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About me

I received my B.Sc. degree in Molecular Biology and Genetics from Dimokritus University of Thrace (Greece - 2005). I subsequently received a Ph.D. in Medical Sciences from B.S.R.C Alexander Fleming (Greece - 2009) with special focus on post-transcriptional modifications and their role in hematopoietic development and colon cancer. In 2010 I had 1 year interruption in research due to my compulsory military service where I specialized as Microbiologist Assistant in the microbiology laboratory of Military Hospital for Special Diseases (414; Athens, Greece). I then joined the group of Professor Eva Hellström-Lindberg and Professor Sten-Eirik Jacobsen at Karoliska Institute (Sweden – 2011) as post-doctorate researcher to focus my research on the hematopoietic and MDS (myelodysplastic syndromes) cancer stem cells. From October 2017, I am an Assistant Professor and research associate for Professor Eva Hellström-Lindberg at Center for Regenerative Medicine and Hematology (HERM), Department of Medicine Huddinge, Karolinska Institutet. Overall, I am specialized in molecular biology, RNA  and post-transcriptional field, in HSC and leukemic/cancer stem cell biology, various molecular biology/genetics and sequencing platforms as well as multi-color flow cytometry sorting.

Education

2005, B.Sc. in Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece 

2009, Ph.D. in Medicine at University of Ioannina and Biomedical Sciences Research Center Alexander Fleming, Greece

2011-2017, Postdoctoral researcher, HERM, Department of Medicine Huddinge, Karolinska Institutet, Sweden

Research description

My research focus is on malignant hematopoietic stem cell (HSC) functions and MDS stem cells. The overreaching aim is to characterize the cellular and molecular heterogeneity but also the RNA usage within MDS stem cells. The vision is to explore novel solutions and tools to treat the disease in its origin by understanding and manipulating the RNA dynamics of MDS stem cells.

Academic honours, awards and prizes

2018, Research Grant awarded from Åke Olsson Foundation for Hematological Research (Sweden)

Publications

Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells
Guzzi N, Cieśla M, Ngoc Pct, Lang S, Arora S, Dimitriou M, et al
Cell 2018;173(5):1204-1216.e26

Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm
Xiao P, Dolinska M, Sandhow L, Kondo M, Johansson As, Bouderlique T, et al
Blood advances 2018;2(5):534-548

Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations
Scharenberg C, Giai V, Pellagatti A, Saft L, Dimitriou M, Jansson M, et al
Haematologica 2017;102(3):498-508

SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells
Mortera-blanco T, Dimitriou M, Woll Ps, Karimi M, Elvarsdottir E, Conte S, et al
Blood 2017;130(7):881-890

Mutations in histone modulators are associated with prolonged survival during azacitidine therapy
Tobiasson M, Mclornan Dp, Karimi M, Dimitriou M, Jansson M, Ben Azenkoud A, et al
Oncotarget 2016;7(16):22103-15

Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality
Dimitriou M, Woll Ps, Mortera-blanco T, Karimi M, Wedge Dc, Doolittle H, et al
Oncotarget 2016;7(45):72685-72698

Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts
Conte S, Katayama S, Vesterlund L, Karimi M, Dimitriou M, Jansson M, et al
British journal of haematology 2015;171(4):478-90

High-throughput mutational screening adds clinically important information in myelodysplastic syndromes and secondary or therapy-related acute myeloid leukemia
Karimi M, Nilsson C, Dimitriou M, Jansson M, Matsson H, Unneberg P, et al
Haematologica 2015;100(6):e223-5

Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis
Yiakouvaki A, Dimitriou M, Karakasiliotis I, Eftychi C, Theocharis S, Kontoyiannis Dl
The Journal of clinical investigation 2012;122(1):48-61

Post-transcriptional regulators in inflammation: exploring new avenues in biological therapeutics
Katsanou V, Dimitriou M, Kontoyiannis Dl
Ernst Schering Foundation symposium proceedings 2006;(4):37-57