Lina Wik

Publications
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Articles

Article: CANCERS. 2021;13(5):1175
CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma
Su Y; Tsagkozis P; Papakonstantinou A; Tobin NP; Gultekin O; Malmerfelt A; Ingelshed K; Neo SY; Lundquist J; Chaabane W; Nisancioglu MH; Leiss LW; Ostman A; Bergh J; Sedimbi S; Lehti K; Lundqvist A; Stragliotto CL; Haglund F; Ehnman M
Article: GLIA. 2020;68(5):979-988
Platelet-derived growth factor receptor α/glial fibrillary acidic protein expressing peritumoral astrocytes associate with shorter median overall survival in glioblastoma patients
Leiss L; Mega A; Bontell TO; Nister M; Smits A; Corvigno S; Rahman MA; Enger PO; Miletic H; Ostman A
Article: GLIA. 2020;68(2):316-327
Astrocytes enhance glioblastoma growth
Mega A; Nilsen MH; Leiss LW; Tobin NP; Miletic H; Sleire L; Strell C; Nelander S; Krona C; Hagerstrand D; Enger PO; Nister M; Ostman A
Article: SCIENTIFIC REPORTS. 2020;10(1):281
Fibroblasts in urothelial bladder cancer define stroma phenotypes that are associated with clinical outcome
Mezheyeuski A; Segersten U; Leiss LW; Malmstrom P-U; Hatina J; Ostman A; Strell C
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1913:3-11
Double Immunohistochemistry and Digital Image Analysis.
Moreno-Ruiz P; Wik Leiss L; Mezheyeuski A; Ehnman M
Article: ISCIENCE. 2018;9:71-83
Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity
Wallmann T; Zhang X-M; Wallerius M; Bolin S; Joly A-L; Sobocki C; Leiss L; Jiang Y; Bergh J; Holland EC; Enger PO; Andersson J; Swartling FJ; Miletic H; Uhrbom L; Harris RA; Rolny C
Article: EXPERIMENTAL CELL RESEARCH. 2017;359(1):257-265
Single factors alone can induce mesenchymal-like morphology, but not promote full EMT in breast cancer cell lines with different hormone statuses.
Tveitarås MK; Reigstad I; Leiss L; Reed RK; Stuhr L
Article: ONCOTARGET. 2017;8(7):12145-12157
Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy.
Zhu H; Leiss L; Yang N; Rygh CB; Mitra SS; Cheshier SH; Weissman IL; Huang B; Miletic H; Bjerkvig R; Enger PØ; Li X; Wang J
Article: BMC CANCER. 2017;17(1):108
Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts.
Leiss L; Mutlu E; Øyan A; Yan T; Tsinkalovsky O; Sleire L; Petersen K; Rahman MA; Johannessen M; Mitra SS; Jacobsen HK; Talasila KM; Miletic H; Jonassen I; Li X; Brons NH; Kalland K-H; Wang J; Enger PØ
Article: NEURO-ONCOLOGY. 2016;18(12):1644-1655
EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.
Eskilsson E; Rosland GV; Talasila KM; Knappskog S; Keunen O; Sottoriva A; Foerster S; Solecki G; Taxt T; Jirik R; Fritah S; Harter PN; Välk K; Al Hossain J; Joseph JV; Jahedi R; Saed HS; Piccirillo SG; Spiteri I; Leiss L; Euskirchen P; Graziani G; Daubon T; Lund-Johansen M; Enger PØ; Winkler F; Ritter CA; Niclou SP; Watts C; Bjerkvig R; Miletic H
Article: BMC CANCER. 2016;16:657
Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models.
Netland IA; Førde HE; Sleire L; Leiss L; Rahman MA; Skeie BS; Gjerde CH; Enger PØ; Goplen D
Article: JOURNAL OF NEURO-ONCOLOGY. 2016;129(1):57-66
Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats.
Netland IA; Førde HE; Sleire L; Leiss L; Rahman MA; Skeie BS; Miletic H; Enger PØ; Goplen D
Article: ONCOGENE. 2015;34(49):5951-5959
Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc^-, leading to glutathione depletion
Sleire L; Skeie BS; Netland IA; Forde HE; Dodoo E; Selheim F; Leiss L; Heggdal JI; Pedersen P-H; Wang J; Enger PO
Article: JOURNAL OF IMMUNOLOGY. 2014;193(12):6192-6206
NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival.
Gras Navarro A; Kmiecik J; Leiss L; Zelkowski M; Engelsen A; Bruserud Ø; Zimmer J; Enger PØ; Chekenya M
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2014;12:278
A co-culture model with brain tumor-specific bioluminescence demonstrates astrocyte-induced drug resistance in glioblastoma.
Yang N; Yan T; Zhu H; Liang X; Leiss L; Sakariassen PØ; Skaftnesmo KO; Huang B; Costea DE; Enger PØ; Li X; Wang J
Article: CANCER CELL INTERNATIONAL. 2014;14(1):541
A novel GFP nude rat model to investigate tumor-stroma interactions.
Yang N; Huang B; Tsinkalovsky O; Brekkå N; Zhu H; Leiss L; Enger PØ; Li X; Wang J
Article: BMC CANCER. 2011;11:524
Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide.
Yan T; Skaftnesmo KO; Leiss L; Sleire L; Wang J; Li X; Enger PØ

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Review: PHARMACOLOGICAL RESEARCH. 2017;124:74-91
Drug repurposing in cancer.
Sleire L; Førde HE; Netland IA; Leiss L; Skeie BS; Enger PØ

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