Likun Du

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Articles

Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(3):471-483

Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome.

Abolhassani H; Landegren N; Bastard P; Materna M; Modaresi M; Du L; Aranda-Guillén M; Sardh F; Zuo F; Zhang P; Marcotte H; Marr N; Khan T; Ata M; Al-Ali F; Pescarmona R; Belot A; Béziat V; Zhang Q; Casanova J-L; Kämpe O; Zhang S-Y; Hammarström L; Pan-Hammarström Q
Article: BMC MEDICINE. 2022;20(1):102

Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant.

Schubert M; Bertoglio F; Steinke S; Heine PA; Ynga-Durand MA; Maass H; Sammartino JC; Cassaniti I; Zuo F; Du L; Korn J; Milošević M; Wenzel EV; Krstanović F; Polten S; Pribanić-Matešić M; Brizić I; Baldanti F; Hammarström L; Dübel S; Šustić A; Marcotte H; Strengert M; Protić A; Piralla A; Pan-Hammarström Q; Čičin-Šain L; Hust M
Article: ISCIENCE. 2022;25(2):103743

Immunity to SARS-CoV-2 up to 15 months after infection.

Marcotte H; Piralla A; Zuo F; Du L; Cassaniti I; Wan H; Kumagai-Braesh M; Andréll J; Percivalle E; Sammartino JC; Wang Y; Vlachiotis S; Attevall J; Bergami F; Ferrari A; Colaneri M; Vecchia M; Sambo M; Zuccaro V; Asperges E; Bruno R; Oggionni T; Meloni F; Abolhassani H; Bertoglio F; Schubert M; Calzolai L; Varani L; Hust M; Xue Y; Hammarström L; Baldanti F; Pan-Hammarström Q
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(1):1-9

X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia.

Abolhassani H; Vosughimotlagh A; Asano T; Landegren N; Boisson B; Delavari S; Bastard P; Aranda-Guillén M; Wang Y; Zuo F; Sardh F; Marcotte H; Du L; Zhang S-Y; Zhang Q; Rezaei N; Kämpe O; Casanova J-L; Hammarström L; Pan-Hammarström Q
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;149(1):65-75.e8

SARS-CoV-2-specific B- and T-cell immunity in a population-based study of young Swedish adults.

Björkander S; Du L; Zuo F; Ekström S; Wang Y; Wan H; Sherina N; Schoutens L; Andréll J; Andersson N; Georgelis A; Bergström A; Marcotte H; Kull I; Hammarström L; Melén E; Pan-Hammarström Q; BAMSE COVID-19 study group
Article: CELL DEATH & DISEASE. 2021;12(5):419

Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma.

Nie M; Du L; Ren W; Joung J; Ye X; Shi X; Ciftci S; Liu D; Wu K; Zhang F; Pan-Hammarström Q
Article: MED. 2021;2(3):281-295.e4

Persistence of SARS-CoV-2-specific B and T cell responses in convalescent COVID-19 patients 6-8 months after the infection.

Sherina N; Piralla A; Du L; Wan H; Kumagai-Braesch M; Andréll J; Braesch-Andersen S; Cassaniti I; Percivalle E; Sarasini A; Bergami F; Di Martino R; Colaneri M; Vecchia M; Sambo M; Zuccaro V; Bruno R; Sachs M; Oggionni T; Meloni F; Abolhassani H; Bertoglio F; Schubert M; Byrne-Steele M; Han J; Hust M; Xue Y; Hammarström L; Baldanti F; Marcotte H; Pan-Hammarström Q
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2020;217(11):e20191688

Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome.

Helfricht A; Thijssen PE; Rother MB; Shah RG; Du L; Takada S; Rogier M; Moritz J; IJspeert H; Stoepker C; van Ostaijen-Ten Dam MM; Heyer V; Luijsterburg MS; de Groot A; Jak R; Grootaers G; Wang J; Rao P; Vertegaal ACO; van Tol MJD; Pan-Hammarström Q; Reina-San-Martin B; Shah GM; van der Burg M; van der Maarel SM; van Attikum H
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2020;146(5):1109-1120.e4

APRIL-dependent lifelong plasmacyte maintenance and immunoglobulin production in humans.

