Maria Bruzelius

Publications
Grants
CV
Public outreach and news

Selected publications

Article: THROMBOSIS AND HAEMOSTASIS. 2024;124(01):32-39
Clinical Implications of Discrepancy between One-Stage Clotting and Chromogenic Factor IX Activity in Hemophilia B
Schmidt DE; Truedsson A; Stralfors A; Hojbjerg JA; Soutari N; Holmstrom M; Ranta S; Letelier A; Bowyer A; Ljung R; Antovic J; Bruzelius M
Letter: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2023;61(12):e248-e250
Laboratory response to paradigm change in hemophilia treatment How to monitor patients simultaneously treated with emicizumab and factor VIII concentrate?
Lambert MS; Bruzelius M; Soutari NMH; Ranta S; Antovic JPP
Article: RESUSCITATION PLUS. 2021;8:100178
In-hospital cardiac arrest due to pulmonary embolism - Treatment and outcomes in a Swedish cohort study
Henriksson CE; Frithiofsson J; Bruchfeld S; Bendz E; Bruzelius M; Djarv T
Article: THROMBOSIS AND HAEMOSTASIS. 2021;121(12):1610-1621
Platelet Count Rose While D-Dimer Levels Dropped as Deaths and Thrombosis Declined-An Observational Study on Anticoagulation Shift in COVID-19
Sjostrom A; Wersall JD; Warnqvist A; Farm M; Magnusson M; Oldner A; Agren A; Antovic J; Bruzelius M
Article: SEMINARS IN THROMBOSIS AND HEMOSTASIS. 2021;47(05):506-511
Impaired Fibrinolysis in the Antiphospholipid Syndrome
Antovic A; Bruzelius M
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2021;19(2):460-469
Overall and abdominal obesity in relation to venous thromboembolism
Yuan S; Bruzelius M; Xiong Y; Hakansson N; Akesson A; Larsson SC
Article: THROMBOSIS AND HAEMOSTASIS. 2021;121(01):27-35
Genetics and Hemostatic Potential in Persons with Mild to Moderate Hemophilia A with a Discrepancy between One-Stage and Chromogenic FVIII Assays
Stralfors A; Mikovic D; Schmidt D; Onelov L; Soutari NMH; Berndtson M; Chaireti R; Holmstrom M; Antovic JP; Bruzelius M
Article: BLOOD. 2017;130(15):1706-1712
Management of rivaroxaban- or apixaban-associated major bleeding with prothrombin complex concentrates: a cohort study
Majeed A; Agren A; Holmstrom M; Bruzelius M; Chaireti R; Odeberg J; Hempel E-L; Magnusson M; Frisk T; Schulman S
Article: BLOOD. 2016;128(23):e59-e66
PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study
Bruzelius M; Iglesias MJ; Hong M-G; Sanchez-Rivera L; Gyorgy B; Carlos Souto J; Franberg M; Fredolini C; Strawbridge RJ; Holmstrom M; Hamsten A; Uhlen M; Silveira A; Manuel Soria J; Smadja DM; Butler LM; Schwenk JM; Morange P-E; Tregouet D-A; Odeberg J
Article: THROMBOSIS AND HAEMOSTASIS. 2016;115(2):406-414
F11 is associated with recurrent VTE in women A prospective cohort study
Bruzelius M; Ljungqvist M; Bottai M; Bergendal A; Strawbridge RJ; Holmstrom M; Silveira A; Kieler H; Hamsten A; Larfars G; Odeberg J
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2015;13(2):219-227
Predicting venous thrombosis in women using a combination of genetic markers and clinical risk factors
Bruzelius M; Bottai M; Sabater-Lleal M; Strawbridge RJ; Bergendal A; Silveira A; Sundstrom A; Kieler H; Hamsten A; Odeberg J
Article: THROMBOSIS RESEARCH. 2014;134(2):426-432
Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism
Bruzelius M; Strawbridge RJ; Tregouet D-A; Wiggins KL; Gertow K; Sabater-Lleal M; Ohrvik J; Bergendal A; Silveira A; Sundstrom A; Kieler H; Syvanen A-C; Smith NL; Morange P-E; Odeberg J; Hamsten A

