Manuel Zeitelhofer

Publications
CV
Public outreach and news

Articles

Article: NATURE COMMUNICATIONS. 2024;15(1):383
The aging mouse CNS is protected by an autophagy-dependent microglia population promoted by IL-34
Berglund R; Cheng Y; Piket E; Adzemovic MZ; Zeitelhofer M; Olsson T; Guerreiro-Cacais AO; Jagodic M
Article: BLOOD. 2022;140(4):388-400
Thrombolytic tPA-induced hemorrhagic transformation of ischemic stroke is mediated by PKCβ phosphorylation of occludin
Goncalves A; Su EJ; Muthusamy A; Zeitelhofer M; Torrente D; Nilsson I; Protzmann J; Fredriksson L; Eriksson U; Antonetti DA; Lawrence DA
Article: SCIENCE ADVANCES. 2022;8(17):eabn1823
Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis
Bronge M; Hogelin KA; Thomas OG; Ruhrmann S; Carvalho-Queiroz C; Nilsson OB; Kaiser A; Zeitelhofer M; Holmgren E; Linnerbauer M; Adzemovic MZ; Hellstrom C; Jelcic I; Liu H; Nilsson P; Hillert J; Brundin L; Fink K; Kockum I; Tengvall K; Martin R; Tegel H; Graslund T; Al Nimer F; Guerreiro-Cacais AO; Khademi M; Gafvelin G; Olsson T; Gronlund H
Article: FRONTIERS IN PUBLIC HEALTH. 2022;10:827645
A Call to Use the Multicomponent Exercise Tai Chi to Improve Recovery From COVID-19 and Long COVID
Castro JP; Kierkegaard M; Zeitelhofer M
Journal article: JOURNAL OF VISUALIZED EXPERIMENTS. 2021;(175)
Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
Üçal M; Haindl MT; Adzemovic MZ; Zeitelhofer M; Schaefer U; Fazekas F; Hochmeister S
Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2021;(175)
Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
Ucal M; Haindl MT; Adzemovic MZ; Zeitelhofer M; Schaefer U; Fazekas F; Hochmeister S
Article: SCIENTIFIC REPORTS. 2020;10(1):22383
Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood-brain barrier
Zeitelhofer M; Adzemovic MZ; Moessinger C; Stefanitsch C; Strell C; Muhl L; Brundin L; Fredriksson L; Olsson T; Eriksson U; Nilsson I
Article: SCIENCE IMMUNOLOGY. 2020;5(52):eabb5077
Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation.
Berglund R; Guerreiro-Cacais AO; Adzemovic MZ; Zeitelhofer M; Lund H; Ewing E; Ruhrmann S; Nutma E; Parsa R; Thessen-Hedreul M; Amor S; Harris RA; Olsson T; Jagodic M
Article: EMBO REPORTS. 2020;21(7):e49343
VEGF-B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol content
Moessinger C; Nilsson I; Muhl L; Zeitelhofer M; Heller Sahlgren B; Skogsberg J; Eriksson U
Article: FRONTIERS IN NEUROLOGY. 2020;11:600401
Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta)
Hochmeister S; Aeinehband S; Dorris C; Berglund R; Haindl MT; Velikic V; Gustafsson SA; Olsson T; Piehl F; Jagodic M; Zeitelhofer M; Adzemovic MZ
Article: PLOS ONE. 2018;13(7):e0200649
Preclinical toxicological assessment of a novel monoclonal antibody targeting human platelet-derived growth factor CC (PDGF-CC) in PDGF-CC^hum mice
Zeitelhofer M; Li H; Adzemovic MZ; Nilsson I; Muhl L; Scott AM; Eriksson U
Article: PLOS ONE. 2018;13(7):e0201089
Development of monoclonal anti-PDGF-CC antibodies as tools for investigating human tissue expression and for blocking PDGF-CC induced PDGFRα signalling in vivo
Li H; Zeitelhofer M; Nilsson I; Liu X; Allan L; Gloria B; Perani A; Murone C; Catimel B; Neville AM; Scott FE; Scott AM; Eriksson U
Article: EXPERIMENTAL NEUROLOGY. 2017;294:32-44
Widespread cortical demyelination of both hemispheres can be induced by injection of pro-inflammatory cytokines via an implanted catheter in the cortex of MOG-immunized rats
