Lilly Schwieler

Publications
CV
Public outreach and news

Articles

Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2023;111:376-385
Immunological protein profiling of first-episode psychosis patients identifies CSF and blood biomarkers correlating with disease severity
Eren F; Schwieler L; Orhan F; Malmqvist A; Piehl F; Cervenka S; Sellgren CM; Fatouros-Bergman H; Engberg G; Erhardt S
Article: PSYCHONEUROENDOCRINOLOGY. 2023;153:106110
Lipopolysaccharide-induced changes in the kynurenine pathway and symptoms of sickness behavior in humans
Balter LJT; Li X; Schwieler L; Erhardt S; Axelsson J; Olsson MJ; Lasselin J; Lekander M
Article: LEUKEMIA. 2023;37(4):888-900
Cognitive impairments correlate with increased central nervous system immune activation after allogeneic haematopoietic stem cell transplantation
Boberg E; Kadri N; Hagey DWW; Schwieler L; El Andaloussi S; Erhardt S; Iacobaeus E; Le Blanc K
Article: NATURE COMMUNICATIONS. 2022;13(1):6427
Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia
Gracias J; Orhan F; Horbeck E; Holmen-Larsson J; Khanlarkani N; Malwade S; Goparaju SK; Schwieler L; Demirel IS; Fu T; Fatourus-Bergman H; Pelanis A; Goold CP; Goulding A; Annerbrink K; Isgren A; Sparding T; Schalling M; Yanez VAC; Gopfert JC; Nilsson J; Brinkmalm A; Blennow K; Zetterberg H; Engberg G; Piehl F; Sheridan SD; Perlis RH; Cervenka S; Erhardt S; Landen M; Sellgren CM
Article: BRITISH JOURNAL OF NUTRITION. 2022;129(6):1-8
Two-day fasting affects kynurenine pathway with additional modulation of short-term whole-body cooling: a quasi-randomised crossover trial
Solianik R; Schwieler L; Trepci A; Erhardt S; Brazaitis M
Article: TRANSLATIONAL PSYCHIATRY. 2022;12(1):229
Identification of cerebrospinal fluid and serum metabolomic biomarkers in first episode psychosis patients
Shang P; Ho AM-C; Tufvesson-Alm M; Lindberg DR; Grant CW; Orhan F; Eren F; Bhat M; Engberg G; Schwieler L; Fatouros-Bergman H; Imbeault S; Iverson RM; Dasari S; Piehl F; Cervenka S; Sellgren CM; Erhardt S; Choi D-S
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2022;101:136-145
Peripheral and central kynurenine pathway abnormalities in major depression
Paul ER; Schwieler L; Erhardt S; Boda S; Trepci A; Kampe R; Asratian A; Holm L; Yngve A; Dantzer R; Heilig M; Hamilton JP; Samuelsson M
Article: MOLECULAR PSYCHIATRY. 2021;26(11):6820-6832
GRK3 deficiency elicits brain immune activation and psychosis
Sellgren CM; Imbeault S; Larsson MK; Oliveros A; Nilsson IAK; Codeluppi S; Orhan F; Bhat M; Tufvesson-Alm M; Gracias J; Kegel ME; Zheng Y; Faka A; Svedberg M; Powell SB; Caldwell S; Kamenski ME; Vawter MP; Schullman A; Goiny M; Svensson CI; Hokfelt T; Schalling M; Schwieler L; Cervenka S; Choi D-S; Landen M; Engberg G; Erhardt S
Article: ANTIOXIDANTS. 2021;10(9):1443
Vitamin C and E Treatment Blocks Changes in Kynurenine Metabolism Triggered by Three Weeks of Sprint Interval Training in Recreationally Active Elderly Humans
Wyckelsma VL; Trepci A; Schwieler L; Venckunas T; Brazaitis M; Kamandulis S; Paulauskas H; Gapeyeva H; Paasuke M; Gastaldello S; Imbeault S; Westerblad H; Erhardt S; Andersson DC