Articles

Article: EJHAEM. 2024;5(4):768-771
Iatrogenic hemorrhage and extensive venous thromboembolism during iTTP treatment with caplacizumab-A case report
Boberg E; Kimiaei A; Karlstrom C; Ljungqvist M; Agren A; Bruzelius M
Article: HAEMOPHILIA. 2024;30(1):98-105
Health-related quality of life and physical activity in Nordic patients with moderate haemophilia A and B (the MoHem study)
Maseide RJ; Berntorp E; Astermark J; Olsson A; Bruzelius M; Frisk T; Nummi V; Lassila R; Tjonnfjord GE; Holme PA
Article: CLINICAL NUTRITION. 2023;42(8):1268-1275
Ultra-processed food intake and incident venous thromboembolism risk: Prospective cohort study
Yuan S; Chen J; Fu T; Li X; Bruzelius M; Akesson A; Larsson SC
Article: HAEMOPHILIA. 2023;29(4):987-996
No difference in quality of life between persons with severe haemophilia A and B
Kihlberg K; Baghaei F; Bruzelius M; Funding E; Holme PA; Lassila R; Nummi V; Ranta S; Andersson NG; Berntorp E; Astermark J
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2023;201(4):783-792
Plasma protein and venous thromboembolism: prospective cohort and mendelian randomisation analyses
Yuan S; Titova OE; Zhang K; Gou W; Schillemans T; Natarajan P; Chen J; Li X; akesson A; Bruzelius M; Klarin D; Damrauer SM; Larsson SC
Article: BMC MEDICAL RESEARCH METHODOLOGY. 2023;23(1):99
Association of ABO blood groups with venous thrombosis recurrence in middle-aged patients: insights from a weighted Cox analysis dedicated to ambispective design
Munsch G; Goumidi L; van Hylckama Vlieg A; Ibrahim-Kosta M; Bruzelius M; Deleuze J-F; Rosendaal FR; Jacqmin-Gadda H; Morange P-E; Tregouet D-A
Article: THROMBOSIS RESEARCH. 2022;217:22-32
Factor IX antibodies and tolerance in hemophilia B in the Nordic countries - The impact of F9 variants and complications
Kihlberg K; Baghaei F; Bruzelius M; Funding E; Holme PA; Lassila R; Martin M; Nummi V; Ranta S; Strandberg K; Andersson NG; Berntorp E; Astermark J
Article: NUTRIENTS. 2022;14(16):3354
Plasma Phospholipid Fatty Acids and Risk of Venous Thromboembolism: Mendelian Randomization Investigation
Yuan S; Li X; Morange P-E; Bruzelius M; Larsson SC
Article: CLINICAL NUTRITION. 2022;41(6):1191-1196
Anti-inflammatory diet and incident peripheral artery disease: Two prospective cohort studies
Yuan S; Bruzelius M; Damrauer SM; Hakansson N; Wolk A; Akesson A; Larsson SC
Article: PLOS ONE. 2022;17(7):e0270865
Markers of neutrophil activation and neutrophil extracellular traps in diagnosing patients with acute venous thromboembolism: A feasibility study based on two VTE cohorts
Smith P; Rosell A; Farm M; Bruzelius M; Gatica KA; Mackman N; Odeberg J; Thalin C
Article: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2022;53(1):43-50
Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation
Yuan S; Bruzelius M; Larsson SC
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2021;10(21):e022286
Cardiometabolic, Lifestyle, and Nutritional Factors in Relation to Varicose Veins: A Mendelian Randomization Study
Yuan S; Bruzelius M; Damrauer SM; Larsson SC
Article: THROMBOSIS AND HAEMOSTASIS. 2021;121(10):1299-1309
The Complex Relationship between C4b-Binding Protein, Warfarin, and Antiphospholipid Antibodies
Grosso G; Sandholm K; Antovic A; Gunnarsson I; Zickert A; Vikerfors A; Truedsson L; Bruzelius M; Nilsson B; Nilsson-Ekdahl K; Svenungsson E
Article: NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. 2021;31(10):2831-2838
Anti-inflammatory diet and venous thromboembolism: Two prospective cohort studies
Yuan S; Bruzelius M; Damrauer SM; Hakansson N; Wolk A; Akesson A; Larsson SC
Article: THROMBOSIS RESEARCH. 2021;202:119-124
Lifestyle factors and venous thromboembolism in two cohort studies
Yuan S; Bruzelius M; Hakansson N; Akesson A; Larsson SC
Article: HAEMOPHILIA. 2021;27(3):366-374
Treatment outcomes in persons with severe haemophilia B in the Nordic region: The B-NORD study
Kihlberg K; Baghaei F; Bruzelius M; Funding E; Holme PA; Lassila R; Nummi V; Ranta S; Osooli M; Berntorp E; Astermark J
Article: HAEMOPHILIA. 2021;27(2):e253-e259
Haemophilia early arthropathy detection with ultrasound and haemophilia joint health score in the moderate haemophilia (MoHem) study
Maseide RJ; Berntorp E; Astermark J; Hansen J; Olsson A; Bruzelius M; Frisk T; Aspdahl M; Nummi V; Tjonnfjord GE; Holme PA
Article: HAEMOPHILIA. 2020;26(5):891-897
Joint health and treatment modalities in Nordic patients with moderate haemophilia A and B - The MoHem study
Maseide RJ; Berntorp E; Astermark J; Olsson A; Bruzelius M; Frisk T; Nummi V; Lassila R; Tjonnfjord GE; Holme PA
Article: EBIOMEDICINE. 2020;59:102956
Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study
Yuan S; Carter P; Bruzelius M; Vithayathil M; Kar S; Mason AM; Lin A; Burgess S; Larsson SC
Article: NUTRIENTS. 2019;11(12):E3001-3001
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study
Yuan S; Back M; Bruzelius M; Mason AM; Burgess S; Larsson S
Article: THROMBOSIS RESEARCH. 2019;178:34-40
Correlation of thromboelastography and thrombin generation assays in warfarin-treated patients
Schmidt DE; Chaireti R; Bruzelius M; Holmstrom M; Antovic J; Agren A
Article: THROMBOSIS RESEARCH. 2017;158:168-173
Thrombin activatable fibrinolysis inhibitor (TAFI) - A possible link between coagulation and complement activation in the antiphospholipid syndrome (APS)
Grosso G; Vikerfors A; Woodhams B; Adam M; Bremme K; Holmstrom M; Agren A; Eelde A; Bruzelius M; Svenungsson E; Antovic A
Article: THROMBOSIS AND HAEMOSTASIS. 2017;117(8):1528-1533
Whole blood ristocetin-activated platelet impedance aggregometry (Multiplate) for the rapid detection of Von Willebrand disease
Schmidt DE; Bruzelius M; Majeed A; Odeberg J; Holmstrom M; Agren A
Article: HAEMOPHILIA. 2017;23(2):309-318
A prospective diagnostic accuracy study evaluating rotational thromboelastometry and thromboelastography in 100 patients with von Willebrand disease
Schmidt DE; Majeed A; Bruzelius M; Odeberg J; Holmstrom M; Agren A
Article: THROMBOSIS RESEARCH. 2014;133(5):936-944
Studies of fibrin formation and fibrinolytic function in patients with the antiphospholipid syndrome
Vikerfors A; Svenungsson E; Agren A; Mobarrez F; Bremme K; Holmstrom M; Eelde A; Bruzelius M; Elgue G; Wallen H; Antovic A
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2012;32(8):2008-2016
A Genome-Wide Association Study Identifies KNG1 as a Genetic Determinant of Plasma Factor XI Level and Activated Partial Thromboplastin Time
Sabater-Lleal M; Martinez-Perez A; Buil A; Folkersen L; Carlos Souto J; Bruzelius M; Borrell M; Odeberg J; Silveira A; Eriksson P; Almasy L; Hamsten A; Manuel Soria J
Article: LUPUS. 2012;21(7):802-805
Studies of microparticles in patients with the antiphospholipid syndrome (APS)
Vikerfors A; Mobarrez F; Bremme K; Holmstrom M; Agren A; Eelde A; Bruzelius M; Antovic A; Wallen H; Svenungsson E
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All other publications

