Lalit Kumar Parameswaran Grace

Lalit Kumar Parameswaran Grace

Principal Researcher | Docent
Visiting address: Forskningsmottagning WHO, QB84 Karolinska vägen 37 A, 17176 Stockholm
Postal address: K6 Kvinnors och barns hälsa, K6 NOGRH Gemzell Danielsson, 171 77 Stockholm
Part of:

About me

  • I am docent /Associate Professor in Experimental Reproductive Medicine and
    working as Principal Researcher in the Department of Women's and Children's
    Health at Karolinska Institute. I lead Experimental Research team
    (https://ki.se/en/kbh/experimental-research [1]) in understanding the
    molecular and cellular mechanism involved in different Gynaecological
    conditions. It's my privilege to be part of a larger group with Clinicians,
    researchers working in basic science and global reproductive health, with
    the focus on Translational Research in Reproductive Health/ Reproductive
    Medicine
    (https://ki.se/en/kbh/research-in-reproductive-health-reproductive-medicine-0
    [2]).
    [1] https://ki.se/en/kbh/experimental-research
    [2] https://ki.se/en/kbh/research-in-reproductive-health-reproductive-medicine-0

Research

  • *Main areas of Research*
    * Endometrial regeneration and endometrial receptivity aiming at managing
    infertility
    * Identifying good quality embryos (GQE) for assisted reproductive
    treatment (ART) based on molecular profile of embryo spent media
    * Develop non-invasive, molecular based method to identify receptive
    endometrium and good quality of embryos for clinical use in ART
    * Endometriosis and endometriosis associated ovarian cancer (EAOC)
    * Effect of SARS-CoV-19 on placental gene expression
    We use 2D and 3D cell culture, single cell RNA sequencing, smartseq2 /
    smartseq3, spatial transcriptomics and bioinformatic tools to understand the
    molecular profile and mechanisms involved in different physiological and
    pathophysiological conditions in female fertility.
    *Few publications*
    1: von Grothusen C, Frisendahl C, Modhukur V, Lalitkumar PG, Peters M,
    Faridani
    OR, Salumets A, Boggavarapu NR, Gemzell-Danielsson K. Uterine fluid microRNAs
    are dysregulated in women with recurrent implantation failure. Hum Reprod.
    2022
    Apr 1
  • 37(4):734-746. doi: 10.1093/humrep/deac019. PMID: 35147192
  • PMCID:
    PMC8971651.
    2: Ponandai-Srinivasan S, Saare M, Boggavarapu NR, Frisendahl C, Ehrström S,
    Riethmüller C, García-Uribe PA, Rettkowski J, Iyengar A, Salumets A,
    Lalitkumar
    PGL, Götte M, Gemzell-Danielsson K. Syndecan-1 modulates the invasive
    potential
    of endometrioma via TGF-β signalling in a subgroup of women with
    endometriosis.
    Hum Reprod. 2020 Oct 1
  • 35(10):2280-2293. doi: 10.1093/humrep/deaa164. PMID:
    32897364.
    3: Sardana P, Banker J, Gupta R, Kotdawala A, Lalitkumar PGL, Banker M. The
    Influence of Delayed Blastocyst Development on the Outcome of Frozen-Thawed
    Transfer of Euploid and Untested Embryos. J Hum Reprod Sci. 2020 Apr-
    Jun
  • 13(2):155-161. doi: 10.4103/jhrs.JHRS_115_19. Epub 2020 Jul 9. PMID:
    32792766
  • PMCID: PMC7394094.
    4: Kasvandik S, Saarma M, Kaart T, Rooda I, Velthut-Meikas A, Ehrenberg A,
    Gemzell K, Lalitkumar PG, Salumets A, Peters M. Uterine Fluid Proteins for
    Minimally Invasive Assessment of Endometrial Receptivity. J Clin Endocrinol
    Metab. 2020 Jan 1
  • 105(1):dgz019. doi: 10.1210/clinem/dgz019. PMID: 31512719.
    5: Kotdawala AP, Mir P, Herrero J, Khajuria R, Lalitkumar PGL, Banker MR.
    Embryonic Aneuploidy after Preimplantation Genetic Screening: Age- and
    Indication-Matched Comparative Study between Indian and Spanish Population. J
    Hum Reprod Sci. 2019 Apr-Jun
  • 12(2):141-149. doi: 10.4103/jhrs.JHRS_109_18.
    PMID:
    31293329
  • PMCID: PMC6594127.
    6: Banker M, Arora P, Banker J, Benani H, Shah S, Lalitkumar PGL. Prevalence
    of
    structural birth defects in IVF-ICSI pregnancies resulting from autologous
    and
    donor oocytes in Indian sub-continent: Results from 2444 births. Acta Obstet
    Gynecol Scand. 2019 Jun
  • 98(6):715-721. doi: 10.1111/aogs.13541. Epub 2019 Feb
    20. PMID: 30663773.
    7: Ponandai-Srinivasan S, Lalitkumar PG, Garcia L, Varghese SJ, Carlson JW,
    Gemzell-Danielsson K, Floter Radestad A. Mifepristone mediates anti-
    proliferative effect on ovarian mesenchymal stem/stromal cells from female
    BRCA1-/2- carriers. Acta Obstet Gynecol Scand. 2019
    Feb
  • 98(2):250-261. doi: 10.1111/aogs.13485. Epub 2018 Nov 15. PMID: 30325501.
    8: von Grothusen C, Lalitkumar PG, Ruiz-Alonso M, Boggavarapu NR, Navarro R,
    Miravet-Valenciano J, Gemzell-Danielsson K, Simon C. Effect of mifepristone
    on
    the transcriptomic signature of endometrial receptivity. Hum Reprod. 2018 Oct
    1
  • 33(10):1889-1897. doi: 10.1093/humrep/dey272. PMID: 30137464.
    9: Ponandai-Srinivasan S, Andersson KL, Nister M, Saare M, Hassan HA,
    Varghese
    SJ, Peters M, Salumets A, Gemzell-Danielsson K, Lalitkumar PGL. Aberrant
    expression of genes associated with stemness and cancer in endometria and
    endometrioma in a subset of women with endometriosis. Hum Reprod. 2018 Oct
    1
  • 33(10):1924-1938. doi: 10.1093/humrep/dey241. PMID: 30020448.
    10: Altmäe S, Koel M, Võsa U, Adler P, Suhorutšenko M, Laisk-Podar T,
    Kukushkina
    V, Saare M, Velthut-Meikas A, Krjutškov K, Aghajanova L, Lalitkumar PG,
    Gemzell-
    Danielsson K, Giudice L, Simón C, Salumets A. Meta-signature of human
    endometrial receptivity: a meta-analysis and validation study of
    transcriptomic
    biomarkers. Sci Rep. 2017 Aug 30
  • 7(1):10077. doi: 10.1038/s41598-017-10098-3.
    PMID: 28855728
  • PMCID: PMC5577343.
    11: Boggavarapu NR, Lalitkumar S, Joshua V, Kasvandik S, Salumets A,
    Lalitkumar
    PG, Gemzell-Danielsson K. Compartmentalized gene expression profiling of
    receptive endometrium reveals progesterone regulated ENPP3 is differentially
    expressed and secreted in glycosylated form. Sci Rep. 2016 Sep 26
  • 6:33811.
    doi:
    10.1038/srep33811. PMID: 27665743
  • PMCID: PMC5036034.

Articles

All other publications

Employments

  • Principal Researcher, Department of Women's and Children's Health, Karolinska Institutet, 2022-

Degrees and Education

  • Docent, Karolinska Institutet, 2021

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