Article: JOURNAL OF NEUROINFLAMMATION. 2021;18(1):158
Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial
Millischer V; Heinzl M; Faka A; Resl M; Trepci A; Klammer C; Egger M; Dieplinger B; Clodi M; Schwieler L
Article: MICROORGANISMS. 2021;9(2):322
The Kynurenine Pathway is Differentially Activated in Children with Lyme Disease and Tick-Borne Encephalitis
Wickstrom R; Fowler A; Goiny M; Millischer V; Ygberg S; Schwieler L
Article: SCHIZOPHRENIA RESEARCH. 2021;228:118-123
Disrupted sensorimotor gating in first-episode psychosis patients is not affected by short-term antipsychotic treatment
Hedberg M; Imbeault S; Erhardt S; Schwieler L
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2021;43:52-62
Central levels of tryptophan metabolites in subjects with bipolar disorder
Trepci A; Sellgren CM; Palsson E; Brundin L; Khanlarkhani N; Schwieler L; Landen M; Erhardt S
Article: SCIENTIFIC REPORTS. 2021;11(1):1669
Differential effects on blood and cerebrospinal fluid immune protein markers and kynurenine pathway metabolites from aerobic physical exercise in healthy subjects
Isung J; Granqvist M; Trepci A; Huang J; Schwieler L; Kierkegaard M; Erhardt S; Jokinen J; Piehl F
Article: JOURNAL OF NEUROIMMUNOLOGY. 2020;349:577401
Repeated administration of LPS exaggerates amphetamine-induced locomotor response and causes learning deficits in mice
Tufvesson-Alm M; Imbeault S; Liu X-C; Zheng Y; Faka A; Choi D-S; Schwieler L; Engberg G; Erhardt S
Article: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. 2020;270(7):933-938
Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid
Johansson V; Erhardt S; Engberg G; Kegel M; Bhat M; Schwieler L; Blennow K; Zetterberg H; Cannon TD; Wetterberg L; Hultman CM; Landen M
Article: NATURE COMMUNICATIONS. 2020;11(1):4016
The genetic architecture of human brainstem structures and their involvement in common brain disorders
Elvsashagen T; Bahrami S; van der Meer D; Agartz I; Alnaes D; Barch DM; Baur-Streubel R; Bertolino A; Beyer MK; Blasi G; Borgwardt S; Boye B; Buitelaar J; Boen E; Celius EG; Cervenka S; Conzelmann A; Coynel D; Di Carlo P; Djurovic S; Eisenacher S; Espeseth T; Fatouros-Bergman H; Flyckt L; Franke B; Frei O; Gelao B; Harbo HF; Hartman CA; Haberg A; Heslenfeld D; Hoekstra PJ; Hogestol EA; Jonassen R; Jonsson EG; Kirsch P; Kloszewska I; Lagerberg TV; Landro NI; Le Hellard S; Lesch K-P; Maglanoc LA; Malt UF; Mecocci P; Melle I; Meyer-Lindenberg A; Moberget T; Nordvik JE; Nyberg L; O'Connell KS; Oosterlaan J; Papalino M; Papassotiropoulos A; Pauli P; Pergola G; Persson K; de Quervain D; Reif A; Rokicki J; van Rooij D; Shadrin AA; Schmidt A; Schwarz E; Selbaek G; Soininen H; Sowa P; Steen VM; Tsolaki M; Vellas B; Wang L; Westman E; Ziegler GC; Zink M; Andreassen OA; Westlye LT; Kaufmann T; Farde L; Flyckt L; Engberg G; Erhardt SS; Fatouros-Bergman H; Cervenka S; Schwieler L; Piehl F; Agartz I; Collste K; Victorsson P; Malmqvist A; Hedberg M; Orhan F; Sellgren CM
Article: BIOANALYSIS. 2020;12(6):379-392
A novel, robust method for quantification of multiple kynurenine pathway metabolites in the cerebrospinal fluid
