Linda Marklund

Publications
CV
Public outreach and news

Articles

Article: EUROPEAN JOURNAL OF CANCER. 2024;211:114329
TNM 8 staging system beyond p16: Double HPV/p16 status is superior to p16 alone in predicting outcome in oropharyngeal squamous cell carcinoma
von Buchwald C; Jakobsen KK; Carlander A-LF; Tous S; Gronhoj C; Rasmussen JH; Brooks J; Taberna M; Mena M; Morey F; Bruni L; Batis N; Brakenhoff RH; Leemans CR; de Jong RJB; Klussmann JP; Wuerdemann N; Wagner S; Dalianis T; Marklund L; Mirghani H; Schache A; James JA; Huang SH; O'Sullivan B; Nankivell P; Broglie MA; Hoffmann M; Quabius ES; Anderson LA; Craig SG; Alemany L; Mehanna H
Article: ORAL ONCOLOGY. 2024;151:106749
Human papillomavirus (HPV) load is higher in HPVDNA/p16 positive than in HPVDNA positive/p16 negative oropharyngeal squamous cell carcinoma but does not differ significantly between various subsites or correlate to survival
Zupancic M; Kostopoulou ON; Holzhauser S; Lukoseviciute M; Jylha C; Marklund L; Nasman A; Sivars L; Dalianis T
Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1455426
Prognostic value of T regulatory cells and immune checkpoints expression in tumor-draining lymph nodes for oral squamous cell carcinoma
Piersiala K; Hjalmarsson E; Lagebro V; da Silva PFN; Bark R; Elliot A; Marklund L; Margolin G; Georen SK; Cardell L-O
Article: INTERNATIONAL JOURNAL OF CANCER. 2023;153(4):854-866
Regulatory B cells producing IL-10 are increased in human tumor draining lymph nodes
Piersiala K; Hjalmarsson E; da Silva PFN; Lagebro V; Kolev A; Starkhammar M; Elliot A; Marklund L; Munck-Wikland E; Margolin G; Georen SK; Cardell L-O
Article: CANCER MEDICINE. 2023;12(11):12524-12534
Sentinel node-assisted neck dissection in advanced oral squamous cell carcinoma-A new protocol for staging and treatment.
Bark R; Kolev A; Elliot A; Piersiala K; Näsman A; Grybäck P; Georén SK; Wendt M; Cardell LO; Margolin G; Marklund L
Article: LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY. 2023;8(2):441-449
Treatment and outcome among patients with laryngeal squamous cell carcinoma in Stockholm-A population-based study
Blomkvist R; Marklund L; Hammarstedt-Nordenvall L; Gottlieb-Vedi E; Maekitie A; Palmgren B
Article: CANCERS. 2023;15(7):1954
High Levels of FGF11 Correlate with Poor Survival in Patients with Human Papillomavirus (HPV)-Positive Oropharyngeal Squamous Cell Carcinoma
de Flon CH; Haeggblom L; Holzhauser S; Kostopoulou ON; Zupancic M; Dalianis T; Munck-Wikland E; Marklund L; Nasman A
Article: THE LANCET ONCOLOGY. 2023;24(3):239-251
Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis
Mehanna H; Taberna M; von Buchwald C; Tous S; Brooks J; Mena M; Morey F; Gronhoj C; Rasmussen JH; Garset-Zamani M; Bruni L; Batis N; Brakenhoff RH; Leemans CR; Jong RJBD; Klussmann JP; Wuerdemann N; Wagner S; Dalianis T; Marklund L; Mirghani H; Schache A; James JA; Huang SH; O'Sullivan B; Nankivell P; Broglie MA; Hoffmann M; Quabius ES; Alemany L
Article: CANCERS. 2023;15(3):656
Accuracy of p16 IHC in Classifying HPV-Driven OPSCC in Different Populations
Gallus R; Nauta IH; Marklund L; Rizzo D; Crescio C; Mureddu L; Tropiano P; Delogu G; Bussu F
Article: TRANSLATIONAL ONCOLOGY. 2022;23:101469
Tumour-draining lymph nodes in head and neck cancer are characterized by accumulation of CTLA-4 and PD-1 expressing Treg cells
Piersiala K; da Silva PFN; Lagebro V; Kolev A; Starkhammar M; Elliot A; Marklund L; Munck-Wikland E; Margolin G; Georen SK; Cardell L-O
Article: VIRUSES. 2022;14(8):1693
Post-Treatment Neck Dissection of Tonsillar and Base of Tongue Squamous Cell Carcinoma in the Era of PET-CT, HPV, and p16
Landin D; Nasman A; Jara SJ; Hammarstedt-Nordenvall L; Munck-Wikland E; Dalianis T; Marklund L
Article: CANCERS. 2021;13(11):2553
Long-Term Survival and Recurrence in Oropharyngeal Squamous Cell Carcinoma in Relation to Subsites, HPV, and p16-Status
Wendt M; Hammarstedt-Nordenvall L; Zupancic M; Friesland S; Landin D; Munck-Wikland E; Dalianis T; Nasman A; Marklund L