Yeh T-W; Okano T; Naruto T; Yamashita M; Okamura M; Tanita K; Du L; Pan-Hammarström Q; Mitsuiki N; Okada S; Kanegane H; Imai K; Morio T
Article: STEM CELL RESEARCH. 2019;41:101613

Generation of human induced pluripotent stem cell lines from patients with selective IgA deficiency.

Arias-Fuenzalida J; Yu J; Du L; Custodio J; Notarangelo LD; Hammarström L; Pan-Hammarström Q
Article: STEM CELL RESEARCH. 2019;41:101612

Generation of a human induced pluripotent stem cell line (PHAi003) from a primary immunodeficient patient with CD70 mutation.

Arias-Fuenzalida J; Yu J; Abolhassani H; Du L; Custodio J; Pan-Hammarström Q
Article: NATURE COMMUNICATIONS. 2018;9(1):1006

The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining.

Li C; Irrazabal T; So CC; Berru M; Du L; Lam E; Ling AK; Gommerman JL; Pan-Hammarström Q; Martin A
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;141(1):408-411.e8

Reduced immunoglobulin gene diversity in patients with Cornelia de Lange syndrome.

Björkman A; Du L; van der Burg M; Cormier-Daire V; Borck G; Pié J; Anderlid B-M; Hammarström L; Ström L; de Villartay J-P; Kipling D; Dunn Walters D; Pan-Hammarström Q
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(3):623-637

EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay.

Volpi S; Yamazaki Y; Brauer PM; van Rooijen E; Hayashida A; Slavotinek A; Sun Kuehn H; Di Rocco M; Rivolta C; Bortolomai I; Du L; Felgentreff K; Ott de Bruin L; Hayashida K; Freedman G; Marcovecchio GE; Capuder K; Rath P; Luche N; Hagedorn EJ; Buoncompagni A; Royer-Bertrand B; Giliani S; Poliani PL; Imberti L; Dobbs K; Poulain FE; Martini A; Manis J; Linhardt RJ; Bosticardo M; Rosenzweig SD; Lee H; Puck JM; Zúñiga-Pflücker JC; Zon L; Park PW; Superti-Furga A; Notarangelo LD
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(1):91-106

Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.

Abolhassani H; Edwards ESJ; Ikinciogullari A; Jing H; Borte S; Buggert M; Du L; Matsuda-Lennikov M; Romano R; Caridha R; Bade S; Zhang Y; Frederiksen J; Fang M; Bal SK; Haskologlu S; Dogu F; Tacyildiz N; Matthews HF; McElwee JJ; Gostick E; Price DA; Palendira U; Aghamohammadi A; Boisson B; Rezaei N; Karlsson AC; Lenardo MJ; Casanova J-L; Hammarström L; Tangye SG; Su HC; Pan-Hammarström Q
Article: SCIENCE IMMUNOLOGY. 2016;1(6):eaah6109

Characterization of T and B cell repertoire diversity in patients with RAG deficiency.

Lee YN; Frugoni F; Dobbs K; Tirosh I; Du L; Ververs FA; Ru H; Ott de Bruin L; Adeli M; Bleesing JH; Buchbinder D; Butte MJ; Cancrini C; Chen K; Choo S; Elfeky RA; Finocchi A; Fuleihan RL; Gennery AR; El-Ghoneimy DH; Henderson LA; Al-Herz W; Hossny E; Nelson RP; Pai S-Y; Patel NC; Reda SM; Soler-Palacin P; Somech R; Palma P; Wu H; Giliani S; Walter JE; Notarangelo LD
Article: BLOOD. 2016;128(6):783-793

Modeling altered T-cell development with induced pluripotent stem cells from patients with RAG1-dependent immune deficiencies.