Schwieler L; Trepci A; Krzyzanowski S; Hermansson S; Granqvist M; Piehl F; Venckunas T; Brazaitis M; Kamandulis S; Lindqvist D; Jones AD; Erhardt S; Brundin L
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2020;13:1178646920978241
Quantification of Plasma Kynurenine Metabolites Following One Bout of Sprint Interval Exercise
Trepci A; Imbeault S; Wyckelsma VL; Westerblad H; Hermansson S; Andersson DC; Piehl F; Venckunas T; Brazaitis M; Kamandulis S; Brundin L; Erhardt S; Schwieler L
Article: NATURE NEUROSCIENCE. 2019;22(10):1617-1623
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Kaufmann T; van der Meer D; Nhat TD; Schwarz E; Lund MJ; Agartz I; Alnaes D; Barch DM; Baur-Streubel R; Bertolino A; Bettella F; Beyer MK; Boen E; Borgwardt S; Brandt CL; Buitelaar J; Celius EG; Cervenka S; Conzelmann A; Cordova-Palomera A; Dale AM; de Quervain DJF; Carlo P; Djurovic S; Dorum ES; Eisenacher S; Elvsashagen T; Espeseth T; Fatouros-Bergman H; Flyckt L; Franke B; Frei O; Haatveit B; Haberg AK; Harbo HF; Hartman CA; Heslenfeld D; Hoekstra PJ; Hogestol EA; Jernigan TL; Jonassen R; Jonsson EG; Kirsch P; Ktoszewska I; Kolskar KK; Landro NI; Hellard S; Lesch K-P; Lovestone S; Lundervold A; Lundervold AJ; Maglanoc LA; Malt UF; Mecocci P; Melle I; Meyer-Lindenberg A; Moberget T; Norbom LB; Nordvik JE; Nyberg L; Oosterlaan J; Papalino M; Papassotiropoulos A; Pauli P; Pergola G; Persson K; Richard G; Rokicki J; Sanders A-M; Selbaek G; Shadrin AA; Smeland OB; Soininen H; Sowa P; Steen VM; Tsolaki M; Ulrichsen KM; Vellas B; Wang L; Westman E; Ziegler GC; Zink M; Andreassen OA; Westlye LT; Farde L; Flyckts L; Engberg G; Erhardt S; Fatouros-Bergmann H; Schwieler L; Piehl F; Collste K; Victorsson P; Malmqvist A; Hedberg M; Orhan F
Article: SCHIZOPHRENIA RESEARCH. 2019;210:221-227
Increased peripheral levels of TARC/CCL17 in first episode psychosis patients
Malmqvist A; Schwieler L; Orhan F; Fatouros-Bergman H; Bauer M; Flyckt L; Cervenka S; Engberg G; Piehl F; Erhardt S; Farde L; Flyckt L; Engberg G; Erhardt S; Fatouros-Bergman H; Cervenka S; Schwieler L; Piehl F; Agartz I; Collste K; Victorsson P; Malmqvist A; Hedberg M; Orhan F
Article: JAMA PSYCHIATRY. 2019;76(7):739-748
Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk
Alnaes D; Kaufmann T; van der Meer D; Cordova-Palomera A; Rokicki J; Moberget T; Bettella F; Agartz I; Barch DM; Bertolino A; Brandt CL; Cervenka S; Djurovic S; Nhat TD; Eisenacher S; Fatouros-Bergman H; Flyckt L; Di Giorgio A; Haatveit B; Jonsson EG; Kirsch P; Lund MJ; Meyer-Lindenberg A; Pergola G; Schwarz E; Smeland OB; Quarto T; Zink M; Andreassen OA; Westlye LT; Farde L; Collste K; Victorsson P; Engberg G; Erhardt S; Malmqvist A; Hedberg M; Orhan F; Sellgren CM; Schwieler L; Piehl F
Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):37
Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls
Sellgren CM; Gracias J; Jungholm O; Perlis RH; Engberg G; Schwieler L; Landen M; Erhardt S
Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):12
Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder
Schwarz E; Nhat TD; Pergola G; Westlye LT; Kaufmann T; Wolfers T; Brecheisen R; Quarto T; Ing AJ; Di Carlo P; Gurholt TP; Harms RL; Noirhomme Q; Moberget T; Agartz I; Andreassen OA; Bellani M; Bertolino A; Blasi G; Brambilla P; Buitelaar JK; Cervenka S; Flyckt L; Frangou S; Franke B; Hall J; Heslenfeld DJ; Kirsch P; McIntosh AM; Noethen MM; Papassotiropoulos A; de Quervain DJ-F; Rietschel M; Schumann G; Tost H; Witt SH; Zink M; Meyer-Lindenberg A; Bettella F; Brandt CL; Clarke T-K; Coynel D; Degenhardt F; Djurovic S; Eisenacher S; Fastenrath M; Fatouros-Bergman H; Forstner AJ; Frank J; Gambi F; Gelao B; Geschwind L; Di Giannantonio M; Di Giorgio A; Hartman CA; Heilmann-Heimbach S; Herms S; Hoekstra PJ; Hoffmann P; Hoogman M; Jonsson EG; Loos E; Maggioni E; Oosterlaan J; Papalino M; Rampino A; Romaniuk L; Selvaggi P; Sepede G; Sonderby IE; Spalek K; Sussmann JE; Thompson PM; Vasquez AA; Vogler C; Whalley H; Farde L; Flyckt L; Engberg G; Erhardt S; Fatouros-Bergman H; Cervenka S; Schwieler L; Agartz I; Collste K; Victorsson P; Malmqvist A; Hedberg M; Orhan F
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2019;12:1178646919891169
Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice
Peyton L; Oliveros A; Tufvesson-Alm M; Schwieler L; Starski P; Engberg G; Erhardt S; Choi D-S
Article: BIOLOGICAL PSYCHIATRY. 2018;84(9):644-654
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
van Erp TGM; Walton E; Hibar DP; Schmaal L; Jiang W; Glahn DC; Pearlson GD; Yao N; Fukunaga M; Hashimoto R; Okada N; Yamamori H; Bustillo JR; Clark VP; Agartz I; Mueller BA; Cahn W; de Zwarte SMC; Pol HEH; Kahn RS; Ophoff RA; van Haren NEM; Andreassen OA; Dale AM; Nhat TD; Gurholt TP; Hartberg CB; Haukvik UK; Jorgensen KN; Lagerberg TV; Melle I; Westlye LT; Gruber O; Kraemer B; Richter A; Zilles D; Calhoun VD; Crespo-Facorro B; Roiz-Santianez R; Tordesillas-Gutierrez D; Loughland C; Carr VJ; Catts S; Cropley VL; Fullerton JM; Green MJ; Henskens FA; Jablensky A; Lenroot RK; Mowry BJ; Michie PT; Pantelis C; Quide Y; Schall U; Scott RJ; Cairns MJ; Seal M; Tooney PA; Rasser PE; Cooper G; Weickert CS; Weickert TW; Morris DW; Hong E; Kochunov P; Beard LM; Gur RE; Gur RC; Satterthwaite TD; Wolf DH; Belger A; Brown GG; Ford JM; Macciardi F; Mathalon DH; O'Leary DS; Potkin SG; Preda A; Voyvodic J; Lim KO; McEwen S; Yang F; Tan Y; Tan S; Wang Z; Fan F; Chen J; Xiang H; Tang S; Guo H; Wan P; Wei D; Bockholt HJ; Ehrlich S; Wolthusen RPF; King MD; Shoemaker JM; Sponheim SR; De Haan L; Koenders L; Machielsen MW; van Amelsvoort T; Veltman DJ; Assogna F; Banaj N; de Rossi P; Iorio M; Piras F; Spalletta G; McKenna PJ; Pomarol-Clotet E; Salvador R; Corvin A; Donohoe G; Kelly S; Whelan CD; Dickie EW; Rotenberg D; Voineskos AN; Ciufolini S; Radua J; Dazzan P; Murray R; Marques TR; Simmons A; Borgwardt S; Egloff L; Harrisberger F; Riecher-Roessler A; Smieskova R; Alpert KI; Wang L; Jonsson EG; Koops S; Sommer IEC; Bertolino A; Bonvino A; Di Giorgio A; Neilson E; Mayer AR; Stephen JM; Kwon JS; Yun J-Y; Cannon DM; McDonald C; Lebedeva I; Tomyshev AS; Akhadov T; Kaleda V; Fatouros-Bergman H; Flyckt L; Busatto GF; Rosa PGP; Serpa MH; Zanetti MV; Hoschl C; Skoch A; Spaniel F; Tomecek D; Hagenaars SP; McIntosh AM; Whalley HC; Lawrie SM; Knoechel C; Oertel-Knoechel V; Staeblein M; Howells FM; Stein DJ; Temmingh HS; Uhlmann A; Lopez-Jaramillo C; Dima D; McMahon A; Faskowitz JI; Gutman BA; Jahanshad N; Thompson PM; Turner JA