Article: ACTA OTO-LARYNGOLOGICA. 2021;141(5):531-536
Sclerotherapy of ranulas with OK-432-a prospective, randomized, double-blinded placebo-controlled study
Wendt M; Papatziamos G; Munck-Wikland E; Marklund L
Article: ONCOLOGY LETTERS. 2021;21(4):277
Psoriasin expression is associated with survival in patients with human papillomavirus-positive base of tongue squamous cell carcinoma
Zupancic M; Haeggblom L; Landin D; Marklund L; Dalianis T; Nasman A
Article: CANCER SCIENCE. 2021;112(3):1048-1059
CD4⁺ and CD8⁺ T cells in sentinel nodes exhibit distinct pattern of PD-1, CD69, and HLA-DR expression compared to tumor tissue in oral squamous cell carcinoma
Piersiala K; da Silva PFN; Hjalmarsson E; Kolev A; Kagedal A; Starkhammar M; Elliot A; Marklund L; Margolin G; Munck-Wikland E; Georen SK; Cardell L-O
Article: SCIENTIFIC REPORTS. 2021;11(1):1782
Tumour inflammation signature and expression of S100A12 and HLA class I improve survival in HPV-negative hypopharyngeal cancer
Mints M; Landin D; Nasman A; Mirzaie L; Ursu RG; Zupancic M; Marklund L; Dalianis T; Munck-Wikland E; Ramqvist T
Article: ACTA OTO-LARYNGOLOGICA. 2021;141(1):89-94
The value of p16 and HPV DNA in non-tonsillar, non-base of tongue oropharyngeal cancer
Hammarstedt L; Holzhauser S; Zupancic M; Kapoulitsa F; Ursu RG; Ramqvist T; Haeggblom L; Nasman A; Dalianis T; Marklund L
Article: EUROPEAN JOURNAL OF CANCER. 2020;139:192-200
Survival of patients with oropharyngeal squamous cell carcinomas (OPSCC) in relation to TNM 8-Risk of incorrect downstaging of HPV-mediated non-tonsillar, non-base of tongue carcinomas
Marklund L; Holzhauser S; de Flon C; Zupancic M; Landin D; Kolev A; Haeggblom L; Munck-Wikland E; Hammarstedt-Nordenvall L; Dalianis T; Nasman A
Article: HEAD AND NECK. 2020;42(11):3206-3217
Immune related proteins and tumor infiltratingCD8+lymphocytes in hypopharyngeal cancer in relation to human papillomavirus (HPV) and clinical outcome
Landin D; Ahrlund-Richter A; Mirzaie L; Mints M; Nasman A; Kolev A; Marklund L; Dalianis T; Munck-Wikland E; Ramqvist T
Article: RHINOLOGY. 2020;58(1):74-79
Stathmin and EGFR correlates to HPV status and clinical outcome in sinonasal inverted papilloma
Elliot A; Nasman A; Westman M; Hammarstedt-Nordenvall L; Stjarne P; Marklund L
Article: ACTA OTO-LARYNGOLOGICA. 2019;139(11):1019-1023
Human papillomavirus and infiltration of CD8-and Foxp3-positive immune cells in sinonasal inverted papillomas
Elliot A; Nasman A; Westman M; Marklund L; Stjarne P; Hammarstedt-Nordenvall L
Article: HEAD AND NECK. 2019;41(6):1583-1590
Changes in incidence and prevalence of human papillomavirus in tonsillar and base of tongue cancer during 2000-2016 in the Stockholm region and Sweden
Haeggblom L; Attoff T; Yu J; Holzhauser S; Vlastos A; Mirzae L; Ahrlund-Richter A; Munck-Wikland E; Marklund L; Hammarstedt-Nordenvall L; Ye W; Ramqvist T; Nasman A; Dalianis T
Article: ACTA OTO-LARYNGOLOGICA. 2018;138(9):855-858
Human papillomavirus (HPV) is absent in branchial cleft cysts of the neck distinguishing them from HPV positive cystic metastasis
Sivars L; Landin D; Rizzo M; Haeggblom L; Bersani C; Munck-Wikland E; Nasman A; Dalianis T; Marklund L
Article: ANTICANCER RESEARCH. 2018;38(8):4683-4690
Overexpression of FGFR3 in HPV-positive Tonsillar and Base of Tongue Cancer Is Correlated to Outcome
Bersani C; Haeggblom L; Ursu RG; Giusca SE; Marklund L; Ramqvist T; Nasman A; Dalianis T
Article: BRITISH JOURNAL OF CANCER. 2018;118(12):1672-1681
Development and external validation of nomograms in oropharyngeal cancer patients with known HPV-DNA status: a European Multicentre Study (OroGrams)
Gronhoj C; Jensen DH; Dehlendorff C; Marklund L; Wagner S; Mehanna H; Munck-Wikland E; Ramqvist T; Nasman A; Wittekindt C; Wuerdemann N; Sharma SJ; Gattenloehner S; Kiss K; Andersen E; Spruce R; Batis N; Robinson M; Harrington K; Winter S; Jones TM; Klussmann JP; Dalianis T; Friborg J; von Buchwald C
Article: ACTA OTO-LARYNGOLOGICA. 2017;137(7):755-761
Regional recurrence in early stage I-II oral tongue cancer: a single institutional study and review of the literature