Letter: RHEUMATOLOGY. 2024;:keae353
Eculizumab and ravulizumab in the treatment of refractory antiphospholipid syndrome-a first case report
Antovic A; Faustini F; Karandyszowska N; Svenungsson E; Yilmaz EB; Bruzelius M; Gunnarsson I
Conference publication: HAEMOPHILIA. 2024;30:23-24
Efficacy and safety of concizumab prophylaxis in haemophilia A or B with and without inhibitors: 56-week cut-off results of the phase 3 explorer7 and explorer8 studies
Windyga J; Apte S; Astermark J; Bruzelius M; Castaman G; Eichler H; Hampton K; Hansen T; Knoebl P; Lebreton A; Linari S; Lyu CJ; Mathias M; Nielsen ARH; Poulsen LH; Trakymiene SS; Tran H; Zaw JJT; d'Oiron R
Preprint: MEDRXIV. 2021
Modelling of time-to-events in an ambispective study: illustration with the analysis of ABO blood groups on venous thrombosis recurrence
Munsch G; Goumidi L; van Hylckama Vlieg A; Ibrahim-Kosta M; Bruzelius M; Deleuze J-F; Rosendaal FR; Jacqmin-Gadda H; Morange P-E; Trégouët D-A
Book chapter: COMPUTATIONAL METHODS IN SYSTEMS BIOLOGY: LECTURE NOTES IN COMPUTER SCIENCE. 2021;p. 108-121
Explainable Artificial Neural Network for Recurrent Venous Thromboembolism Based on Plasma Proteomics
Razzaq M; Goumidi L; Iglesias M-J; Munsch G; Bruzelius M; Ibrahim-Kosta M; Butler L; Odeberg J; Morange P-E; Tregouet DA
Thesis / dissertation: 2015
Exploration of novel mechanisms and biomarkers for venous thromboembolism : a genetics and proteomics study
Bruzelius, Maria
Book chapter: ESSENTIAL GUIDE TO BLOOD COAGULATION. 2013;p. 56-61
Critical bleeding
Bruzelius M; Ågren A; Johnsson H
Letter: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2012;10(8):1693-1695
Lack of association of non-synonymous FUT2 and ALPL polymorphisms with venous thrombosis
Tregouet D-A; Sabater-Lleal M; Bruzelius M; Emmerich J; Amouyel P; Dartigues J-F; Kieler H; Morange P-E