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2018;138(5):432-440
Increased number of monocytes and plasma levels of MCP-1 and YKL-40 in first-episode psychosis
Orhan F; Schwieler L; Fatouros-Bergman H; Malmqvist A; Cervenka S; Collste K; Flyckt L; Farde L; Sellgren CM; Piehl F; Engberg G; Erhardt S
Article: NEUROPHARMACOLOGY. 2018;138:130-139
Importance of kynurenine 3-monooxygenase for spontaneous firing and pharmacological responses of midbrain dopamine neurons: L Check for Relevance for schizophrenia
Tufvesson-Alm M; Schwieler L; Schwarcz R; Goiny M; Erhardt S; Engberg G
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(22):E5154-E5163
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
Kong X-Z; Mathias SR; Guadalupe T; Glahn DC; Franke B; Crivello F; Tzourio-Mazoyer N; Fisher SE; Thompson PM; Francks C
Article: MOLECULAR PSYCHIATRY. 2018;23(5):1244-1250
CSF GABA is reduced in first-episode psychosis and associates to symptom severity
Orhan F; Fatouros-Bergman H; Goiny M; Malmqvist A; Piehl F; Cervenka S; Collste K; Victorsson P; Sellgren CM; Flyckt L; Erhardt S; Engberg G
Article: PSYCHOLOGICAL MEDICINE. 2018;48(1):82-94
Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium
Walton E; Hibar DP; van Erp TGM; Potkin SG; Roiz-Santianez R; Crespo-Facorro B; Suarez-Pinilla P; van Haren NEM; de Zwarte SMC; Kahn RS; Cahn W; Doan NT; Jorgensen KN; Gurholt TP; Agartz I; Andreassen OA; Westlye LT; Melle I; Berg AO; Morch-Johnsen L; Faerden A; Flyckt L; Fatouros-Bergman H; Jonsson EG; Hashimoto R; Yamamori H; Fukunaga M; Jahanshad N; De Rossi P; Piras F; Banaj N; Spalletta G; Gur RE; Gur RC; Wolf DH; Satterthwaite TD; Beard LM; Sommer IE; Koops S; Gruber O; Richter A; Kraemer B; Kelly S; Donohoe G; McDonald C; Cannon DM; Corvin A; Gill M; Di Giorgio A; Bertolino A; Lawrie S; Nickson T; Whalley HC; Neilson E; Calhoun VD; Thompson PM; Turner JA; Ehrlich S
Article: JOURNAL OF NEUROIMMUNOLOGY. 2017;313:1-9
LPS-induced cortical kynurenic acid and neurogranin-NFAT signaling is associated with deficits in stimulus processing during Pavlovian conditioning
Oliveros A; Wininger K; Sens J; Larsson MK; Liu XC; Choi S; Faka A; Schwieler L; Engberg G; Erhardt S; Choi DS
Article: MALARIA JOURNAL. 2017;16(1):303
Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria
Holmberg D; Franzen-Rohl E; Idro R; Opoka RO; Bangirana P; Sellgren CM; Wickstrom R; Farnert A; Schwieler L; Engberg G; John CC
Article: MOLECULAR PSYCHIATRY. 2017;22(6):850-856
Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [¹¹C]PBR28
Collste K; Plaven-Sigray P; Fatouros-Bergman H; Victorsson P; Schain M; Forsberg A; Amini N; Aeinehband S; Erhardt S; Halldin C; Flyckt L; Farde L; Cervenka S