Kamali A; Gahm C; Palmgren B; Marklund L; Halle M; Hammarstedt-Nordenvall L
Article: HEAD AND NECK. 2017;39(3):419-426
Human papillomavirus DNA detection in fine-needle aspirates as indicator of human papillomavirus-positive oropharyngeal squamous cell carcinoma: A prospective study
Sivars L; Landin D; Haeggblom L; Tertipis N; Grun N; Bersani C; Marklund L; Ghaderi M; Nasman A; Ramqvist T; Nordfors C; Munck-Wikland E; Tani E; Dalianis T
Article: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2017;274(3):1445-1448
Incidence of IP and risk of malignant transformation in the Swedish population 1960-2010
Elliot A; Marklund L; Hakansson N; Song H; Ye W; Stjarne P; Hammarstedt-Nordenvall L
Article: ANTICANCER RESEARCH. 2017;37(2):665-673
Validation of Human Papillomavirus as a Favourable Prognostic Marker and Analysis of CD8⁺ Tumour-infiltrating Lymphocytes and Other Biomarkers in Cancer of Unknown Primary in the Head and Neck Region
Sivars L; Landin D; Grun N; Vlastos A; Marklund L; Nordemar S; Ramqvist T; Munck-Wikland E; Nasman A; Dalianis T
Article: EUROPEAN JOURNAL OF CANCER. 2015;51(12):1580-1587
A model for predicting clinical outcome in patients with human papillomavirus-positive tonsillar and base of tongue cancer
Tertipis N; Hammar U; Nasman A; Vlastos A; Nordfors C; Grun N; Ahrlund-Richter A; Sivars L; Haeggblom L; Marklund L; Hammarstedt-Nordenvall L; Chaturvedi AK; Munck-Wikland E; Ramqvist T; Bottai M; Dalianis T
Article: RHINOLOGY. 2015;53(1):75-80
Sinonasal malignancies in Sweden 1960-2010; a nationwide study of the Swedish population
Elliot A; Jangard M; Marklund L; Hakansson N; Dickman P; Hammarstedt-Nordenvall L; Stjarne P
Article: EUROPEAN JOURNAL OF CANCER. 2015;51(1):55-61
Incidence of human papillomavirus positive tonsillar and base of tongue carcinoma: A stabilisation of an epidemic of viral induced carcinoma?
Nasman A; Nordfors C; Holzhauser S; Vlastos A; Tertipis N; Hammar U; Hammarstedt-Nordenvall L; Marklund L; Munck-Wikland E; Ramqvist T; Bottai M; Dalianis T
Article: ACTA OTO-LARYNGOLOGICA. 2014;134(10):1094-1100
Management of the neck in node-positive tonsillar cancer
Marklund L; Lundberg B; Hammarstedt-Nordenvall L
Article: HEAD AND NECK. 2014;36(1):107-112
Presence of human papillomaviruses and p16 expression in hypopharyngeal cancer
Wendt M; Romanitan M; Nasman A; Dalianis T; Hammarstedt L; Marklund L; Ramqvist T; Munck-Wikland E
Article: CANCER MEDICINE. 2013;2(4):507-518
Absent/weak CD44 intensity and positive human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma indicates a very high survival
Nasman A; Nordfors C; Grun N; Munck-Wikland E; Ramqvist T; Marklund L; Lindquist D; Dalianis T
Article: EUROPEAN JOURNAL OF CANCER. 2013;49(11):2522-2530
CD8⁺ and CD4⁺ tumour infiltrating lymphocytes in relation to human papillomavirus status and clinical outcome in tonsillar and base of tongue squamous cell carcinoma
Nordfors C; Grun N; Tertipis N; Ahrlund-Richter A; Haeggblom L; Sivars L; Du J; Nyberg T; Marklund L; Munck-Wikland E; Nasman A; Ramqvist T; Dalianis T
Article: PLOS ONE. 2013;8(10):e77025
HLA Class I and II Expression in Oropharyngeal Squamous Cell Carcinoma in Relation to Tumor HPV Status and Clinical Outcome
Nasman A; Andersson E; Marklund L; Tertipis N; Hammarstedt-Nordenvall L; Attner P; Nyberg T; Masucci GV; Munck-Wikland E; Ramqvist T; Dalianis T
Article: INTERNATIONAL JOURNAL OF CANCER. 2012;131(5):1124-1130
Survival in patients with human papillomavirus positive tonsillar cancer in relation to treatment
Attner P; Nasman A; Du J; Hammarstedt L; Ramqvist T; Lindholm J; Munck-Wikland E; Dalianis T; Marklund L
Article: CANCER MEDICINE. 2012;1(1):82-88
Prevalence of human papillomavirus and survival in oropharyngeal cancer other than tonsil or base of tongue cancer
Marklund L; Nasman A; Ramqvist T; Dalianis T; Munck-Wikland E; Hammarstedt L
Article: PLOS ONE. 2012;7(6):e38711
