Maria Gierisch

Maria Gierisch

Research Specialist
Visiting address: Solnavägen 9, 17165 Stockholm
Postal address: C5 Cell- och molekylärbiologi, C5 CMB Dantuma, 171 77 Stockholm
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About me

  • My scientific interest centers all around protein degradation by the ubiquitin-proteasome system, both in health and disease. I studied Molecular Medicine at the University Hospital Charite in Berlin, Germany, and investigated in my master dissertation how cullin-ring ligase cycles are regulated , both under steady-state conditions and during the process of adipogenesis. I then moved to Switzerland and graduated from the Children's Hospital/ University of Zurich in Cancer Biology. During my time there, I investigated targeted protein degradation of oncogenic fusion protein in pediatric sarcoma. To further focus in more detail on mechanism of targeted proteasomal degradation, I joined the lab of Nico Dantuma here at the Institute for Cell and Molecular Biology at Karolinska Institute to investigate mechanism and trageted potential of proteasomal degradation in neurological diseases.

Research

  • Protein degradation by the ubiquitin-proteasome system is a highly regulated process and the many layers of its regulation are both challenges and potential in diseases such as cancer, neurological and neurodevelopmental disorders. In my research line, I am focussing on targeted protein degradation in various diseases. Enhanced clearance of proteins by the ubiquitin-proteasome system shows high chances to develop new therapeutic strategies. Emerging fields are targeting driver oncogenic proteins in cancer or aggregation-prone proteins in neurological diseases.

Teaching

  • I am regularly supervising master and Erasmus students in both laboratory and theoretical work.

Articles

All other publications

Employments

  • Research Specialist, Department of Cell and Molecular Biology, Karolinska Institutet, 2024-
  • Postdoctoral Researcher, Department of Cell and Molecular Biology, Karolinska Institutet, 2017-
  • PhD student, University Children's Hospital Zurich, 2011-2016

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