Brauer PM; Pessach IM; Clarke E; Rowe JH; Ott de Bruin L; Lee YN; Dominguez-Brauer C; Comeau AM; Awong G; Felgentreff K; Zhang YH; Bredemeyer A; Al-Herz W; Du L; Ververs F; Kennedy M; Giliani S; Keller G; Sleckman BP; Schatz DG; Bushman FD; Notarangelo LD; Zúñiga-Pflücker JC
Article: JOURNAL OF IMMUNOLOGY. 2015;195(12):5608-5615

DNA-PKcs Is Involved in Ig Class Switch Recombination in Human B Cells.

Björkman A; Du L; Felgentreff K; Rosner C; Pankaj Kamdar R; Kokaraki G; Matsumoto Y; Davies EG; van der Burg M; Notarangelo LD; Hammarström L; Pan-Hammarström Q
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2015;136(1):140-U276

Functional analysis of naturally occurring DCLRE1C mutations and correlation with the clinical phenotype of ARTEMIS deficiency.

Felgentreff K; Lee YN; Frugoni F; Du L; van der Burg M; Giliani S; Tezcan I; Reisli I; Mejstrikova E; de Villartay J-P; Sleckman BP; Manis J; Notarangelo LD
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2015;212(6):939-951

Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia.

Boisson B; Laplantine E; Dobbs K; Cobat A; Tarantino N; Hazen M; Lidov HGW; Hopkins G; Du L; Belkadi A; Chrabieh M; Itan Y; Picard C; Fournet J-C; Eibel H; Tsitsikov E; Pai S-Y; Abel L; Al-Herz W; Casanova J-L; Israel A; Notarangelo LD
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(7):2157-2162

Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells.

Björkman A; Qvist P; Du L; Bartish M; Zaravinos A; Georgiou K; Børglum AD; Gatti RA; Törngren T; Pan-Hammarström Q
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(24):8889-8894

Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells.

Felgentreff K; Du L; Weinacht KG; Dobbs K; Bartish M; Giliani S; Schlaeger T; DeVine A; Schambach A; Woodbine LJ; Davies G; Baxi SN; van der Burg M; Bleesing J; Gennery A; Manis J; Pan-Hammarström Q; Notarangelo LD
Article: MUCOSAL IMMUNOLOGY. 2014;7(3):511-520

IgA subclass switch recombination in human mucosal and systemic immune compartments.

Lin M; Du L; Brandtzaeg P; Pan-Hammarström Q
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2013;210(12):2503-2513

A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination.

Enervald E; Du L; Visnes T; Björkman A; Lindgren E; Wincent J; Borck G; Colleaux L; Cormier-Daire V; van Gent DC; Pie J; Puisac B; de Miranda NF; Kracker S; Hammarström L; de Villartay J-P; Durandy A; Schoumans J; Ström L; Pan-Hammarström Q
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2012;90(6):986-1001

Deleterious mutations in LRBA are associated with a syndrome of immune deficiency and autoimmunity.

Lopez-Herrera G; Tampella G; Pan-Hammarström Q; Herholz P; Trujillo-Vargas CM; Phadwal K; Simon AK; Moutschen M; Etzioni A; Mory A; Srugo I; Melamed D; Hultenby K; Liu C; Baronio M; Vitali M; Philippet P; Dideberg V; Aghamohammadi A; Rezaei N; Enright V; Du L; Salzer U; Eibel H; Pfeifer D; Veelken H; Stauss H; Lougaris V; Plebani A; Gertz EM; Schäffer AA; Hammarström L; Grimbacher B
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2012;209(2):291-305

Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis.

Du L; Peng R; Björkman A; Filipe de Miranda N; Rosner C; Kotnis A; Berglund M; Liu C; Rosenquist R; Enblad G; Sundström C; Hojjat-Farsangi M; Rabbani H; Teixeira MR; Revy P; Durandy A; Zeng Y; Gennery AR; de Villartay J-P; Pan-Hammarström Q
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2009;29(6):777-785

Novel mutations in TACI (TNFRSF13B) causing common variable immunodeficiency.

