Linda Marklund

Linda Marklund

Affiliated to Research | Docent
Visiting address: ,
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLINTEC Öron näs o halssjukd, 141 52 Huddinge

About me

  • Number of Completed supervisions as principal supervisor: 2


    Ongoing supervisors as principal supervisor: 7


    Number of Completed supervisions as co-supervisor: 3


    Ongoing supervisors as co-supervisor: 4


    My research focuses on head and neck cancer, with particular emphasis on HPV-associated oropharyngeal cancer. Through translational and clinical studies, I investigate biomarkers, tumour biology, diagnostic strategies, and treatment outcomes to enable more precise and individualized care. The overarching goal is to improve survival while reducing treatment-related morbidity and preserving quality of life for patients with head and neck cancer

Research

  • My research focuses on improving treatment outcomes and quality of life for patients with head and neck cancer. Through translational, clinical, and population-based studies, I investigate tumour biology, HPV-associated cancers, biomarkers, diagnostic pathways, and treatment outcomes to support more precise and personalized care.


    A major focus of my work is the development and implementation of minimally invasive diagnostic and treatment strategies that can reduce unnecessary treatment-related morbidity while maintaining excellent oncological outcomes. In particular, I have a longstanding interest in sentinel lymph node biopsy and its role in individualizing treatment decisions. Building on its established use in early-stage oral cancer, my research explores how sentinel node techniques can be extended to additional tumour groups and more advanced disease settings, with the aim of tailoring treatment intensity to each patient's risk profile.


    By integrating clinical research with molecular and pathological insights, I seek to improve risk stratification, optimize treatment selection, and identify patients who may benefit from de-escalated or intensified therapies. The overarching goal is to maximize cure rates while preserving speech, swallowing, function, and long-term quality of life for patients with head and neck cancer.

Articles

All other publications

Grants

  • Swedish Research Council
    1 January 2025 - 31 December 2028
    Background: Despite aggressive surgery coupled with radiation/chemoradiation, the 5-year overall survival rate of oral squamous cell carcinoma (OSCC) has stagnated at 50% for decades. While cancer immunotherapy holds promise, OSCC patients typically experience only modest enhancements compared to other cancer types. Advancing immunotherapies requires a deeper understanding of cancer immunity mechanisms. Insights into neutrophil immunity, with their potential to influence pro- and anti-cancer responses, particularly within tumor-draining lymph nodes (TDLNs), remain limited.Goal: To dissect the immunomodulatory roles of neutrophils in TDLNs across various stages of OSCC and characterize their potential as facilitators of metastasis within these nodes. The project has 4 aims that synergistically build upon one another.Methods: Several techniques, including single-cell sequencing, flow cytometry, and spatial transcriptomics, will be deployed to characterize fresh samples of OSCC tumors, TDLNs, and non-TDLNs, alongside lymph nodes from non-cancer patients. Boyden chambers, in conjunction with an orthotopic xenograft model, will be utilized to investigate the involvement of tumor-associated neutrophils in cancer dissemination to TDLNs.Clinical Implications: A successful outcome has the potential to catalyze the development of novel strategies aimed at bolstering immune responses against cancer, thereby potentially enhancing the effectiveness of existing cancer immunotherapies.

Employments

  • Affiliated to Research, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2026-2029

Degrees and Education

  • Docent, Karolinska Institutet, 2020

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