Tumor Infiltrating CD8⁺ and Foxp3⁺ Lymphocytes Correlate to Clinical Outcome and Human Papillomavirus (HPV) Status in Tonsillar Cancer
Nasman A; Romanitan M; Nordfors C; Grun N; Johansson H; Hammarstedt L; Marklund L; Munck-Wikland E; Dalianis T; Ramqvist T
Article: HYDROGEOLOGY JOURNAL. 2011;19(8):1531-1543
The use of spectral analysis-based exact solutions to characterize topography-controlled groundwater flow
Marklund L; Worman A
Article: ORAL ONCOLOGY. 2011;47(7):636-641
Differential survival trends for patients with tonsillar, base of tongue and tongue cancer in Sweden
Hammarstedt L; Lu Y; Marklund L; Dalianis T; Munck-Wikland E; Ye W
Article: INTERNATIONAL JOURNAL OF CANCER. 2011;128(12):2892-2897
Human papillomavirus and survival in patients with base of tongue cancer
Attner P; Du J; Nasman A; Hammarstedt L; Ramqvist T; Lindholm J; Marklund L; Dalianis T; Munck-Wikland E
Article: JOURNAL OF ORAL PATHOLOGY & MEDICINE. 2011;40(5):385-389
Cyclooxygenase-2 expression in oral tongue squamous cell carcinoma
Ryott M; Marklund L; Wangsa D; Elmberger G; Munck-Wikland E
Article: JOURNAL OF ONCOLOGY. 2011;2011:509036-6
Impact of HPV in Oropharyngeal Cancer.
Marklund L; Hammarstedt L
Article: INTERNATIONAL JOURNAL OF CANCER. 2010;126(12):2879-2884
The role of human papillomavirus in the increased incidence of base of tongue cancer
Attner P; Du J; Nasman A; Hammarstedt L; Ramqvist T; Lindholm J; Marklund L; Dalianis T; Munck-Wikland E
Article: INTERNATIONAL JOURNAL OF CANCER. 2009;125(2):362-366
Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: An epidemic of viral-induced carcinoma?
Nasman A; Attner P; Hammarstedt L; Do J; Eriksson M; Giraud G; Ahrlund-Richter S; Marklund L; Romanitan M; Lindquist D; Ramqvist T; Lindholm J; Sparen P; Ye W; Dahistrand H; Munck-Wikland E; Dalianis T
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2009;27(15_suppl):6030
Frequency of HPV-associated tonsillar cancer in Sweden
Attner P; Näsman A; Marklund L; Hammarstedt L; Lindholm J; Ramquist T; Dalianis T; Munck-Wikland E
Article: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2004;94(5):245-251
Cellular potassium ion deprivation enhances apoptosis induced by cisplatin.
Marklund L; Andersson B; Behnam-Motlagh P; Sandström P-E; Henriksson R; Grankvist K
Journal article: EJC SUPPLEMENTS. 2003;1(5):s186
620 Cellular potassium ion deprivation may enhance apoptosis induced by cisplatin
Grankvist K; Behnam-Motlagh P; Sandstrom P-E; Henriksson R; Marklund L
Article: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2001;48(6):781-786
Bumetanide annihilation of amphotericin B-induced apoptosis and cytotoxicity is due to its effect on cellular K+ flux.
Marklund L; Behnam-Motlagh P; Henriksson R; Grankvist K
Article: INTERNATIONAL JOURNAL OF CANCER. 2001;93(4):577-583
Cisplatin-induced apoptosis of mesothelioma cells is affected by potassium ion flux modulator amphotericin B and bumetanide.
Marklund L; Henriksson R; Grankvist K
Journal article: EUROPEAN JOURNAL OF CANCER. 2001;37:s360
Cisplatin-induced apoptosis of mesothelioma cells is affected by potassium ion flux modulator amphotericin b and bumetanide
Grankvist K; Henriksson R; Marklund L
Article: LIFE SCIENCES. 2000;66(23):PL319-PL324
Amphotericin B-induced apoptosis and cytotoxicity is prevented by the Na+, K+, 2Cl(-)-cotransport blocker bumetanide.
Marklund L; Henriksson R; Grankvist K
Journal article: EUROPEAN JOURNAL OF CANCER. 1999;35:s109
K+-efflux modulation of cisplatin-induced apoptosis and cytotoxicity to cultured mesothelioma cells
Marklund L; Henriksson R; Grankvist K
Journal article: EUROPEAN UROLOGY. 1998;33 Suppl 3:16-19
Self-esteem in children with nocturnal enuresis and urinary incontinence: improvement of self-esteem after treatment.
Hägglöf B; Andrén O; Bergström E; Marklund L; Wendelius M
Journal article: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, SUPPLEMENT. 1997;183:79-82
Self-esteem before and after treatment in children with nocturnal enuresis and urinary incontinence.
Hägglöf B; Andrén O; Bergström E; Marklund L; Wendelius M
Show more