Uecal M; Haindl MT; Adzemovic MZ; Strasser J; Theisl L; Zeitelhofer M; Kraitsy K; Ropele S; Schaefer U; Fazekas F; Hochmeister S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(9):E1678-E1687
Functional genomics analysis of vitamin D effects on CD4+T cells in vivo in experimental autoimmune encephalomyelitis
Zeitelhofer M; Adzemovic MZ; Gomez-Cabrero D; Bergman P; Hochmeister S; N'diaye M; Paulson A; Ruhrmann S; Almgren M; Tegner JN; Ekstrom TJ; Guerreiro-Cacais AO; Jagodic M
Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2016;(117)
Immunohistochemical Analysis in the Rat Central Nervous System and Peripheral Lymph Node Tissue Sections
Adzemovic MZ; Zeitelhofer M; Leisser M; Koeck U; Kury A; Olsson T
Article: CELL AND TISSUE RESEARCH. 2016;365(1):51-63
Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney
Muhl L; Moessinger C; Adzemovic MZ; Dijkstra MH; Nilsson I; Zeitelhofer M; Hagberg CE; Huusko J; Falkevall A; Yla-Herttuala S; Eriksson U
Article: ACTA NEUROPATHOLOGICA. 2016;131(3):453-464
Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration
Lewandowski SA; Nilsson I; Fredriksson L; Lonnerberg P; Muhl L; Zeitelhofer M; Adzemovic MZ; Nichterwitz S; Lawrence DA; Hedlund E; Eriksson U
Article: PLOS ONE. 2016;11(5):e0154797
Lipocalin-2 as an Infection-Related Biomarker to Predict Clinical Outcome in Ischemic Stroke
Hochmeister S; Engel O; Adzemovic MZ; Pekar T; Kendlbacher P; Zeitelhofer M; Haindl M; Meisel A; Fazekas F; Seifert-Held T
Journal article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2016;108(3)
Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells (vol 107, djv209, 2015)
Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; Garcia-Ibanez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Ostman A; Bergh J; Poljakovic M; Genove G
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2015;107(10):djv209
Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells
Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; Garcia-Ibanez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Ostman A; Bergh J; Poljakovic M; Genove G
Article: GENES AND IMMUNITY. 2014;15(7):457-465
The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation
Laaksonen H; Guerreiro-Cacais AO; Adzemovic MZ; Parsa R; Zeitelhofer M; Jagodic M; Olsson T
Article: EXPERIMENTAL NEUROLOGY. 2013;249:39-48
Efficacy of vitamin D in treating multiple sclerosis-like neuroinflammation depends on developmental stage
Adzemovic MZ; Zeitelhofer M; Hochmeister S; Gustafsson SA; Jagodic M
Article: PLOS ONE. 2013;8(2):e56586
Imatinib Ameliorates Neuroinflammation in a Rat Model of Multiple Sclerosis by Enhancing Blood-Brain Barrier Integrity and by Modulating the Peripheral Immune Response
Adzemovic MZ; Zeitelhofer M; Eriksson U; Olsson T; Nilsson I
Article: EPIGENETICS. 2012;7(6):585-593
Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity
Esteki-Zadeh A; Karimi M; Straat K; Ammerpohl O; Zeitelhofer M; Jagodic M; Mehrab-Mohseni M; Sjoholm L; Rahbar A; Soderberg-Naucler C; Ekstrom TJ
Article: PLOS ONE. 2012;7(7):e39794
Expression of Ccl11 Associates with Immune Response Modulation and Protection against Neuroinflammation in Rats
Adzemovic MZ; Ockinger J; Zeitelhofer M; Hochmeister S; Beyeen AD; Paulson A; Gillett A; Hedreul MT; Covacu R; Lassmann H; Olsson T; Jagodic M