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2017;135(5):439-447
Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium
Walton E; Hibar DP; van Erp TGM; Potkin SG; Roiz-Santianez R; Crespo-Facorro B; Suarez-Pinilla P; Van Haren NEM; de Zwarte SMC; Kahn RS; Cahn W; Doan NT; Jorgensen KN; Gurholt TP; Agartz I; Andreassen OA; Westlye LT; Melle I; Berg AO; Morch-Johnsen L; Faerden A; Flyckt L; Fatouros-Bergman H; Jonsson EG; Hashimoto R; Yamamori H; Fukunaga M; Preda A; De Rossi P; Piras F; Banaj N; Ciullo V; Spalletta G; Gur RE; Gur RC; Wolf DH; Satterthwaite TD; Beard LM; Sommer IE; Koops S; Gruber O; Richter A; Kraemer B; Kelly S; Donohoe G; McDonald C; Cannon DM; Corvin A; Gill M; Di Giorgio A; Bertolino A; Lawrie S; Nickson T; Whalley HC; Neilson E; Calhoun VD; Thompson PM; Turner JA; Ehrlich S
Article: PSYCHIATRY RESEARCH. 2017;247:105-112
Kynurenic acid and psychotic symptoms and personality traits in twins with psychiatric morbidity
Kegel ME; Johansson V; Wetterberg L; Bhat M; Schwieler L; Cannon TD; Schuppe-Koistinen I; Engberg G; Landen M; Hultman CM; Erhardt S
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2016;84(5):262-271
Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes
Orhan F; Bhat M; Sandberg K; Stahl S; Piehl F; Svensson C; Erhardt S; Schwieler L
Article: NEUROCHEMICAL RESEARCH. 2016;41(9):2243-2255
Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice
Larsson MK; Faka A; Bhat M; Imbeault S; Goiny M; Orhan F; Oliveros A; Stahl S; Liu XC; Choi DS; Sandberg K; Engberg G; Schwieler L; Erhardt S
Article: JOURNAL OF NEUROINFLAMMATION. 2016;13(1):51
Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients
Schwieler L; Samuelsson M; Frye MA; Bhat M; Schuppe-Koistinen I; Jungholm O; Johansson AG; Landen M; Sellgren CM; Erhardt S
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2015;40(2):126-133
Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia - significance for activation of the kynurenine pathway
Schwieler L; Larsson MK; Skogh E; Kegel ME; Orhan F; Abdelmoaty S; Finn A; Bhat M; Samuelsson M; Lundberg K; Dahl M-L; Sellgren C; Schuppe-Koistinen I; Svensson CI; Erhardt S; Engberg G
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2015;8:49-52
Chronic Antipsychotic Treatment in the Rat - Effects on Brain Interleukin-8 and Kynurenic Acid.
Larsson MK; Schwieler L; Goiny M; Erhardt S; Engberg G
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2014;36:80-89
Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment - Role of brain kynurenic acid
Liu X-C; Holtze M; Powell SB; Terrando N; Larsson MK; Persson A; Olsson SK; Orhan F; Kegel M; Asp L; Goiny M; Schwieler L; Engberg G; Karlsson H; Erhardt S
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2014;7:15-22
Imbalanced kynurenine pathway in schizophrenia.
Kegel ME; Bhat M; Skogh E; Samuelsson M; Lundberg K; Dahl M-L; Sellgren C; Schwieler L; Engberg G; Schuppe-Koistinen I; Erhardt S
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2013;6:89-96
Sustained elevation of kynurenic Acid in the cerebrospinal fluid of patients with herpes simplex virus type 1 encephalitis.