Mohammadi J; Liu C; Aghamohammadi A; Bergbreiter A; Du L; Lu J; Rezaei N; Amirzargar AA; Moin M; Salzer U; Pan-Hammarström Q; Hammarström L
Article: PLOS ONE. 2009;4(5):e5427

CD27(-) B-cells produce class switched and somatically hyper-mutated antibodies during chronic HIV-1 infection.

Cagigi A; Du L; Dang LVP; Grutzmeier S; Atlas A; Chiodi F; Pan-Hammarström Q; Nilsson A
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2008;205(13):3031-3040

Involvement of Artemis in nonhomologous end-joining during immunoglobulin class switch recombination.

Du L; van der Burg M; Popov SW; Kotnis A; van Dongen JJM; Gennery AR; Pan-Hammarström Q
Article: PLOS ONE. 2008;3(6):e2482

A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation.

Du L; Dunn-Walters DK; Chrzanowska KH; Stankovic T; Kotnis A; Li X; Lu J; Eggertsen G; Brittain C; Popov SW; Gennery AR; Taylor AMR; Pan-Hammarström Q
Article: BMC IMMUNOLOGY. 2008;9:3

Screening of functional and positional candidate genes in families with common variable immunodeficiency.

Salzer U; Neumann C; Thiel J; Woellner C; Pan-Hammarström Q; Lougaris V; Hagena T; Jung J; Birmelin J; Du L; Metin A; Webster DA; Plebani A; Moschese V; Hammarström L; Schäffer AA; Grimbacher B
Article: INFECTION AND IMMUNITY. 2007;75(11):5118-5126

Expression of Helicobacter pylori virulence factors and associated expression profiles of inflammatory genes in the human gastric mucosa.

Wen S; Velin D; Felley CP; Du L; Michetti P; Pan-Hammarström Q
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2007;204(5):1207-1216

A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair.

Péron S; Pan-Hammarström Q; Imai K; Du L; Taubenheim N; Sanal O; Marodi L; Bergelin-Besançon A; Benkerrou M; de Villartay J-P; Fischer A; Revy P; Durandy A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(17):7193-7198

Role for Msh5 in the regulation of Ig class switch recombination.

Sekine H; Ferreira RC; Pan-Hammarström Q; Graham RR; Ziemba B; de Vries SS; Liu J; Hippen K; Koeuth T; Ortmann W; Iwahori A; Elliott MK; Offer S; Skon C; Du L; Novitzke J; Lee AT; Zhao N; Tompkins JD; Altshuler D; Gregersen PK; Cunningham-Rundles C; Harris RS; Her C; Nelson DL; Hammarström L; Gilkeson GS; Behrens TW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2006;203(1):99-110

Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation.

Pan-Hammarström Q; Lähdesmäki A; Zhao Y; Du L; Zhao Z; Wen S; Ruiz-Perez VL; Dunn-Walters DK; Goodship JA; Hammarström L
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KI thesis / dissertation: 2011

Role of DNA repair in class switch recombination and somatic hypermutation

Du, Likun
Review: ADVANCES IN IMMUNOLOGY, VOL 150. 2010;108:45-109

Mapping of switch recombination junctions, a tool for studying DNA repair pathways during immunoglobulin class switching.

Stavnezer J; Björkman A; Du L; Cagigi A; Pan-Hammarström Q
Review: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 2009;364(1517):653-665

Non-homologous end joining in class switch recombination: the beginning of the end.

Kotnis A; Du L; Liu C; Popov SW; Pan-Hammarström Q
Letter: NATURE GENETICS. 2007;39(4):429-430

Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency.

Pan-Hammarström Q; Salzer U; Du L; Björkander J; Cunningham-Rundles C; Nelson DL; Bacchelli C; Gaspar HB; Offer S; Behrens TW; Grimbacher B; Hammarström L

Employments

Laboratory Coordinator, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2023-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2011

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