Article: CURRENT PROTOCOLS IN NEUROSCIENCE. 2009;Chapter 4:Unit4.32-4.32.21
Transfection of cultured primary neurons via nucleofection.
Zeitelhofer M; Vessey JP; Thomas S; Kiebler M; Dahm R
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2009;87(1):289-300
High-efficiency transfection of short hairpin RNAs-encoding plasmids into primary hippocampal neurons.
Zeitelhofer M; Karra D; Vessey JP; Jaskic E; Macchi P; Thomas S; Riefler J; Kiebler M; Dahm R
Article: AMERICAN JOURNAL OF PATHOLOGY. 2008;173(6):1669-1681
After injection into the striatum, in vitro-differentiated microglia- and bone marrow-derived dendritic cells can leave the central nervous system via the blood stream.
Hochmeister S; Zeitelhofer M; Bauer J; Nicolussi E-M; Fischer M-T; Heinke B; Selzer E; Lassmann H; Bradl M
Article: JOURNAL OF NEUROSCIENCE. 2008;28(30):7555-7562
Dynamic interaction between P-bodies and transport ribonucleoprotein particles in dendrites of mature hippocampal neurons.
Zeitelhofer M; Karra D; Macchi P; Tolino M; Thomas S; Schwarz M; Kiebler M; Dahm R
Article: NEUROBIOLOGY OF DISEASE. 2007;28(3):261-275
Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system.
Grundtner R; Dornmair K; Dahm R; Flügel A; Kawakami N; Zeitelhofer M; Schoderboeck L; Nosov M; Selzer E; Willheim M; Kiebler M; Wekerle H; Lassmann H; Bradl M
Article: NATURE PROTOCOLS. 2007;2(7):1692-1704
High-efficiency transfection of mammalian neurons via nucleofection.
Zeitelhofer M; Vessey JP; Xie Y; Tübing F; Thomas S; Kiebler M; Dahm R
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Editorial comment: ANNALS OF PALLIATIVE MEDICINE. 2023;12(2):265-268
Understanding others is knowledge, understanding oneself is enlightenment.
Castro JP; Zeitelhofer M
Editorial comment: FRONTIERS IN NEUROLOGY. 2022;13:925216
Editorial: Neuropathology of Autoimmune Inflammatory Demyelination Disorders
Zeitelhofer M; Hochmeister S; Adzemovic MZ
Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S78
Inhibition of VEGF-B signalling prevents non-alcoholic fatty liver disease development and progression
Falkevall A; Mehlem A; Folestad E; Zeitelhofer M; Scotney P; Eriksson U
Preprint: BIORXIV. 2021
Reduced myofibroblast transdifferentiation and fibrotic scarring in ischemic stroke after imatinib treatment
Zeitelhofer M; Stefanitsch C; Protzmann J; Torrente D; Adzemovic MZ; Lewandowski SA; Muhl L; Eriksson U; Nilsson I; Su EJ; Lawrence DA; Fredriksson L
Corrigendum: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2016;108(3):djv434
Erratum.
Corrigendum: PLOS ONE. 2015;10(4):e0123142
Imatinib Ameliorates Neuroinflammation in a Rat Model of Multiple Sclerosis by Enhancing Blood-Brain Barrier Integrity and by Modulating the Peripheral Immune Response (vol 8, e56586, 2013)
Adzemovic ZM; Zeitelhofer M; Eriksson U; Olsson T; Nilsson I
Review: RNA BIOLOGY. 2008;5(4):244-248
Perplexing bodies: The putative roles of P-bodies in neurons.
Zeitelhofer M; Macchi P; Dahm R
Review: METHODS IN CELL BIOLOGY. 2008;85:293-327
Visualizing mRNA localization and local protein translation in neurons.
Dahm R; Zeitelhofer M; Götze B; Kiebler MA; Macchi P

Employments

Teacher, MBB, Karolinska Institute, 2023-
Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2018-2025

Degrees and Education

Docent, Karolinska Institutet, 2023

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