Atlas A; Franzen-Röhl E; Söderlund J; Jönsson EG; Samuelsson M; Schwieler L; Sköldenberg B; Engberg G
Article: JOURNAL OF INTERNAL MEDICINE. 2012;272(4):394-401
Elevated cerebrospinal fluid kynurenic acid levels in patients with tick-borne encephalitis
Holtze M; Mickiene A; Atlas A; Lindquist L; Schwieler L
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2012;37(1):53-57
Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls
Holtze M; Saetre P; Engberg G; Schwieler L; Werge T; Andreassen OA; Hall H; Terenius L; Agartz I; Jonsson EG; Schalling M; Erhardt S
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2009;12(4):501-512
Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: implications for schizophrenia
Olsson SK; Andersson AS; Linderholm KR; Holtze M; Nilsson-Todd LK; Schwieler L; Olsson E; Larsson K; Engberg G; Erhardt S
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2008;86(16):3674-3683
Induction of the Kynurenine Pathway by Neurotropic Influenza A Virus Infection
Holtze M; Asp L; Schwieler L; Engberg G; Karlsson H
Article: LIFE SCIENCES. 2008;83(5-6):170-175
Clozapine interacts with the glycine site of the NMDA receptor: Electrophysiological studies of dopamine neurons in the rat ventral tegmental area
Schwieler L; Linderholm KR; Nilsson-Todd LK; Erhardt S; Engberg G
Article: PHYSIOLOGY AND BEHAVIOR. 2007;92(1-2):203-209
The kynurenic acid hypothesis of schizophrenia
Erhardt S; Schwieler L; Nilsson L; Linderholm K; Engberg G
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2007;21(1):86-91
Acute psychotic symptoms in HIV-1 infected patients are associated with increased levels of kynurenic acid in cerebrospinal fluid
Atlas A; Gisslen M; Nordin C; Lindstrom L; Schwieler L
Article: SYNAPSE. 2006;59(5):290-298
Effects of COX-1 and COX-2 inhibitors on the firing of rat midbrain dopaminergic neurons - Possible involvement of endogenous kynurenic acid
Schwieler L; Erhardt S; Nilsson L; Linderholm K; Engberg G
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2005;8(3):329-339
Activation of noradrenergic locus coeruleus neurons by clozapine and haloperidol: involvement of glutamatergic mechanisms
Nilsson LK; Schwieler L; Engberg G; Linderholm KR; Erhardt S
Article: JOURNAL OF NEURAL TRANSMISSION. 2005;112(7):863-872
Prostaglandin-mediated control of rat brain kynurenic acid synthesis - opposite actions by COX-1 and COX-2 isoforms
Schwieler L; Erhardt S; Erhardt C; Engberg G
Article: BIOLOGICAL PSYCHIATRY. 2004;56(4):255-260
Endogenous kynurenic acid disrupts prepulse inhibition
Erhardt S; Schwieler L; Emanuelsson C; Geyer M
Article: SYNAPSE. 2004;52(2):114-122
Clozapine modulates midbrain dopamine neuron firing via interaction with the NMDA receptor complex
Schwieler L; Engberg G; Erhardt S
Article: NEUROPSYCHOPHARMACOLOGY. 2003;28(10):1770-1777
Inhibitory action of clozapine on rat ventral tegmental area dopamine neurons following increased levels of endogenous kynurenic acid
Schwieler L; Erhardt S
Article: LIFE SCIENCES. 2003;72(24):2793-2801
The anaesthetic agent propofol interacts with GABA_B-receptors:: an electrophysiological study in rat
Schwieler L; Delbro DS; Engberg G; Erhardt S
Article: SYNAPSE. 2002;43(4):227-237
Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine
Erhardt S; Schwieler L; Engberg L
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Corrigendum: MOLECULAR PSYCHIATRY. 2022;27(3):1855
GRK3 deficiency elicits brain immune activation and psychosis (May, 10.1038/s41380-021-01106-0, 2021)
Sellgren CM; Imbeault S; Larsson MK; Oliveros A; Nilsson IAK; Codeluppi S; Orhan F; Bhat M; Tufvesson-Alm M; Gracias J; Kegel ME; Zheng Y; Faka A; Svedberg M; Powell SB; Caldwell S; Kamenski ME; Vawter MP; Schulmann A; Goiny M; Svensson CI; Hokfelt T; Schalling M; Schwieler L; Cervenka S; Choi D-S; Landen M; Engberg G; Erhardt S
Letter: SCHIZOPHRENIA RESEARCH. 2019;208:490-492
Neurogranin as a potential synaptic marker in the cerebrospinal fluid of patients with a first episode psychosis
Santillo AF; Lundgren S; Xu C; Orhan F; Fatouros-Bergman H; Blennow K; Zetterberg H; Portelius E; Cervenka S; Jonsson EG; Erhardt S; Engberg G
Letter: BIOLOGICAL PSYCHIATRY. 2019;85(7):e35-e39
Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?
van Erp TGM; Walton E; Hibar DP; Schmaal L; Jiang W; Glahn DC; Pearlson GD; Yao N; Fukunaga M; Hashimoto R; Okada N; Yamamori H; Clark VP; Mueller BA; de Zwarte SMC; Ophoff RA; van Haren NEM; Andreassen OA; Gurholt TP; Gruber O; Kraemer B; Richter A; Calhoun VD; Crespo-Facorro B; Roiz-Santianez R; Tordesillas-Gutierrez D; Loughland C; Catts S; Fullerton JM; Green MJ; Henskens F; Jablensky A; Mowry BJ; Pantelis C; Quide Y; Schall U; Scott RJ; Cairns MJ; Seal M; Tooney PA; Rasser PE; Cooper G; Weickert CS; Weickert TW; Hong E; Kochunov P; Gur RE; Gur RC; Ford JM; Macciardi F; Mathalon DH; Potkin SG; Preda A; Fan F; Ehrlich S; King MD; De Haan L; Veltman DJ; Assogna F; Banaj N; de Rossi P; Iorio M; Piras F; Spalletta G; Pomarol-Clotet E; Kelly S; Ciufolini S; Radua J; Murray R; Marques TR; Simmons A; Borgwardt S; Schoenborn-Harrisberger F; Riecher-Roessler A; Smieskova R; Alpert KI; Bertolino A; Bonvino A; Di Giorgio A; Neilson E; Mayer AR; Yun J-Y; Cannon DM; Lebedeva I; Tomyshev AS; Akhadov T; Kaleda V; Fatouros-Bergman H; Flyckt L; Rosa PGP; Serpa MH; Zanetti MV; Hoschl C; Skoch A; Spaniel F; Tomecek D; McIntosh AM; Whalley HC; Knoechel C; Oertel-Knoechel V; Howells FM; Stein DJ; Temmingh HS; Uhlmann A; Lopez-Jaramillo C; Dima D; Faskowitz JI; Gutman BA; Jahanshad N; Thompson PM; Turner JA; Farde L; Flyckt L; Fatouros-Bergman H; Cervenka S; Collste K; Victorsson P; Engberg G; Erhardt S; Schwieler L; Malmqvist A; Hedberg M; Orhan F; Piehl F; Agartz I
Letter: SCHIZOPHRENIA RESEARCH. 2018;199:438-441
Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients
Checa A; Malmqvist A; Flyckt L; Schwieler L; Samuelsson M; Skogh E; Cervenka S; Dahl M-L; Piehl F; Erhardt S; Wheelock CE
Review: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2018;90:212-220
Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression
Price JB; Bronars C; Erhardt S; Cullen KR; Schwieler L; Berk M; Walder K; McGee SL; Frye MA; Tye SJ
Letter: SCHIZOPHRENIA RESEARCH. 2018;195:406-408
First-episode psychosis patients display increased plasma IL-18 that correlates with cognitive dysfunction
Orhan F; Fatouros-Bergman H; Schwieler L; Cervenka S; Flyckt L; Sellgren CM; Engberg G; Erhardt S
Review: NEUROPHARMACOLOGY. 2017;112(Pt B):297-306
The kynurenine pathway in schizophrenia and bipolar disorder
Erhardt S; Schwieler L; Imbeault S; Engberg G
Letter: SCHIZOPHRENIA RESEARCH. 2011;127(1-3):270-272
Kynurenine 3-monooxygenase (KMO) polymorphisms in schizophrenia: An association study
Holtze M; Saetre P; Erhardt S; Schwieler L; Werge T; Hansen T; Nielsen J; Djurovic S; Melle I; Andreassen OA; Hall H; Terenius L; Agartz I; Engberg G; Jonsson EG; Schalling M
Thesis / dissertation: 2006
Endogenous kynurenic acid and schizophrenia : physiological and pharmacological aspects
Schwieler, Lilly
Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2003;527:155-165
Kynurenic acid and schizophrenia
Erhardt S; Schwieler L; Engberg G

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Affiliated to Research, Department of Physiology and Pharmacology, Karolinska Institutet, 2024-2025

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Docent, Karolinska Institutet, 2021
Doctor Of Philosophy, Department of Physiology and Pharmacology, Karolinska Institutet, 2006

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