomous and paracrine mechanisms underlaying Pik3ca-driven vascular malformations, 2024
- Alessandra Vaccaro, Examination board member, Immunology, Genetics, and Pathology, Uppsala University, Tertiary lymphoid structures in glioblastoma, 2024
- Federico Cantoni, Examination board member, Department of Materials Science and Engineering, Uppsala University, Fabrication advances of microvasculature models on-chip, 2023
- Nina Daubel, Examination board member, Department of Immunology, Genetics, and Pathology, Uppsala University, Lymphatic vasculature morphogenesis: from progenitors to functional vessels, 2022
- Frida Olsson, Examination board member, Farmaceutisk Biovetenskap, Uppsala University, Half-time seminar: Studies of cellular signaling via pathways involving steroids and tyrosine kinase receptors, 2022
- Ana Maria Porras, Examination board member, Department of Materials Science and Engineering, Uppsala University, Micropatterning of hyaluronic acid hydrogels for in vitro models, 2022
- Balboa Amanda, Examination board member, Department of Medical Cell Biology, Uppsala University, Experimental mechanisms in aneurysms formation, 2022
- Minna Kihlström, External thesis reviewer, University of Oulu, Characterization of angiopoietin ligands: Role of angiopoietin-4 in retinal venous development and angiopoietin-2 variant in tumor vasculature, 2019
- Minna Kihlström, External thesis reviewer, University of Oulu, Characterization of angiopoietin ligands: role of angiopoietin-4 in retinal venous development and angiopoietin-2 variant in tumor vasculature, 2019
- Maria Georganaki, Examination board member, Department of Immunology, Genetics, and Pathology, Uppsala University, Vascular targeting for enhanced cancer immunotherapy, 2018
- Anja Nitzsche, Examination board member, Department of Immunology, Genetics, and Pathology, Uppsala University, The role of Paladin in endothelial cell signaling and angiogenesis, 2016
- Sofia Nordling, Examination board member, Immunology, Genetics, and pathology, Uppsala University, Vascular Interactions in Innate Immunity and Immunothrombosis, Models of Endothelial Protection, 2016
- Luuk van Hooren, Examination board member, Immunology, Genetics, and Pathology, Uppsala University, Half-time seminar, 2015
- Eric Morin, Examination board member, Immunology, Genetics, and Pathology, Uppsala University, Half-time seminar, 2015
Other expert reviewer/evaluation assignment
- Reviewer of candidates proposed for academic positions, Expert evaluation for Docent (Jessica Cedervall), Uppsala University, 2019-2019
- Other evaluation assignments, Kidney Week 2015 - Abstract reviewer, American Society of Nephrology, 2015-2015
- Other evaluation assignments, Abstract Reviewer, WCN Congress, Hong Kong, World Congress of Nephrology, 2013-2013
- Other evaluation assignments, Abstract Reviewer
- Gordon Research Conference, Endothelial Phenotypes in Health and Disease, Gordon Research Conferences, 2012-2012
Conference/event participation
- Oral presenter of own accepted abstract, European Renal Association, Stockholm, Sweden, TIE2 activation promotes vascular protection of tubules to reduce PDGFB driven tubulointerstitial fibrosis in experimental chronic kidney disease«, 2024
- Invited speaker, pre-meeting European Renal Association, Uppsala, Sweden, TIE2 activation promotes vascular protection of tubules to reduce PDGFB driven tubulointerstitial fibrosis in experimental chronic kidney disease«, 2024
- Invited speaker, VascBio seminar
- Uppsala Unversity, Uppsala, Sweden, TIE-ing 2gether endothelial dysfunction and fibrosis in chronic kidney disease, 2024
- Invited speaker, Yale-Uppsala seminar, TIE2 activation as therapeutic intervention in chronic kidney disease (CKD), 2023
- Invited speaker, Clinical Immunology seminar
- Uppsala University, Uppsala, Sweden, Elevated Angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients, 2021
- Invited speaker, SciLifeLab seminar, Uppsala, Elevated angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients, 2021
- Invited speaker, Seminar
- AstraZeneca, Gothenburg, Sweden, Tie2 signaling in chronic kidney disease, 2020
- Invited speaker, Seminar