All other publications

Conference publication: 2023;:a1044
941 Tumour draining lymph nodes contain immunosuppressive B cell phenotypes
Piersiala K; Lagebro V; Hjalmarsson E; Neves da Silva PF; Kolev A; Starkhammar M; Elliot A; Marklund L; Munck-Wikland E; Margolin G; Georén SK; Cardell L
Conference publication: ANTICANCER RESEARCH. 2014;34(10):5872-5873
HUMAN PAPILLOMAVIRUS (HPV) AND OTHER BIOMARKERS FOR PREDICTION OF CLINICAL OUTCOME IN OROPHARYNGEAL SQUAMOUS CELL CARCINOMA (OPSCC)
Nasman A; Nordfors C; Tertipis N; Grun N; Du J; Ahrlund-Richter A; Haeggblom L; Sivars L; Vlastos A; Lindquist D; Nordvall LH; Marklund L; Munck-Wikland E; Ramqvist T; Dalianis T
Corrigendum: INTERNATIONAL JOURNAL OF CANCER. 2012;131(9):e1183
Survival in patients with human papillomavirus positive tonsillar cancer in relation to treatment (vol 131, pg 1124, 2012)
Attner P; Naesman A; Du J; Hammarstedt L; Ramqvist T; Lindholm J; Munck-Wikland E; Dalianis T; Marklund L
Corrigendum: INTERNATIONAL JOURNAL OF CANCER. 2012;131(9):e1182
Human papillomavirus and survival in patients with base of tongue cancer (vol 128, pg 2892, 2011)
Attner P; Du J; Naesman A; Hammarstedt L; Ramqvist T; Lindholm J; Marklund L; Dalianis T; Munck-Wikland E
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2009;27(15)
Frequency of HPV-associated tonsillar cancer in Sweden
Attner P; Nasman A; Marklund L; Hammarstedt L; Lindholm J; Ramquist T; Dalianis T; Munck-Wikland E

Employments

Affiliated to Research, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2023-2025

Degrees and Education

Docent, Karolinska Institutet, 2020

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI