The potential of IGF-1 and TGFbeta1 for promoting "adult" articular cartilage repair: an in vitro study.
Tissue Eng Part A 2008 Jul;14(7):1251-61
Oral Mucosal Progenitor Cells. P. Stephens and Davies LC Stem Cell Biology and Tissue Engineering in Dental Sciences. Elsevier Inc., 2015. Edited by:Ajay Vishwakarma, Paul Sharpe, Shi Songtao and Murugan Ramalingam
Immunological Modulation of Stem Cells. LC Davies and Le Blanc K Tissue Engineering and Reparative Dentistry: Current Strategies. Wiley Blackwell, 2017. Edited by: Rachel J. Waddington and Alastair J. Sloan
BSc (Hons) Applied and Human Biology, Aston University, Birmingham UK (1998-2001)
PhD Biochemistry, Cardiff University, Cardiff UK (2002-2006)
Fellowship of The Higher Education Academy, UK (2014)
My academic career has centred on the fields of stem cell biology and tissue engineering with respect to wound healing and the role of endogenous stem cells. My postdoctoral research focussed on stem cell immunology and the identification of a novel progenitor cell (PC) population within the oral mucosa lamina propria suitable for allogeneic tissue engineering. This work has stemmed from my interest in the preferential healing seen within the oral mucosa compared to the skin. Within the oral mucosa rapid healing is seen within no/minimal scar formation upon wounding. My recent work has focussed on characterising this newly discovered PC population, which may contribute to this preferential healing response. In particular this research has focussed on determining the neural-crest origin of this cell population, and successfully differentiating the cells down mesenchymal, neuronal and glial lineages with a view to future therapeutic applications (Davies et al., 2010). My continuing research focuses on the mechanisms by which oral mucosal PCs are able to both modulate the immune response (Davies et al., 2012) and regulate the oral microflora through the constitutive secretion of antibacterial factors.
Academic honours, awards and prizes
Senior Colgate Prize for research at the British Society of Dental Research/Nordisk Odontologisk Frening conference, 2007
International Association for Dental Research (IADR) Travel Award, 2008