Grants

Increased risk for thrombotic complications in patients with rheumatic diseases -from register data to individual patient and biomarkers
Stockholm County Council and Karolinska Institutet (ALF)
1 January 2024 - 31 December 2025

Employments

Affiliated To Research, K2 Department of Medicine, Solna, Karolinska Institutet, 2023-
Clinical Post Doctor, Karolinska Instutet/Region Stockholm, 2018-2021

Degrees and Education

Docent, Associated Professor, Internal Medicine, Karolinska Institutet, 2023
Doctor of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2015
Specialist in Coagulation and bleeding disorders, National Board of Health and Welfare, 2009
Specialist in Internal Medicine, National Board of Health and Welfare, 2006
Doctor of Medicine, Lund University, 1998

Supervisor

Natali Karandyszowska, Diagnostic and therapeutic challenges in patients with antiphospholipid syndrome, 2021
Emma Bendz, Pulmonary embolism as the cause of out of hospital cardiac arrest in women - A Swedish population-based register study, 2021
Shuai Yuan, Modifiable Risk Factors, Blood Proteins and Venous Thromboembolism, https://openarchive.ki.se/xmlui/handle/10616/48888, 2020
Ann Sjöström, Severe COVID-19 and routine biomarker pattern, http://hdl.handle.net/10616/48787, 2019

Thesis evaluation

Fridtjof Balteskard Rinde, Opponent, University of Tromsø, D-dimer for diagnosis and risk assessment first and recurrent venous Thromboembolism, https://hdl.handle.net/10037/29270, 2023
Joakim Knutsen Sejrup, Opponent, University of Tromsø, Risk Factors and Triggers of Venous Thromboembolism in Patients with Myocardial Infarction, https://hdl.handle.net/10037/25377, 2022

Selected publications

Articles

All other publications

Grants

Employments

Degrees and Education

Supervisor

Thesis evaluation

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