- Integrated Cardio Metabolic Centre, Huddinge, Sweden, Endothelial-pericyte cross talk via Tie2 and Pdgfb affect capillary rarefaction and tubulointerstitial fibrosis in chronic kidney disease, 2019
- Invited speaker, Seminar, Renal medicine Baxter Novum, Angiopoietin-1 and Tie2 signaling in capillary rarefaction and CKD, 2019
- Oral presenter of own accepted abstract, Kidney Week, American Society of Nephrology, Washington, DC, USA, Capillaries are Primary Targets in CKD and Loss of Tie2 Signaling Increases Vascular Injury, 2019
- Invited speaker, Presentation
- Karo Kidney meeting, Angiopoietin-1 and Tie2 signaling in capillary rarefaction and CKD, 2018
- Invited speaker, Symposia for Erik Ilso Christensen, Aarhus University, Myths and truths in tubular handling of albumin, 2018
- Invited speaker, IGP-day, Uppsala University, Sweden, 2018
- Chair, Kidney Week, American Society of Nephrology, New Orleans, Chair for the session: Diabetsity, still a big problem?, 2017
- Invited speaker, Seminar
- AstraZeneca, Angiopoietin-1/Tie2 signaling in kidney fibrosis, 2017
- Chair, Kidney Week, American Society of Nephrology, New Orleans, USA, Chair
- Diabesity, still a big problem?, 2017
- Invited speaker, VascBio Seminars series, Uppsala University, Angiopoietin-1 in tumor growth and metastasis, 2015
- Invited speaker, Bristol University, UK, Angiopoietins - the yin and yang of vascular diseases, 2014
- Invited speaker, Seminar
- Lunenfeld-Tannenbaum Research Institute, Toronto, Canada, Angiopoietin-1 – a protective factor in diabetes, fibrosis, and tumor metastasis, 2013
- Invited speaker, Seminar
- Karolinska Institutet, Stockholm, Sweden, Angiopoietin-1 – a protective factor in diabetes, fibrosis, and tumor metastasis, 2013
- Invited speaker, Seminar
- Uppsala University, Uppsala, Sweden, Angiopoietin-1 – a protective factor in diabetes, fibrosis, and tumor metastasis, 2013
- Invited speaker, Seminar
- Sahlgrenska University Hospital, Gothenburg, Sweden, Angiopoietin-1 – a protective factor in diabetes, fibrosis, and tumor metastasis, 2012
- Invited speaker, Lunenfeld-Tannenbaum Research Institute Annual Retreat, Geneva Park, Angiopoietin-1 in mouse vasculature, 2012
- Invited speaker, Experimental Biology, Physiology in Focus session. San Diego, Ca, USA., New advances in the pathophysiology and treatment of chronic glomerular diseases, 2012
- Chair, Gordon Research Seminars
- Endothelial Phenotypes in Health and Disease, 2012
- Invited speaker, Seminar
- Venture Sinai Women 2, Discovery of New Therapeutic Targets in Human Disease through Animal Models
- Future uses of Angiopoietin-1, 2012
- Invited speaker, Lunch Seminars
- Lunenfeld-Tannebaum Research institute, Toronto, Canada, Angiopoietin-1 is essential in mouse vasculature during development and in response to injury, 2011
- Oral presenter of own accepted abstract, Renal Week, American Society of Nephrology, Denver, CO, USA, Multiple roles for Angiopoietin-1 in renal health and diseases, 2010
- Invited speaker, Renal Rounds, Toronto General Hospital, Toronto, Canada, Angiopoietins in diabetic nephropathy, 2010
- Invited speaker, Renal Week, American Society of Nephrology, San Diego, CA, USA, scientific session, 2009
- Oral presenter of own accepted abstract, Renal Week, American Society of Nephrology, San Diego, CA, USA., Multiple roles for Angiopoietin-1 in health and disease, 2009
- Invited speaker, Renal Rounds
- Toronto general Hospital, Toronto, Canada, Angiopoietin-1 is critical for vascular development and renal repair in diabetes mellitus, 2009
- Invited speaker, Annual Retreat
- Samuel Lunenfeld Research Institute, Great Lakes, Canada, Angiopoietin-1 is critical for vascular development and renal repair in diabetes mellitus, 2009
- Invited speaker, Lunch seminar
- Lunenfeld-Tannenbaum Research Institute, Toronto, Canada, Angiopoietin-1 in glomerular function and the vasculature, 2008
- Invited speaker, Renal rounds, Toronto General Hospital, Toronto, Canada, Angiopoietin-1 in vascular development and glomerular function, 2008
- Invited speaker, Scandinavian Society of Nephrology, Gothenburg, Sweden, Functional properties of the glomerular barrier, 2007